startups

True Digital Park lures startups

True Digital Park has opened its Work Space, a co-working and office zone with capacity for 4,500 workers, in a bid to provide an affordable area for startups to develop and attract venture capital funding.




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Upfront Ventures Raises > $650 Million for Startups and Returns > $600 Million to LPs




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Japan’s Startups Drive AI Innovation With NVIDIA Accelerated Computing

Lifelike digital humans engage with audiences in real time. Autonomous systems streamline complex logistics. And AI-driven language tools break down communication barriers on the fly. This isn’t sci-fi. This is Tokyo’s startup scene. Supercharged by AI — and world-class academic and industrial might — the region has become a global innovation hub. And the NVIDIA Read Article




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Innovation Works opens grant application for hardware startups

The grant program provides hardware startups with reimbursement for working with local manufacturers.




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Startups Launch Life-Saving Tech for the Opioid Crisis



Tech startups are stepping up to meet the needs of 60 million people worldwide who use opioids, representing about 1 percent of the world’s adult population. In the United States, deaths involving synthetic opioids have risen 1,040 percent from 2013 to 2019. The COVID-19 pandemic and continued prevalence of fentanyl have since worsened the toll, with an estimated 81,083 fatal overdoses in 2023 alone.

Innovations include biometric monitoring systems that help doctors determine proper medication dosages, nerve stimulators that relieve withdrawal symptoms, wearable and ingestible systems that watch for signs of an overdose, and autonomous drug delivery systems that could prevent overdose deaths.

Helping Patients Get the Dosage They Need

For decades, opioid blockers and other medications that suppress cravings have been the primary treatment tool for opioid addiction. However, despite its clinical dominance, this approach remains underutilized. In the United States, only about 22 percent of the 2.5 million adults with opioid use disorder receive medication-assisted therapy such as methadone, Suboxone, and similar drugs.

Determining patients’ ideal dosage during the early stages of treatment is crucial for keeping them in recovery programs. The shift from heroin to potent synthetic opioids, like fentanyl, has complicated this process, as the typical recommended medication doses can be too low for those with a high fentanyl tolerance.

A North Carolina-based startup is developing a predictive algorithm to help clinicians tailor these protocols and track real-time progress with biometric data. OpiAID, which is currently working with 1,000 patients across three clinical sites, recently launched a research pilot with virtual treatment provider Bicycle Health. Patients taking Suboxone will wear a Samsung Galaxy Watch6 to measure their heart rate, body movements, and skin temperature. OpiAID CEO David Reeser says clinicians can derive unique stress indications from this data, particularly during withdrawal. (He declined to share specifics on how the algorithm works.)

“Identifying stress biometrically plays a role in how resilient someone will be,” Reeser adds. “For instance, poor heart rate variability during sleep could indicate that a patient may be more susceptible that day. In the presence of measurable amounts of withdrawal, the potential for relapse on illicit medications may be more likely.”

Nerve Stimulators Provide Opioid Withdrawal Relief

While OpiAID’s software solution relies on monitoring patients, electrical nerve stimulation devices take direct action. These behind-the-ear wearables distribute electrodes at nerve endings around the ear and send electrical pulses to block pain signals and relieve withdrawal symptoms like anxiety and nausea.

The U.S. Food and Drug Administration (FDA) has cleared several nerve stimulator devices, such as DyAnsys’ Drug Relief, which periodically administers low-level electrical pulses to the ear’s cranial nerves. Others include Spark Biomedical’s Sparrow system and NET Recovery’s NETNeuro device.

Masimo’s behind-the-ear Bridge device costs US $595 for treatment providers.Masimo

Similarly, Masimo’s Bridge relieves withdrawal symptoms by stimulating the brain and spinal cord via electrodes. The device is intended to help patients initiating, transitioning into, or tapering off medication-assisted treatment. In a clinical trial, Bridge reduced symptom severity by 85 percent in the first hour and 97 percent by the fifth day. A Masimo spokesperson said the company’s typical customers are treatment providers and correctional facilities, though it’s also seeing interest from emergency room physicians.

Devices Monitor Blood Oxygen to Prevent Overdose Deaths

In 2023, the FDA cleared Masimo’s Opioid Halo device to monitor blood oxygen levels and alert emergency contacts if it detects opioid-induced respiratory depression, the leading cause of overdose deaths. The product includes a pulse oximeter cable and disposable sensors connected to a mobile app.

Opioid Halo utilizes Masimo’s signal extraction technology, first developed in the 1990s, which improves upon conventional oxygen monitoring techniques by filtering out artifacts caused by blood movement. Masimo employs four signal-processing engines to distinguish the true signal from noise that can lead to false alarms; for example, they distinguish between arterial blood and low-oxygen venous blood.

Masimo’s Opioid Halo system is available over-the-counter without a prescription. Masimo

Opioid Halo is available over-the-counter for US $250. A spokesperson says sales have continued to show promise as more healthcare providers recommend it to high-risk patients.

An Ingestible Sensor to Watch Over Patients

Last year, in a first-in-human clinical study, doctors used an ingestible sensor to monitor vital signs from patients’ stomachs. Researchers analyzed the breathing patterns and heart rates of 10 sleep study patients at West Virginia University. Some participants had episodes of central sleep apnea, which can be a proxy for opioid-induced respiratory depression. The capsule transmitted this data wirelessly to external equipment linked to the cloud.

Celero’s Rescue-Rx capsule would reside in a user’s stomach for one week.Benjamin Pless/Celero Systems

“To our knowledge, this is the first time anyone has demonstrated the ability to accurately monitor human cardiac and respiratory signals from an ingestible device,” says Benjamin Pless, one of the study’s co-authors. “This was done using very low-power circuitry including a radio, microprocessor, and accelerometer along with software for distinguishing various physiological signals.”

Pless and colleagues from MIT and Harvard Medical School started Celero Systems to commercialize a modified version of that capsule, one that will also release an opioid antagonist after detecting respiratory depression. Pless, Celero’s CEO, says the team has successfully demonstrated the delivery of nalmefene, an opioid antagonist similar to Narcan, to rapidly reverse overdoses.

Celero’s next step is integrating the vitals-monitoring feature for human trials. The company’s final device, Rescue-Rx, is intended to stay in the stomach for one week before passing naturally. Pless says Rescue-Rx’s ingestible format will make the therapy cheaper and more accessible than wearable autoinjectors or implants.

Celero’s capsule can detect vital signs from within the stomach. www.youtube.com

Autonomous Delivery of Overdose Medication

Rescue-Rx isn’t the only autonomous drug-delivery project under development. A recent IEEE Transactions on Biomedical Circuits and Systems paper introduced a wrist-worn near-infrared spectroscopy sensor to detect low blood oxygen levels related to an overdose.

Purdue University biomedical engineering professor Hugh Lee and graduate student Juan Mesa, who both co-authored the study, say that while additional human experiments are necessary, the findings represent a valuable tool in counteracting the epidemic. “Our wearable device consistently detected low-oxygenation events, triggered alarms, and activated the circuitry designed to release the antidote through the implantable capsule,” they wrote in an email.

Lee and Purdue colleagues founded Rescue Biomedical to commercialize the A2D2 system, which includes a wristband and an implanted naloxone capsule that releases the drug if oxygen levels drop below 90 percent. Next, the team will evaluate the closed-loop system in mice.

This story was updated on 27 August 2024 to correct the name of Masimo’s Opioid Halo device.



  • Blood oxygen monitoring
  • Electrical nerve stimulation
  • Opioid addiction treatment
  • Opioids
  • Biometrics

startups

Troy Carter's Atom Factory Set to Welcome Second Cohort to Smashd Labs in Fall 2016 for Startups That Can Influence Culture - Atom Factory Presents: Smashd Labs Season 2

SMASHD Labs Season 2 is a 10-week accelerator program based out of Los Angeles talent firm Atom Factory. We are inviting companies at the intersection of entertainment, technology, and culture to work alongside our team to accelerate their growth. Join us and our roster of world-class mentors for a masterclass in hustle.




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Quoroom acquires Investory to scale up its capital-raising platform for startups

These days, private investors have a range of options for investing in startups without having to deal with them in real life. This ecosystem more or less started with AngelList, but there are now a plethora of options — such as Carta, Allocations, Vauban, and Odin — that startups can use to raise funding and […]

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General Catalyst raises $8B in fresh funds to back startups globally

U.S. venture capital giant General Catalyst has announced a fresh $8 billion in funds as it looks to ramp up its investments in multi-sector early-stage startups globally, with a specific focus on the U.S., Europe, and India. The capital constitutes around $4.5 billion for its “core VC funds,” which spans seed and growth equity funding, […]

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How startups are turning data into software gold

Storing great pools of data is an increasingly figured-out challenge. Between public clouds, and data lakes more specifically, you can stick oceans of corporate data in any number of places. But leveraging that data into something useful is another challenge altogether. The analogy that data is this era’s oil is at best half-baked. Oil takes […]

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Tofino Capital reaches first close of $10M fund to back startups in frontier markets

Tofino Capital, a venture capital firm targeting early-stage startups in emerging markets, has launched its $10 million fund. It is announcing the first close of this fund at $5 million and hopes to achieve a final close nine months from now.   The firm, founded by Eliot Pence and Aubrey Hruby, wants to back startups in Africa, […]

© 2024 TechCrunch. All rights reserved. For personal use only.




startups

PwC collaborates with startups to create innovative cloud solution - 23 Feb

PwC today announced it was collaborating with a range of Australasian startups and emerging technology companies to deliver a purpose-built cloud platform that brings together some of the leading cloud solutions in the market today, all in one place.




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Flying Taxi Startups Seek a Quiet Takeoff

If eVTOL aircraft companies are to achieve their commercial ambition of becoming flying taxis, then first they’ll need to ensure their aircrafts are quiet enough to work in cities without disturbing residents. WSJ’s George Downs looks into just how quiet these crafts need to be to take off. Photo composite: George Downs




startups

How startups are expanding the EV charging network

With generous funding, a host of newbie companies are revving up the expansion of the country’s EV charging network




startups

When talent becomes unaffordable for startups

Why good leadership is increasingly beyond the means of startups looking to build great products




startups

Google Cloud expands support for early-stage AI Startups with new initiatives, partnerships




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Startups must have mentors to succeed, says experts




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The very best VDR pertaining to Startups

Using VDRs to store and share documents makes the due diligence procedure easier for all those stakeholders. Additionally, it can save money and time by eliminating the need to send physical documents to multiple locations or discuss with a team. Additionally , a VDR can allow all users to access your data from any device, […]




startups

AWS announces first space tech accelerator program in India with 24 shortlisted startups

The program is a result of the MoU agreement AWS signed with the Indian Space Research Organization and the Indian National Space Promotion and Authorisation Centre in 2023




startups

Waiting for the Payday? The Market for Startups and the Timing of Entrepreneurial Exit [electronic journal].

National Bureau of Economic Research




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Startups and Employment Following the COVID-19 Pandemic: A Calculator [electronic journal].




startups

Do Temporary Demand Shocks have Long-Term Effects for Startups? [electronic journal].




startups

Startups join the party with craft mixers

How non-alcoholic mixers, handcrafted by small players, are edging out sugary soft drinks, sodas in cocktail glasses




startups

S. Korea woos startups in India with ‘grand challenge’

Wants them to look at Korea as a testing bed for their ventures




startups

IIITH's social incubator hosts roundtable on climate-tech startups




startups

Razorpay launches venture investment program to support early-stage B2B startups

Aimed at startups, the program will offer tech integration, market access, and personalized mentorship




startups

Google Cloud announces initiatives for early-stage AI startups

AI-first startups will receive even greater support with $350,000 in credits given the compute-heavy needs of the technology




startups

Green Chemistry Startups: Some Lessons Learned

Green Chem., 2024, Accepted Manuscript
DOI: 10.1039/D3GC05187K, Perspective
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jason P. Hallett
There has been an explosive growth in environmentally driven startups in recent years. Much of this has included university spin-outs aiming to translate academic research into commercial practice. This activity...
The content of this RSS Feed (c) The Royal Society of Chemistry









startups

IITs Witness a Decline in the Number of Startups Enrolling for this Year's Recruitment Program

With per-placement orders catapulted up by 25-30 pct, 2016 has been a year of opportunities for IIT’s when compared to last year. But, in spite of the rise in placements




startups

Startups Weekly: SEC temporarily loosens crowdfunding regulations on small companies

A specific type of small startup has a window to raise crowdfunding in a somewhat less regulated way than normally required in the US based on a temporary set of rule changes by the SEC announced this week. Excited yet?




startups

Containing Covid-19: Nasscom CoE incubated startups show their mettle

While DronaMaps is helping map Covid-19 patients in Haryana and other states, Blinkin has provided remote tech support for installing air ventilation systems in two Wuhan hospitals




startups

Startups in Tokyo abandon offices amid coronavirus upheaval










startups

Startups Weekly: SEC temporarily loosens crowdfunding regulations on small companies

A specific type of small startup has a window to raise crowdfunding in a somewhat less regulated way than normally required in the US based on a temporary set of rule changes by the SEC announced this week. Excited yet?




startups

Startups Infected




startups

IIT-Madras startups develop PPEs from 3D printers and regular stationery materials

Initial batches have been supplied in Chennai, while some were in the process of being scaled up towards mass production for use in hospitals and clinics across the country.




startups

Southern startups get day in the sun with Southland

The new conference introduces investors from across the country to Southeastern companies to shed more light on business in the region.




startups

Appinventiv Recognized as Top App Development Agency for Startups by Clutch

Clutch Picked Appinventiv as No. 1 App Development Agency for Startups




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Global Bike and Scooter Sharing Startups Report-H1 2018 Edition

This report profiles the top 25 bike and scooter sharing start-ups. It discusses the top investors active in this space. It also provides an independent outlook of bike and scooter sharing market in US, Europe, Singapore and China.




startups

MIK INNOVATION HOT SPOT Showcases Korean Startups to the World

CES 2020, the world's largest technology exhibition, was held Jan. 7-11 in Las Vegas. During the exhibition period, MIK (MADE IN KOREA) INNOVATION HOT SPOT zone was held at Eureka Park located at Sands Expo to introduce Korean startups to the world




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Virgin Adds to VIRGINIC Case New Litigation Against 3 More Small Startups - Appetite For Destruction in this David vs Goliath Case Increases

Virgin opened personal lawsuits against shocked and distressed key employees of VIRGINIC calling them in Wyoming court an "alter ego" of VIRGINIC company itself. Then proceeded to bring to suit 3 unrelated startups VIRGINIC managers used to work for.