CEO Kim Ho-yeon has won a prize for an innovative idea at a human interface device contest when working for Intel, and predicted that human interfaces will be used by many people in metaverse (virtual reality) in the future.

41 Metre Superyacht designed by Italian Studio VYD

Ann Marie Sabath's groundbreaking book, The Wannabe Investor: 40 Must-Know Facts Before Buying Your First Stock, released to coincide with Financial Literacy Month

Coming soon on Kickstarter.

In a remarkable display of faith and community, over 70,000 people gathered for the Busan Crusade of the Word, igniting a powerful atmosphere that stirred hearts and transformed minds!

In a remarkable display of faith and community, over 70,000 people gathered for the Busan Crusade of the Word, igniting a powerful atmosphere that stirred hearts and transformed minds!

Roots Rocker Releases Acoustic EP.

Casey Bloys exemplifies his passion for storytelling and his willingness to take risks, as evidenced by personal accounts of his career. With a keen eye for talent and a commitment to quality content, Bloys has cemented his status as a top executive.

The broader implication of?of stage four KM is that we may?be beginning to move with more speed into the world of the?semantic web.

Above, from left, John Featherston, Tina Lapp, Heather Stenson and Brian Joyner During its 28th Annual Power Broker Reception & Dinner held at the Renaissance Boston Seaport Hotel Friday night, RISMedia announced its 2024 Real Estate Rookie of the Year winner, Heather Stenson, a REALTORⓇ with Connect Realty in The Woodlands, Texas. Designed to honor…

The post RISMedia’s 2024 Real Estate Rookie of the Year Revealed at Annual Power Broker Gala appeared first on RISMedia.

Jamestown, the Truth Revealed produces a vivid picture of the settlement that is far more complex, incorporating the most recent archaeology and using twenty-first-century technology to give Jamestown its rightful place in history and thus contributing to a broader understanding of the transatlantic world.

Nope you're not seeing double! Take a look at the new wax figure of Mary Earps at Madame Tussauds.

More than 70,000 people are expected to attend this year’s highly anticipated event in Lisbon.

Read more: Revealed: The Irish start-ups heading to Web Summit 2024

Bob Schieffer, Chief Washington Correspondent and Anchor of Face The Nation, joins UTTM to discuss Pres. Obama's prime time speech presenting his plan to defeat ISIS.

“Dancing With the Stars” hit a new milestone on Nov. 12, and revealed who was heading to the semifinals for Season 33. The 500th episode opened with pros — including returning favorite Sharna Burgess — for the opening number, “Crazy in Love,” the same opening number from the 2005 series premiere. Many past competitors returned […]

Logistics UK has revealed the shortlist for its Logistics Awards 2024, the event that recognises the achievement of businesses and individuals from across the sector. Logistics UK’s Board will now complete the final round of independent judging before winners are announced at this year’s awards presentation event on Thursday 12 December 2024.

We Mean Business Coalition’s chief executive officer Maria Mendiluce, Zapmap’s co-founder and chief operating officer Melanie Shufflebotham, and co-leader of the Green Party England and Wales Carla Denyer are among those to have been awarded an inaugural Women in Green Business Award celebrating their work driving the UK's net zero transition. 

2025 can't come soon enough. #StrangerThings #Netflix #TvShows

Location: Electronic Resource- 

The Duke of Edinburgh's cause of death is listed as 'old age,' two weeks after he was laid to rest in a private funeral at St George's Chapel, Windsor Castle.

War and Craig Charles to perform in the park.

THE design for the final commercial tower in Parramatta Square has been released — showcasing the 16-storey, 35,000sq m office tower in the heart of Western Sydney.

After winning his third regular-season MVP award in four seasons, Nikola Jokic has earned a virtual accolade.

Star Trek: Prodigy, the upcoming, youth-aimed, animated series heading to Paramount+ and Nickelodeon later this...

1. New prime time kings as AFL’s 2025 Thurs night blockbusters revealed  Fox Sports
2. Three Thursday night fixtures revealed  Collingwood
3. What we know about the 2025 fixture: Thursday nights back with a bang, Smith to face Dogs in blockbuster  The Age

Discover simple yet effective methods to remove coffee and tea stains from mugs, maintaining their shine and cleanliness. Our article offers practical steps and household products you can use, helping you enjoy your beverages stain-free. Goodbye, stubborn stains!

The post The Best Way to Remove Coffee and Tea Stains from Mugs: Foolproof Methods Revealed appeared first on Unclutterer.

"People in the media are aware of how illegitimately they've done their jobs that they think they're on the verge of being locked up" —Scott Adams

The NOVA Universe Revealed Community Outreach Toolkit contains strategies for organizing events around the content of the five-part series as well as examples of hands-on activities and a wide range of multimedia educational resources aligned to the content of each episode.

Cameras started rolling for The White Lotus cast on the Thai islands in February

Presented by the Middle East Forum on Nov. 18, 2022 Panel discussion with Daniel Pipes, Cynthia Farahat, and Jonathan Schanzer:

The main protease (3CL Mpro) from SARS–CoV-2, the etiological agent of COVID-19, is an essential enzyme for viral replication. 3CL Mpro possesses an unusual catalytic dyad composed of Cys145 and His41 residues. A critical question in the field has been what the protonation states of the ionizable residues in the substrate-binding active-site cavity are; resolving this point would help understand the catalytic details of the enzyme and inform rational drug development against this pernicious virus. Here, we present the room-temperature neutron structure of 3CL Mpro, which allowed direct determination of hydrogen atom positions and, hence, protonation states in the protease. We observe that the catalytic site natively adopts a zwitterionic reactive form in which Cys145 is in the negatively charged thiolate state and His41 is doubly protonated and positively charged, instead of the neutral unreactive state usually envisaged. The neutron structure also identified the protonation states, and thus electrical charges, of all other amino acid residues and revealed intricate hydrogen-bonding networks in the active-site cavity and at the dimer interface. The fine atomic details present in this structure were made possible by the unique scattering properties of the neutron, which is an ideal probe for locating hydrogen positions and experimentally determining protonation states at near-physiological temperature. Our observations provide critical information for structure-assisted and computational drug design, allowing precise tailoring of inhibitors to the enzyme's electrostatic environment.

Alfred C. O. Vertegaal
Dec 1, 2006; 5:2298-2310
Research

Connexin (Cx) protein forms hemichannels and gap junctional channels, which play diverse and profound roles in human physiology and diseases. Gap junctions are arrays of intercellular channels formed by the docking of two hemichannels from adjacent cells. Each hexameric hemichannel contains the same or different Cx isoform. Although homomeric Cxs forms have been largely described functionally and structurally, the stoichiometry and arrangement of heteromeric Cx channels remain unknown. The latter, however, are widely expressed in human tissues and variation might have important implications on channel function. Investigating properties of heteromeric Cx channels is challenging considering the high number of potential subunit arrangements and stoichiometries, even when only combining two Cx isoforms. To tackle this problem, we engineered an HA tag onto Cx26 or Cx30 subunits and imaged hemichannels that were liganded by Fab-epitope antibody fragments via atomic force microscopy. For Cx26-HA/Cx30 or Cx30-HA/Cx26 heteromeric channels, the Fab-HA binding distribution was binomial with a maximum of three Fab-HA bound. Furthermore, imaged Cx26/Cx30-HA triple liganded by Fab-HA showed multiple arrangements that can be derived from the law of total probabilities. Atomic force microscopy imaging of ringlike structures of Cx26/Cx30-HA hemichannels confirmed these findings and also detected a polydisperse distribution of stoichiometries. Our results indicate a dominant subunit stoichiometry of 3Cx26:3Cx30 with the most abundant subunit arrangement of Cx26-Cx26-Cx30-Cx26-Cx30-Cx30. To our knowledge, this is the first time that the molecular architecture of heteromeric Cx channels has been revealed, thus providing the basis to explore the functional effect of these channels in biology.

Replication protein A (RPA) is a eukaryotic ssDNA-binding protein and contains three subunits: RPA70, RPA32, and RPA14. Phosphorylation of the N-terminal region of the RPA32 subunit plays an essential role in DNA metabolism in processes such as replication and damage response. Phosphorylated RPA32 (pRPA32) binds to RPA70 and possibly regulates the transient RPA70-Bloom syndrome helicase (BLM) interaction to inhibit DNA resection. However, the structural details and determinants of the phosphorylated RPA32–RPA70 interaction are still unknown. In this study, we provide molecular details of the interaction between RPA70 and a mimic of phosphorylated RPA32 (pmRPA32) using fluorescence polarization and NMR analysis. We show that the N-terminal domain of RPA70 (RPA70N) specifically participates in pmRPA32 binding, whereas the unphosphorylated RPA32 does not bind to RPA70N. Our NMR data revealed that RPA70N binds pmRPA32 using a basic cleft region. We also show that at least 6 negatively charged residues of pmRPA32 are required for RPA70N binding. By introducing alanine mutations into hydrophobic positions of pmRPA32, we found potential points of contact between RPA70N and the N-terminal half of pmRPA32. We used this information to guide docking simulations that suggest the orientation of pmRPA32 in complex with RPA70N. Our study demonstrates detailed features of the domain-domain interaction between RPA70 and RPA32 upon phosphorylation. This result provides insight into how phosphorylation tunes transient bindings between RPA and its partners in DNA resection.

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers and known for its extensive genetic heterogeneity, high therapeutic resistance, and strong variation in intrinsic radiosensitivity. To understand the molecular mechanisms underlying radioresistance, we screened the phenotypic response of 38 PDAC cell lines to ionizing radiation. Subsequent phosphoproteomic analysis of two representative sensitive and resistant lines led to the reproducible identification of 7,800 proteins and 13,000 phosphorylation sites (p-sites). Approximately 700 p-sites on 400 proteins showed abundance changes after radiation in all cell lines regardless of their phenotypic sensitivity. Apart from recapitulating known radiation response phosphorylation markers such as on proteins involved in DNA damage repair, the analysis uncovered many novel members of a radiation-responsive signaling network that was apparent only at the level of protein phosphorylation. These regulated p-sites were enriched in potential ATM substrates and in vitro kinase assays corroborated 10 of these. Comparing the proteomes and phosphoproteomes of radiosensitive and -resistant cells pointed to additional tractable radioresistance mechanisms involving apoptotic proteins. For instance, elevated NADPH quinine oxidoreductase 1 (NQO1) expression in radioresistant cells may aid in clearing harmful reactive oxygen species. Resistant cells also showed elevated phosphorylation levels of proteins involved in cytoskeleton organization including actin dynamics and focal adhesion kinase (FAK) activity and one resistant cell line showed a strong migration phenotype. Pharmacological inhibition of the kinases FAK by Defactinib and of CHEK1 by Rabusertib showed a statistically significant sensitization to radiation in radioresistant PDAC cells. Together, the presented data map a comprehensive molecular network of radiation-induced signaling, improves the understanding of radioresistance and provides avenues for developing radiotherapeutic strategies.

Which types of exercise can help keep the brain healthy?

Matthew F. Glasser
Aug 10, 2011; 31:11597-11616
BehavioralSystemsCognitive

The brain's extracellular matrix (ECM) regulates neuronal plasticity and animal behavior. ECM staining shows a net-like structure around a subset of neurons, a ring-like structure at the nodes of Ranvier, and diffuse staining in the interstitial matrix. However, understanding the structural features of ECM deposition across various neuronal types and subcellular compartments remains limited. To visualize the organization pattern and assembly process of the hyaluronan-scaffolded ECM in the brain, we fused a HaloTag to hyaluronan proteoglycan link protein 1, which links hyaluronan and proteoglycans. Expression or application of the probe in primary rat neuronal cultures enables us to identify spatial and temporal regulation of ECM deposition and heterogeneity in ECM aggregation among neuronal populations. Dual-color birthdating shows the ECM assembly process in culture and in vivo. Sparse expression in mouse brains of either sex reveals detailed ECM architectures around excitatory neurons and developmentally regulated dendritic ECM. Our study uncovers extensive structural features of the brain's ECM, suggesting diverse roles in regulating neuronal plasticity.

Discover astonishing butterfly facts and delight in learning about the superlatives of butterflies, from the largest to the smallest to the fastest. Whether you're a nature enthusiast, an avid butterfly lover, or simply someone looking to expand their knowledge, this video is sure to leave you spellbound. Subscribe to our channel for more exciting videos exploring the wonders of the natural world. Don't miss out on future uploads where we uncover the secrets and hidden beauty of various flora and fauna, aiming to instill a deeper appreciation for the enchanting world we live in. --- Digital Editorial Director: Brian Wolly Supervising Producer & Scriptwriter: Michelle Mehrtens Video Editor: Sierra Theobald

A short movie explores 3D scans of some of the mid-Cretaceous lizards found trapped in amber. (courtesy of Daza et al., Science Advances)

Experts are carefully uncovering traces of the original paint and fragments of gold leaf that once adorned the 2,000-year-old Temple of Edfu

The final 3D atlas of the sky will help scientists study dark matter and dark energy, which make up 96 percent of the universe but remain mysterious

An investigation by David D. Kirkpatrick of the New York Times revealed the buyer's identity

Realme GT 7 Pro will launch in India on November 26 at 12pm IST. The phone was unveiled in China earlier this month. The Indian variant is expected to be similar to its Chinese counterpart. Now Realme has revealed several camera specifications and features of the Realme GT 7 Pro.

iQOO 13 is set to launch in India in December, and the handset is anticipated to arrive in global markets with identical specifications as the model that was launched in China last month. The company has now announced that the iQOO 13 will be offered in India in two colour options.

The final entry of Queen Elizabeth's private diary has been made public. During her record-breaking 70-year reign, the monarch, who died in 2022 at age 96, kept a private diary to take note of the events of the day and record her activities.

Day-long series of activities on May 21, 2022 explores the 1798 sinking of HMS DeBraak.