Continuing Medical Education for Nurse Practitioners, Physician Assistants & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants, Registered Nurses & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants, Registered Nurses & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants, Registered Nurses & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants, Registered Nurses & Physicians

Continuing Medical Education for Nurse Practitioners, Physician Assistants, Registered Nurses & Physicians

Alsco and Richard Childress Racing celebrate 10-year partnership

Action Packed Weekend of Racing Planned

Statement Highlights: A new scientific statement outlines the role of primary care professionals in helping their patients achieve Life's Essential 8, the key measures for improving and maintaining cardiovascular health defined by the American Heart ...

"An extraordinary, path-breaking, and penetrating book on the life and work and creative inspirations of the great children's book genius Maurice Sendak, who since his death in 2012 has only grown in his stature and recognition as a major American artist, period. Polymath and master interviewer Jonathan Cott first interviewed Maurice Sendak in 1976 for Rolling Stone, just at the time when Outside Over There, the concluding and by far the strangest volume of a trilogy that began with Where The Wild Things Areand In the Night Kitchen, was gestating. Over the course of their wide-ranging and revelatory conversation about his life, work, and the fantasies and obsessions that drove his creative process, they focused on many of the themes and images that would appear in the new book five years later. Drawing on that interview, There's a Mystery There is a profound examination of the inner workings of a complicated genius's torments and inspirations that ranges over the entirety of his work and his formative life experiences, and uses Outside Over There, brilliantly and originally, as the key to understanding just what made this extravagantly talented man tick. To gain multiple perspectives on that intricate and multifaceted book, Cott also turns to four "companion guides": a Freudian analyst, a Jungian analyst, an art historian, and Sendak's great friend and admirer, the playwright Tony Kushner. The book is richly illustrated with examples from Sendak's work and other related images." -- Provided by publisher.

Per the DOE’s second annual “National Energy Employment Analysis,” a total of 6.4 million Americans now work in the traditional energy and energy-efficiency industries. More than 300,000 net new jobs were added in 2016, which accounted for 14 percent of the nation’s job growth.

Book for our free primary school screenings taking place at Showcase sites this June and July

Jim Grisanzio from Oracle Developer Relations talks with Oracle ACE Director Rita Nunez from Argentina to preview the upcoming 2021 LAOUC Evento de Primavera November 9-10. The event will be held online in Spanish, Portuguese, and English, and it's free and open to developers globally. Technologies discussed will be Oracle Database, security, APEX, Java, development tools, cloud, and more. Get involved here.

Rita Nunez, Oracle ACE Director

• https://twitter.com/ritan2000 

Jim Grisanzio, Oracle Developer Relations

• https://twitter.com/jimgris 
• https://www.linkedin.com/in/jimgris/ 
• https://developer.oracle.com/team/ 
• https://oraclegroundbreakers.libsyn.com/ 

BERLIN/WARSAW, 8 April 2016 – Political leaders must play a primary role in in countering discrimination and prejudice against Roma and Sinti and improving their situation, Frank-Walter Steinmeier, OSCE Chairperson-in-Office and Germany’s Federal Foreign Minister, and Michael Georg Link, Director of the OSCE Office for Democratic Institutions and Human Rights (ODIHR), said today, on the occasion of International Roma Day.

“Political leaders at all levels must be at the forefront of efforts to end the systematic discrimination and racism that have long afflicted Roma and Sinti communities and individuals in many countries in the OSCE region,” OSCE  Chairperson-in-Office Steinmeier said. “They have to lead both by word, in delivering positive messages and not resorting to negative stereotypes and scapegoating, and by example, in ensuring the implementation of policies at all levels of government to promote the integration and full political, economic and social participation of Roma and Sinti in their societies.”

In particular, they condemned the use by some politicians of racist language and messages aimed either at promoting hatred towards Roma and Sinti or reinforcing negative stereotypes.

“Alarmingly, we still see instances where politicians resort to the politics of fear and hatred for their own perceived gain, thus stoking unfair and dangerous prejudice against Roma and Sinti. This contributes to an atmosphere in which members of Europe’s largest minority are in danger of being targeted with hate crimes, including violent assaults, and even murder,” Director Link said. “Leaders must not only refrain from such statements, but take a step further – they must publicly condemn racist speech and acts against Roma and Sinti, and counter racism and discrimination in a systematic way.”

The subject of racist, anti-Roma rhetoric used by politicians was addressed at a side event organized by ODIHR and the Central Council for German Sinti and Roma, during the Human Dimension Implementation Meeting in Warsaw, on 30 September 2015, at which participants highlighted the important role of state institutions in overcoming racism.

The Organization’s work in this area is guided by the Action Plan on Improving the Situation of Roma and Sinti in the OSCE Area, adopted in 2003, which includes measures to combat racism and discrimination, to promote greater public and economic participation, and to ensure equal access and opportunities in the areas of education, employment, housing and health services.

“The blueprint for addressing racism and discrimination against Roma and Sinti and for improving their situation already exists, in the form of the Action Plan,” said Mirjam Karoly, Chief of ODIHR’s Contact Point for Roma and Sinti Issues. “Greater political will and leadership are vital to making this a reality.”

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• OSCE States explore role for the Organization regarding migration and refugee flows
• 2016 OSCE Annual Security Review Conference focuses on reviving co-operative security in a challenging environment

Potential for primary energy savings in TLC/ICT centres through free cooling

TP-GSTR-GNSS - Considerations on the use of GNSS as a primary time reference in telecommunications
This report, initially posted on 1 July, was reposted on 12 October 2020 with a correct date of approval

[Premium Times] The cleric commended the government for ensuring that the scope of intervention of TETFund expanded from building infrastructure to carrying out research programmes.

By Michael Turner, freelance writer.The commercial trucking industry in the United States is one of the most developed in the world, but even there some problems occur, especially when it comes to transporting perishable goods.

Agnès Lacreuse investigates cognitive aging and women’s health in nonhuman primates.

Gov. Kathy Hochul of New York will face Representative Lee Zeldin this fall. Two Trump-endorsed candidates won key primaries in Illinois. Here’s what else happened.

Former President Donald J. Trump’s endorsement has helped propel some candidates to victory, but he’s also had some notable defeats.

Panelistas analizaron el papel de China y Rusia en la política internacional de Joe Biden. También hicieron un balance de los diez años de la Primavera Árabe.

Federico Pardo, biólogo y documentalista invita a visitar la experiencia multimedia y adentrarse en las profundidades de los bosques. 

Ludmila Padrino, enfatizó en que Vladimir Padrino López fue cambiando conforme fue adquiriendo poder durante su carrera. 

 José Manuel Restrepo, exministro de Hacienda, explicó en 6AM de Caracol Radio cuáles serían los impactos económicos que enfrentaría el país en caso de no ampliarse el cupo de endeudamiento.

"If you take politics as a game, you have to play underneath the rules. You can't appear to be disagreeable; you have to appear to voters as someone who’s getting things done."

Warwick Academy were crowned the Bermuda School Sports Federation’s Primary School Division One Netball champions at the Bernard Park Netball courts. Warwick Academy edged past Northlands Primary 5 – 4 in a very close encounter. Quin Burgess scored four goals to lead Warwick with Francesca Cressall-Haycock scoring the other. Sofia Odouri led Northlands with three […]

Somerset Primary School students recently hosted an International Dinner for students and parents, where the students highlighted the culture and cuisine of countries, including Japan, Mexico, India, and Bermuda. The event offered a variety of dishes for attendees to sample, celebrating the diversity within the school community. In honor of Diwali, the PTA also organized […]

Somerset Primary School is set to host its International Day Dinner today [November 5], offering students and their families a rich experience of global cuisine and culture. The event will take place in the school’s Assembly Hall from 4 pm to 6 pm. Each class will represent a different country such as Bermuda, Mexico, Japan, […]

Após cinco anos de pesquisa usando técnicas como imagem digital e inteligência artificial, oito restauradores começarão a "Operação Night Watch" de restauração da obra de arte

Alison M. Kurimchak
Dec 1, 2020; 19:2068-2089
Research

Endometrial carcinoma (EC) is the most common gynecologic malignancy in the United States, with limited effective targeted therapies. Endometrial tumors exhibit frequent alterations in protein kinases, yet only a small fraction of the kinome has been therapeutically explored. To identify kinase therapeutic avenues for EC, we profiled the kinome of endometrial tumors and normal endometrial tissues using Multiplexed Inhibitor Beads and Mass Spectrometry (MIB-MS). Our proteomics analysis identified a network of kinases overexpressed in tumors, including Serine/Arginine-Rich Splicing Factor Kinase 1 (SRPK1). Immunohistochemical (IHC) analysis of endometrial tumors confirmed MIB-MS findings and showed SRPK1 protein levels were highly expressed in endometrioid and uterine serous cancer (USC) histological subtypes. Moreover, querying large-scale genomics studies of EC tumors revealed high expression of SRPK1 correlated with poor survival. Loss-of-function studies targeting SRPK1 in an established USC cell line demonstrated SRPK1 was integral for RNA splicing, as well as cell cycle progression and survival under nutrient deficient conditions. Profiling of USC cells identified a compensatory response to SRPK1 inhibition that involved EGFR and the up-regulation of IGF1R and downstream AKT signaling. Co-targeting SRPK1 and EGFR or IGF1R synergistically enhanced growth inhibition in serous and endometrioid cell lines, representing a promising combination therapy for EC.

At a recent clinical meeting, I heard that GPs local to me are about to lose the ability to request magnetic resonance imaging (MRI) scans for patients presenting with musculoskeletal symptoms. We’re instead advised to refer our patients to a musculoskeletal clinical assessment and triage service (CATS)—staffed largely by musculoskeletal advanced practitioners, who will assess our patients and determine whether imaging is warranted.The hope is that fewer patients will have unnecessary imaging and that this will reduce the potential harms of overdiagnosis. Radiologists rarely report musculoskeletal MRI scans as entirely normal, and it can be hard to know what to do with abnormal findings on an MRI. More often than not, patients with abnormal scans are referred to orthopaedic teams, even though there may not necessarily be a surgical target.At a population level, this is problematic on two fronts. Firstly, MRI scans are expensive and need to be used judiciously....

C-X-C motif chemokine receptor 4 (CXCR4)–directed imaging has gained clinical interest in aiding clinical diagnostics in primary aldosteronism (PA). We retrospectively evaluated the feasibility of CXCR4-directed scintigraphy using the novel CXCR-4 ligand [^99mTc]Tc-pentixatec in patients with PA. Methods: Six patients (mean age ± SD, 49 ± 15 y) underwent CXCR4-directed scintigraphy (including planar imaging and SPECT/CT) 30, 120, and 240 min after injection of 435 ± 50 MBq of [^99mTc]Tc-pentixatec. Adrenal CXCR4 expression was analyzed by calculating lesion-to-contralateral ratios (LCRs). Imaging results were correlated to clinical information. Histopathology and clinical follow-up served as the standard of reference. Results: Three subjects showed lateralization of adrenal tracer accumulation, with a mean maximum lesion-to-contralateral ratio of 1.65 (range, 1.52–1.70), which correlated with morphologic findings on CT. One individual underwent adrenalectomy and presented with complete biochemical and clinical remission at follow-up. Histopathologic workup confirmed unilateral aldosterone-producing adenoma. Conclusion: [^99mTc]Tc-pentixatec scintigraphy with SPECT in patients with PA is feasible and might offer a valuable alternative to CXCR4-directed imaging with [⁶⁸Ga]Ga-pentixafor PET.

Cancer of unknown primary (CUP) represents a heterogeneous group of metastatic tumors for which standardized diagnostic work-up fails to identify the primary site. We aimed to describe the Peter MacCallum Cancer Centre experience with ¹⁸F-FDG PET/CT in extracervical CUP with respect to detection of a primary site and its impact on management. A secondary aim was to compare overall survival (OS) in patients with and without a detected primary site. Methods: CUP patients treated between 2014 and 2020 were identified from medical oncology clinics and ¹⁸F-FDG PET/CT records. Information collated from electronic medical records included the suspected primary site and treatment details before and after ¹⁸F-FDG PET/CT. Clinicopathologic details and genomic analysis were used to determine the clinically suspected primary site and compared against 2 independent masked reads of ¹⁸F-FDG PET/CT images by nuclear medicine specialists to determine sensitivity, specificity, accuracy, and the rate of detection of the primary site. Results: We identified 147 patients, 65% of whom had undergone molecular profiling. The median age at diagnosis was 61 y (range, 20–84 y), and the median follow-up time was 74 mo (range, 26–83 mo). Eighty-two percent were classified as having an unfavorable CUP subtype as per international guidelines.¹⁸F-FDG PET/CT demonstrated a primary site detection rate of 41%, resulted in a change in management in 22%, and identified previously occult disease sites in 37%. Median OS was 16.8 mo for all patients and 104.7 and 12.1 mo for favorable and unfavorable CUP subtypes, respectively (P < 0.0001). Median OS in CUP patients when using ¹⁸F-FDG PET/CT, clinicopathologic, and genomic information was 19.8 and 8.5 mo when a primary site was detected and not detected, respectively (P = 0.016). Multivariable analysis of survival adjusted for age and sex remained significant for identification of a potential primary site (P < 0.001), a favorable CUP (P < 0.001), and an Eastern Cooperative Oncology Group status of 1 or less (P < 0.001). Conclusion: ¹⁸F-FDG PET/CT plays a complementary role in CUP diagnostic work-up and was able to determine the likely primary site in 41% of cases. OS is improved with primary site identification, demonstrating the value of access to diagnostic ¹⁸F-FDG PET/CT for CUP patients.

After a couple years of clashes with teachers in the state, West Virginia Senate President Mitch Carmichael was ousted in Tuesday's Republican primary election by a teacher.

Charter schools are playing a notable role in remarks about education from candidates like Joe Biden and Bernie Sanders. Yet it's not clear what if any role they'll have in important states like Iowa and New Hampshire.