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One of the main mechanisms of azole resistance of Aspergillus fumigatus is thought to be a reduction in the drug’s affinity for the target molecule, Cyp51A, due to its amino acid mutation(s). It is known that the azole resistance pattern is closely related to the mutation site(s) of the molecule. In this study, we tried to develop a simple and rapid detection method for cyp51A mutations using the endonuclease Surveyor nuclease. The Surveyor nuclease assay was verified using several azole-resistant strains of A. fumigatus that possess point mutations in Cyp51A. For validation of the Surveyor nuclease assay, blind tests were conducted using 48 strains of A. fumigatus (17 azole-resistant and 31 azole-susceptible strains). The Surveyor nuclease assay could rapidly detect cyp51A mutations with one primer set. Also, all the tested strains harboring different cyp51A single point mutations could be clearly distinguished from the wild type. The Surveyor nuclease assay is a simple method that can detect cyp51A mutations rapidly.

Advanced preliminary release for Q4 2019 quarterly data on total credit to the non-financial sectors; comprising private non-financial sector and general government for 44 economies and regional aggregates have been updated. Data are available for the following borrowing subsectors: general government, private non-financial sector (series on credit from domestic banks as lending sector are also available), non-financial corporations and households. Data are presented in three versions: in billions of local currency and US dollars, and as a percentage of GDP.

Close to 300 series at various frequencies for 60 countries have been updated.

Monthly and annual data have been updated for 60 countries. The average length of the monthly series is more than to 55 years. Some annual series go back to the middle of the 19th century - or even earlier for several countries.

Advanced preliminary release for Q4 2019 quarterly data on debt service ratios (DSRs) for the private non-financial sector (PNFS) for 32 countries have been updated. DSRs for PNFS breakdown sectors, ie for households and for non-financial corporations are also available for 17 countries.

BCBS Press release "Basel Committee publishes stocktake report on climate-related financial risk initiatives'", 30 April 2020

This report summarises the main results of a stocktake conducted by the Basel Committee of its members' initiatives on climate-related financial risks.

We develop a parsimonious model to study the effect of regulations aimed at reducing counterparty risk on the structure of over-the-counter securities markets. We find that such regulations promote entry of dealers, thus fostering competition and lowering spreads. Greater competition, however, has an indirect negative effect on market-making profitability.

Introductory remarks (by videoconference) by Mr Luis de Guindos, Vice-President of the European Central Bank, to the Committee on Economic and Monetary Affairs of the European Parliament, Frankfurt am Main, 7 May 2020.

Daily data on monetary policy rates have been updated. This covers 38 central banks with the earliest data starting in 1946.

Are financial intermediaries inherently unstable and, if so, why? To address this, we analyse whether model economies with financial intermediation are particularly prone to multiple, cyclic or stochastic equilibria.

Inflation pressure could be weak even after consumer demand for non-discretionary goods and services begins to grow as the economy gets back on its feet.

Bank of Italy Working Papers by Giorgio Albareto, Andrea Cardillo, Andrea Hamaui and Giuseppe Marinelli

Bank of Italy Working Papers by Luca Metelli, Filippo Natoli and Luca Rossi

Bank of Italy Working Papers by Eleonora Porreca and Alfonso Rosolia

Bank for International Settlements BIS Working Papers by David Cook and Nikhil Patel

Bank for International Settlements BIS Working Papers by Claudio Borio, Marc Farag and Nikola Tarashev

Bank of Finland Research Discussion Papers by Eleonora Granziera and Markus Sihvonen

Bank of England Working Papers by Cristiano Cantore and Lukas Freund

Netherlands Bank DNB Occasional Studies by Peter Wierts and Harro Boven

Bank for International Settlements BIS Working Papers by Francesca Carapella and Cyril Monnet

European Systemic Risk Board Occasional Papers by Greg Ros

Bank of Spain Working Papers by Henrique S. Basso and Juan F. Jimeno

Central Bank of Chile Working Papers by Andrés Sagner

Central Bank of Chile Working Papers by Tomás Gómez, Alejandro Jara and David Moreno

Central Bank of Chile Working Papers by Gee Hee Hong, Matthew Klepacz, Ernesto Pasten and Raphael Schoenle

Danes haven’t built a “socialist” country. Just one that works.

Ready to "switch" things up on your desktop? A mechanical keyboard can make everything click again. Here's a guide to the most common mechanical key types, as well as the top performers in our testing.

Penn State is implementing a new opt-in grading system for the spring 2020 semester that will give students flexibility, help preserve GPAs and minimize impacts to students’ transcripts during the academic challenges presented by the novel coronavirus public health crisis.

Amanda Moore, of Chambersburg, Pennsylvania, is on track to graduate from Penn State Mont Alto this May with a degree in psychology. She credits her academic success with Mont Alto's strong focus on research and varied program offerings.

As college campuses closed and the COVID-19 virus began casting a larger shadow in south central Pennsylvania, members of the nursing and physical therapist assistant programs at Penn State Mont Alto took stock of all the medical personal protection equipment (PPE) items in their labs. The two programs were supplied with hundreds of gloves and dozens of medical gowns and masks, plus other items such as disposable stethoscopes, shoe covers and safety glasses — items no longer needed as the campus transitioned to remote instruction.

Penn State Mont Alto recognizes and honors winners during awards ceremony

The Penn State Mont Alto campus held its annual Academic and Leadership Awards Ceremony online on Sunday, April 19. Eighty-eight students were recognized for their academic achievements and campus leadership during the 2019-20 academic year. Three faculty members and one staff member were also recognized for their above-and-beyond contributions to the learning environment at Penn State Mont Alto.

Penn State Mont Alto unveiled its new project and supply chain management degree in response to a local and global need.

Staying active and maintaining physical fitness has many benefits to all elements of wellness, including mental and emotional well-being that may be taxed during social distancing. At Penn State Mont Alto, the athletic department has been releasing weekly at-home workout and challenge videos that are accessible on our Facebook and Instagram pages to keep our student-athletes engaged.

Beware men who never admit having been wrong.

Penn State’s PROmoting School-community-university Partnerships to Enhance Resilience (PROSPER) project is continuing to connect and engage Pennsylvania families and keep schools informed during the COVID-19 pandemic.