discovery

How an expedition to Arunachal Pradesh led to the discovery of a new tortoise species

If it were easy it wouldn't be an expedition. A team of Bengaluru-based wildlife researchers embarked on a mission to distant forest in Arunachal Pradesh, confronted hardship and turned lucky when they chanced upon two individuals (a male and a female)




discovery

HCV. Volume II [Electronic book] : the journey from discovery to a cure / Michael J. Sofia, editor.

Cham : Springer, 2020.




discovery

HCV [Electronic book] : the journey from discovery to a cure.

[S.l.] : SPRINGER NATURE, 2020.




discovery

Deendayal West Discovery

Deendayal West Discovery




discovery

The Doctrine of discovery: unmasking the domination code

Hayden Library - KF8205.D638 2015




discovery

Drug discovery and development : technology in transition / edited by H. P. Rang ; foreword by Daniel Vasella




discovery

Molecular pathology in drug discovery and development / edited by J. Suso Platero




discovery

Textbook of drug design and discovery / edited by Povl Krogsgaard-Larsen, Kristian Strømgaard, Ulf Madsen




discovery

Discriminative pattern discovery on biological networks / Fabio Fassetti, Simona E. Rombo, Cristina Serrao

Online Resource




discovery

Bioinformation discovery: data to knowledge in biology / Pandjassarame Kangueane

Online Resource




discovery

[ASAP] Accelerated Protein Biomarker Discovery from FFPE Tissue Samples Using Single-Shot, Short Gradient Microflow SWATH MS

Journal of Proteome Research
DOI: 10.1021/acs.jproteome.9b00671




discovery

[ASAP] Discovery of an Isothiazolinone-Containing Antitubercular Natural Product Levesquamide

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00339




discovery

[ASAP] Discovery, Structure–Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02164




discovery

[ASAP] Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00035




discovery

[ASAP] Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02161




discovery

[ASAP] Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00388




discovery

[ASAP] Discovery and Structure–Activity Relationship Study of (<italic toggle="yes">Z</italic>)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00227




discovery

[ASAP] Discovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02097




discovery

[ASAP] Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong <italic toggle="yes">In Vivo</italic> Antitumor Activity

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00547




discovery

[ASAP] Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02035




discovery

[ASAP] Discovery of (2<italic toggle="yes">R</italic>)-<italic toggle="yes">N</italic>-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1<italic toggle="yes">H</italic>-indol-7

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01392




discovery

[ASAP] Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01336




discovery

[ASAP] Computational Chemistry on a Budget: Supporting Drug Discovery with Limited Resources<subtitle>Miniperspective</subtitle>

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02126




discovery

[ASAP] Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00245




discovery

[ASAP] Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00337




discovery

[ASAP] Discovery of <italic toggle="yes">N</italic>-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1<italic toggle="yes">H</italic>-pyrrolo[2,3-<italic toggle=&q

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00628




discovery

[ASAP] Discovery of a Silicon-Containing Pan-Genotype Hepatitis C Virus NS5A Inhibitor

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00082




discovery

[ASAP] Discovery and Optimization of Glucose Uptake Inhibitors

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02153




discovery

[ASAP] Discovery of a Cyclic Choline Analog That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00005




discovery

[ASAP] Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00601




discovery

[ASAP] Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00681




discovery

[ASAP] Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR?t Inverse Agonist

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00063




discovery

[ASAP] Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00008




discovery

[ASAP] Discovery of an Atropisomeric PI3Kß Selective Inhibitor through Optimization of the Hinge Binding Motif

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00095




discovery

[ASAP] Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00155




discovery

[ASAP] Discovery of RO7185876, a Highly Potent ?-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00109




discovery

[ASAP] Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00025




discovery

[ASAP] Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00085




discovery

[ASAP] De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00022




discovery

Discovery of [1,2,4]triazolo[4,3-a]pyrazine derivatives bearing 4-oxo-pyridazinone moiety as potential c-Met kinase inhibitors

New J. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0NJ00575D, Paper
Binliang Zhang, Xiaobo Liu, Hehua Xiong, Qian Zhang, Xin Sun, Zunhua Yang, Shan Xu, Pengwu Zheng, Wufu Zhu
Two series of [1,2,4]triazolo[4,3-a]pyrazine derivatives bearing 4-oxo-pyridazinone moiety (compounds 21a-l and 22a-l) were designed and evaluated for the IC50 values against three cancer cell lines (A549, MCF-7 and Hela) and...
The content of this RSS Feed (c) The Royal Society of Chemistry




discovery

[ASAP] Discovery of Cephalosporin-3'-Diazeniumdiolates That Show Dual Antibacterial and Antibiofilm Effects against <italic toggle="yes">Pseudomonas aeruginosa</italic> Clinical Cystic Fibrosis Isolates and Efficacy in a Murine R

ACS Infectious Diseases
DOI: 10.1021/acsinfecdis.0c00070




discovery

Discovery of new polymorphs of the tuberculosis drug isoniazid

CrystEngComm, 2020, 22,2705-2708
DOI: 10.1039/D0CE00440E, Communication
Keke Zhang, Noalle Fellah, Alexander G. Shtukenberg, Xiaoyan Fu, Chunhua Hu, Michael D. Ward
Two new metastable polymorphs of the tuberculosis drug isoniazid, considered monomorphic for sixty years, were discovered using melt crystallization and nanoscale confinement.
The content of this RSS Feed (c) The Royal Society of Chemistry




discovery

Data warehousing and knowledge discovery : 16th International Conference, DaWaK 2014, Munich, Germany, September 2-4, 2014 : proceedings / Ladjel Bellatreche, Mukesh K. Mohania (eds.)

DaWaK (Conference) (16th : 2014 : Munich, Germany),




discovery

Transactions on large-scale data- and knowledge-centered systems. XXVI : special issue on data warehousing and knowledge discovery / Abdelkader Hameurlain, Josef Küng, Roland Wagner, Ladjel Bellatreche, Mukesh Mohania (Eds.)

DaWaK (Conference) (16th : 2014 : Munich, Germany),




discovery

Correction: Synthetic-biology-based discovery of a fungal macrolide from Macrophomina phaseolina

Org. Biomol. Chem., 2020, 18,3392-3392
DOI: 10.1039/D0OB90051F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Yohei Morishita, Terutaka Sonohara, Tohru Taniguchi, Kiyohiro Adachi, Makoto Fujita, Teigo Asai
The content of this RSS Feed (c) The Royal Society of Chemistry




discovery

Genomics data analysis: false discovery rates and empirical Bayes methods / David R. Bickel, University of Ottawa, Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Department of Mathematics and Statistics

Dewey Library - QH438.4.S73 B53 2019




discovery

GlaxoSmithKline (GSK): Seeking AI and ML experts for data-driven drug discovery and development

GlaxoSmithKline (GSK) is creating a data-focused culture and a global machine-learning team.




discovery

[ASAP] Computational Approaches to Identify Structural Alerts and Their Applications in Environmental Toxicology and Drug Discovery

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00006




discovery

Ridley Scott Explains What He’d Change in “The Martian” Based on NASA’s New Discovery

“The Martian” director Ridley Scott explains how NASA’s latest discovery on Mars would have affected the film’s plot and why he has zero interest in traveling to the far-off planet himself.




discovery

The search and discovery of the Higgs boson : a brief introduction to particle physics / Luis Roberto FLores Castillo

Flores Castillo, Luis Roberto, author