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Why we are finally within reach of a room-temperature superconductor

A practical superconductor would transform the efficiency of electronics. After decades of hunting, several key breakthroughs are inching us very close to this coveted prize




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Sunlight-trapping device can generate temperatures over 1000°C

A solar energy absorber that uses quartz to trap heat reached 1050°C in tests and could offer a way to decarbonise the production of steel and cement




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Atoms at temperatures beyond absolute zero may be a new form of matter

Physicists have coaxed a cloud of atoms into having a temperature beyond absolute zero and placed them in a geometric structure that could produce an unknown form of matter




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Mexico Farm Tied to Stomach Bug Back in Operation

Title: Mexico Farm Tied to Stomach Bug Back in Operation
Category: Health News
Created: 8/27/2013 4:36:00 PM
Last Editorial Review: 8/28/2013 12:00:00 AM




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As Temperatures Fall, Heart Attacks May Rise

Title: As Temperatures Fall, Heart Attacks May Rise
Category: Health News
Created: 8/29/2017 12:00:00 AM
Last Editorial Review: 8/30/2017 12:00:00 AM




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Temperature matters: the potential impact of thermoregulatory mechanisms in brain-body physiology [Special Section: Symposium Outlook]

Thermoregulation, responsible for maintaining a stable core temperature during wide fluctuations in external and internal thermal environments, is an iconic homeostatic process. However, we suggest that despite its fundamental physiological significance, the potential for required cool housing temperatures and thermoregulatory mechanisms to influence the interpretation of experimental data is not sufficiently appreciated. Moreover, although it is generally assumed that the major thermoregulatory pathways are well understood, here we discuss new research that suggests otherwise and reveals the emergence of a new wave of exciting ideas for this "old" field of research.




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{Delta}9-Tetrahydrocannabinol Alleviates Hyperalgesia in a Humanized Mouse Model of Sickle Cell Disease [Special Section: Cannabinoid Signaling in Human Health and Disease]

People with sickle cell disease (SCD) often experience chronic pain as well as unpredictable episodes of acute pain, which significantly affects their quality of life and life expectancy. Current treatment strategies for SCD-associated pain primarily rely on opioid analgesics, which have limited efficacy and cause serious adverse effects. Cannabis has emerged as a potential alternative, yet its efficacy remains uncertain. In this study, we investigated the antinociceptive effects of 9-tetrahydrocannabinol (THC), cannabis’ intoxicating constituent, in male HbSS mice, which express >99% human sickle hemoglobin, and male HbAA mice, which express normal human hemoglobin A, as a control. Acute THC administration (0.1–3 mg/kg–1, i.p.) dose-dependently reduced mechanical and cold hypersensitivity in human sickle hemoglobin (HbSS) but not human normal hemoglobin A (HbAA) mice. In the tail-flick assay, THC (1 and 3 mg/kg–1, i.p.) produced substantial antinociceptive effects in HbSS mice. By contrast, THC (1 mg/kg–1, i.p.) did not alter anxiety-like behavior (elevated plus maze) or long-term memory (24-hour novel object recognition). Subchronic THC treatment (1 and 3 mg/kg–1, i.p.) provided sustained relief of mechanical hypersensitivity but led to tolerance in cold hypersensitivity in HbSS mice. Together, the findings identify THC as a possible therapeutic option for the management of chronic pain in SCD. Further research is warranted to elucidate its mechanism of action and possible interaction with other cannabis constituents.

SIGNIFICANCE STATEMENT

The study explores 9-tetrahydrocannabinol (THC)’s efficacy in alleviating pain in sickle cell disease (SCD) using a humanized mouse model. Findings indicate that acute THC administration reduces mechanical and cold hypersensitivity in SCD mice without impacting emotional and cognitive dysfunction. Subchronic THC treatment offers sustained relief of mechanical hypersensitivity but leads to cold hypersensitivity tolerance. These results offer insights into THC's potential as an alternative pain management option in SCD, highlighting both its benefits and limitations.




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Utility of Early Postoperative DWI to Assess the Extent of Resection of Adult-Type World Health Organization Grade 2 and 3 Diffuse Gliomas [CLINICAL PRACTICE]

BACKGROUND AND PURPOSE:

World Health Organization (WHO) grade 2 and 3 diffuse gliomas account for approximately 5% of primary brain tumors. They are invasive and infiltrative tumors and have considerable morbidity, causing progressive neurologic deterioration. The mean survival time is <10 years from diagnosis. Surgical debulking represents first-line management. The extent of resection is associated with progression-free and overall survival. Radiologic assessment of the extent of resection is challenging. This can be underestimated on early postoperative MRI, meaning that accurate assessment may be achieved only on delayed follow-up imaging. We hypothesized that DWI may help facilitate more reliable estimates of the extent of resection on early postoperative MRI. This study aimed to assess the utility of DWI in early postoperative MRI to evaluate the extent of resection.

MATERIALS AND METHODS:

A single-center observational cohort study was performed. All patients with histologically confirmed WHO grade 2 and 3 gliomas managed with surgical debulking between January 2015 and December 2020 were identified. Preoperative, early postoperative, and follow-up imaging were reviewed independently by 2 consultant neuroradiologists. The extent of resection was estimated with and without DWI sequences for each case.

RESULTS:

Two hundred twenty-four patients with WHO grade 2 and 3 gliomas were managed with surgical debulking between 2015 and 2020. DWI was not performed on early postoperative MRI in 2 patients. With the use of DWI, the extent of resection was upgraded in 30% of cases (n = 66/222) and classified as "complete" or "supramaximal" in 58% of these patients (n = 38/66). In cases in which the extent of resection was upgraded with the use of DWI, signal abnormality was stable or reduced at follow-up in 78% (n = 49/63). In cases with worsening signal abnormality, 64% were deemed to be secondary to adjuvant radiation therapy (n = 9/14). Eight percent (n = 5/63) of patients with an increased estimated extent of resection using DWI demonstrated signal progression attributed to true disease progression at follow-up.

CONCLUSIONS:

DWI is a helpful and reliable adjunct in differentiating residual tumor from marginal ischemia in early postoperative MRI in WHO grade 2 and 3 diffuse gliomas and increases the accuracy in assessing the extent of resection. It should be used routinely in these cases.




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Preoperative Assessment of Meningioma Consistency Using a Combination of MR Elastography and DTI [RESEARCH]

BACKGROUND AND PURPOSE:

Preoperative assessment of meningioma consistency is beneficial for optimizing surgical strategy and prognosis of patients. We aim to develop a noninvasive prediction model for meningioma consistency utilizing MR elastography and DTI.

MATERIALS AND METHODS:

Ninety-four patients (52 ± 22 years old, 69 women, 25 men) diagnosed with meningioma were recruited in the study. Each patient underwent preoperative T1WI, T2WI, DTI, and MR elastography. Combined MR elastography–DTI model was developed based on multiple logistic regression. Intraoperative tumor descriptions served as clinical criteria for evaluating meningioma consistency. The diagnostic efficacy in determining meningioma consistency was evaluated by using a receiver operating characteristic curve. Further validation was conducted in 27 stereotactic biopsies by using indentation tests and underlying mechanism was investigated by histologic analysis.

RESULTS:

Among all the imaging modalities, MR elastography demonstrated the highest efficacy with the shear modulus magnitude (|G*|) achieving an area under the curve (AUC) of 0.81 (95% CI: 0.699–0.929). When combined with DTI, the diagnostic accuracy further increased (AUC: 0.88, 95% CI: 0.784–0.971), surpassing any technique alone. Indentation measurement based on stereotactic biopsies further demonstrated that the MR elastography–DTI model was suitable for predicting intratumor consistency. Histologic analysis suggested that meningioma consistency may be correlated with tumor cell density and fibrous content.

CONCLUSIONS:

The MR elastography–DTI combined model is effective in noninvasive prediction of meningioma consistency.




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Man Utd fans DESPERATE for Alexis Sanchez to CELEBRATE if he scores against Arsenal

ALEXIS SANCHEZ returns to former club Arsenal tonight - and Manchester United fans are desperate to see him celebrate if he scores at the Emirates..




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Pornhub operator broke Canadian privacy law, watchdog rules

The company behind Pornhub and other popular pornographic sites broke Canadian privacy law by allowing intimate images to be shared on its websites without the direct knowledge or consent of everyone depicted, the federal privacy commissioner has ruled. The Office of the Privacy Commissioner’s (OPC) investigation into Aylo (formerly MindGeek), one of the world’s largest […]

The post Pornhub operator broke Canadian privacy law, watchdog rules first appeared on ITBusiness.ca.




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In a Landmark Study, Scientists Discover Just How Much Earth's Temperature Has Changed Over Nearly 500 Million Years

Researchers show the average surface temperature on our planet has shifted between 51.8 to 96.8 degrees Fahrenheit




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The Role of MES Consultants in Streamlining Manufacturing Operations

Manufacturing efficiency has always been a priority. As competition grows, optimizing every aspect of production becomes critical. Manufacturers turn to experts to make the right improvements and introduce systems that boost overall performance. One key area where many businesses seek help is through Manufacturing Execution Systems (MES). MES consultants play a pivotal role in achieving […]

The post The Role of MES Consultants in Streamlining Manufacturing Operations appeared first on Chart Attack.




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Law enforcement operation takes down 22,000 malicious IP addresses worldwide

Operation Synergia II took aim at phishing, ransomware, and information stealing.




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Trudeau government bans TikTok from operating in Canada — but Canadians can still use it

Citing national security concerns, the federal government has ordered TikTok to shutter its Canadian operations — but users will still be able to access the popular video app.




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What the federal ban on TikTok's Canadian operations means for you

The federal government ordered an end to TikTok's Canadian operations on Wednesday, citing national security concerns. But its decision to keep the app itself available has privacy experts puzzled.




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Fancy a night at the Opera?

Sydney Opera House is considering introducing a lottery for guests to stay for free in the landmark.




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DoP releases operational guidelines for Strengthening of Medical Device Industry scheme

The Department of Pharmaceuticals (DoP) has released the operational guidelines for the newly announced central sector scheme for Strengthening of Medical Device Industry (SMDI), aiming at providing




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Researchers Explore How the Human Body Senses Temperature

As winter arrives and daylight hours decrease, it gets easier to hit the snooze button and stay in bed. It turns out that there’s a scientific reason behind this phenomenon that helps to explain why people struggle to adjust their internal clocks—also known as circadian rhythm or sleep-wake cycle—when the weather turns colder.




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236332: US saw &quot;additional opportunities&quot; to embed own troops in Pakistan military&rsquo;s FATA operations




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226157: Pakistan accepted U.S. military role in counter-insurgency operations




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207373: U.S. Special Forces embedded with Pakistan Special Services Group and Frontier Corps for operations in NWFP




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204652: US. &quot;boots on the ground&quot; were to accompany Pakistan Frontier Corps for a joint operation, but were &quot;denied deployment&quot; at the last minute




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204260: U.S. special forces were embedded with Pakistan troops in 2009 anti-Taliban operations in the North-West Frontier Province




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191725: Ambassador presses Menon to implement civil nuclear cooperation with U.S.

The Indian civil nuclear bureaucracy understands it is "essential" to advance cooperation with the U.S., but claims progress is stymied by the inability of U.S. firms to share sensitive technical information pending the authorizations required under U.S. licensing regulations.





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The 50th Anniversary of GPS: New Avenues for Cooperating with Europe's Galileo

This paper delves into the evolution and future prospects of Global Navigation Satellite Systems (GNSS), with a particular focus on the United States' Global Positioning System (GPS) and Europe's Galileo. As GPS celebrates its 50th anniversary, it is a timely moment to assess its historical trajectory, current status, and future directions, especially considering the emergence of new competitors like China's BeiDou. Based on interviews with two GNSS experts from the European Commission, this study aims to analyze the potential for cooperation between GPS and Galileo, exploring avenues for collaboration and mutual learning.




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Mapping a Path Forward for Arctic Cooperation with Russia: A Biodiversity Case Study

For most of this century, the Arctic has been a place of peaceful cooperation in science and environmental protection, an approach built on a foundation of multiple agreements reached in the twentieth century. The Russian invasion of Ukraine and the geopolitical reverberations of the war have disrupted or outright halted most collaboration between Western and Russian scientists and conservationists.




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Current and Future Arctic Cooperation: Where to Next?

Viktoria Waldenfels MPA 2025 reflects on promising ways forward for Arctic cooperation.

This study group, led by Arctic Initiative Senior Fellow Margaret Williams, is evaluating the costs and benefits of renewing cooperation with Russia on science and conservation issues.




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Africa Beyond the Headlines: A Kaleidoscopic Exploration of Contemporary African Politics and International Cooperation

Dr. Gloria Ayee led a study group over the course of five sessions during the Spring of 2024, exploring the current pivotal moment on the African continent. Participants of the study group were invited to reflect on the role that international cooperation must play in supporting inclusive, sustainable development in Africa, as well as to move beyond outdated perspectives and learn about Africa’s profound transformation through trade, investments in clean energy and health, and youth empowerment initiatives.




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Beyond the Headlines: A Kaleidoscopic Exploration of Contemporary African Politics and International Cooperation

Dr. Gloria Ayee led a study group over the course of five sessions during the Spring of 2024, exploring the current pivotal moment on the African continent. Reflecting back, Dr. Ayee highlights the key takeaways from the study group.




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US-China Cooperation Remains Possible

Joseph S. Nye advocates for identifying areas for cooperation between the United States and China such as climate change and public health.





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They Say There’s No Room for Immigrants While Desperate Rural Towns Lie Empty All Across the Western World

Here’s a thing I keep noticing, and it drives me nuts. In Italy, a ship captain is arrested for bringing immigrants to shore after rescuing from them near death at sea: The number of migrants reaching Italy’s shores has drastically diminished – just 2,800 so far this year – and the country is now led […]




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Competition and Cooperation

The question of competition versus cooperation among humans has come up on my Twitter timeline again. It emerges every now and then, when someone desperate to find a defense for capitalism falls back on, “You socialists want to eliminate competition, but competition is a part of nature, so eliminating it is impossible.” Okay, let’s talk … Continue reading Competition and Cooperation




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Probability of operating an alarm clock Rubix cube, doable with hours of concentration Qauntum physicists have yet to unravel the mysteries

Probability of operating an alarm clock




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Dengue Virus Grows More Virulent in Warmer Temperatures

medlinkDengue/medlink, a recurring tropical disease that experiences outbreaks during the monsoon season, becomes more aggressive and severe in animal




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Increased Temperatures Pose Growing Dengue Risk

The escalating impact of climate change is anticipated to expand the reach of medlinkdengue/medlink, a mosquito-borne disease claiming thousands of




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Predicting Global Dengue Patterns With Sea Surface Temperature Anomalies

Chinese scientists found that anomalies in tropical Indian Ocean sea surface temperatures can forecast the severity of global medlinkdengue outbreaks/medlink (!--ref1--).





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Childhood Home Temperatures Predict Adult Thermostat Settings

The temperature of one's medlinkchildhood/medlink home and the sense of community connectedness can help predict how U.S. residents set their thermostats,




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Sleep Well Before Surgery to Avoid Postoperative Delirium

Poor sleep in the month before surgery raises the risk of postoperative delirium, warns a new study. The findings of the study will be presented at




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Development of a composite drought indicator for operational drought monitoring in the MENA region

The composite drought indicator (CDI) supports operational drought management decision making in Jordan, Lebanon, Morocco and Tunisia.

The post Development of a composite drought indicator for operational drought monitoring in the MENA region first appeared on International Water Management Institute (IWMI).




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IWMI and GWP promote water cooperation through a study tour to Central Asia

The visit for water professionals from South Asia laid the groundwork for furthering dialogue on transboundary river management for water security.

The post IWMI and GWP promote water cooperation through a study tour to Central Asia first appeared on International Water Management Institute (IWMI).






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Warner Chilcott Reports Operating Results for the Quarter Ended March 31, 2010

Warner Chilcott Reports Operating Results for the Quarter Ended March 31, 2010




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Bird Flu Virus Gets Killed at Cooking Temperature

Bird flu or avian influenza virus does not infect people as the virus is heat liable, degraded and killed when subjected to high temperature, said health experts.




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How Aphy Transformed citizenM’s Operations With Automation

citizenM, a global leader in modern, affordable luxury hotels, has long prioritized offering a premium level of service. For that, they believe in empowering their team, rather than having them hindered by manual processes. This led them to seek a solution that could optimize their workforce capabilities.




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India's first railway test track for high-speed trials to be operational in Dec 2025

India's first dedicated railway test track, under construction in Rajasthan, is expected to be completed by December 2025 with a total investment of Rs 820 crore, according to the Ministry of Railways.