“It’s been horrible; I’ve been sick on and off for the last 10 days,” said 29-year-old asthmatic Natasha Sohail, who teaches A-Level students at three private schools in Lahore. Last week, her condition worsened with a vertigo attack and fever. “It’s criminal what is happening here,” said an incensed Sohail, referring to the “band-aid measures” […]

This week, we journey to the early 2030s, when machine learning first allowed us to communicate with sperm whales. Rowan Hooper tells us what they have to say

Our arm of the Milky Way is filled with older, metal-rich stars. New research suggests these might provide the best conditions for life to form on their planets

A story passed down in folklore led scientists to evidence of an 8-metre tsunami that hit an island in Hawaii hundreds of years ago

Anthropologists have been arguing for 20 years about whether Sahelanthropus, a hominin that lived about 7 million years ago, was one of the first bipedal apes

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α-Synuclein (α-Syn) aggregation in Lewy bodies and Lewy neurites has emerged as a key pathogenetic feature in Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Various factors, including posttranslational modifications (PTMs), can influence the propensity of α-Syn to misfold and aggregate. PTMs are biochemical modifications of a protein that occur during or after translation and are typically mediated by enzymes. PTMs modulate several characteristics of proteins including their structure, activity, localization, and stability. α-Syn undergoes various posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, glycation, O-GlcNAcylation, nitration, oxidation, polyamination, arginylation, and truncation. Different PTMs of a protein can physically interact with one another or work together to influence a particular physiological or pathological feature in a process known as PTMs crosstalk. The development of detection techniques for the cooccurrence of PTMs in recent years has uncovered previously unappreciated mechanisms of their crosstalk. This has led to the emergence of evidence supporting an association between α-Syn PTMs crosstalk and synucleinopathies. In this review, we provide a comprehensive evaluation of α-Syn PTMs, their impact on misfolding and pathogenicity, the pharmacological means of targeting them, and their potential as biomarkers of disease. We also highlight the importance of the crosstalk between these PTMs in α-Syn function and aggregation. Insight into these PTMS and the complexities of their crosstalk can improve our understanding of the pathogenesis of synucleinopathies and identify novel targets of therapeutic potential.

Practicing family medicine is really hard; the emotional toll of sharing patients’ distress, vulnerability, and trauma can build up and become overwhelming. A family physician experienced such a moment during one particularly complex morning. Feeling nearly ready to walk out of patient care, she reached out to the team nurse, who helped her get through the moment and re-engage with the waiting patients. Sharing vulnerability in the moment, and later reflecting and deciding to write about it shows the power of prioritizing teamwork in practice.

Writer-director partners Scott Beck and Bryan Woods dive into the biggest spoilers of their new Hugh Grant thriller.

Jade Ho explains what is possible for university students when they are given opportunities to learn about –and get involved with– social justice and labour issues in their own communities.

The post Students can be agents of change: Talking about activism in universities with Jade Ho appeared first on rabble.ca.

Chris gets trolled by the bear cave. Jason sets optics to stun. Josh is hiding in a rest stop bathroom. Kelley stretches harder than she did for The Witch and the Hundred Knight. Also, find out how to increase your poop by 10 and express your opinions about Dragon Quest Soundtracks.

The post RPG Cast – Episode 664: “We Need to Talk About Gambit” appeared first on RPGamer.

Could tower defence be the ultimate "it's Friday and I am here in body only" genre? I haven't really thought about it before, but Rift Riff's effusively laidback crowd control has me pondering those optimal moments in any tower defender when the incoming horde hits the flamer-MG triangle just right, and you can settle back comfortably into the role of clockwatcher.

Rift Riff encourages this behaviour by being nice to look at. Created by a trio of developers including Hidden Folks designer Adriaan de Jongh, it's a world of spacey, sun-carved mountains, forests and monoliths. The towers resemble the sacred architecture of Monument Valley, and the colour scheme and general ambience remind me of Cocoon. There's a demo, if you fancy it.

Read more

"A lot of puzzle games can leave you staring at the same static screen for ages, but here, I’m always pushing you forward," says Mark Brown of Game Maker’s Toolkit. For a decade now, Brown has been releasing accessible deep dives on game design for his popular YouTube channel, like "How Game Designers Protect Players From Themselves" and "The Two Types of Random in Game Design." This week, he’s releasing his own for the first time.

Read more

Astronomers have identified patterns within the motion of stars stretching across the Milky Way, hinting at the presence of a vast wave

The Polaris Dawn mission will include the first ever civilian spacewalk, and with a new spacesuit and no airlock, it may also be the most dangerous spacewalk ever

Four private astronauts are riding a SpaceX Crew Dragon capsule further from Earth than any human since 1972, where they will attempt the first ever civilian spacewalk

A groundbreaking civilian spacewalk saw two astronauts partially exit a SpaceX Crew Dragon capsule wearing a brand new design of spacesuit. Every previous spacewalk completed before this was performed by government-trained astronauts.

Are humanoid robots the future of space exploration? New Scientist reporter James Woodford took NASA's Valkyrie for a spin to find out

NASA’s Valkyrie is undergoing tests to understand what it would take to get a humanoid robot onto offshore facilities or into space. New Scientist's James Woodford took the controls to see what it is capable of

A lithium-ion battery made from three droplets of hydrogel is the smallest soft battery of its kind – and it could be used in biocompatible and biodegradable implants

Emma Raducanu struck a deal to return to one of her favourite tournaments.

Video Friday is your weekly selection of awesome robotics videos, collected by your friends at IEEE Spectrum robotics. We also post a weekly calendar of upcoming robotics events for the next few months. Please send us your events for inclusion.

ICRA@40: 23–26 September 2024, ROTTERDAM, NETHERLANDS

IROS 2024: 14–18 October 2024, ABU DHABI, UAE

ICSR 2024: 23–26 October 2024, ODENSE, DENMARK

Cybathlon 2024: 25–27 October 2024, ZURICH

Enjoy today’s videos!

Researchers at the Max Planck Institute for Intelligent Systems and ETH Zurich have developed a robotic leg with artificial muscles. Inspired by living creatures, it jumps across different terrains in an agile and energy-efficient manner.

[ Nature ] via [ MPI ]

Thanks, Toshi!

ETH Zurich researchers have now developed a fast robotic printing process for earth-based materials that does not require cement. In what is known as “impact printing,” a robot shoots material from above, gradually building a wall. On impact, the parts bond together, and very minimal additives are required.

[ ETH Zurich ]

How could you not be excited to see this happen for real?

[ arXiv paper ]

Can we all agree that sanding, grinding, deburring, and polishing tasks are really best done by robots, for the most part?

[ Cohesive Robotics ]

Thanks, David!

Using doors is a longstanding challenge in robotics and is of significant practical interest in giving robots greater access to human-centric spaces. The task is challenging due to the need for online adaptation to varying door properties and precise control in manipulating the door panel and navigating through the confined doorway. To address this, we propose a learning-based controller for a legged manipulator to open and traverse through doors.

[ arXiv paper ]

Isaac is the first robot assistant that’s built for the home. And we’re shipping it in fall of 2025.

Fall of 2025 is a long enough time from now that I’m not even going to speculate about it.

[ Weave Robotics ]

By patterning liquid metal paste onto a soft sheet of silicone or acrylic foam tape, we developed stretchable versions of conventional rigid circuits (like Arduinos). Our soft circuits can be stretched to over 300% strain (over 4x their length) and are integrated into active soft robots.

[ Science Robotics ] via [ Yale ]

NASA’s Curiosity rover is exploring a scientifically exciting area on Mars, but communicating with the mission team on Earth has recently been a challenge due to both the current season and the surrounding terrain. In this Mars Report, Curiosity engineer Reidar Larsen takes you inside the uplink room where the team talks to the rover.

[ NASA ]

I love this and want to burn it with fire.

[ Carpentopod ]

Very often, people ask us what Reachy 2 is capable of, which is why we’re showing you the manipulation possibilities (through teleoperation) of our technology. The robot shown in this video is the Beta version of Reachy 2, our new robot coming very soon!

[ Pollen Robotics ]

The Scalable Autonomous Robots (ScalAR) Lab is an interdisciplinary lab focused on fundamental research problems in robotics that lie at the intersection of robotics, nonlinear dynamical systems theory, and uncertainty.

[ ScalAR Lab ]

Astorino is a 6-axis educational robot created for practical and affordable teaching of robotics in schools and beyond. It has been created with 3D printing, so it allows for experimentation and the possible addition of parts. With its design and programming, it replicates the actions of #KawasakiRobotics industrial robots, giving students the necessary skills for future work.

[ Astorino ]

I guess fish-fillet-shaping robots need to exist because otherwise customers will freak out if all their fish fillets are not identical, or something?

[ Flexiv ]

Watch the second episode of the ExoMars Rosalind Franklin rover mission—Europe’s ambitious exploration journey to search for past and present signs of life on Mars. The rover will dig, collect, and investigate the chemical composition of material collected by a drill. Rosalind Franklin will be the first rover to reach a depth of up to two meters below the surface, acquiring samples that have been protected from surface radiation and extreme temperatures.

[ ESA ]

NASA said Thursday that the study of UFOs will require new scientific techniques, including advanced satellites as well as a shift in how unexplained sightings are perceived.

Kaseya, a provider of unified IT management and security software for managed service providers (MSPs) and small to midsize business (SMBs), today released its 2024 MSP Benchmark Report, which surveyed close to 1,000 MSPs from the Americas, EMEA (Europe, Middle East and Africa) and APAC (Asia Pacific) regions and includes responses from both IT professionals […]

A small team of local scientists are fighting rapid industrialization, misinformation and more to save Europe’s iconic cat

"I did not say I was uncomfortable talking about it. I said we're not going to talk about it."

In the final broadcast of TOTN, NPR senior Washington editor Ron Elving, senior business editor Marilyn Geewax and science correspondent Richard Harris discuss the big stories they're covering. Callers talk about the issues that have their communities and social circles abuzz.

With a macrotrend/backdrop of platformization and convergence, the industry is exploring places where identity security, endpoint security, and network security naturally meet.

The post Identity, Endpoint, and Network Security Walk into a Bar appeared first on Gigaom.

Team at Kolkata institute engineers bacteria to solve maths problems  The Hindu

1. Magnus Carlsen returns to Kolkata after almost five years at Tata Steel India Rapid and Blitz 2024  ChessBase India
2. "It's Chaotic": Chess World No. 1 Magnus Carlsen Reveals Why He Does Not Play In India  NDTV Sports
3. King Carlsen hails growth of Indian chess, praises Praggnanandhaa's fighting spirit  Telegraph India
4. Tata Steel Chess set for a Carlsen-Pragg opening  Hindustan Times
5. Tata Steel Chess India Rapid & Blitz 2024: Schedule, Venue, Players, Tickets, Prize Money  Firstpost