The last two months have not been kind to clean energy stocks. Most commentators attribute the weakness to declining oil prices and the Republicans' strong showing in the midterm elections.

This document compiles information on the current methodologies, tools and models and helps readers identify appropriate models/ and methodologies for estimating substance-specific removal/emissions from wastewater treatment systems. It could support efforts to improve these models and tools.

Molecular replacement (MR) is the predominant route to solution of the phase problem in macromolecular crystallography. Where the lack of a suitable homologue precludes conventional MR, one option is to predict the target structure using bioinformatics. Such modelling, in the absence of homologous templates, is called ab initio or de novo modelling. Recently, the accuracy of such models has improved significantly as a result of the availability, in many cases, of residue-contact predictions derived from evolutionary covariance analysis. Covariance-assisted ab initio models representing structurally uncharacterized Pfam families are now available on a large scale in databases, potentially representing a valuable and easily accessible supplement to the PDB as a source of search models. Here, the unconventional MR pipeline AMPLE is employed to explore the value of structure predictions in the GREMLIN and PconsFam databases. It was tested whether these deposited predictions, processed in various ways, could solve the structures of PDB entries that were subsequently deposited. The results were encouraging: nine of 27 GREMLIN cases were solved, covering target lengths of 109–355 residues and a resolution range of 1.4–2.9 Å, and with target–model shared sequence identity as low as 20%. The cluster-and-truncate approach in AMPLE proved to be essential for most successes. For the overall lower quality structure predictions in the PconsFam database, remodelling with Rosetta within the AMPLE pipeline proved to be the best approach, generating ensemble search models from single-structure deposits. Finally, it is shown that the AMPLE-obtained search models deriving from GREMLIN deposits are of sufficiently high quality to be selected by the sequence-independent MR pipeline SIMBAD. Overall, the results help to point the way towards the optimal use of the expanding databases of ab initio structure predictions.

Research from the US helps paint a clearer picture of the extent of global sea level rise, by considering new satellite data on the Earth’s gravity. Its findings support reports of accelerating ice melt and suggest that most of the change in sea levels is caused by receding polar ice sheets and mountain glaciers.

Openwave Mobility released predictions for 2018 based on two major pieces of analysis- the mobile video index (MVI) based on live data gathered from over 30 global mobile operators and the NFV Playbook, based on NFV trials and deployments with insight from leading industry analysts.

The effects of climate change on the distribution of species can be predicted more accurately by considering the genetic differences between different groups of the same species, a new study suggests. The researchers found that a computer model which incorporated genetic information on different groups of a US tree species was up to 12 times more accurate in predicting tree locations than a non-genetically informed model.

The technology industry is spurred by those who think ahead and think big — but these predictions were all wrong.

Sometimes it's not that hard to predict the future and that's just what happened with Hurricane Irene.

Electric vehicles, hybrids and plug-ins will be on the market by the end of the year. Here's a look into the crystal ball.

But don't be put off by the headline: I'm excited about what I'm hearing about what's coming next year.

When crisis hits, the jokesters come out of the woodwork. Here is what to expect.

If the Main Door of your flat/office/building faces South West, then read on to find out how you will fare in 2006 in your Career/Business, Health, Wealth, Relationships, Harmony and Love.

If the Main Door of your flat/office/building faces North, then read on to find out how you will fare in 2006 in your Career/Business, Health, Wealth, Relationships, Harmony and Love. Be aware of your strengths and be warned of the negative energy that you may have to face, to plan your strategies well ahead. Also advice regarding directions to be avoided for renovation, reconstruction, redecoration, etc. in 2006. Get to know the Fengshui Enhancers and Cures that can help you, too.

If the Main Door of your flat/office/building faces South, then read on to find out how you will fare in 2006 in your Career/Business, Health, Wealth, Relationships, Harmony and Love. Be aware of your strengths and be warned of the negative energy that you may have to face, to plan your strategies well ahead. Also advice regarding directions to be avoided for renovation, reconstruction, redecoration, etc. in 2006. Get to know the Fengshui Enhancers and Cures that can help you, too.

If the Main Door of your flat/office/building faces East, then read on to find out how you will fare in 2006 in your Career/Business, Health, Wealth, Relationships, Harmony and Love. Be aware of your strengths and be warned of the negative energy that you may have to face, to plan your strategies well ahead. Also advice regarding directions to be avoided for renovation, reconstruction, redecoration, etc. in 2006. Get to know the Fengshui Enhancers and Cures that can help you, too.

If the Main Door of your flat/office/building faces West, then read on to find out how you will fare in 2006 in your Career/Business, Health, Wealth, Relationships, Harmony and Love. Be aware of your strengths and be warned of the negative energy that you may have to face, to plan your strategies well ahead. Also advice regarding directions to be avoided for renovation, reconstruction, redecoration, etc. in 2006. Get to know the Fengshui Enhancers and Cures that can help you, too.

If the Main Door of your flat/office/building faces North East, then read on to find out how you will fare in 2006 in your Career/Business, Health, Wealth, Relationships, Harmony and Love. Be aware of your strengths and be warned of the negative energy that you may have to face, to plan your strategies well ahead. Also advice regarding directions to be avoided for renovation, reconstruction, redecoration, etc. in 2006. Get to know the Fengshui Enhancers and Cures that can help you, too.

If the Main Door of your flat/office/building faces North West, then read on to find out how you will fare in 2006 in your Career/Business, Health, Wealth, Relationships, Harmony and Love. Be aware of your strengths and be warned of the negative energy that you may have to face, to plan your strategies well ahead. Also advice regarding directions to be avoided for renovation, reconstruction, redecoration, etc. in 2006. Get to know the Fengshui Enhancers and Cures that can help you, too.

If the Main Door of your flat/office/building faces South East, then read on to find out how you will fare in 2006 in your Career/Business, Health, Wealth, Relationships, Harmony and Love. Be aware of your strengths and be warned of the negative energy that you may have to face, to plan your strategies well ahead. Also advice regarding directions to be avoided for renovation, reconstruction, redecoration, etc. in 2006. Get to know the Fengshui Enhancers and Cures that can help you, too.

Discover legal marketing trends & predictions in SEO, PPC, Web Design, Content, and Social Media that will impact lawyers in 2020, and get actionable tips from Consultwebs to apply in your law firm.

Ashton Whiteley: Despite persistent political uncertainty, the German economy looks set to continue its upward trend in 2018.

At the beginning of a new homecoming season, Occasion Brands, LLC, releases this 2019 issue of Pulse of Homecoming with pre-season predictions of consumer purchasing trends for homecoming 2019 dresses.

Check out this curated collection of coronavirus-related projections, dashboards, visualizations, and data that we have encountered on the internet.

Digital transformation has just begun.

Not a single industry is safe from the unstoppable wave of digitization that is sweeping through finance, retail, healthcare, and more.

In 2020, we expect to see even more transformative developments that will change our businesses, careers, and lives.

See the rest of the story at Business Insider

See Also:

• GoBear has acquired AsiaKredit to drive growth through digital consumer lending
• US personal savings rate increases due to lowered spending amid social distancing
• RBS is shuttering its standalone digital bank Bó due to coronavirus fallout

As we approach a new year?and a new decade?executives from multiple industry sectors offer predictions on the intertwined areas of CX, information governance and compliance, and automation and AI

Consider the following prediction problem. Assume that there is a block box that produces bits according to some unknown computable distribution on the binary tree. We know first $n$ bits $x_1 x_2 ldots x_n$. We want to know the probability of the event that that the next bit is equal to $1$. Solomonoff suggested to use universal semimeasure $m$ for solving this task. He proved that for every computable distribution $P$ and for every $b in {0,1}$ the following holds: $$sum_{n=1}^{infty}sum_{x: l(x)=n} P(x) (P(b | x) - m(b | x))^2 < infty .$$ However, Solomonoff's method has a negative aspect: Hutter and Muchnik proved that there are an universal semimeasure $m$, computable distribution $P$ and a random (in Martin-L{"o}f sense) sequence $x_1 x_2ldots$ such that $lim_{n o infty} P(x_{n+1} | x_1ldots x_n) - m(x_{n+1} | x_1ldots x_n) rightarrow 0$. We suggest a new way for prediction. For every finite string $x$ we predict the new bit according to the best (in some sence) distribution for $x$. We prove the similar result as Solomonoff theorem for our way of prediction. Also we show that our method of prediction has no that negative aspect as Solomonoff's method.

Copyright 2020 NPR. To see more, visit https://www.npr.org.

Copyright 2020 NPR. To see more, visit https://www.npr.org.

There's only a few days left until this year's Oscars are handed out, so now's a good time to catch up on your film viewing. In this week's "Cinema Chat," WEMU's David Fair talks to Michigan and State Theater executive director Russ Collins about the latest movie news and all of the new flicks landing on the big screen this weekend.

Rob Minshull produces Weekends with Warren and is an avid reader. You can hear Dan Gardner being interviewed by Warren Boland on Sunday 13th Weekends with Warren.

The dystopian best-seller 1984 was published exactly seventy years ago. Its influence has been profound. But does it really speak to today’s politico-cultural environment?

The dystopian best-seller 1984 was published exactly seventy years ago. Its influence has been profound. But does it really speak to today’s politico-cultural environment?

A model predicts COVID-19 deaths in the U.S. will drop to zero by June. Another suggests without a vaccine, the coronavirus will be with us for years.

As U.S. faces its most trying coronavirus pandemic days, industry leaders imagine the future of travel.

With Tom Brady out of the picture, how will the Jets fare this season?

With Tom Brady out of the picture, how will the Jets fare this season?

Predicting the four acting races for the 2020 Oscars is easy this year, but there's still drama in the best picture race and others

NOSTRADAMUS is hailed as the world's greatest prophetic mind, with three predictions people think he got right. Did he predict the coronavirus outbreak?

Digital transformation has just begun.

Not a single industry is safe from the unstoppable wave of digitization that is sweeping through finance, retail, healthcare, and more.

In 2020, we expect to see even more transformative developments that will change our businesses, careers, and lives.

To help you stay ahead of the curve, Business Insider Intelligence has put together a list of 30 Big Tech Predictions for 2020 across Banking, Connectivity & Tech, Digital Media, Payments & Commerce, Fintech, and Digital Health.

This exclusive report can be yours for FREE today.

Join the conversation about this story »

This past year, I predicted the fall of both Zuck and Trump, not to mention the triumph of cannabis and rationale markets. But in 2019, the sociopaths won – bigly. Damn, was I wrong. One year ago this week, I sat down to write my annual list of ten or so predictions for the coming … Continue reading "Predictions Review: Trump, Zuck Crush My Optimism In 2019"

A new year brings another run at my annual predictions: For 17 years now, I’ve taken a few hours to imagine what might happen over the course of the coming twelve months. And my goodness did I swing for the fences last year — and I pretty much whiffed. Batting .300 is great in the majors, but it … Continue reading "Predictions 2020: Facebook Caves, Google Zags, Netflix Sells Out, and Data Policy Gets Sexy"

1 April 2020

1 April 2020

The presentation of peptides on class I human leukocyte antigen (HLA-I) molecules plays a central role in immune recognition of infected or malignant cells. In cancer, non-self HLA-I ligands can arise from many different alterations, including non-synonymous mutations, gene fusion, cancer-specific alternative mRNA splicing or aberrant post-translational modifications. Identifying HLA-I ligands remains a challenging task that requires either heavy experimental work for in vivo identification or optimized bioinformatics tools for accurate predictions. To date, no HLA-I ligand predictor includes post-translational modifications. To fill this gap, we curated phosphorylated HLA-I ligands from several immunopeptidomics studies (including six newly measured samples) covering 72 HLA-I alleles and retrieved a total of 2,066 unique phosphorylated peptides. We then expanded our motif deconvolution tool to identify precise binding motifs of phosphorylated HLA-I ligands. Our results reveal a clear enrichment of phosphorylated peptides among HLA-C ligands and demonstrate a prevalent role of both HLA-I motifs and kinase motifs on the presentation of phosphorylated peptides. These data further enabled us to develop and validate the first predictor of interactions between HLA-I molecules and phosphorylated peptides.

1 April 2020

19th century.

2019 is nearly over, so let's look ahead to what awaits the video game industry in the first year of the new decade. Informed opinions and hot takes abound.

History is witness to the many scientific leaders and technology visionaries who all tried to predict what innovations will exist in the future. While not all predictions come to fruition, others were not so far off. We may not have flying cars like The...