After a long hiatus, the syndicated one-hour weekly show, LOST & FOUND hosted by LUKE CRAMPTION, is offering 13 new shows to public radio free of charge. The shows can be accessed either … more

With the debut of Vert.x, the asynchronous framework is reaching an inflection point, suggests Andrew Cholakian. With Vert.x, the software is packaged together in such a way as to be extremely practical, he states. For some JVM zealots, Vert.x may meet needs recently and apparently addressed by node.js. Vert.x is an asynchronous application server – Read the rest...

This paper deals with an optimal control problem associated to the Kuramoto model describing the dynamical behavior of a network of coupled oscillators. Our aim is to design a suitable control function allowing us to steer the system to a synchronized configuration in which all the oscillators are aligned on the same phase. This control is computed via the minimization of a given cost functional associated with the dynamics considered. For this minimization, we propose a novel approach based on the combination of a standard Gradient Descent (GD) methodology with the recently-developed Random Batch Method (RBM) for the efficient numerical approximation of collective dynamics. Our simulations show that the employment of RBM improves the performances of the GD algorithm, reducing the computational complexity of the minimization process and allowing for a more efficient control calculation.

We develop a distributional framework for the shearlet transform $mathcal{S}_{psi}colonmathcal{S}_0(mathbb{R}^2) omathcal{S}(mathbb{S})$ and the shearlet synthesis operator $mathcal{S}^t_{psi}colonmathcal{S}(mathbb{S}) omathcal{S}_0(mathbb{R}^2)$, where $mathcal{S}_0(mathbb{R}^2)$ is the Lizorkin test function space and $mathcal{S}(mathbb{S})$ is the space of highly localized test functions on the standard shearlet group $mathbb{S}$. These spaces and their duals $mathcal{S}_0^prime (mathbb R^2),, mathcal{S}^prime (mathbb{S})$ are called Lizorkin type spaces of test functions and distributions. We analyze the continuity properties of these transforms when the admissible vector $psi$ belongs to $mathcal{S}_0(mathbb{R}^2)$. Then, we define the shearlet transform and the shearlet synthesis operator of Lizorkin type distributions as transpose mappings of the shearlet synthesis operator and the shearlet transform, respectively. They yield continuous mappings from $mathcal{S}_0^prime (mathbb R^2)$ to $mathcal{S}^prime (mathbb{S})$ and from $mathcal{S}^prime (mathbb S)$ to $mathcal{S}_0^prime (mathbb{R}^2)$. Furthermore, we show the consistency of our definition with the shearlet transform defined by direct evaluation of a distribution on the shearlets. The same can be done for the shearlet synthesis operator. Finally, we give a reconstruction formula for Lizorkin type distributions, from which follows that the action of such generalized functions can be written as an absolutely convergent integral over the standard shearlet group.

In this paper, we work on intra-variable handwriting, where the writing samples of an individual can vary significantly. Such within-writer variation throws a challenge for automatic writer inspection, where the state-of-the-art methods do not perform well. To deal with intra-variability, we analyze the idiosyncrasy in individual handwriting. We identify/verify the writer from highly idiosyncratic text-patches. Such patches are detected using a deep recurrent reinforcement learning-based architecture. An idiosyncratic score is assigned to every patch, which is predicted by employing deep regression analysis. For writer identification, we propose a deep neural architecture, which makes the final decision by the idiosyncratic score-induced weighted average of patch-based decisions. For writer verification, we propose two algorithms for patch-fed deep feature aggregation, which assist in authentication using a triplet network. The experiments were performed on two databases, where we obtained encouraging results.

To implement a blockchain, we need a blockchain protocol for all the nodes to follow. To design a blockchain protocol, we need a block publisher selection mechanism and a chain selection rule. In Proof-of-Stake (PoS) based blockchain protocols, block publisher selection mechanism selects the node to publish the next block based on the relative stake held by the node. However, PoS protocols may face vulnerability to fully adaptive corruptions. In literature, researchers address this issue at the cost of performance.

In this paper, we propose a novel PoS-based blockchain protocol, QuickSync, to achieve security against fully adaptive corruptions without compromising on performance. We propose a metric called block power, a value defined for each block, derived from the output of the verifiable random function based on the digital signature of the block publisher. With this metric, we compute chain power, the sum of block powers of all the blocks comprising the chain, for all the valid chains. These metrics are a function of the block publisher's stake to enable the PoS aspect of the protocol. The chain selection rule selects the chain with the highest chain power as the one to extend. This chain selection rule hence determines the selected block publisher of the previous block. When we use metrics to define the chain selection rule, it may lead to vulnerabilities against Sybil attacks. QuickSync uses a Sybil attack resistant function implemented using histogram matching. We prove that QuickSync satisfies common prefix, chain growth, and chain quality properties and hence it is secure. We also show that it is resilient to different types of adversarial attack strategies. Our analysis demonstrates that QuickSync performs better than Bitcoin by an order of magnitude on both transactions per second and time to finality, and better than Ouroboros v1 by a factor of three on time to finality.

In this paper, we present three distributed algorithms to solve a class of generalized Nash equilibrium (GNE) seeking problems in strongly monotone games. The first one (SD-GENO) is based on synchronous updates of the agents, while the second and the third (AD-GEED and AD-GENO) represent asynchronous solutions that are robust to communication delays. AD-GENO can be seen as a refinement of AD-GEED, since it only requires node auxiliary variables, enhancing the scalability of the algorithm. Our main contribution is to prove converge to a variational GNE of the game via an operator-theoretic approach. Finally, we apply the algorithms to network Cournot games and show how different activation sequences and delays affect convergence. We also compare the proposed algorithms to the only other in the literature (ADAGNES), and observe that AD-GENO outperforms the alternative.

The patterns in which the syntax of different languages converges and diverges are often used to inform work on cross-lingual transfer. Nevertheless, little empirical work has been done on quantifying the prevalence of different syntactic divergences across language pairs. We propose a framework for extracting divergence patterns for any language pair from a parallel corpus, building on Universal Dependencies. We show that our framework provides a detailed picture of cross-language divergences, generalizes previous approaches, and lends itself to full automation. We further present a novel dataset, a manually word-aligned subset of the Parallel UD corpus in five languages, and use it to perform a detailed corpus study. We demonstrate the usefulness of the resulting analysis by showing that it can help account for performance patterns of a cross-lingual parser.

Diagnosis of high impedance fault (HIF) is a challenge for nowadays distribution network protections. The fault current of a HIF is much lower than that of a normal load, and fault feature is significantly affected by fault scenarios. A detection and feeder identification algorithm for HIFs is proposed in this paper, based on the high-resolution and synchronous waveform data. In the algorithm, an interval slope is defined to describe the waveform distortions, which guarantees a uniform feature description under various HIF nonlinearities and noise interferences. For three typical types of network neutrals, i.e.,isolated neutral, resonant neutral, and low-resistor-earthed neutral, differences of the distorted components between the zero-sequence currents of healthy and faulty feeders are mathematically deduced, respectively. As a result, the proposed criterion, which is based on the distortion relationships between zero-sequence currents of feeders and the zero-sequence voltage at the substation, is theoretically supported. 28 HIFs grounded to various materials are tested in a 10kV distribution networkwith three neutral types, and are utilized to verify the effectiveness of the proposed algorithm.

Multi-view data capture permits free-viewpoint video (FVV) content creation. To this end, several users must capture video streams, calibrated in both time and pose, framing the same object/scene, from different viewpoints. New-generation network architectures (e.g. 5G) promise lower latency and larger bandwidth connections supported by powerful edge computing, properties that seem ideal for reliable FVV capture. We have explored this possibility, aiming to remove the need for bespoke synchronisation hardware when capturing a scene from multiple viewpoints, making it possible through off-the-shelf mobiles. We propose a novel and scalable data capture architecture that exploits edge resources to synchronise and harvest frame captures. We have designed an edge computing unit that supervises the relaying of timing triggers to and from multiple mobiles, in addition to synchronising frame harvesting. We empirically show the benefits of our edge computing unit by analysing latencies and show the quality of 3D reconstruction outputs against an alternative and popular centralised solution based on Unity3D.

In the Alexa Skills for Node.JS ASK SDK development world, the Alexa Skills Kit (ASK) Command-Line Interface (CLI) is one of the most overlooked tools.

Boosting Developer Productivity

With proper use, one could really increase productivity when developing Alexa Skills. This is especially so if you are creating many Alexa Skills, either because you are in the learning process or you are just managing multiple Alexa Skills projects for yourself or your clients.

A library of macrocyclic compounds of the formula (I) where part (A) is a bivalent radical, a —(CH2)y— bivalent radical or a covalent bond;where part (B) is a bivalent radical, a —(CH2)z— bivalent radical, or a covalent bond;where part (C) is a bivalent radical, a —(CH2)t— bivalent radical, or a covalent bond; andwhere part (T) is a —Y-L-Z— radical wherein Y is CH2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.

The present invention provides a process for preparing a compound of formula (VI) or a salt thereof, the process comprising: (i) reacting 4-methoxyphenyl acetone with an amine of formula (VIII) under conditions of reductive amination to produce a compound of formula (II) or a salt thereof, wherein there is no isolation of an imine intermediate formed during the reductive amination; (ii) condensing the compound (II) or the acid addition salt thereof with an α-haloketone of formula (III) to produce the compound of formula (IV); (iii) reducing the compound (IV) to a compound of formula (V); and (iv) reducing the compound (V) to the compound of formula (VI), wherein the reduction is carried out in the presence of either (1) a hydrogen donating compound in the presence of a hydrogen transfer catalyst; or (2) ammonium formate using a hydrogenation catalyst, wherein R1 and R2 are independently optionally substituted arylalkyl, and Hal is selected from chloro or bromo.

A method, system and computer program product for generating answers to questions. In one embodiment, the method comprises receiving an input query, decomposing the input query into a plurality of different subqueries, and conducting a search in one or more data sources to identify at least one candidate answer to each of the subqueries. A ranking function is applied to each of the candidate answers to determine a ranking for each of these candidate answers; and for each of the subqueries, one of the candidate answers to the subquery is selected based on this ranking. A logical synthesis component is applied to synthesize a candidate answer for the input query from the selected the candidate answers to the subqueries. In one embodiment, the procedure applied by the logical synthesis component to synthesize the candidate answer for the input query is determined from the input query.

The invention relates to the use of a conjugated seed oil modified with an activated vinyl monomer via a Deils-Alder reaction to generate a modified reactive diluent used to enhance the physical properties of coating systems. In one embodiment, a reactive diluent containing tung oil modified by the addition of an acrylate monomer is mixed with an auto-oxidative alkyd, a metal drier package, and a wetting agent to achieve cross-linked films exhibiting improved tensile strength, tensile modulus, cross-link density, and glass transition temperature, among other physical parameters.

A method for preparing 13C labeled plasmalogens as represented by Formula B: The method involves producing a 13C labeled cyclic plasmalogen precursor of Formula A: and conversion of the precursor to a plasmalogen of Formula B.

Compositions and methods for the solid phase synthesis of organic compounds are provided. The compositions are solid supports having an attached traceless linker precursor and are represented by the formula: ##STR1## In this formula, S0 is a solid support; B is a connecting group; M is a transition metal, for example ruthenium, chromium, iron, molybdenum and manganese; each L is independently a transition metal ligand; the letter n represents an integer of from 1 to 4, such that M has a sufficient number of ligands to fill the available valences; and X- represents an anion which is typically a non-nucleophilic anion.

Disclosed is a process for biomass conversion which includes co-processing the biomass with thermoplastic and non-thermoplastic polymer based materials in a catalytic pyrolysis reactor to convert such to liquid hydrocarbons; wherein hydrogen atoms originating with the polymer materials can remove oxygen from oxygenated hydrocarbons produced in the conversion of the biomass in the reactor.

In a method for fabricating a graphene structure, there is formed on a fabrication substrate a pattern of a plurality of distinct graphene catalyst materials. In one graphene synthesis step, different numbers of graphene layers are formed on the catalyst materials in the formed pattern. In a method for fabricating a graphene transistor, on a fabrication substrate at least one graphene catalyst material is provided at a substrate region specified for synthesizing a graphene transistor channel and at least one graphene catalyst material is provided at a substrate region specified for synthesizing a graphene transistor source, and at a substrate region specified for synthesizing a graphene transistor drain. Then in one graphene synthesis step, at least one layer of graphene is formed at the substrate region for the graphene transistor channel, and at the regions for the transistor source and drain there are formed a plurality of layers of graphene.

Stone is formed from 5 to 60% by weight of polymerised, low-viscosity, transparent or low-colour-resin, 20 to 90% by weight of spherical alumina trihidrate Al2O3.3H2O containing less regular particles containing, advantageously 0 to 100% by weight of a transparent or translucent substitute of alumina trihydrate, and/or with 0 to 20% or pre-prepared particulate, filled resin of a chosen colour, and/or mineral particles and less than 2% by weight of luminophor. These individual components are mixed intensely whilst extracting included gaseous parts. Extraction is carried out whilst mixing, and/or after mixing, and/or before mixing. The mixture is initiated by introducing a starter and intensely mixing it into the mixture. The mixture is poured into a mould or onto a moving endless belt. The cured synthetic stone is removed from the mould or the hardened composite is taken off the the belt. Synthetic stone can be used in products as a light carrier.

An organic synthesis of materials to achieve removal of low molecular weight ionic species, such as transition metal ions including cobalt, iron, nickel, and zinc, from aqueous solutions. The synthesis includes the steps of providing a cation exchange resin, functionalizing the cation exchange resin using a chloride intermediate to form a sulfonyl chloride resin, and reacting a multi-amine based ligand with the sulfonyl chloride resin to form a sequestration resin. The synthesis further includes the steps of cooling the sequestration resin, and washing and drying the sequestration resin.

A sine wave generator for a Direct Digital Synthesizer (DDS) converts a digital phase input into a digital sine wave output. Sine values and slopes are stored in read-only memory (ROM) for coarse upper phase bits in a first quadrant. A quadrant folder and phase splitter reflects and inverts values from the first quadrant to generate amplitudes for all four quadrants. Each sine value and slope is stored for a range of lower phase bits. A Delta bit separates upper and lower phase bits. Delta conditionally inverts the lower phase bits, the sine value, and the final polarity. A reduced AND logic array multiplies the slope by the conditionally inverted lower phase bits. A reconstructed ADD logic array then adds the conditionally inverted sine value. The conditionally inverted polarity is added to generate the final sine value. Sine generation logic is streamlined with conditional inversion based on the Delta bit.

Systems, devices, processors, and methods are described which may be used for the reception of a wireless broadband signal at a user terminal from a gateway via a satellite. A wireless signal may include a series of physical layer frames, each frame including a physical layer header and payload. The received signal is digitized and processed using various novel physical layer headers and related techniques to synchronize the physical layer frames and recover data from physical layer headers for purposes of demodulation and decoding.

The description generally relates to a system designed to synchronize the rendering of a media file between a master device and a sister device. The system is designed so that a media file is simultaneously rendered on a master device and a sister device beginning from identical temporal starting points.

A method for efficient dispatch/completion of a work element within a multi-node data processing system. The method comprises: selecting specific processing units from among the processing nodes to complete execution of a work element that has multiple individual work items that may be independently executed by different ones of the processing units; generating an allocated processor unit (APU) bit mask that identifies at least one of the processing units that has been selected; placing the work element in a first entry of a global command queue (GCQ); associating the APU mask with the work element in the GCQ; and responsive to receipt at the GCQ of work requests from each of the multiple processing nodes or the processing units, enabling only the selected specific ones of the processing nodes or the processing units to be able to retrieve work from the work element in the GCQ.

An illustrative embodiment of a computer-implemented process for scalable group synthesis receives a group definition, applies a sub-set of conditions to the group definition to form a conditioned group definition, receives a set of entities and populates group membership using the received set of entities and the conditioned group definition, wherein each member responds in the affirmative to the sub-set of conditions.

A method of synthesizing an alkyl cyclopentadiene compound is disclosed. The method includes contacting at least one cyclopentadienyl anion source and at least one alkyl group source to form at least one alkyl cyclopentadiene compound. The method further includes extracting the alkyl cyclopentadiene compound with a hydrocarbon solvent. The alkyl cyclopentadiene compound may be converted to a metallocene catalyst compound.

A method for preparing 13C labeled iodotridecane represented by Formula A: The method comprises the conversion of 13C labeled propargyl alcohol to 13C labeled iodotridecane via alkylation of propargyl alcohol with iododecane.

A method for synthesizing catalyst beads of bulk transmission metal carbides, nitrides and phosphides is provided. The method includes providing an aqueous suspension of transition metal oxide particles in a gel forming base, dropping the suspension into an aqueous solution to form a gel bead matrix, heating the bead to remove the binder, and carburizing, nitriding or phosphiding the bead to form a transition metal carbide, nitride, or phosphide catalyst bead. The method can be tuned for control of porosity, mechanical strength, and dopant content of the beads. The produced catalyst beads are catalytically active, mechanically robust, and suitable for packed-bed reactor applications. The produced catalyst beads are suitable for biomass conversion, petrochemistry, petroleum refining, electrocatalysis, and other applications.

A cancelation registry provides a cancelation interface whose implementation registers cancelable items such as synchronous operations, asynchronous operations, type instances, and transactions. Items may be implicitly or explicitly registered with the cancelation registry. A consistent cancelation interface unifies cancelation management for heterogeneous items, and allows cancelation of a group of items with a single invocation of a cancel-registered-items procedure.

A para-methoxy protected benzaldehyde useful in preparation of treprostinil, and of formula: (Formula (1)) is prepared by subjecting to Claisen re-arrangement a substituted benzaldehyde of formula (1a): (Formula (Ia)) to form the m-hydroxy-substituted benzaldehyde of formula (1b): (Formula (Ib)) and then reacting compound (1b) with a p-methoxybenzyl (PMB) compound to form a PMB-substituted benzaldehyde of formula (1).

In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.

A system, method, and computer program product for automatically generating equivalent assertions in different forms for different verification tools, which may be analog or digital. A user submits a set of logic assertions that, if unclocked, are converted to clocked assertions by generating and skewing clocks to ensure simulator uniformity. A stimulus is generated, perhaps at random, or input. A test bench is either input or synthesized. For each verification tool, the test bench is simulated and simulation results are captured. An assertion status difference engine evaluates result differences between the verification tools, and identifies and outputs differences indicating a significant inconsistency. Errors in verification tool implementation and user assertion coding can be detected. The simulators used may include SPICE and Verilog, or any other simulators that differ in type, simulation algorithm, input format, or vendor implementation.

A method for designing a transformer in an integrated circuit includes receiving one or more desired characteristics of the transformer from user input and iteratively determining a design solution for the transformer through one or more simulations and modifications using a rule-set. The method combines the one or more desired characteristics with other preset characteristics of the transformer or the integrated circuit. A first model of the transformer is defined with typical load impedances and simulated having the combined characteristics to determine performance. Results of the simulation are processed to calculate performance with the load impedances specified by the user. The results are further processed to obtain a mathematical model that includes tuning capacitors. The first and subsequent models are modified by drawing on a rule-set of expert knowledge relating to general dependency of at least one design criterion, such as a physical, geometrical or performance characteristic, with another design criterion.

Methods for the design of microwave filters comprises comprising preferably the steps of inputting a first set of filter requirements, inputting a selection of circuit element types, inputting a selection of lossless circuit response variables, calculating normalized circuit element values based on the input parameters, and generate a first circuit, insert parasitic effects to the normalized circuit element values of the first circuit, and output at least the first circuit including the post-parasitic effect circuit values. Additional optional steps include: requirements to a normalized design space, performing an equivalent circuit transformation, unmapping the circuit to a real design space, performing a survey, and element removal optimization. Computer implement software, systems, and microwave filters designed in accordance with the method are included.

In one embodiment of the invention, an integrated circuit (IC) design tool is provided for synthesizing logic, including one or more software modules to synthesize a gate-level netlist of a squarer functional block. The software modules include a bitvector generator, a bitvector reducer, and a hybrid multibit adder generator. The bitvector generator multiplies bits of a vector together to generate partial products for a plurality of bitvectors and then optimizes a plurality of least significant bitvectors. The bitvector reducer reduces the partial products in the bitvectors of the squarer functional block down to a pair of final vectors. The hybrid multibit adder generator generates a hybrid multibit adder including a first adder and a second adder coupled together by a carry bit with bit widths being responsive to a dividerbit. The hybrid multibit adder adds the pair of final vectors together to generate a final result for the squarer functional block.

An embodiment of an analysis filterbank for filtering a plurality of time domain input frames, wherein an input frame comprises a number of ordered input samples, comprises a windower configured to generate a plurality of windowed frames, wherein a windowed frame comprises a plurality of windowed samples, wherein the windower is configured to process the plurality of input frames in an overlapping manner using a sample advance value, wherein the sample advance value is less than the number of ordered input samples of an input frame divided by two, and a time/frequency converter configured to provide an output frame comprising a number of output values, wherein an output frame is a spectral representation of a windowed frame.

A speech recognition method including the steps of receiving a speech input from a known speaker of a sequence of observations and determining the likelihood of a sequence of words arising from the sequence of observations using an acoustic model. The acoustic model has a plurality of model parameters describing probability distributions which relate a word or part thereof to an observation and has been trained using first training data and adapted using second training data to said speaker. The speech recognition method also determines the likelihood of a sequence of observations occurring in a given language using a language model and combines the likelihoods determined by the acoustic model and the language model and outputs a sequence of words identified from said speech input signal. The acoustic model is context based for the speaker, the context based information being contained in the model using a plurality of decision trees and the structure of the decision trees is based on second training data.

A visualization can include a set of swim lanes, each swim lane representing information about an event type. An event type can be specified, e.g., as those events having certain keywords and/or having specified value(s) for specified field(s). The swim lane can plot when (within a time range) events of the associated event type occurred. Specifically, each such event can be assigned to a bucket having a bucket time matching the event time. A swim lane can extend along a timeline axis in the visualization, and the buckets can be positioned at a point along the axis that represents the bucket time. Thus, the visualization may indicate whether events were clustered at a point in time. Because the visualization can include a plurality of swim lanes, the visualization can further indicate how timing of events of a first type compare to timing of events of a second type.

A composition having a mixture of the below compounds having a mole ratio of at least 1:20. Ar1 and Ar2 are independently selected aromatic groups. A composition comprising phthalonitrile compounds that comprise at least 5 mol % of the first compound below. A method of: providing a solution of a dichloroaromatic compound having an electron-withdrawing group bound to each aromatic ring containing one of the chloride groups; a dihydroxyaromatic compound or anion thereof; an organic transition metal complex or a transition metal salt; an alkaline hydroxide base; and a solvent; and heating the solution to a temperature at which the dichloroaromatic compound and the dihydroxyaromatic compound react to form a dimetallic salt of an aromatic ether oligomer. The molar ratio of the dihydroxyaromatic compound to the dichloroaromatic compound is greater than 2:1. Water formed during the heating is concurrently distilled from the solution.

The esterfication of hypophosphorous acid is followed by reaction with another molecule of alcohol under the action of a nickel catalyst to provide a green method for the preparation of H-phosphonate diesters. This method avoids the need for any stoichiometric chlorine unlike those based on phosphorous trichloride.

A method and device for synchronizing the time between at least two integrated circuits (201, 202), which receive the same pulse signal. In the integrated circuits (201, 202) a counter (204, 206) is used to count the number of pulses in the received pulse signal to synchronize the common time between said integrated circuits.

An abstraction for storage class memory is provided that hides the details of the implementation of storage class memory from a program, and provides a standard channel programming interface for performing certain actions, such as controlling movement of data between main storage and storage class memory or managing storage class memory.

An abstraction for storage class memory is provided that hides the details of the implementation of storage class memory from a program, and provides a standard channel programming interface for performing certain actions, such as controlling movement of data between main storage and storage class memory or managing storage class memory.

The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof.

An ammonium hydroxyfluoroalkanesulfinate is obtained by using an organic base while sulfinating a bromofluoroalcohol with a sulfinating agent. An ammonium hydroxyfluoroalkanesulfonate is obtained by oxidizing the ammonium hydroxyfluoroalkanesulfinate. An onium fluoroalkanesulfonate is obtained by converting the ammonium hydroxyfluoroalkanesulfonate into an onium salt through esterification. This onium fluoroalkanesulfonate is useful as a photoacid generator in chemically amplified resists and the like.

This invention relates to a process for preparing an oligonucleotide 5'-triphosphate. The process comprises the steps of: (a) synthesizing an oligonucleotide having a 5' hydroxyl moiety; (b) reacting the 5' hydroxyl moiety with a reagent of formula I: to convert the 5' hydroxyl moiety to a 5'-H-phosphonate, wherein R1 and R2 are each independently selected from the group consisting of haloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycle, and substituted heterocycle, acyl, phosphoryl, substituted alkyl acyl, substituted heteroalkyl acyl, substituted aryl acyl or substituted heteroaryl acyl, substituted alkyl phosphoryl, substituted heteroalkyl acyl, substituted aryl phosphoryl, and substituted heteroaryl phosphoryl; (c) activating the H-phosphonate of step (b) by reacting the H-phosphonate with a silylating agent, a halogenated oxidizing agent, a nitrogen-containing heteroaryl, or a combination thereof, to form an activated H-phosphonate; and (d) treating the oligonucleotide having an activated H-phosphonate from step (c) with a poly(alkylammonium)pyrophosphate.

The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

A composition comprising an SL0101 [kaempferol 3-O-(3″,4″-di-O-acetyl-α-L-rhamnopyranoside)] derivative compound that has enhanced ability to inhibit RSK activity, relative to the parent compound is provided. The compounds have utility for treating any disease or conditions characterized or associated with excess or undesirable RSK activity. For example the RSK inhibitors of the present invention can be used to reduce the proliferation of neoplastic cells or for inhibiting the establishment or maintenance of an intracellular pathogenic infection by pathogens whose pathogenicity derives in part from the pathogen's ability to impede endosomal/phagosomal maturation in the host cell.

The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.