A joint EU BON WP3-WP4 meeting took place on 25-27 November 2013 in Solsona, Spain. The main aim of the meeting was to officially kick off WP3 and provide forum for discussion of the planned work. The two work packages were presented with their main aims, scope and objectives. The place of the two work packages in the broader framework of EU BON, and the cross-links between the two, were also discussed.

In the following interview Hannu Saarenmaa and Klaus Henle share insights from the meeting:

1) WP3 ‘Improving tools and methods for data analysis and interface’ and WP 4 ‘Link environment to biodiversity: analyses of patterns, processes and trends’ are two of the core work packages in EU BON that are expected to accumulate a lot of genuine data and develop new tools for data analysis and interface. Can you explain in short what will your main activities involve?

HS: I can contribute to the project and these WPs a large-scale modelling technology from the BioVeL project that can process hundreds of species. This would be an engine to compute the first real Essential Biodiversity Variables (EBV).

KH: Our main activities will involve an analysis how available effort is best allocated in time and space to optimize results from monitoring. We will further assess how different sources of uncertainty influence conclusions derived from the analysis of monitroing data

2) What were the main results of the meeting in terms of the planned work and WP management?

HS: It was proposed to set up an EBV Task Force across the EU BON project.  If we can do that, it would really give a thrust for the project. If we could pick up the Database of Monitoring Schemes from the EUMON project, as discussed, that would give us access to some large datasets.

KH: One main result was the identification of the concrete responsibilities (e.g. data provision, data analysis for terrestrial, freshwater and marine biodiversity) within the workpackage and to identify explicitly links to other workpackages.

3) What novelty will the work in these two work packages bring and what will the major results be?

HS: If they can create a new Ecological Niche Modelling algorithm that can also deal with spatial patterns, that would be interesting.  Such a model actually exists in MigClim, but it is not yet widely used.

KH: We will get recommendations how monitoring can be optimized and a more comprehensive understanding of changes in biodiversity and their underlying causes

4) What are the immediate planned activities and when can the first results be expected?

KH: The most immediate planned activities it the screening of potentially available data needed for the analysis

5) How will the WP3/4 interact with GEO BON?

HS: The proposed EBV Task Force would need to interface very closely with GEO BON.

KH: We are engaged directly with key members of GEO-BON; e.g. we have regular meetings with Henrique Perreira.

Group337, a team of experts focused on activating the companies, brands and people in the security industry through insights, intuition and ideas, announced a partnership with Momentum Security Training, an online, context-based education platform serving the physical security industry and its users. 

The unit applies labels to round and cylindrical containers at high speeds.

Manufacturer of specialized digital printing equipment Primera Technology Inc. announced its AP380 Label Applicator.

The YouTube Music app is the ultimate one to get drawn in the melodious magic. The new TuneFab YouTube Music Converter has opened an ocean of opportunities with futuristic features & fabulous functions.

Naomi’s brother Nathan is staying with us at the moment and he cooked us a Mexican dinner of stuffed peppers. 1/40sec f2.0 ISO1250 via Flickr http://flic.kr/p/hGs7G3

A butterfly pauses to rest on some bluebells on a sunny afternoon. 1/500sec f9 ISO1000 500mm via Flickr http://flic.kr/p/hGuGMy

Some beautiful blossoms in the yard of our friends Guy and Jean, on one of the first warm days of the season. 1/125sec f5.6 ISO100 via Flickr http://flic.kr/p/hGvUoV

U-Boot with GRUB support for BeagleBoard and BeagleBoard-xM

U-Boot with Extlinux support for BeagleBoard and BeagleBoard-xM

Felienne interviews Marian Petre & André van der Hoek on their book ‘Software Design Decoded’, which contains 66 scientifically backed insights for the design process.

Jafar Soltani of Rare (Microsoft Studios) discusses Continuous Delivery in AAA Games and how it can increase quality, reduce crunch, and deliver games faster. Topics include implementation and architecture, asset and delivery pipelines, and special challenges of games.

Avi Kivity of Scylladb deep dives into the internals of Scylladb and what makes it a high performant version of Cassandra, a distributed key-value datastore. The discussion covers the architecture of Scylladb, its relationship with high performance...

Pat Helland talks to host Akshay Manchale about Data Management at scale in a Microservices world. Pat talks about trends in managaging data in a distributed microservices world, immutability, idempotence, inside and outside data, descriptive...

" The mainstream PCIe Gen 3x4 P34A60 mainstream SSD from Silicon Power does offer good all-around performance and does not drop to very slow speeds when the cache fills up completely, as we could notice from the HD Tune Pro write test. When copying large files continuously to the drive, we haven�t seen drops of under 90MB/s, which is great for a TL... [PCSTATS]

The inclusion of an all-new label liner rewinder further optimizes operations by keeping the waste liner material off the floor and winding it into a roll for easy disposal.

Case studies of radio frequency- electromagnetic field (RF-EMF) assessment

ITU-T K.118 - Requirements for lightning protection of fibre to the distribution point equipment - Modelling earth potential rise

ITU-T K.118 - Requirements for lightning protection of fibre to the distribution point equipment - Overview

Case studies of radio frequency- electromagnetic field (RF-EMF) assessment

ITU-T X.805 - Supplement on security guidelines for mobile virtual network operators

ITU-T X.660 - Supplement on guidelines for using object identifiers for the Internet of things

ITU-T X.1231 - Supplement on technical framework for countering telephone service scams

ITU-T X.1058 - Supplement on code of practice for personally identifiable information (PII) protection for telecommunication organizations

ITU-T X.1051 - Supplement on code of practice for information security controls for telecommunication organizations

Having a label applied accurately, precisely and wrinkle-free is important as it elevates the product presentation, a critical factor in driving sales.

http://www.musicxray.com/xrays/2672413 chrissloanmusic - Your Love Is Gone Mix Final MP3

http://www.musicxray.com/xrays/2672427 DjHappyDSG - THE TRUTH FL Studio Phoria um2 AUX0002.MP3

http://www.musicxray.com/xrays/2672455 dj_happy_dsg - AUX0012.MP3

http://www.musicxray.com/xrays/2672456 DjHappyDSG - THE TRUTH FL Studio Phoria um2 AUX0011.MP3

http://www.musicxray.com/xrays/2672457 dj_happy_dsg - AUX0001.MP3

The debate rages between the Fraunhofer encoder and the LAME encoder for encoding podcasts. Listen for yourself and see if you can tell the difference.

The post Which is the Best MP3 Encoder for Podcasts? appeared first on Richard Farrar.

velocityconf: RT @OReillyAnimals Advice, please! Elephant Listening Project asks for ideas/solutions/help with 3 practical problems http://t.co/Y90YP3maoz

The human cardiovascular system has adapted to function optimally in Earth's 1G gravity, and microgravity conditions cause myocardial abnormalities, including atrophy and dysfunction. However, the underlying mechanisms linking microgravity and cardiac anomalies are incompletely understood. In this study, we investigated whether and how calpain activation promotes myocardial abnormalities under simulated microgravity conditions. Simulated microgravity was induced by tail suspension in mice with cardiomyocyte-specific deletion of Capns1, which disrupts activity and stability of calpain-1 and calpain-2, and their WT littermates. Tail suspension time-dependently reduced cardiomyocyte size, heart weight, and myocardial function in WT mice, and these changes were accompanied by calpain activation, NADPH oxidase activation, and oxidative stress in heart tissues. The effects of tail suspension were attenuated by deletion of Capns1. Notably, the protective effects of Capns1 deletion were associated with the prevention of phosphorylation of Ser-345 on p47phox and attenuation of ERK1/2 and p38 activation in hearts of tail-suspended mice. Using a rotary cell culture system, we simulated microgravity in cultured neonatal mouse cardiomyocytes and observed decreased total protein/DNA ratio and induced calpain activation, phosphorylation of Ser-345 on p47phox, and activation of ERK1/2 and p38, all of which were prevented by calpain inhibitor-III. Furthermore, inhibition of ERK1/2 or p38 attenuated phosphorylation of Ser-345 on p47phox in cardiomyocytes under simulated microgravity. This study demonstrates for the first time that calpain promotes NADPH oxidase activation and myocardial abnormalities under microgravity by facilitating p47phox phosphorylation via ERK1/2 and p38 pathways. Thus, calpain inhibition may be an effective therapeutic approach to reduce microgravity-induced myocardial abnormalities.

Tuberculosis (TB), caused by the infection of Mycobacterium tuberculosis (MTB), is one of the leading causes of death worldwide, especially in children. However, the mechanisms by which MTB infects its cellular host, activates an immune response, and triggers inflammation remain unknown. Mitochondria play important roles in the initiation and activation of the nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) inflammasome, where mitochondria-associated endoplasmic reticulum membranes (MAMs) may serve as the platform for inflammasome assembly and activation. Additionally, mitofusin 2 (MFN2) is implicated in the formation of MAMs, but, the roles of mitochondria and MFN2 in MTB infection have not been elucidated. Using mircroarry profiling of TB patients and in vitro MTB stimulation of macrophages, we observed an up-regulation of MFN2 in the peripheral blood mononuclear cells of active TB patients. Furthermore, we found that MTB stimulation by MTB-specific antigen ESAT-6 or lysate of MTB promoted MFN2 interaction with NLRP3 inflammasomes, resulting in the assembly and activation of the inflammasome and, subsequently, IL-1β secretion. These findings suggest that MFN2 and mitochondria play important role in the pathogen-host interaction during MTB infection.

Hi

I'm learning Hb analysis for the IIP3 simulation of a gilbert mixer. My f_RF=5GHz, f_LO=4GHz and f_IF=1GHz . I'm a bit confused about setting the 1st order and 3rd order harmonic at the Direct plot form. I have set 1st order harmonic = 1GHz and 3rd order harminic = 2*f_LO-f_RF = 3GHz and it gives me the following results.

This is my 1dB compression point result

Hb analysis window

Direct plot window

Please let me know if my harmonic selection is correct and whether I'm getting a correct IIP3 and P1db curve

9000 rp3440 manual

The CYP3A7 enzyme accounts for ~50% of the total cytochrome P450 (P450) content in fetal and neonatal livers and is the predominant P450 involved in neonatal xenobiotic metabolism. Additionally, it is a key player in healthy birth outcomes through the oxidation of dehydroepiandrosterone (DHEA) and DHEA-sulfate. The amount of the other hepatic CYP3A isoforms, CYP3A4 and CYP3A5, expressed in neonates is low but highly variable, and therefore the activity of individual CYP3A isoforms is difficult to differentiate due to their functional similarities. Consequently, a better understanding of the contribution of CYP3A7 to drug metabolism is essential to identify the risk that drugs may pose to neonates and developing infants. To distinguish CYP3A7 activity from CYP3A4/5, we sought to further characterize the selectivity of the specific CYP3A inhibitors CYP3cide, clobetasol, and azamulin. We used three substrate probes, dibenzylfluorescein, luciferin-PPXE, and midazolam, to determine the IC₅₀ and metabolism-dependent inhibition (MDI) properties of the CYP3A inhibitors. Probe selection had a significant effect on the IC₅₀ values and P450 inactivation across all inhibitory compounds and enzymes. CYP3cide and azamulin were both identified as MDIs and were most specific for CYP3A4. Contrary to previous reports, we found that clobetasol propionate (CP) was not an MDI of CYP3A5 but was more selective for CYP3A5 over CYP3A4/7. We further investigated CYP3cide and CP’s ability to differentiate CYP3A7 activity in an equal mixture of recombinant CYP3A4, CYP3A5, and CYP3A7, and our results provide confidence of CYP3cide’s and CP’s ability to distinguish CYP3A7 activity in the presence of the other CYP3A isoforms.

Early detection of drug-drug interactions (DDIs) can facilitate timely drug development decisions, prevent unnecessary restrictions on patient enrollment, resulting in clinical study populations that are not representative of the indicated study population, and allow for appropriate dose adjustments to ensure safety in clinical trials. All of these factors contribute to a streamlined drug approval process and enhanced patient safety. Here we describe a new approach for early prediction of the magnitude of change in exposure for cytochrome P450 (P450) CYP3A4-related DDIs of small-molecule anticancer drugs based on the model-based extrapolation of human-CYP3A4-transgenic mice pharmacokinetics to humans. Victim drugs brigatinib and lorlatinib were evaluated with the new approach in combination with the perpetrator drugs itraconazole and rifampicin. Predictions of the magnitude of change in exposure deviated at most 0.99- to 1.31-fold from clinical trial results for inhibition with itraconazole, whereas exposure predictions for the induction with rifampicin were less accurate, with deviations of 0.22- to 0.48-fold. Results for the early prediction of DDIs and their clinical impact appear promising for CYP3A4 inhibition, but validation with more victim and perpetrator drugs is essential to evaluate the performance of the new method.

15 years on, Winamp "still lives"—but mismanagement blunted its llama-whipping.

The Galaxy Z Flip3 and Fold3 are Samsung's newest folding phones. Both have bright and colorful 120-Hz screens that are easy to read in daylight, and both have an IPX8 water-resistance rating. And while the Flip3 is wonderfully compact, the Fold3 has made multitasking even easier. Reviews Editor Julian Chokkattu takes us through both phones and why you don't necessarily need a folding phone, but you may want one.