National Bureau of Economic Research

National Bureau of Economic Research

Providence, Rhode Island : American Mathematical Society, [2019]

Providence, Rhode Island : American Mathematical Society, [2019]

Crystalline needles of bone mineral form helical patterns around collagen fibrils

Researchers are using knowledge gained from rat studies to develop better therapeutics

The Navi Mumbai international airport will boast three interconnect­ed multi-level terminals with a lotus-inspired design, according to the master plan prepared by its outgoing developer.The GVK group, which completed 15 years of airport business, shared the first look of the Navi Mumbai airport.The group in 2018 had comm­iss­ioned British firm Zaha Hadid Architects to design the main terminal and air traffic control tower.The master plan of the airport was approved by the City and Industrial Development Corporation (CIDCO) in 2019.

The carmaker is set to redefine SUVs with the all-new Scorpio N. Rajesh Karkera offers a peak.

In the latest MOTD podcast the experts discussed the top 10 Ballon d'Or winners of the Premier League era - and here's how you ranked them.

The two upcoming Benellis - Imperiale 530 retro cruiser and the 600N naked streetfighter have been revealed in a couple of patent images. Here is what to expect!

The new 2020 Suzuki Burgman 200 will be available for sale in three colours of white, black and silver.

Both, the BS6 compliant Yamaha FZ 25 and the FZS 25 will be launched in India post lockdown. Ahead of the official launch, the company has revealed the official accessories for the two bikes along with their prices.

BS6 Yamaha FZ 25 will be on sale in two colour options while the FZS 25 will get three shades.

Royal Enfield Meteor 350 Fireball is expected to come with multiple optional accessories. Very recently, images that appear to be the screenshots of the official configurator have leaked on the web revealing some juicy details.

Mechanically, the FTR Carbon is identical to the other non-Carbon versions. It is powered by the same 1,203cc V-twin engine that puts out 123 hp and has been tuned for a flat torque curve.

Photographs of Hawke's Bay taken from space almost a year apart show the effects of its drought.The photos, taken by National Aeronautics and Space Administration (Nasa), compare the region on May 2, 2019, and April 29 this year....

[Zimbabwe Standard] HE might have just made a paltry eight appearances for Belgian Pro League football side Anderlecht, scoring just one goal since his big move in July 2018, but Warriors captain Knowledge Musona is the fourth highest paid player at the Brussels club earning over US$1 million annually.

LONDON: Britain’s spy agency has revealed the last messages from a German military communications network that were intercepted during World War II at Bletchley Park, the mansion house where Nazi codes were cracked. The secret messages, sent on May 7, 1945, were made public for the first...

LONDON: Britain’s spy agency has revealed the last messages from a German military communications network that were intercepted during World War II at Bletchley Park, the mansion house where Nazi codes were cracked. The secret messages, sent on May 7, 1945, were made public for the first...

Tune into our new show Fox League Live on Channel 502 Monday to Friday at 6.30pm and on Saturday at 3pm and Sunday at 5pm.

A reported hook-up between the AFL and coaches has come to light, which took place mere hours before the Crows’ training breach came to light.

The immune system of this mosquito is of great importance as scientists believe it plays a key role in controlling the transmission of viruses that cause

During COVID-19, queries like e-learning, work from home jobs and recipe in 5 minutes have seen massive growth and these clues to digital searches can

With Indians now being online like never before due to COVID-19 restrictions, searches for queries like e-learning, work from home jobs and recipe in 5 minutes have seen massive growth.

The application Jessica Ennis-Hill made for a SportsAid grant as a 15-year-old has been revealed by the organisation's Twitter account on the day she announced her retirement.

Scientists are developing a predictive model to help Nasa anticipate conflicts and communication breakdowns among crew members and head off problems that could make or break the US space agency's future manned mission to Mars. Nasa has formalised plans to send a crewed spacecraft to Mars, a journey that could involve 250 million miles of travel.

The iPhone 7 Plus 32GB, 128GB and 256GB will cost Rs 72,000, Rs 82,000 and Rs 92,000 respectively

टोयोटा और सुजुकी ने भारतीय और वैश्विक बाजारों के लिए नई कारों, प्लेटफार्मों और प्रौद्योगिकियों को विकसित करने के लिए मिलाया है। टोयोटा ने 2019 में बलेनो पर आधारित ग्लैंजा हैचबैक लॉन्च किया था, और अब जॉइंट वेंचर के तहत दूसरे

Within no time, Alia Bhatt has proved herself to be one of the greatest actors of her generation. Cinephiles are thrilled to watch Alia on the screen, but not many would know that her decision to be an actor was made

Rocking star Yash’s success story is unlike several actors from the industry. The actor who hails from a village in Mysore with no movie background whatsoever is now one of the most desired actors of the entire nation. The unprecedented success

Nissan India has officially revealed the Kicks BS6 in the Indian market. The upcoming SUV will feature a host of upgrades over the previous-gen BS4 models. The Nissan Kicks BS6 will be offered in four variants, and two engine and transmission options to choose from.

The Hyundai Grand i10 NIOS BS6 petrol variant mileage figures have been revealed. The company had updated the petrol engine to achieve BS6 compliance earlier this year, and also added a new turbo-engine to the Grand i10 NIOS BS6.

Within no time, Alia Bhatt has proved herself to be one of the greatest actors of her generation. Cinephiles are thrilled to watch Alia on the screen, but not many would know that her decision to be an actor was made

Vespa Elegante BS6 125 and the 149 models have been revealed ahead of its India launch. The Vespa 125 and the 149 Elegante models are the top-of-the-line variants in the 125cc and the 149cc categories, respectively.

A combined biophysical approach was applied to map gas-docking sites within murine neuroglobin (Ngb), revealing snapshots of events that might govern activity and dynamics in this unique hexacoordinate globin, which is most likely to be involved in gas-sensing in the central nervous system and for which a precise mechanism of action remains to be elucidated. The application of UV–visible microspectroscopy in crystallo, solution X-ray absorption near-edge spectroscopy and X-ray diffraction experiments at 15–40 K provided the structural characterization of an Ngb photolytic intermediate by cryo-trapping and allowed direct observation of the relocation of carbon monoxide within the distal heme pocket after photodissociation. Moreover, X-ray diffraction at 100 K under a high pressure of dioxygen, a physiological ligand of Ngb, unravelled the existence of a storage site for O2 in Ngb which coincides with Xe-III, a previously described docking site for xenon or krypton. Notably, no other secondary sites were observed under our experimental conditions.

Solute carriers are a large class of transporters that play key roles in normal and disease physiology. Among the solute carriers, heteromeric amino-acid transporters (HATs) are unique in their quaternary structure. LAT1–CD98hc, a HAT, transports essential amino acids and drugs across the blood–brain barrier and into cancer cells. It is therefore an important target both biologically and therapeutically. During the course of this work, cryo-EM structures of LAT1–CD98hc in the inward-facing conformation and in either the substrate-bound or apo states were reported to 3.3–3.5 Å resolution [Yan et al. (2019), Nature (London), 568, 127–130]. Here, these structures are analyzed together with our lower resolution cryo-EM structure, and multibody 3D auto-refinement against single-particle cryo-EM data was used to characterize the dynamics of the interaction of CD98hc and LAT1. It is shown that the CD98hc ectodomain and the LAT1 extracellular surface share no substantial interface. This allows the CD98hc ectodomain to have a high degree of movement within the extracellular space. The functional implications of these aspects are discussed together with the structure determination.

This work presents the crystal structure determination of two elusive polymorphs of furazidin, an antibacterial agent, employing a combination of crystal structure prediction (CSP) calculations and an NMR crystallography approach. Two previously uncharacterized neat crystal forms, one of which has two symmetry-independent molecules (form I), whereas the other one is a Z' = 1 polymorph (form II), crystallize in P21/c and P1 space groups, respectively, and both are built by different conformers, displaying different intermolecular interactions. It is demonstrated that the usage of either CSP or NMR crystallography alone is insufficient to successfully elucidate the above-mentioned crystal structures, especially in the case of the Z' = 2 polymorph. In addition, cases of serendipitous agreement in terms of 1H or 13C NMR data obtained for the CSP-generated crystal structures different from the ones observed in the laboratory (false-positive matches) are analyzed and described. While for the majority of analyzed crystal structures the obtained agreement with the NMR experiment is indicative of some structural features in common with the experimental structure, the mentioned serendipity observed in exceptional cases points to the necessity of caution when using an NMR crystallography approach in crystal structure determination.

In recent research on Santa Rosa Island off the coast of Southern California, isotope readings of carbon and nitrogen found in the bones of Chumash Indians and domestic dogs excavated from archaeological sites show that both humans and dogs have nearly identical signatures of stable isotopes.

The post Ancient bond between humans and dogs revealed in isotopic signatures of their bones appeared first on Smithsonian Insider.

Astronomers are confident the Cygnus X-1 system contains a black hole, and with these latest studies they have remarkably precise values of its mass, spin, and distance from Earth.

The post New details on birth of black hole Cygnus X-1 revealed by Chandra X-ray Observatory appeared first on Smithsonian Insider.

The Institute of Medicine today presented the Gustav O. Lienhard Award to Linda Aiken, Claire M. Fagin Leadership Professor of Nursing at the University of Pennsylvania School of Nursing, for her rigorous research demonstrating the importance of nursing care and work environments in achieving safe, effective, patient-centered, and affordable health care.

Agri-environment schemes (AES) are widely researched; some important issues, however, remain unstudied. Researchers have investigated some of these issues using a sample of olive growers in southern Spain. Their study reveals the level of monetary incentive needed for farmers to accept an ‘ecological focus area’, and a general unwillingness to participate collectively. These results could help policymakers design more cost-effective AES.

Climate change will substantially increase the severity and length of droughts in Europe by the end of the century, according to new research. The study showed that some European countries could experience a reduction in river flow of up to 80% by the 2080s.

Conservation efforts should focus on species that have recently declined in number, are harmless or are perceived as high value, according to a European public survey. Participants also felt that disappearing habitats should be targeted for protection. The results suggest that, by choosing different criteria that more closely match the public's values and criteria, conservationists could improve public support for their work.

A recent study, which assessed 100 streams across Europe, reveals that a key ecosystem process, leaf litter breakdown, is slowed when nutrient concentrations in the water are either very low or very high, has the highest potential at moderate nutrient concentrations and is inhibited in heavily polluted waters, implying that the relationship between nutrient levels and ecosystem processes, such as leaf litter breakdown, is complex. The researchers suggest that including an assessment of the functioning of ecosystem processes can make an important contribution to the overall evaluation of stream health.

Trawling's impacts on marine ecosystems can be assessed using simple metrics which characterise easy-to-obtain samples of fish, new research suggests. The Portuguese study shows that groups of fish become dominated by fewer species as fishing intensity increases, while their total biomass declines. Moreover, in the most fished areas there were other noteworthy changes, such as substantial reductions in the proportion of sharks and rays.

Mathematical models created to help design marine reserves have tended to focus on fish species where larvae are highly mobile but adults occupy relatively small areas. However, new research has extended these models to include fish species with different life histories, such as groupers and flounders, showing that they also benefit substantially from reserve protection.