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7-Eleven starts talks with ACT on $47bn takeover bid as ‘white knight’ emerges

Convenience store operator receives rival buyout offer from members of founding family







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Will a Robot Take Your God?

Societies grow and change all the time, but it can be tough to think about big-picture shifts when you’re living through the practical details of the day to day. Take the recent popularity of large language models (LLMs). In the short term, we face important sociological questions about how they fit into the norms of […]




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10 Ways to Take Stunning Portraits (Portrait Photography Guide)

The post 10 Ways to Take Stunning Portraits (Portrait Photography Guide) appeared first on Digital Photography School. It was authored by Darren Rowse.

How do you do portrait photography that has the wow factor? Capturing stunning portraits often seems difficult, but it’s actually pretty easy once you know a few tips and tricks. Below, I share my 10 absolute favorite techniques for shooting portraits, including tips for lighting, composition, perspective, and much more. I’ve also included plenty of […]

The post 10 Ways to Take Stunning Portraits (Portrait Photography Guide) appeared first on Digital Photography School. It was authored by Darren Rowse.




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Take All The Time You Need, Even From The Past!

Client: “So you got everything you need? Take all the time you want. We really believe we understand the mind of the creative individual. We know it takes time to create a powerful ad.”

Me: “Yeah. It does. Thanks.”

Client: “But it’s urgent. Just imagine that it should have been done as of yesterday.”

Me: “But no deadline?”

Client: “Right. Well, I mean, we need it for four days, but otherwise, yeah; no deadline.”




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If You Had A Nickel For Every Mistake...

I do in-house design work for my boss. I’ve worked with her for ten years and she swings wildly back and forth from being surprisingly design-savvy (not for a literal decade of trying on my part) and being a client from Hell. Today, she swung somewhere in the middle.

I have spent the entire time I’ve known her explaining how you cannot just pull photos from Google; I’ve explained copyright, public domain, etc. She refuses to buy photos 99% of the time, so I usually use free stock photos when possible. When she absolutely needs to buy a photo, she emails our web guy and has him buy one for her and add it to her next bill.

Me: “I see you got [Web Guy] to purchase the photo for the ad and forwarded me the email with the file. Unfortunately, the file is too small. Unless he sent you a separate email with a larger file, I will just email him for the correct one.”

Boss: “Maybe it’s how I sent it. I’ll try again.”

She forwards me the same email.

Me: “No, no, it’s not you. The file he sent you is labelled “thumbnail,” which is a preview file. He probably just sent the wrong one by accident. I have emailed him.”

Boss: “What about this one?”

She sends an email with the same photo attached.

Me: “That’s the same one. I have emailed [Web Guy]. Don’t worry about it. You don’t have the correct file.”

She forwards the same original email from [Web Guy].

Boss: “What about now?”

Me: “No, boss, I’ll get it from [Web Guy].”

She forwards the individual email she sent me.

Boss: “How about now?”

Me: “Boss, no.”

Closure: She now has a stock photo account that I have access to.




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Find out what it takes to be an ecotourist

Vacations are an integral part of every person’s life. Following long seasons of hard work, it is well deserved to get away from busy schedules and enjoy nature. The tourism industry is fully built around the need for vacations. While tourism is good, it has its dark side. The entire industry thrives on the existence of nature, yet it tends to erode away what is left of natural resources.[...]





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Space Ladies Can't Take A Hint...

Well, HELLO handsome... Don't TOUCH me, you evil wenches! Can't you see by these FABULOUS tights and my jaunty antenna I'm far too gay for the likes of you!




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Oh My of the Day: George Takei Has Perfect Response For Facebook Troll

George Takei really sucks—and he's proud of it!

The Star Trek legend and Internet darling had the prefect response this week for a Facebook troll trying to bring him down.

He shared a screenshot of the exchange with the caption: "Sorry, couldn't help myself.‪ #‎Trollololollol‬"

BOOM!

Takei is known for his epic Internet takedowns, so mark this one down as another win for Sulu.





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Hot takes on an 11 year old game: Mass Effect 2

I completed Mass Effect 2 a couple of days ago for the first time. This article contains spoilers…




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Law enforcement operation takes down 22,000 malicious IP addresses worldwide




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Inside the Cure’s Big Halloween Comeback: Concert, BBC Takeover and ‘Lost World’ Album

From Variety:


Brit Beat: Inside the Cure’s Big Halloween Comeback: Concert, BBC Takeover and ‘Lost World’ Album

By Mark Sutherland

It’s been 16 long years since legendary British alternative rockers the Cure last released a studio album, but the campaign for the band’s new outing, “Lost World,” has made it feel like they’ve never been away.

And the band has also returned “home” to the Fiction-via-Polydor label, which released the band’s recordings up until 2004’s self-titled album. The most recent two Cure albums came out via America on Geffen, but Polydor Label Group President Ben Mortimer says he made it his “mission” to bring the band back to the record company.

“I actually can’t believe it’s happened because it’s been a conversation that’s been going on for so long,” Mortimer tells Variety. “Robert Smith sits alongside Paul Weller, who we brought back to Polydor a few years ago, as one of those people who are really in the fabric of the label. [The return] has really energized the whole label and tapped into the soul of what we do.”

Mortimer says “huge credit” should also go to Fiction Records Managing Director Jim Chancellor, “who has had a brilliant relationship with Robert for a long time.” Smith manages the band himself and Mortimer says the release plan came together over numerous emails featuring Smith’s trademark “all caps firmly on” style.

Key to the strategy was a suitably gothic Cure takeover of the BBC on Halloween, the day before “Songs of a Lost World” dropped, with a live session on BBC Radio 6 Music and a career-spanning BBC Radio 2 “In Concert” recording, which was also televised as part of a BBC 2 Cure night on November 2. The “In Concert” recording reportedly received the most ticket applications of any show in the long-running series.

“One of the stipulations Robert had on doing the deal was that the album to come out straight after Halloween,” Mortimer says. “Our production team had to jump through hoops to deliver vinyl and everything in time. It was really touch and go but Robert was very clear, unless it’s coming November 1, we ain’t doing this!”

The band also made a spectacular full live return with an intimate show at London’s Troxy venue on November 1, which featured a full rendition of the new album as well as many other songs. It was livestreamed around the world on YouTube and attended by many other musicians, from Green Day’s Billie Joe Armstrong to Culture Club’s Boy George.

All that attention – and some of the best reviews of the band’s career – has also translated into record sales, with the album set to debut at No.1 in the Official U.K. Albums Chart on November 8. It had already passed 40,000 units by Monday, according to the Official Charts Company. That’s despite this being the band’s first album release of the streaming age – previous studio album “4:13 Dream” came out in 2008 – with Mortimer saying the band racked up huge numbers of Spotify pre-saves.

“The Universal catalog team, alongside Robert, have done a very good job of keeping things alive for years, but it’s more than that,” says Mortimer. “If you look at their streams, there are tracks at over 700 million on Spotify, so there is a young audience there that streams the Cure.

“We’ve brought in new ideas – Robert’s remarkably open to modern ways of thinking, he’s such an intelligent man, he grasps things so quickly – but I don’t think it changed his strategy,” Mortimer adds. “Some artists are able to speak to different generations, and the Cure are one of those.”

With the band likely to announce further touring plans, Mortimer is expecting a long campaign for the album, one of the first big releases through the new Polydor Label Group, after a major Universal U.K. restructure: Mortimer now also oversees the Capitol U.K. and 0207 Def Jam labels, run by Jo Charrington and Alec Boateng respectively.

“It’s been a crazy year across the whole business, but I’m really thankful about the new responsibilities that I have,” says Mortimer. “Working with Jo and Alec is just an absolute dream, they’re some of the best A&R executives of recent generations and they’ve brought so many brilliant artists into our system, so I’m feeling really lucky. Everyone complements each other really well.”

Meanwhile, the American release of “Songs of a Lost World” goes through Capitol, meaning Mortimer has reunited with his former Polydor co-president Tom March, now chairman/CEO of Capitol Music Group (“Tom’s wonderful – having a Brit over there who gets it has been really helpful”). The pair revived Polydor’s fortunes in the 2010s and Mortimer is hopeful the Cure’s renewed success could also bring back the buzz to music from this side of the pond.

“It feels like there’s real interest in what the U.K. and Ireland does really well again,” he says. “You look at Oasis, the Cure, plus we’re getting such an explosion of interest on Sam Fender at the moment and we’re seeing growth on a band like Inhaler… We’ve been talking about it for 15 years but it’s genuinely happening now.”




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Gene Jarrett takes us back to the Gilded Age in his new biography of Paul Laurence Dunbar

The book joins others by Princeton faculty on The New Yorker list of the year’s best. Jarrett gives a talk at Labyrinth Books on Thursday, Nov. 3.





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'On October 8, American Jews woke up': New documentary 'October H8TE' explains what's at stake


Director Wendy Sachs attributes the steep rise in antisemitism to social media, from where so many young people get news that has no validation.




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7 Bad Signs for Democrats: A Satirical Take on America’s Return to Normalcy

The following article, 7 Bad Signs for Democrats: A Satirical Take on America’s Return to Normalcy, was first published on The Black Sphere.

Yes, the Democrats got shellacked in the last election. And while that’s a breath of fresh air, it’s hardly the only sign that the political winds are changing.

Continue reading 7 Bad Signs for Democrats: A Satirical Take on America’s Return to Normalcy ...





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Which rural area will take the UK’s nuclear waste?

The UK's nuclear waste needs a permanent home - but finding a community willing to take it is tricky.




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Ferguson takes hat-trick as NZ win dramatic T20

Lockie Ferguson takes a hat-trick and Glenn Phillips claims three wickets in the final over as New Zealand win a low-scoring second T20 against Sri Lanka.




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Gold, prices, and jobs: What's at stake in Ghana's elections?

In an echo of the US, the current vice-president is up against an ex-president in the 7 December vote.




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We set the theme, you take the pictures

Each week, we ask you to send in your pictures on a set theme and a selection of these are then published each Thursday on our In pictures page




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More toilets will take 'worry' out of London travel

Billie Nicholls, who has ulcerative colitis, says some people don't have the luxury of waiting.





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What's at stake in the Irish general election?

After growing speculation, the Irish prime minister has called a general election.




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Mings penalty mistake biggest I've ever witnessed - Emery

Tyrone Mings became the first Englishman to concede a penalty on his Champions League debut in bizarre fashion as Aston Villa lost to Brugge.




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'It's down to me' - Postecoglou takes responsibility for 'hugely disappointing' defeat

Tottenham boss Ange Postecoglou accepts responsibility for his side's 2-1 Premier League defeat at home by a previously winless Ipswich.




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News24 | Businessman Alix Didier Fils-Aime takes over as PM of crisis-hit Haiti

Businessman Alix Didier Fils-Aime was sworn in as Haiti's new prime minister on Monday as a gun attack on a passenger jet at the capital's airport underscored the utter breakdown in law and order in the Caribbean country.





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SaaStr Annual 2019 – Key Takeaways and Highlights

The 2Checkout team kicked off Feb 2019 by joining over 12,000 participants in San Jose for SaaStr Annual 2019, the largest conference in the world for B2B software. The general consensus of 2Checkout team members at the end of the conference was simple and to the point: “It. Was. Amazing.”




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Bitcoin’s market cap briefly overtakes silver’s at $89,000 level

Earlier today, Bitcoin’s market cap briefly overtook that of silver, as the world’s first cryptocurrency reached never-before-seen heights. CoinMarketCap data… Continue reading Bitcoin’s market cap briefly overtakes silver’s at $89,000 level

The post Bitcoin’s market cap briefly overtakes silver’s at $89,000 level appeared first on ReadWrite.




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IVT Takes Webcasting Software Platform to the Cloud

IVT, Inc. has moved its industry-leading MediaPlatform webcasting software platform to the cloud. With MediaPlatform increasingly being used in large-scale webcasts by media producers, as well as Fortune 500 clients, the company is elevating its delivery capacity through a partnership with a tier-1 cloud infrastructure provider.

“Our mission has always been to deliver the best quality of service and enable our clients to produce webcasts at literally any audience size without concern for infrastructure,” said Jim McGovern, Chief Executive Officer of IVT. “Now that cloud-based platforms are gaining widespread acceptance across the IT world, we can give our clients the benefit of switching capacity on and off when required.”

This is not the first time IVT has been ahead of the technology curve in the webcasting industry. The company pioneered the concept of offering webcasting software on a Software-as-a-Service (SaaS) basis with MediaPlatform. With MediaPlatform in the cloud, IVT enables its clients to benefit from what is rapidly emerging as the new paradigm for corporate computing.

In the cloud, MediaPlatform’s web services architecture can more readily serve diverse client needs by integrating with a range of enterprise systems, both cloud-based and on-premises.
The cloud, an approach to computing that places servers and infrastructure in remote, abstracted datacenters, is ideal for webcasting, which is known for unpredictable spikes in system load. By working with a tier-1 cloud infrastructure provider, IVT gains virtually unlimited capacity and world-class security, reliability, redundancy, failover, and load management.

IVT will continue to support the numerous on-premises installations of its software, including major deployments at global enterprises. IVT prides itself on offering its clients the choice between hosted and on-premises options.





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Don’t take their word for it

A few weeks ago, we needed some hardware fast. After some back and forth with the vendor, they promised “expedited delivery”. That sounded like a good thing, but it meant nothing. To us, expedited delivery meant overnight delivery. That’s what we had in our head. Our experiences elsewhere equated expedited as overnight, but expedited isn’t… keep reading




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Sport | Marco Jansen hopes for better showing against spin as T20 series takes Highveld turn

Proteas all-rounder Marco Jansen, while acknowledging that spin has been a challenge for them in the ongoing T20 series against India, reckons things could be a bit different for Wednesday's third T20 in Centurion.




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Newsroom: Amazon Music Overtakes Pandora as No. 2 in the US

Spotify still No. 1 by wide margin February 24, 2022 (New York, NY) – Pandora, once the dominant player in terms of digital music streaming, will be eclipsed by Amazon […]




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China’s high-stakes incursion in the heights of Bhutan

China’s high-stakes incursion in the heights of Bhutan The World Today mhiggins.drupal 28 September 2022

Why is Beijing establishing settlements over the Bhutanese border? To undermine India’s strategic security, say John Pollock and Damien Symon.

A confrontation is fomenting on the roof of the world in a country that rarely warrants international attention.

In the tiny Kingdom of Bhutan, China is building villages in isolated, mountainous regions, upping the pressure on the capital Thimphu to yield contested areas to Beijing. In doing so, China risks a collision with South Asia’s largest state and Bhutan’s principal security guarantor, India.


Sitting on top of fragile geopolitical fault lines in the Himalayas, China’s Central Military Commission has seemingly authorized a series of incursions into the Bhutanese regions of Doklam, Jakarlung, and Pasamlung. Beijing has also announced fresh claims in the east towards Sakteng. Taken together, these amount to 12 per cent of Bhutan’s total territory according to Nathan Ruser, an analyst at the Australian Strategic Policy Institute.

India is wary of Beijing’s increased assertiveness in the Himalayas following a large-scale incursion by the Chinese People’s Liberation Army (PLA) into Ladakh two years ago when dozens of Indian and Chinese soldiers were killed in a stand-off.

The appearance of Chinese roads, villages and a host of other infrastructure projects within largely uninhabited areas of Bhutan close to Tibet, have, for sections of India’s national security establishment, confirmed their worst fears – Beijing is altering the status quo across the Himalayas in a bid to undermine India’s strategic security through territorial alterations.

As a country of only 780,000 people, Bhutan is greatly influenced by New Delhi when it comes to its foreign affairs. In exchange, India guarantees the defence of the kingdom and trains the Royal Bhutanese Army. The appearance of Chinese villages on its territory risks Bhutan becoming a victim of the wider regional tensions.

The trauma of China-Bhutan border relations

Bhutan is no stranger to the territorial aspirations of its northern neighbour. Thousands of refugees fled into the country after China annexed Tibet, damaging longstanding cultural and religious links between the Tibetan and Bhutanese people – a trauma still being felt today.

Now, Beijing is laying claim to three areas within Bhutan, including Doklam in the west. This plateau is close to the Siliguri Corridor which connects to the ‘Seven Sister’ states in northeast India. Indeed, such is India’s concern over any Chinese presence near Doklam that in 2017 local Indian commanders sent troops into Bhutan to prevent PLA engineers building a road near the Doka La pass, resulting in a 72-day stand-off on Bhutanese soil between India and China, an experience Thimphu is unwilling to repeat.

Once again, China is looking to force the border issue unilaterally, altering the status quo and building villages and outposts on Bhutanese soil. On the available evidence, it has been doing so for at least three years.

The presence of Chinese villages in uninhabited areas of Bhutan serves a strategic purpose. They appear to be intended to pressure Bhutan into accepting an earlier version of a border deal that concedes Doklam to the Chinese.

Bhutan’s increasing concern is that China now views the Sino-Bhutanese border dispute as a way of unravelling India’s strategic position by stealth. Here we see a growing pattern of behaviour across the Himalayas. China is testing the boundaries in isolated and contested areas of India to attain local advantages that ensure New Delhi’s gaze remains fixed on the Himalayas.

The costly choice facing Bhutan

Bhutan for its part has very deliberately opted to remain silent, despite clear violations of its border deal with Beijing. Thimphu has made no public comment on any of the Chinese incursions.

The choice now facing Bhutan is a costly one. To concede Doklam would devastate relations with India, its closest partner. But to ignore China’s ambitions would be to risk further violations of its sovereign territory.

Bhutan may yet agree in principle to a land swap but then delay its implementation in the hope China limits any further advances. Thus Bhutan, India and China stand at a crossroads, with an impending confrontation that has not yet arrived and one that through Thimphu’s delicate diplomacy, Bhutan hopes never does.

China’s incursions into Bhutan

Key to map: 1 - Pangda; 2 - Dramana and Shakhatoe; 3 - Menchuma Valley. Areas of incursion are circled; the red shaded areas are disputed. The star is the capital Thimphu, and the international airport lies to the west.

1. Pangda

Aerial image of Pangda, a village of some 124 people established by China which sits 2km over the border with Bhutan. Image: Maxar (March 2022).

The most high-profile incursion is in the disputed areas in Doklam. Running adjacent to the previous Doka La stand-off site, a series of Chinese projects are visible, following the Amo Chu River that runs from the Chumbi Valley in Tibet into Bhutan.

The most well-known of these xiaokang – meaning peaceful and prosperous – border projects is Pangda, a village of 124 people that sits roughly two kilometres within Bhutan from the border. First spotted by open-source intelligence analysts in October-November 2020, Chinese state media says that 27 households were moved from the Shangdui village to Pangda in September of that year and that the village is located in Yadong County, Tibet. Pangda, however, lies on territory internationally recognized as belonging to Bhutan.

Since Pangda was first identified, two more villages and an additional excavation site have been noted through satellite photographs taken in March this year, steadily following the river further into Bhutanese territory. In recent reporting by journalist Vishnu Som, a connecting road is also visible that runs 9km into Bhutan.

Given the geopolitical sensitivities of the area vis-a-vis India, speculation points to Chinese attempts to increase pressure on the Jampheri ridge overlooking the 2017 stand-off site, which according to journalist Tenzing Lamsang, is currently occupied by a small Royal Bhutanese Army detachment. As ever in the Himalayas, small tactical alterations have strategic implications. Chinese control of the Jampheri ridge would command views towards Sikkim, increase the scope of China’s surveillance operations near the border and place India’s Eastern Theatre Command at a terrain disadvantage were it to intervene as it did at Doka La.

 

2. Dramana and Shakhatoe

Aerial image showing one of several villages recently built by China in the Dramana and Shakhatoe region of Bhutan. The Chinese military is said to be patrolling this area aggressively. Image: Maxar (2022). 

Further north of Doklam, at Dramana and Shakhatoe, more villages have been identified, with recent photographs taken in November 2021 showing a collection of structures nestled between snow-capped mountains. Varying in size, the largest village identified by journalist Devjyot Ghoshal comprises more than 84 buildings with construction having been started in December 2020 and seemingly completed by December 2021.

Little is known about the nature of these villages or their occupants other than their size and location. However, the Chinese PLA has patrolled these areas aggressively, warning away Bhutanese herders and challenging counter patrols by the Royal Bhutanese Army.

A permanent PLA presence in the area would be a significant change to the status quo. Informed speculation suggests that these may house either civilian contractors brought in from Tibet to oversee construction projects in the area, Tibetan or Chinese citizens brought across the border, or they could even be barracks for the PLA to help facilitate increased patrols in these contested areas.

3. Menchuma Valley

Aerial image of one of several Chinese-built settlements in and around Menchuma Valley in Bhutan; the area is home to holy sites important to both Bhutanese and Tibetan culture. Image: PlanetLabs (2022). 

Amid the sustained activity in the west of Bhutan, we are seeing similar levels of activity mirrored in the northern contested areas in Jakarlung, Pasumlung and the Menchuma Valley, a well-known entry point into Tibet for Bhutanese pilgrims.

In May 2021, a team of researchers led by Robert Barnett from the London School of Oriental and African Studies discovered three additional villages in these contested areas, alongside a series of infrastructure projects, sitting between 3km and 5km south of the Chinese border in Bhutan. Barnett identified what appears to be police and military posts near these villages, as well as a communications tower.

While the building efforts at Doklam are seen as having a geopolitical intent towards India, these villages and their locations are seemingly aimed to maximize China’s leverage over Bhutan. They are considered sacred in Tibetan Buddhist teachings as the birthplace of ancient Himalayan cultural heroes, with strong links to the Bhutanese royal family. Today they are the home to holy sites and temples, such as the Singye Dzong.

For China to intrude on this area, and in some cases even deny entry to parts of it, is suppression of Bhutanese history, culture and traditions. By design or by default, Beijing is managing Tibetan religion and culture beyond the borders of the Tibetan Administrative Region.

 

 

 




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Trust in US democracy is at stake in this election

Trust in US democracy is at stake in this election Expert comment rgold.drupal

A narrow win for either side could make things worse. The rest of the world should be prepared for a disruptive transition.

With less than two weeks to election day in the United States, polls suggest the gap between Harris and Trump has narrowed even further in the swing states where the election will be decided. A fierce contest has ensued as each campaign seeks to drive voter turnout. In such a tight race, this will be decisive. But in an election that many Americans perceive as being existential for the country’s future, a narrow victory by either side will heighten the risk of a contested election.

Many Americans are pessimistic about the ability of democracy to deliver a reliable result. Two thirds of Republican voters continue to believe that the 2020 election was stolen from Donald Trump and for many of these, Biden’s inauguration may have demonstrated the weakness, not the strength, of US democracy. 

This environment has contributed to widespread anticipation of a contested election, as well as preparations for the possibility of a delayed result. Political disinformation and deep polarization across the country could mean that a narrow victory leads to more legal challenges and even political violence.  6 January, the anniversary of the assault on the US Capitol and the day Congress will certify the Electoral College has been designated a National Special Security Event. 

The issue of how quickly and reliably votes are certified has become an arena for argument. In the 2022 midterms, 22 county officials in key states voted to delay certification. Democrats have noted with alarm that this year, around 70 pro-Trump election ‘conspiracists’ are positioned to review the results in swing states.

Those nervous about the possibility of a narrow vote being overturned will be watching to see if Republicans maintain or increase their majority in the House of Representatives, since the newly elected House will shape who holds the gavel when a joint session of Congress returns to certify the US presidential election result. Republican control of the House could give the former president more ability to influence this vote. 

A resilient democracy

But there should be room for optimism. Democracy in America has been remarkably resilient. In 2016, Democrats swallowed their unease with Donald Trump. Despite rumours of Russian interference in the election, they accepted the election result.

If fears of another contested election materialise, it will be the third time in recent history that the US has struggled to confirm a result. 

Four years later, the US was far more polarized, trust in institutions had decreased, and challenges to the elections reflected this. The Trump campaign filed more than 60 lawsuits in 9 states challenging election processes and voter certification. In every single case, courts confirmed the results.  After the 6 January insurrection on the US Capitol, Congress returned to its chambers and, on the very same day, confirmed the electoral results. 

If fears of another contested election materialise, it will be the third time in recent history that the US has struggled to confirm a result. In 2000, the Supreme Court intervened to decide on a recount in Florida, effectively delivering victory to George W Bush – a memory alongside the 6 January Capitol riots contributing to America’s anxiety ahead of polling day. 

International response

The US’s partners and rivals may be ill-prepared for a contested election. 

If Trump or Harris, or both, claim victory before it is clearly settled, world leaders will need to decide how to react. Diplomatic protocol may dictate that leaders wait until the US confirms the results through official channels but there are concerns that not everyone will play by these rules. 




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LEGO Taken 2008

bradders1999 posted a photo:

Each item refers to a scene from the iconic movie, progressing from left to right.

Minifigures made, photographed and edited by me.




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Threshold approximations for the exponential of a factorized operator family with correctors taken into account

T. A. Suslina
St. Petersburg Math. J. 35 (), 537-570.
Abstract, references and article information




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Passenger Sees Worker Unscrewing Plane Part Before Takeoff




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The Translation of Dosimetry into Clinical Practice: What It Takes to Make Dosimetry a Mandatory Part of Clinical Practice




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[18F]F-AraG Uptake in Vertebral Bone Marrow May Predict Survival in Patients with Non-Small Cell Lung Cancer Treated with Anti-PD-(L)1 Immunotherapy

Visual Abstract




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Problem Notes for SAS®9 - 66542: The initial loading of a rule set and a rule flow takes significantly longer in SAS Business Rules Manager 3.3 compared with release 3.2

In SAS Business Rules Manager 3.3, the initial loading of a rule set and a rule flow takes significantly longer than it does in release 3.2. When this problem happens, long time gaps are evident in the local




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Should adults take vitamin D supplements to prevent disease?




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Time for a detente in the war on the mechanism of cellular fatty acid uptake [Letters to the Editor]




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Genetic susceptibility, dietary cholesterol intake, and plasma cholesterol levels in a Chinese population [Patient-Oriented and Epidemiological Research]

Accompanied with nutrition transition, non-HDL-C levels of individuals in Asian countries has increased rapidly, which has caused the global epicenter of nonoptimal cholesterol to shift from Western countries to Asian countries. Thus, it is critical to underline major genetic and dietary determinants. In the current study of 2,330 Chinese individuals, genetic risk scores (GRSs) were calculated for total cholesterol (TC; GRSTC, 57 SNPs), LDL-C (GRSLDL-C, 45 SNPs), and HDL-C (GRSHDL-C, 65 SNPs) based on SNPs from the Global Lipid Genetics Consortium study. Cholesterol intake was estimated by a 74-item food-frequency questionnaire. Associations of dietary cholesterol intake with plasma TC and LDL-C strengthened across quartiles of the GRSTC (effect sizes: –0.29, 0.34, 2.45, and 6.47; Pinteraction = 0.002) and GRSLDL-C (effect sizes: –1.35, 0.17, 5.45, and 6.07; Pinteraction = 0.001), respectively. Similar interactions with non-HDL-C were observed between dietary cholesterol and GRSTC (Pinteraction = 0.001) and GRSLDL-C (Pinteraction = 0.004). The adverse effects of GRSTC on TC (effect sizes across dietary cholesterol quartiles: 0.51, 0.82, 1.21, and 1.31; Pinteraction = 0.023) and GRSLDL-C on LDL-C (effect sizes across dietary cholesterol quartiles: 0.66, 0.52, 1.12, and 1.56; Pinteraction = 0.020) were more profound in those having higher cholesterol intake compared with those with lower intake. Our findings suggest significant interactions between genetic susceptibility and dietary cholesterol intake on plasma cholesterol profiles in a Chinese population.