[Dalsan Radio] A plane carrying aid supplies for use in the fight against the coronavirus crashed in Somalia on Monday, killing all six people on board, the Somali transport minister said.

[Nation] Kenya has asked Somalia to investigate "unclear circumstances" under which a light aircraft was shot down in Bardale area, Baidoa.

[Shabelle] Kenya on Tuesday called for an urgent investigation into the fatal crash of a private cargo plane in Somalia amid unconfirmed reports it may have been shot down.

Maher Obeid, member of the Hamas 'political bureau,' said that any prisoner swap must include 'all the symbols, from Marwan Barghouti to Ahmad Sa’adat.'

MULTAN: The LPG Industries Association Pakistan has demanded a bailout package in the budget 2020-2021 so that the industry could survive in the most effective way.Talking to journalists here on Friday, LPGIAP chairman Irfan Khokhar said that the budget proposals had been dispatched to Prime...

PESHAWAR: The Pakistan People’s Party and the representatives of medical organisations of Khyber Pakhtunkhwa have demanded an end to the privatisation of healthcare facilities in the province and provision of automated coronavirus testing machines to medical staff. The demand was made...

Investors and lawmakers in Hong Kong are urging regulators to seek compensation for people who lose money when listed companies collapse shortly after their initial public offerings.Under the current system, when banks sponsoring IPOs are found to have fallen short in their due diligence duties, the proceeds of any fine imposed by the watchdog goes to the government, not investors. Those fines amount to almost HK$1 billion (US$130 million) over the last 20 years, according to calculations by…

PESHAWAR: The Pakistan People’s Party and the representatives of medical organisations of Khyber Pakhtunkhwa have demanded an end to the privatisation of healthcare facilities in the province...

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LAHORE: Pakistan Muslim League-N President and National Assembly opposition leader Shahbaz Sharif has demanded an in-depth investigation into the medicine scandal through a parliamentary...

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LAHORE: Pakistan Muslim League-N President and National Assembly opposition leader Shahbaz Sharif has demanded an in-depth investigation into the medicine scandal through a parliamentary committee.“Coming on the heels of sugar, wheat and IPPs scandals, the latest drug scandal indicates how...

LAHORE: Pakistan Muslim League-N President and National Assembly opposition leader Shahbaz Sharif has demanded an in-depth investigation into the medicine scandal through a parliamentary committee.“Coming on the heels of sugar, wheat and IPPs scandals, the latest drug scandal indicates how...

LAHORE: Pakistan Muslim League-N President and National Assembly opposition leader Shahbaz Sharif has demanded an in-depth investigation into the medicine scandal through a parliamentary committee. Sugar, wheat and IPPs scandals, the latest drug scandal indicates how powerful mafias within the...

U.S. President Donald Trump is reportedly demanding US$1.3 billion a year to maintain American troops in Korea. That is a whopping 53.3 percent higher than the W1.4 trillion Korea had to pay last year. A senior U.S. official told the Chosun Ilbo on Thursday, "The U.S. faces many difficulties, includ...

Rawalpindi: Pakistan Businessmen and Intellectuals Forum President Mian Zahid Hussain has said that sales tax should be withdrawn on cottonseed, oil cake, etc. while withholding tax refunds stuck since a decade should be released.He said the largest foreign exchange earning sector is in trouble,...

According to a study by India Ratings, lack of credit availability and ongoing economic slowdown in India due to the coronavirus pandemic could lead to the residential sector witnessing weak demand in the fiscal year 2020-21.  Residential demand could remain muted in the next financial year, 2020-21 due to the increasing risks to India’s growth in case the economic impact of coronavirus continues beyond the first quarter.   Moreover, the housing sector faces a liquidity crunch and refinancing challenges due to increasing uncertainty over the availability of credit in the market, coupled with poor demand. This is in the backdrop of the recent meltdown in the financial market and rising risk […]

Villagers placed the bodies of three victims of a deadly gas leak from an LG Polymers plant in southern India at the gates of the site on Saturday, and demanded the factory be shut down immediately and its top management arrested.

Title: Device Spots Lymphedema Early in Breast Cancer Patients, to Help Stop It
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM

Title: As Demand for Hand Sanitizer Soars, FDA Warns of Makers' Bogus Claims
Category: Health News
Created: 4/27/2020 12:00:00 AM
Last Editorial Review: 4/28/2020 12:00:00 AM

Brad A. Seibel and Curtis Deutsch

The capacity to extract oxygen from the environment and transport it to respiring tissues in support of metabolic demand reportedly has implications for species’ thermal tolerance, body-size, diversity and biogeography. Here we derive a quantifiable linkage between maximum and basal metabolic rate and their oxygen, temperature and size dependencies. We show that, regardless of size or temperature, the physiological capacity for oxygen supply precisely matches the maximum evolved demand at the highest persistently available oxygen pressure and this is the critical PO₂ for the maximum metabolic rate. For most terrestrial and shallow-living marine species, this "P_crit-max" is the current atmospheric pressure, 21 kPa. Any reduction in oxygen partial pressure from current values will result in a calculable decrement in maximum metabolic performance. However, oxygen supply capacity has evolved to match demand across temperatures and body sizes and so does not constrain thermal tolerance or cause the well-known reduction in mass-specific metabolic rate with increasing body mass. The critical oxygen pressure for resting metabolic rate, typically viewed as an indicator of hypoxia tolerance, is, instead, simply a rate-specific reflection of the oxygen supply capacity. A compensatory reduction in maintenance metabolic costs in warm-adapted species constrains factorial aerobic scope and the critical PO₂ to a similar range, between ~2 and 6, across each species’ natural temperature range. The simple new relationship described here redefines many important physiological concepts and alters their ecological interpretation.

Approximately 40% of patients with diabetic macular edema (DME) are resistant to anti–vascular endothelial growth factor (VEGF) therapy (rDME). Here, we demonstrate that significant correlations between inflammatory cytokines and VEGF, as observed in naive DME, are lost in patients with rDME. VEGF overexpression in the mouse retina caused delayed inflammatory cytokine upregulation, monocyte/macrophage infiltration (CD11b⁺ Ly6C⁺ CCR2⁺ cells), macrophage/microglia activation (CD11b⁺ CD80⁺ cells), and blood-retinal barrier disruption due to claudin-5 redistribution, which did not recover with VEGF blockade alone. Phosphorylated protein analysis of VEGF-overexpressed retinas revealed rho-associated coiled-coil–containing protein kinase (ROCK) activation. Administration of ripasudil, a selective ROCK inhibitor, attenuated retinal inflammation and claudin-5 redistribution. Ripasudil also contributed to the stability of claudin-5 expression by both transcriptional enhancement and degradation suppression in inflammatory cytokine–stimulated endothelium. Notably, the anti-VEGF agent and the ROCK inhibitor were synergic in suppressing cytokine upregulation, monocyte/macrophage infiltration, macrophage/microglia activation, and claudin-5 redistribution. Furthermore, in vitro analysis confirmed that claudin-5 redistribution depends on ROCK2 but not on ROCK1. This synergistic effect was also confirmed in human rDME cases. Our results suggest that ROCK-mediated claudin-5 redistribution by inflammation is a key mechanism in the anti-VEGF resistance of DME.

In 1966, the Eliza program couldn’t say much—but it was enough

Whether it be about spanking sounds or male pasties, RPGamer has a long history of being an authoritative source of information. That said, we're still trying to figure out what version of EarthBound Kelley is playing.

With cinemas closed and major titles delaying their release, the Academy has changed its rules to welcome some streaming titles. Will they regret it?

‘What about the Oscars?” might not be the question at the top of your mind as you consider the manifold uncertainties raised by the coronavirus pandemic. A Hollywood awards ceremony scheduled for the end of February 2021, one might think, has fewer immediate concerns than most cultural institutions do right now. Yet panic has been rising within the Academy: the show itself may go on, but with cinemas closed for the foreseeable future and dozens of major titles either rescheduling or indefinitely delaying their release dates, will it have have enough standout films to celebrate?

For some weeks now, the joke around the industry has been that Leigh Whannell’s hit psychothriller The Invisible Man – one of the few popular and critical successes to be released in the year’s early months – may as well collect its gongs now. But a crucial rule change announced on Tuesday by Academy CEO Dawn Hudson and president David Rubin has ensured that it will face some competition after all, even if its rivals never see the inside of a cinema.

New Delhi, May 09: Chhattisgarh Chief Minister Bhupesh Baghel has written a letter to Prime Minister Narendra Modi demanding of a package worth Rs 30,000 crore to help the state battle the economic crisis due to the coronavirus pandemic, ANI reported.

Visakhapatnam, May 09: Days after styrene gas leak from the LG Polymers Private Limited in Vizag that claimed 11 lives and caused 800 others to be hospitalised, locals staged a protest at the factory. Protesters demand the relocation of the chemical

Villagers placed the bodies of three victims of a deadly gas leak from an LG Polymers plant in southern India at the gates of the site on Saturday, and demanded the factory be shut down immediately and its top management arrested.

Liverpool already have one song synonymous with the club but they did attempt to officially do likewise with another. The Reds tried to trademark 'Allez Allez Allez'..

Lucianne Walkowicz says the American Girl doll 'Luciana Vega' stole her name and likeness

Prosecutor Tom Durden has vowed to convene a grand jury to discuss possible charges against the suspects - but only when coronavirus pandemic restrictions are eased, which could take several weeks.

Republicans on the House Oversight Committee said Friday repeated efforts to learn how the cash-strapped U.S. Postal Service intends to become financially stable have been stymied by U.S. Postmaster General Megan Brennan.

The lawmakers say they've requested a financial plan from Ms. Brennan three different times, but it hasn't been ...

Seed firms report huge rise in sales with people worldwide turning to gardening as hobby

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While the world may feel rather grey at times right now, lockdown has at least enabled some people to go green and inject colour into their gardens.

Britain is blooming – in one sense at least – with a record demand for seeds, and delphiniums, hollyhocks and hydrangeas are having their moment in the sun.

Japan's Sharp Corp, an Apple Inc supplier, cut its full-year profit forecast by 48% on Friday, as demand for technology devices took a hit from the coronavirus outbreak.

Follow our LIVE updates about the coronavirus outbreak here Coronavirus: The symptoms

The Government is facing calls from cross-party MPs to urgently recall of parliament in "virtual" form so that their coronavirus response can be properly scrutinised.

Scientist tells ministers to get act together over virus tests and planning 'Brexit-style level of control needed' Follow our live coronavirus updates HERE Coronavirus: the symptoms

Follow our LIVE updates about the coronavirus outbreak here Coronavirus: The symptoms

Follow our live coronavirus updates here

Oil prices in the US have dropped into negative territory due to collapse in demand amid the coronavirus pandemic.

Labour leader Sir Keir Starmer has called for a coronavirus lockdown "exit strategy" with the Government facing increasing pressure to reveal its next steps.

You can donate here virginmoneygiving.com/fund/FoodforLondonNOW

It comes after the UK's Covid-19 death toll jumped by 3,811 on Wednesday to top 26,000 when care home victims were factored in for the first time.

Armed protesters descended on Michigan's state capitol building last night as they called for an end to the state's coronavirus lockdown restrictions.

Union bosses have written to Sadiq Khan to demand a reversal of Transport for London's "disgraceful" decision to deny free travel to London Underground's cleaners.

The Government is requesting a refund or replacement for 400,000 medical gowns flown over from Turkey which were later deemed "unusable".

Uber on Wednesday said it would lay off 3,700 full-time employees, or roughly 17 per cent of its head count.

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The post Demand Protections for People on the Front Lines appeared first on The Nation.

The smartphone market registered 1.5 per cent year-on-year growth in the March quarter with shipments touching 32.5 million units, IDC said in a statement. Despite the low figure, India was the only country among the top three nations to see any growth.

Read the full interview HERE