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Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00537F, Research Article
Open Access
Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry Lomberget
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.
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Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00600C, Research Article
Open Access
Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa Lamberti
Biological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.
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544: Feedback, RSS Talk, Arc Brower, and Product Talk

Getting feedback for what you're building or writing, RSS feed reminiscing, Arc browser thoughts, products that didn't make that should have.




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568: Display Contents, Passkeys Follow Up, Yellow Fade Technique, and TOTK Talk

Macho Man Randy Standards stops by for a quick chat, Passkeys follow up, discussing the safety of Display: contents, the yellow fade technique, how hot CSS is right now (so hot), and a check in on how everyone's doing with Tears of the Kingdom.




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595: MedTalk Show, Plagiarism and Code Grifting, and How We’re Testing Code

Blood pressure, stress, and COVID highlight the MedTalk Show portion of this episode, a new "Did You Know" segment about dev tools in Chrome, 4 hour video on plagiarism and code grifters, typography, breaking out of CSS Grid, the oldest things Chris and Dave worked on, and what the testing process is like at Luro or CodePen.




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625: CarTalk, Ownership of A Book Apart, and URL Shorteners

Dave's putting together a platform for his presidential bid and workshops his policies, discussing vehicle options for a family in 2024, Chris and other authors get ownership of their A Book Apart books back, and the ramifications and reasoning behind Google killing a URL shortener.




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Walk to work homes

Relocating within the same city to avoid hours of commuting is a wise decision




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Can we escape the gas chamber we have walked into?

All countries are falling short of their promise to do their mite for climate action




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MSP law cannot be brought in a hurry; farmers should come forward for talks with govt: Arjun Munda

Union Agriculture Minister Arjun Munda cautioned protesting farmers about some elements usurping their protest for political benefits




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‘Dairy dilemma’ engulfs women farmers in CM Chandrababu Naidu’s constituency Kuppam with sudden fall in milk price

Recently, the dairy industry has experienced a decrease of ₹5 per liter in the milk price, causing concern among the predominantly women farmers involved in the sector. 




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Shivraj Chouhan blames Congress again for problems in agricultural sector; Opposition walks out in Rajya Sabha

Chairman Jagdeep Dhankhar asks Mr. Chouhan to look at pending issues of farmers




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Centre talks to States on new mechanism to gather crop data

The national conference discusses the Digital General Crop Estimation Survey to enhance agricultural statistics accuracy and transparency for policy formulation and planning





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Kohli the run-machine goes past Tendulkar but...

Kohli's knock of 88 (94) was his 10th 50-plus score in the ODI format this year second only to Shubman Gill who leads the charts with twelve 50-plus ODI scores in 2023.




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Volkswagen India enters compact sedan segment




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Jindal Group in talks to acquire Czech-based Vitkovice Steel for €150 million

The Naveen Jindal-owned business house already has a significant presence in geographies like Australia, Mozambique and Oman in sectors such as steel, power and mining




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25 tribal girls to undergo skill development training under Tholkudi scheme




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ONGC conducts mock drill at Kovilkalappal GGS




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Towards a universal model for the foaming behavior of surfactants: a case study on per- and polyfluoroalkyl substances (PFAS)

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00931B, Paper
Muchu Zhou, Reza Foudazi
Foam fractionation offers a promising solution for the separation of surface-active contaminants from water.
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Revealing microscale bulk structures in polymer–carbon nanocomposites using spin-echo SANS

Soft Matter, 2024, 20,8663-8674
DOI: 10.1039/D4SM00578C, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
L. V. Tiihonen, M. P. Weir, A. J. Parnell, S. C. Boothroyd, D. W. Johnson, R. M. Dalgliesh, M. Bleuel, C. P. Duif, W. G. Bouwman, R. L. Thompson, K. S. Coleman, N. Clarke, W. A. Hamilton, A. L. Washington, S. R. Parnell
Spin-echo small-angle neutron scattering (SESANS) revealed structure in polymer–carbon nanocomposites over multiple length scales with unprecedented range (10 nm–16 μm). Data from two SESANS instruments and other methods were analysed with SasView.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Self-consistent electrostatic formalism of bulk electrolytes based on the asymmetric treatment of the short- and long-range ion interactions

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01174K, Paper
Sahin Buyukdagli
Internal energy of monovalent electrolytes (left) and dimensionless screening parameter of multivalent electrolytes (right).
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The style file from the Lakme Fashion Week that got us talking

Lakmé Fashion Week x FDCI 2023 showcased gender-agnostic styles, recycled accessories and modern Indian draping techniques – we explore what will influence your wardrobe this year



  • Life & Style

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The long walk to fitness

A recent panel discussion on wellness emphasised on the need for women to take care of themselves




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Golden milk




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Coimbatore-based Walkaroo footwear hosts the 11th edition of Coimbatore Marathon

Coimbatore-based Walkaroo footwear has joined hands with Coimbatore Cancer Foundation to host the 11th edition of the Coimbatore Marathon




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The Agony of Jimmy Quinlan / directed by: George Mihalka, George Williams ; produced by: Robert Duncan, Janice Brown, Andy Thomson, Peter Katadotis ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2008




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Four from Kurnool selected for national gymnastic competition in Kolkata




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The end of the bell lap for Kolkata’s tramway

Rather than ending India’s last remaining passenger tram network, attempts should have been made to revitalise and modernise it




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Tropical algebraic geometry [electronic resource] / Ilia Itenberg, Grigory Mikhalkin, Eugenii Shustin

Basel ; Boston : Birkhauser, 2007




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Guarantee scheme detractors disillusioned over Karnataka’s economic growth, says Laxmi Hebbalkar

Karnataka has achieved 10.2% GDP in 2023-24, higher to national average of 8.2%, says Udupi district in-charge minister




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Body of man found on railway track in Mulky; wife and son found dead in room

Mangaluru police claim 32-year-old resident of Mulky allegedly killed his 27-year-old wife and their four-year-old son before ending his life on a railway track




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Warrior prince and talking heads

The playfulness to the writing around Ravana and his ten perennially bickering heads could have made the film oddly amusing. But alas, the humour remains just a flash




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Pulkit TMT introduces innovative ‘Lab on Wheels’ for quality testing in Kerala 

The initiative aims to raise awareness about the significance of using high-quality TMT bars in construction projects and empower consumers, builders, and dealers to make informed decisions about their steel choices.




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Nexus Select Trust in talks to acquire Axis Mall in Kolkata

The acquisition of the mall would require a different structure to be set in place since it does not have a single owner or promoter




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Photocatalytic hydrotrichloromethylation of unactivated alkenes with chloroform

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01496K, Research Article
Dawei Gong, Caiyu Gao, Qixuan Li, Yufei Li, Lina Zhao, Degong Kong
Trichloromethyl compounds are essential constituents in synthetic and medicinal chemistry.
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Palladium-catalyzed hydrocarbonylative cross-coupling with two different alkenes

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01312C, Research Article
Yi Chen, Jianing Wu, Yongzheng Ding, Hanmin Huang
Transition metal-catalyzed hydrocarbonylation of alkenes has been widely studied; however, the hydrocarbonylation reaction that took place between two alkenes has been largely unexplored.
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General ppm-level Pd-catalysed asymmetric diarylalkyne hydrosilylation to access structurally diverse Si-stereogenic vinylsilanes

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01698J, Research Article
Heng Xu, Han-Xiao Yu, An-Jiu Wen, Fang-Ying Ling, Fei Ye, Li Li, Fuk Yee Kwong, Li-Wen Xu
The first example of enantioselective Pd-catalyzed hydrosilylation of symmetric and asymmetric diarylalkynes to access novel Si-stereogenic vinylsilanes with excellent ee and a high TON is realized under mild reaction conditions.
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Synthesis of bambusurils with perfluoroalkylthiobenzyl groups as highly potent halide receptors

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01746C, Research Article
Open Access
Matúš Chvojka, Hennie Valkenier, Vladimír Šindelář
Four new fluorinated bambusuril macrocycles were prepared to show exceptional high binding affinity towards halide anions in acetonitrile.
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Photocatalytic arylation/alkylation of olefins/alkynes via halogen-atom transfer mediated by NHC-BH3

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01562B, Research Article
Xinhan Li, Yao Zhong, Fengsong Tan, Yusong Fei, Xiaohan Zhao, Jianbin Xu, Baomin Fan
A versatile method for radical reductive cross-coupling of iodides and activated olefins under mild conditions, facilitated by NHC-BH3 through photocatalysis, was developed.
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Photoinduced cobaloxime catalysis for allylic mono- and diphosphinylation of alkenes with hydrogen evolution

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01638F, Research Article
Aijun Zhang, Miao-Miao Li, Lei Guo, Huaixiang Yang, Jiefei Guo, Da Xu, Wei Ding
A highly efficient allylic radical mono- and diphosphinylation of alkenes with secondary phosphine oxides is developed, via visible-light-induced cobaloxime catalysis.
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The reactivity of alkenyl boron reagents in catalytic reactions: recent advances and perspectives

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01703J, Review Article
Ya-Li Feng, Bo-Wen Zhang, Youzhi Xu, Shengnan Jin, Daniele Mazzarella, Zhong-Yan Cao
Recent advances focusing on novel reactivity of alkenyl boron reagents in polar or radical pathways within catalytic reactions by employing transition metal catalysis, organocatalysis have been summarized and discussed.
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Visible-light excited copper activating unactivated alkyl iodides for radical addition/cyclization to access oxindole derivatives

Org. Chem. Front., 2024, 11,6380-6384
DOI: 10.1039/D4QO01329H, Research Article
Hang Luo, Fangnian Yu, Luqing Lin
The photocopper catalyst facilitates halogen atom transfer to give unactivated alkyl radicals, which is critical for achieving radical cyclization in the absence of an exogenous photocatalyst.
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Visible-light-promoted catalytic epoxidation of alkenes under metal-free conditions

Org. Chem. Front., 2024, 11,6437-6443
DOI: 10.1039/D4QO01265H, Research Article
Dabao Tan, Xiaoyan Cai, Lele Zhang, Boyu Liu, Jianbin Zeng, Feiming Li, Zhixiong Cai, Mingqiang Huang, Xiaoping Chen, Shunyou Cai
In this work, we report a method for the synthesis of functionalized epoxy analogues using the synergistic interaction of 4CzIPN and oxygen under visible light stimulation.
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Carbonate-assisted selectively deoxygenative cross-coupling reaction between aryl and aliphatic aldehydes: a straightforward route to access α-alkylated aryl ketones

Org. Chem. Front., 2024, 11,6510-6517
DOI: 10.1039/D4QO01517G, Research Article
Yu Sun, Yi Wang, Zhijun Zuo
A novel reductive cross-coupling reaction of two different aldehydes for rapidly assembling α-alkylated aryl ketones has been developed. The inexpensive carbonate served not only as a base but also as an efficient electron donor.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Shining light on sulfonium salts and sulfur ylides: recent advances in alkylation under photoredox catalysis

Org. Chem. Front., 2024, 11,6573-6588
DOI: 10.1039/D4QO01644K, Review Article
Zhe Jin, Tingwei Yu, Hui Wang, Penghao Jia, You Huang
Recent advancements in photoredox alkylation with sulfur ylides, sulfonium salts and related analogues are summarized in this review.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Copper-catalyzed alkynyldisulfuration of arynes: an efficient access to unsymmetrical disulfides

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01844C, Research Article
Shuai Huang, Yumin Zhang, Yuekai Li, Chen-Ho Tung, Xin Li, Zhenghu Xu
This article investigates a copper-catalyzed alkynyl disulfuration reaction of aryne formed in situ to synthesize o‑alkynyl aryl disulfides. The transformation proceeds through the in situ generation of aryne, followed by...
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Charge Transfer Complex Enabled Mechanochemical Synthesis of Chalcogenoacetylenes via Alkynyl Radicals

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01827C, Research Article
Open Access
Fang Tan, Chang-Zhen Fang, Bing-Sheng Qiu, He Sheng, Yong-Liang Tu, Xiang-Yu Chen
Mechanochemistry has become an appealing strategy to enable numerous organic transformations. While significant advances have been achieved, the radical coupling reaction under mechanochemical conditions is still in its infancy. In...
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Thiocyanoalkylation of Alkenes via Dual Photoredox and Copper Catalysis

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01864H, Research Article
Xu Wang, Bi-Yin Xiao, Qi-Xuan Jiang, Wei Huang, Feng-Hua Zhang
Organic thiocyanates are commonly used as an essential organic synthesis intermediate and widely present in various drug molecules and bioactive molecules. Herein, a copper and photoredox catalyzed thiocyanoalkylation reaction of...
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Nickel-catalyzed reductive 1,2-alkylarylation of alkenes via a 1,5-hydrogen atom transfer (HAT) cascade

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01875C, Research Article
Xi Chen, Qiang Wang, Xiao-Ping Gong, Rui-Qiang Jiao, Xue-Yuan Liu, Yong-Min Liang
A nickel-catalyzed 1,2-alkylarylation of alkenes has been developed, leveraging amidyl radical-triggered 1,5-HAT with electrophiles as functionalizing reagents.
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Stereocontrolled synthesis of heterocycles from unactivated alkynes by photoredox/nickel dual-catalyzed cyclization

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01627K, Research Article
Bo-Rong Leng, Feng Yang, Jin-Lian Bai, Yu-Wen Huang, Qing-Quan Liu, Ping Wei, De-Cai Wang, Yi-Long Zhu
We report a nickel/photoredox dual catalysis method for synthesizing heterocyclics from unactivated alkynes and aryl iodides, offering a direct, selective, and green alternative to traditional synthesis with potential in medicinal chemistry.
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