Whoever says fast food is unhealthy for the body and the environment hasn’t been introduced to Sweetgreen, a chain restaurant dedicated to changing how we view food production, consumption and waste. [...]

This episode is the audio only version of our live podcast with our friends from ArsenalVision. It was recorded live at Ally Pally Theatre on Saturday May 18th, the day before the final game of the season – so the discussion reflects that.

You can see a video version on YouTube here: https://youtu.be/UYlUR0pkqSo

Get extra bonus content and help support Arseblog by becoming an Arseblog Member on Patreon: https://www.patreon.com/arseblog

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Vampire bats rely on amino acids from their blood diet to fuel their exercise, scientists discovered after observing the animals on tiny treadmills.

Meta has been fined 21.62 billion won ($15.67 million) by South Korea's data privacy watchdog for illegally collecting sensitive personal information from Facebook users, including data about their political views and sexual orientation, and sharing it with advertisers without their consent. The country's Personal Information Protection Commission (PIPC) said Meta gathered information such as

Professional women’s basketball is a cesspool of mediocrity full of women gatekeeping so the sport can’t change. Fortunately, incoming rookie Caitlin Clark is worth more than the entire WNBA due to her sponsorships. This means that unlike other players, Clark doesn’t work for the WNBA she works for her sponsors and her fans. Also, Clark […]

The post WNBA is totally annoying, here’s how to fix it for Caitlin Clark’s arrival appeared first on Penelope Trunk Careers.

The post Russia With Weapons by a Mentally Ill Artist appeared first on English Russia.

From Food & Wine:

On the genius of The Cure's Robert Smith

"Disintegration is one of my favorite albums. Young people listening to this podcast right now, are like, 'What the f--- are they talking about?' It's the 'Friday I'm in Love' guys. Check it out. 'Just Like Heaven' is a perfect pop song. It is like carbon on the periodic table of perfectly executed, joyous, catchiest, most perfect things. 'Pictures of You' is probably one of the most tragic pop songs ever written, and it's perfect. 'A Forest' — I remember when Nouvelle Vague covered that, and I was just like, 'Oh my gosh.' I don't know why The Cure doesn't get more recognition for how important they were.

To go from punk into New Wave, into — I think at any moment if Robert Smith wanted to, he could be like, 'I can write the poppiest song of all time.' Like Kurt Cobain, where it's just, 'I can do this all day long. But I'm going to put sandpaper in it and make your brain turn upside down.' But then you're like, 'What just happened to me?'"

1. Automatisierte Bots auf X greifen in den US-Wahlkampf ein (zeit.de, Eva Wolfangel) “Die Sorge, dass das Internet von Bots zersetzt wird, gibt es schon lange. Jetzt gibt es erstmals klare Belege für solche KI-Accounts – manche machen Stimmung für Trump.” Eva Wolfangel gibt einen Einblick in die derzeitige Forschung zu Bot-Netzwerken. Weiterer Lesetipp: Elon […]

Voting registration rates among Princeton undergraduate and graduate students have more than doubled largely thanks to the program.

In this talk, Graham Neubig will discuss a new frontier in AI models, vision-language models that understand the world's cultures. The talk will be in two parts. First, Neubig will discuss training of multilingual multimodal multicultural models that understand images and text, and have increased ability to answer culture-specific questions about multimodal data. Second, he will discuss work on "image transcreation", where models have been developed that can transform images to make them more relevant to a particular culture. This work has applications in a number of areas, such as cultural localization of educational materials (to accompany translated text). While these methods cover many languages, African and not, the talk will focus on examples specifically from the African context, and challenges we currently face therein.

RSS is a valuable open standard that has found a new purpose in our connected world. You might not be able to access detailed analytics, but there are lots of other good reasons to keep it.

The post Is RSS Really Dead? appeared first on RSSground.com.

IFTTT (If This Then That) – is a platform that helps millions of users to connect and automate various services.  You create applets where one service acts as a trigger (If This) and another service acts as an action (Then That).  If you have never heard of them, you should definitely give them a try. […]

The post IFTTT integration is finally here! appeared first on RSSground.com.

Kelly was an American actress who gained critical and popular praise for her performances in High Noon and The Country Girl, for which she won an Academy Award. She also starred in three Alfred Hitchcock films but cut short her promising acting career in 1956 when she married Prince Rainier III, becoming Princess Grace of Monaco and retiring from acting. In 1982, she died in an accident after suffering a stroke while driving on a mountain road. How did she and Prince Rainier meet?

Two hours before asteroid 2022 EB5 entered Earth’s atmosphere, scientists knew exactly when and where the space rock would strike.

Mushrooms are remarkably forgiving. Here’s the science of why.

Here’s how hot air can “fry” food.

NASA’s massive SLS rocket and Orion spacecraft kick off a series of missions to put humans back on the Moon.

The next generation of wireless communication technology is much more advanced, but it requires a lot of new infrastructure.

Hot’s Bad Boy debuts Nov. 21, joined by Daum's Life is a Difficult Age, Crystal’s Before, and Armageddon Time on Netflix.

The following article, The First Wave of Hollyweirdos Leaving America, was first published on The Black Sphere.

Too bad we can't send the FBI to raid the houses of all the dumb ass Leftists who promised to leave if Trump was elected.

Continue reading The First Wave of Hollyweirdos Leaving America ...

A new update is rolling out that automatically starts Microsoft's Edge browser and prompts users to import their Chrome tabs -- a move that has sparked criticism over its invasive tactics to encourage Edge adoption. The Verge's Tom Warren reports: My colleague Richard Lawler noticed that Edge started automatically on his PC last week at boot and offered up a new prompt to "enhance your browsing experience." The pop-up has a "bring over your data from other browsers regularly" option ticked by default, and encourages people to confirm and continue with a big blue button. If you want to dismiss this prompt there's a tiny white X button that looks similar to the sparkles Microsoft is using in the background of the prompt. If you simply hit confirm and continue then Microsoft Edge will import your Chrome data and continually import your tabs if you have Chrome set as default. The prompt seems to mainly appear on PCs with Chrome installed, suggesting that Microsoft is once again targeting Chrome users. Microsoft confirmed the new "feature" to The Verge. "This is a notification giving people the choice to import data from other browsers," explains Microsoft spokesperson Caitlin Roulston. "There is an option to turn it off."

Read more of this story at Slashdot.

By Robert Schmad The Department of Health and Human Services (HHS) spends tens of millions of dollars annually on diversity-related expenses, according to a new report from the watchdog group Open The Books. American taxpayers foot a bill of roughly $38.7 million every year to employ 297 staffers conducting diversity, equity and inclusion (DEI) work […]

The post Biden-Harris Health Department Spent Tens Of Millions Annually On DEI appeared first on Liberty Unyielding.

(Oct. 24)  Gov. Tim Walz (D-MN) could be the next person inaugurated as president of the United States. No, this is not a prediction. And it’s not a likelihood. But […]

The post Say hello to President…. Walz? Really? appeared first on Quin Hillyer.

Fans congratulate the Transformers star, who's spoken about a previous pregnancy ending in miscarriage.

He is on course to become the battleground state's first Latino US senator, according to a CBS News.

Dozens of videos involving a senior civil servant in Equatorial Guinea have flooded social media, shocking people in the country.

President Trump officially announced that he has selected Judge Amy Coney Barrett as his nominee to fill the vacancy of late Justice Ruth Bader Ginsburg to the Supreme Court, setting up a bitter Senate confirmation battle with just five weeks left until Election Day. “I stand before you today to fulfill one of my highest […]

The post Trump Officially Nominates Amy Coney Barrett To Fill Supreme Court Vacancy appeared first on Hispolitica.

Generative AI Is Your Ally for Smart Staging, Selling

Bryan Lanza tells the BBC there needs to be an "honest conversation" with Kyiv and returning Crimea is not a US priority.

velocityconf: RT @oreillyanimals Vote Instant Wild's Digital Eyes & Ears for Wildlife Protection to win Google Global Impact Award http://t.co/Z0EetiQshZ

velocityconf: RT @courtneynash: Bill Scott's #fluentconf keynote theme also rings true re #velocityconf: tech change is really about people/culture change

velocityconf: RT @OReillyAnimals Advice, please! Elephant Listening Project asks for ideas/solutions/help with 3 practical problems http://t.co/Y90YP3maoz

Bond yields spiked aggressively as investors awaited Wednesday's inflation data for October.

Informational text — resources whose purpose is to inform — is essential to daily life and fundamental to literacy. Unfortunately, young children typically have limited exposure to informational text. Two 9-week randomized controlled trials with 263 first-grade children from low-income communities examined whether free educational videos and digital games from the PBS KIDS show “Molly of Denali” supported children’s ability to use informational text to answer real-world questions. Study 1 found significant positive intervention impacts on child outcomes; Study 2 replicated these findings.

Teacher question: One of my colleagues told us that we should not be teaching guided reading lessons or comprehension skills or strategies. We’re using a core reading program that includes those kinds of things. He says that the science of reading proves that we would get higher reading achievement by teaching more social studies and science (he’s our science teacher) and dropping the comprehension instruction that we are providing. He’s really vocal about this. Can you help us shut him up? Shanahan’s response

Bitcoin has been reaching new all-time highs almost daily, fueling a parabolic bull run that’s pushing various cryptocurrencies to surge… Continue reading Flockerz Capitalizes on Bitcoin Rally, Raising $1.6M in Presale

The post Flockerz Capitalizes on Bitcoin Rally, Raising $1.6M in Presale appeared first on ReadWrite.

When Ebrahim Rasool returns to Washington in December as South Africa's ambassador, one of his primary goals is to reposition Pretoria as a "moral superpower"

Neuroscientists have confirmed what every stoner already knows: music sounds better when you're high on weed. In a paper titled "Exploring the interaction between cannabis, hearing, and music," researchers from Toronto Metropolitan University reported results from a study in which participants "reported significantly greater hearing sensitivity and levels of state absorption while high compared to sober." — Read the rest

The post Music really does sound better when you're high, scientists report appeared first on Boing Boing.

TL;DR: Get 37% off this touchscreen infotainment system with CarPlay and Android Auto compatibility. 

Elon, who?? Okay, maybe Teslas have cool infotainment systems, but you don't have to pay crazy prices for an over-hyped screen—just grab one of these CarPlay displays for your old beater. — Read the rest

The post Teslas suck! What you really need is this whizz-bang CarPlay screen appeared first on Boing Boing.

The following article, Will These Deranged Celebrities Who Promised To End Their Lives Or Flee The Country If Trump Wins Actually Follow Through?, was first published on Conservative Firing Line.

(Natural News) Similar to what happened in 2016, a host of celebrities and influencers made wild claims that they would leave the country or even end their lives if Donald Trump won another term in the White House. Will any of them actually follow through? Take Rob Reiner, for instance. He promised to “set himself on …

Continue reading Will These Deranged Celebrities Who Promised To End Their Lives Or Flee The Country If Trump Wins Actually Follow Through? ...

Touch down in Vancouver and it was raining. Listening to friends from the Pacific Northwest talk, I always kind of suspected that they were lying when they complained about how grey it was and how much it rains. I’d been to the region four or five times, at across all time of the year and always […]

The article A Perfect Day in Vancouver (Finally!) originated at EverInTransit.com

This morning we awoke to one story dominating the tech news landscape: OpenAI is “expanding into search,” launching SearchGPT, a prototype that appears to be a direct competitor to Google (and Bing and Perplexity, not that they really matter). But despite the voluminous coverage, my initial take is that once the hype cycle passes – … Continue reading "What’s SearchGPT Really About? Moving Past the Training Data Dilemma."

There is a reason Joe Rogan became the world's largest podcaster. He doesn't take his audience -- or his guests -- for granted. He wants MEANINGFUL conversations.

The post Joe Rogan Officially Backs A Candidate… Could Be The Biggest Endorsement Yet appeared first on Clash Daily.

There are a few moments in this race that historians will wrangle over as the 'real' reason Kamala lost. There are a couple of key events that are sure to make the list.

The post The RIGHT Rally: On Election Night, MAGA Takes Moment To Honor God Beautifully appeared first on Clash Daily.

Pro-Trump businessmen Elon Musk (the richest man in the world) and Vivek Ramaswamy have officially joined the incoming Trump administration. President-elect Donald Trump announced in a statement published Tuesday that […]

The post Breaking: Musk, Ramaswamy Officially Join Trump Administration - Their Job Is to Destroy Bureaucracy appeared first on The Western Journal.

Marcelo Campos, Matthew Jenssen, Marcus Michelen and Julian Sahasrabudhe
J. Amer. Math. Soc. 38 (), 179-224.
Abstract, references and article information

An important mechanism of resistance to β-lactam antibiotics is via their β-lactamase–catalyzed hydrolysis. Recent work has shown that, in addition to the established hydrolysis products, the reaction of the class D nucleophilic serine β-lactamases (SBLs) with carbapenems also produces β-lactones. We report studies on the factors determining β-lactone formation by class D SBLs. We show that variations in hydrophobic residues at the active site of class D SBLs (i.e. Trp105, Val120, and Leu158, using OXA-48 numbering) impact on the relative levels of β-lactones and hydrolysis products formed. Some variants, i.e. the OXA-48 V120L and OXA-23 V128L variants, catalyze increased β-lactone formation compared with the WT enzymes. The results of kinetic and product studies reveal that variations of residues other than those directly involved in catalysis, including those arising from clinically observed mutations, can alter the reaction outcome of class D SBL catalysis. NMR studies show that some class D SBL variants catalyze formation of β-lactones from all clinically relevant carbapenems regardless of the presence or absence of a 1β-methyl substituent. Analysis of reported crystal structures for carbapenem-derived acyl-enzyme complexes reveals preferred conformations for hydrolysis and β-lactone formation. The observation of increased β-lactone formation by class D SBL variants, including the clinically observed carbapenemase OXA-48 V120L, supports the proposal that class D SBL-catalyzed rearrangement of β-lactams to β-lactones is important as a resistance mechanism.

Heterotrimeric G-proteins are signaling switches broadly divided into four families based on the sequence and functional similarity of their Gα subunits: Gs, Gi/o, Gq/11, and G12/13. Artificial mutations that activate Gα subunits of each of these families have long been known to induce oncogenic transformation in experimental systems. With the advent of next-generation sequencing, activating hotspot mutations in Gs, Gi/o, or Gq/11 proteins have also been identified in patient tumor samples. In contrast, patient tumor-associated G12/13 mutations characterized to date lead to inactivation rather than activation. By using bioinformatic pathway analysis and signaling assays, here we identified cancer-associated hotspot mutations in Arg-200 of Gα13 (encoded by GNA13) as potent activators of oncogenic signaling. First, we found that components of a G12/13-dependent signaling cascade that culminates in activation of the Hippo pathway effectors YAP and TAZ is frequently altered in bladder cancer. Up-regulation of this signaling cascade correlates with increased YAP/TAZ activation transcriptional signatures in this cancer type. Among the G12/13 pathway alterations were mutations in Arg-200 of Gα13, which we validated to promote YAP/TAZ-dependent (TEAD) and MRTF-A/B-dependent (SRE.L) transcriptional activity. We further showed that this mechanism relies on the same RhoGEF-RhoGTPase cascade components that are up-regulated in bladder cancers. Moreover, Gα13 Arg-200 mutants induced oncogenic transformation in vitro as determined by focus formation assays. In summary, our findings on Gα13 mutants establish that naturally occurring hotspot mutations in Gα subunits of any of the four families of heterotrimeric G-proteins are putative cancer drivers.

Christian Tagwerker
Apr 1, 2006; 5:737-748
Research