Mervyn Affoon, who taught at the Academy of Hospitality and Tourism at hospitality at Erasmus Hall High School in Flatbush, is accused of sexually abusing the teen about 15 times between March 2017 and June 2017.

Collecting and analyzing real-time data on the number of cases and deaths during a disease outbreak is crucial. Here's why we've failed.

The Netflix documentary "A Secret Love" recounts the 72-year relationship between Pat Henschel and Terry Donahue, who had to hide their true selves from the world.

THE iconic gown Princess Diana wore to a state banquet at the White House in 1985 is currently being held in quarantine.

JOHN LENNON revealed his least favourite Beatles song was one he "knocked off" from Elvis Presley.

THE AIRLINE INDUSTRY has seen major losses in profit due to the coronavirus pandemic, with many companies seeing job losses and uncertain futures. But this is how the airline industry may recover after the pandemic.

Rafael Nadal expressed his worry this week that there may not be any more tennis in 2020 due to the coronavirus pandemic.

JOHN LENNON revealed his least favourite Beatles song was one he "knocked off" from Elvis Presley.

LINE OF DUTY has been keeping BBC viewers hooked for nearly a decade and with the show set to return for its sixth season in the coming months, could one of its key cast members be revealed as a corrupt officer in a huge twist?

Manchester United chief Ed Woodward is convinced he'll beat Borussia Dortmund to the signing of Jude Bellingham.

PRINCE CHARLES tested positive for coronavirus in March and it is believed he may have caught it from the Prince Albert II of Monaco - but there is another potential explanation.

ROCK legend Little Richard has died aged 87, but what was the cause of death?

MICHAEL COLLINS made a candid confession over his role in the Moon landings after 50 years, admitting he "had some regrets" about the way things played out.

LINE OF DUTY has been keeping BBC viewers hooked for nearly a decade and with the show set to return for its sixth season in the coming months, could one of its key cast members be revealed as a corrupt officer in a huge twist?

PRINCE CHARLES tested positive for coronavirus in March and it is believed he may have caught it from the Prince Albert II of Monaco - but there is another potential explanation.

ALAN TITCHMARSH, TV legend and much loved gardener, once revealed his top tips to get the very best strawberries grown at home.

MARVEL is on a little bit of a break at present, but many will want to catch up with the movies before the next phase begins - but how can you do it?

PS5 fans may not have too much longer to wait for the reveal of the next-gen PlayStation. Here's when Sony's PlayStation 5 State of Play could air.

MARGARET THATCHER's first Right To Buy council house was purchased for more than 20 times its original value 33 years later, unearthed reports reveal.

Anthony Joshua and Tyson Fury are within touching distance of fighting one another.

THE AIRLINE INDUSTRY has seen major losses in profit due to the coronavirus pandemic, with many companies seeing job losses and uncertain futures. But this is how the airline industry may recover after the pandemic.

MIDNIGHT SUN is finally being released, the brand new novel in Stephenie Meyer's Twilight franchise, which will be told all from Edward Cullen's perspective.

New techniques are being used to transform images from Hubble into spectacular 3D visualisations.

Archaic computer technology is hampering the effort to combat the effects of covid-19 in the United States.

Alfred C. O. Vertegaal
Dec 1, 2006; 5:2298-2310
Research

(Center for Genomic Regulation) An analysis of 13,000 tumours highlights two previously overlooked genes as potential new therapeutic targets for cancer treatment. Researchers also identify potential new therapeutic targets for male infertility. Both findings are the result of the most comprehensive evolutionary analysis of RNA modification proteins to date, published today in the journal Genome Biology.

Sonia Podvin
Apr 15, 2020; 0:RA120.002079v1-mcp.RA120.002079
Research

Accumulation and propagation of hyperphosphorylated tau (p-tau) is a common neuropathological hallmark associated with neurodegeneration of Alzheimer's disease (AD), frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and related tauopathies. Extracellular vesicles, specifically exosomes, have recently been demonstrated to participate in mediating tau propagation in brain. Exosomes produced by human induced pluripotent stem cell (iPSC)-derived neurons expressing mutant Tau (mTau), containing the P301L and V337M Tau mutations of FTDP-17, possess the ability to propagate p-tau pathology after injection into mouse brain.  To gain an understanding of the mTau exosome cargo involved in tau pathogenesis, these pathogenic exosomes were analyzed by proteomics and bioinformatics. The data showed that mTau expression dysregulates the exosome proteome to result in (1) proteins uniquely present only in mTau, and not control exosomes, (2) the absence of proteins in mTau exosomes, uniquely present in control exosomes, and (3) shared proteins which were significantly up-regulated or down-regulated in mTau compared to control exosomes. Notably, mTau exosomes (not control exosomes) contain ANP32A (also known as I1PP2A), an endogenous inhibitor of the PP2A phosphatase which regulates the phosphorylation state of p-tau.  Several of the mTau exosome-specific proteins have been shown to participate in AD mechanisms involving lysosomes, inflammation, secretases, and related processes.  Furthermore, the mTau exosomes lacked a substantial portion of proteins present in control exosomes involved in pathways of localization, vesicle transport, and protein binding functions. The shared proteins present in both mTau and control exosomes represented exosome functions of vesicle-mediated transport, exocytosis, and secretion processes. These data illustrate mTau as a dynamic regulator of the biogenesis of exosomes to result in acquisition, deletion, and up- or down-regulation of protein cargo to result in pathogenic mTau exosomes capable of in vivo propagation of p-tau neuropathology in mouse brain. 

The Washington Capitals have placed former Winterhawks wing Brendan Leipsic on unconditional waivers with the intention of his contract being terminated after private messages revealed misogynistic comments. > The Washington Capitals have placed Brendan Leipsic on unconditional waivers for purposes of terminating his contract.https://t.co/UnADibu2yQ

Randy L. Buckner
Feb 11, 2009; 29:1860-1873
Neurobiology of Disease

Mauritians are Africa's wealthiest individuals, while Zimbabweans count as the poorest, according to the latest Africa Wealth Report.

Four Portugal players, three from Germany and two each representing France and Wales have made the official UEFA EURO 2016 Team of the Tournament.

The details of the BS6 Vespa Elegante 149 are out. We believe the scooter will be launched in India soon.

The coronavirus outbreak exposed "shortcomings" in China's public healthcare system, a top health official admitted Saturday, saying that reforms are underway to improve the country's disease...

The original launch plan for Skoda Karoq has had to be updated due to the nationwide lockdown and now it will launch after 17 May. It will be a digital launch and bookings have been open for Rs 50,000.

The Union Minister also said that the upgraded configuration in Chandrayaan-3 will make the spacecraft more robust in terms of design and it will also have an enhanced spacecraft capacity without compromising with the heritage of Chandrayaan-2.

The first round of the Contracts for Difference (CfD) programme — the UK scheme that is designed to support low-carbon generation and a capacity margin in the energy sector — has concluded. Contracts were offered to 27 renewable electricity projects with a total value of some £315 million (US$500 million), which include two offshore wind farms with a total planned capacity of more than 1.1 GW, 15 onshore wind projects and five solar projects. In total, more 2 GW of new low-carbon capacity (including renewables, nuclear and carbon capture and storage) could be built under the CfD scheme.