p3

NLRP3 inflammasome activity as biomarker for primary progressive multiple sclerosis




p3

Intronic variant in <i>IQGAP3</i> associated with hereditary neuropathy with proximal lower dominancy, urinary disturbance, and paroxysmal dry cough




p3

Vettel edges out Button in FP3

Sebastian Vettel set the fastest time of final practice for the Brazilian Grand Prix as the weather stayed dry ahead of qualifying




p3

URIDU fights poverty & empowers rural illiterate women with solar powered MP3 players

The MP3ForLife device is loaded with 400+ answers to common questions about health, nutrition, family planning, and more, translated into more than 100 languages.






p3

Chris Evans reviews Piaggio MP3 500 Sport: Fast, nimble, stable – and it scythes through rush-hour traffic

Oh, and by all means take a friend – there’s loads of room for a pillion and there are grab handles at the rear of the seat. Again, no additional qualification is required to carry a passenger.




p3

[ASAP] Discovery, Structure–Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02164




p3

[ASAP] Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00155




p3

Visible light induced 3-position-selective addition of arylpropiolic acids with ethers via C(sp3)–H functionalization

Org. Biomol. Chem., 2020, 18,3258-3262
DOI: 10.1039/D0OB00480D, Communication
Zi-juan Wan, Xiao-feng Yuan, Jun Luo
Although the 2-position-selective decarboxylative coupling or addition of arylpropiolic acids with cyclic ethers has been intensively investigated, selective functionalization of arylpropiolic acids at the 3-position is still a big challenge.
The content of this RSS Feed (c) The Royal Society of Chemistry




p3

Synthesis of phenanthridines by I2-mediated sp3 C–H amination

Org. Biomol. Chem., 2020, 18,3312-3323
DOI: 10.1039/D0OB00433B, Paper
Benyao Fang, Jiao Hou, Jinyue Tian, Wenquan Yu, Junbiao Chang
An I2-mediated transition-metal-free sp3 C–H amination reaction is established for phenanthridine synthesis in an efficient and scalable manner.
The content of this RSS Feed (c) The Royal Society of Chemistry




p3

Enhancing P3HT/PCBM blend stability by thermal crosslinking using poly(3-hexylthiophene)-S,S-dioxide

J. Mater. Chem. C, 2020, Advance Article
DOI: 10.1039/D0TC00109K, Paper
M. Milanovich, T. Sarkar, Y. Popowski, J. Z. Low, L. M. Campos, S. Kenig, G. L. Frey, E. Amir
A statistical copolymer containing thiophene and thiophene-S,S-dioxide rings was utilized as a thermal crosslinker in a blend of P3HT and PCBM, demonstrating an effective strategy for preventing agglomeration of PCBM and enhancing blend stability.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




p3

Allylic C(sp3)–H alkylation via synergistic organo- and photoredox catalyzed radical addition to imines

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC00819B, Edge Article
Open Access
Jiaqi Jia, Rajesh Kancherla, Magnus Rueping, Long Huang
A new catalytic method for the direct alkylation of allylic C(sp3)–H bonds from unactivated alkenes via synergistic organo- and photoredox catalysis is described.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




p3

Intramolecular Csp3–H/C–C bond amination of alkyl azides for the selective synthesis of cyclic imines and tertiary amines

Chem. Sci., 2020, 11,4482-4487
DOI: 10.1039/C9SC05522C, Edge Article
Open Access
Xiaojin Wen, Xinyao Li, Xiao Luo, Weijin Wang, Song Song, Ning Jiao
A novel intramolecular cyclization of alkyl azides for the synthesis of cyclic imines and tertiary amines has been developed. The aliphatic C–H or C–C bond was selectively cleaved with the efficient formation of two C–N single bonds or a CN double bond.
The content of this RSS Feed (c) The Royal Society of Chemistry




p3

Observations of tetrel bonding between sp3–carbon and THF

Chem. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0SC01559H, Edge Article
Open Access
Victoria V. L. Heywood, T. P. J. Alford, Julius J.J. Roeleveld, Siebe S. J. Lekanne-Deprez, Abraham A. Verhoofstad, Jarl Ivar van der Vlugt, Melanie Schnell, Sérgio R Domingos, Anthony P. Davis, Tiddo Jonathan Mooibroek
We report the direct observation of tetrel bonding interactions between sp3-carbons of the supramolecular synthon 3,3-dimethyl-tetracyanocyclopropane (1) and tetrahydrofuran in the gas and crystalline phase. The intermolecular contact is established...
The content of this RSS Feed (c) The Royal Society of Chemistry




p3

Si–C(sp3) bond activation through oxidative addition at a Rh(I) centre

Dalton Trans., 2020, 49,5416-5419
DOI: 10.1039/D0DT00725K, Communication
S. Azpeitia, A. J. Martínez-Martínez, M. A. Garralda, A. S. Weller, M. A. Huertos
Rhodium promoted a fast, quantitative and room temperature Si–CH3 bond activation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Hierarchical Mo-doped CoP3 interconnected nanosheet arrays on carbon cloth as an efficient bifunctional electrocatalyst for water splitting in an alkaline electrolyte

Dalton Trans., 2020, 49,5563-5572
DOI: 10.1039/D0DT00671H, Paper
Shasha Zhang, Mingjing Guo, Shuyi Song, Ke Zhan, Ya Yan, Junhe Yang, Bin Zhao
Hierarchical Mo-doped CoP3 nanosheet arrays were fabricated on carbon cloth to serve as an efficient and robust bifunctional electrocatalyst for overall water splitting in alkaline media.
The content of this RSS Feed (c) The Royal Society of Chemistry




p3

Could an NLRP3 inhibitor be the one drug to conquer common diseases?

A large number of diseases have been linked to the NLRP3 inflammasome. The race is on to develop drugs that disrupt it




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[ASAP] Astragalin Exerted Antidepressant-like Action through SIRT1 Signaling Modulated NLRP3 Inflammasome Deactivation

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.0c00156




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Effects of compound K, a metabolite of ginsenosides, on memory and cognitive dysfunction in db/db mice involve the inhibition of ER stress and the NLRP3 inflammasome pathway

Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02602A, Paper
Chu-Wen Li, Min-Zhen Deng, Zhi-Jie Gao, Yuan-Ye Dang, Guo-Dong Zheng, Xiu-Juan Yang, Ying-Xin Chao, Ye-Feng Cai, Xiao-Li Wu
The metabolite of ginsenosides, compound K improves memory and cognitive dysfunction in diabetes mellitus mice.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] Inhibitory Effect of Cannabidiol on the Activation of NLRP3 Inflammasome Is Associated with Its Modulation of the P2X7 Receptor in Human Monocytes

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00138




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Effect of intensity increment on P300 amplitude




p3

A P300-based brain-computer interface




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An assessment of cognitive and sensorimotor deficits associated with appsw and p301l mouse models of alzheimer's disease




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Direct C(sp3)–H acyloxylation of indolin-3-ones with carboxylic acids catalysed by KI

Green Chem., 2020, 22,2354-2358
DOI: 10.1039/C9GC04446A, Communication
Yong-Long Zhao, Yong-Qin Tang, Xing-Hai Fei, Fen-Fen Yang, Zhuo-Xian Cao, Dong-Zhu Duan, Qing-Jie Zhao, Yuan-Yong Yang, Meng Zhou, Bin He
The first KI-catalyzed direct acyloxylation of indolin-3-ones with carboxylic acids has been developed using 30% aq. H2O2 as a green oxidant at room temperature. Moreover, mechanism studies indicated that a radical oxidation process may be involved for this transformation.
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p3

Electrochemical Oxidative C(sp3)-H Azolation of Lactams Under Mild Conditions

Green Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0GC00687D, Communication
Zhaohua Wan, Dan Wang, Zixuan Yang, Heng Zhang, Shengchun Wang , Aiwen Lei
Lactam-containing structural compounds are ubiquitous in drugs and biomolecules. An electrochemical oxidative direct C(sp3)-H azolation of lactams has been reported under metal catalyst free and external oxidant free conditions. This...
The content of this RSS Feed (c) The Royal Society of Chemistry