The first public demonstration of colour TV broadcast happened this week 90 years ago, setting the foundation for a major change in the way audio-visual media is consumed.

In this month's edition of AppleVis Unleashed, Thomas Domville, Randy Rusnak, and Mike Malarsie discuss recent Apple news and other topics of interest. Topics featured in this podcast include:

• Amazon updates Echo lineup: better audio quality, an Echo Dot with a clock, and more
• Amazon will keep track of your dog with Fetch
• All the major announcements from Apple's 2019 iPhone Event
• AppleVis Extra 68: Recapping Apple's September 10, 2019 "By Innovation Only" Event
• Get a free year of Apple TV+ with purchase of new hardware
• AppleCare+ monthly plans switch to subscription model
• What to expect from Apple in October
• The Accessibility Bugs Introduced and Resolved in iOS 13 for Blind and Low Vision Users
• Apple to Release iOS 13.1 and iPadOS 13.1 on 24 September; Bringing Many Bug Fixes and Some New Bugs for Blind and Low Vision Users
• AppleVis Extra 69: The iOS and iPadOS 13 Roundtable
• Everything you can do with Voice Control on iPhone and iPad
• Apple to supply parts to independent repair shops for first time
• AudioWizards
• What to do if you forget your iPhone or iPad passcode

You can contact the Unleashed Team with feedback or questions at unleashed@applevis.com

Nevermind the freaky ghoulish creatures behind the curtains... the music inside will make you a proud Brainiac.

Brainstorm return with a solid effort that takes a step forward in the evolution of their sound while staying true to the Power Metal subgenre.

The hardcore trailblazers may have another classic LP in them, but this isn’t it.

Believe it or not … a Formula 1 car can be driven by someone just using their brain. We consider the neurogeneration: people who in the future are likely to be using some kind of brain-powered technology to do their job or to extend their knowledge. But we don’t leave the past behind, there’s also a peek into the brain collection of Cornell University.

First, the coronavirus pandemic claimed the state basketball championships. Then, it forced CHSAA to cancel the spring season altogether on April 21.

Alexis Hockley hooked it up with a quick and informative thread on what's potentially taking place in our brains right now, as result of the strange shift in external circumstances. Now more than ever is a time to spread that love and kindness. 

It's not your imagination -- you and your baby really are on the same wavelength. A team of Princeton researchers has now measured baby and adult brain activity moving in sync as they play and interact together.

Two men born without arms showcase the brain’s extraordinary flexibility.

In a new study, brain-like organoids made from human cells were slower to mature than their chimpanzee and macaque counterparts.

In Indiana, everyone knows the best restaurants to get the best pie, fried chicken, tenderloins and yes...fried brains.

Digital vs paper: ink on paper may still have the advantage In a recent edition of Scientific American, Ferris Jabr took a look at how technology is affecting the way we read and the differences between reading on screens and …

Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of α-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient centrifugation and transiently transfected HEK 293T cells to identify the species of α-synuclein from the brains of homozygous, symptomatic mice transgenic for human mutant A53T α-synuclein (line M83) that seed aggregation. The most potent fractions contained Sarkosyl-insoluble assemblies enriched in filaments. We also analyzed six cases of idiopathic Parkinson's disease (PD), one case of familial PD, and six cases of multiple system atrophy (MSA) for their ability to induce α-synuclein aggregation. The MSA samples were more potent than those of idiopathic PD in seeding aggregation. We found that following sucrose gradient centrifugation, the most seed-competent fractions from PD and MSA brains are those that contain Sarkosyl-insoluble α-synuclein. The fractions differed between PD and MSA, consistent with the presence of distinct conformers of assembled α-synuclein in these different samples. We conclude that α-synuclein filaments are the main driving force for amplification and propagation of pathology in synucleinopathies.

Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of α-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient centrifugation and transiently transfected HEK 293T cells to identify the species of α-synuclein from the brains of homozygous, symptomatic mice transgenic for human mutant A53T α-synuclein (line M83) that seed aggregation. The most potent fractions contained Sarkosyl-insoluble assemblies enriched in filaments. We also analyzed six cases of idiopathic Parkinson's disease (PD), one case of familial PD, and six cases of multiple system atrophy (MSA) for their ability to induce α-synuclein aggregation. The MSA samples were more potent than those of idiopathic PD in seeding aggregation. We found that following sucrose gradient centrifugation, the most seed-competent fractions from PD and MSA brains are those that contain Sarkosyl-insoluble α-synuclein. The fractions differed between PD and MSA, consistent with the presence of distinct conformers of assembled α-synuclein in these different samples. We conclude that α-synuclein filaments are the main driving force for amplification and propagation of pathology in synucleinopathies.

In February World Health Organization (WHO) declared the microcephaly epidemic in South America an international public health emergency. Today, the US Centers for Disease Control and Prevention, the CDC, has confirmed that it’s is Zika virus which is causing that microcephaly.  The outbreak was originally spotted in Recife, in Brazil, and it’s...

Certain characteristics of the sleep environment increase the risk for sleep-related, sudden, and unexplained infant death. These characteristics have the potential to generate asphyxia. The relationship between the deaths occurring in these environments and neurochemical abnormalities in the brainstem that may impair protective responses to asphyxia is unknown.

We report neurochemical brainstem abnormalities underlying cases of sudden infant death that are associated with and without potential asphyxial situations in the sleep environment at death. The means to detect and treat these abnormalities in infants at risk are needed. (Read the full article)

Adding second-stage automated auditory brainstem response (ABR) testing for infants who failed the initial OAE test in a two-stage neonatal hearing screening has been shown to reduce false referrals to the hearing clinic.

Infants with hearing loss may be missed by a 2-stage hearing screening because they pass the automated ABR test. In our study, a significant number of infants with hearing loss >45 decibel hearing level passed screening with automated ABR. (Read the full article)

Boys and girls start out on the same biological footing when it comes to math, finds the first neuroimaging study of math gender differences in children, published this month in the journal Science of Learning.

Boys and girls start out on the same biological footing when it comes to math, according to the first neuroimaging study of math gender differences in children.

Boys and girls start out on the same biological footing when it comes to math, finds the first neuroimaging study of math gender differences in children, published this month in the journal Science of Learning.

A group of business stalwarts, top academics and senior bureaucrats will invest Rs 300 crore to build the Masters’ Union School of Business, a business school in Gurgaon, near Delhi. It’s a B-school where classes will be taken by CXOs; campus in Cyber City, Gurgaon

Watching brain activity in fish as they try to “swim” in virtual reality helps us understand their perception abilities and how they interact with other animals

Our ape cousins have asymmetrical brains just like we do, which might require us to rethink ideas on the evolution of brain specialism in our hominin ancestors

This week, watch Netflix's I Am Not Okay With This, catch up with positive stories about how our brains age, and listen as a podcast reveals the built world

Our conceptions of alien life are based on a sample of one: Earth’s life. That means even our wildest imaginings are likely to be completely off beam

Title: Prenatal Pesticide Exposure May Harm Kids' Brains
Category: Health News
Created: 5/1/2012 11:01:00 AM
Last Editorial Review: 5/1/2012 12:00:00 AM

Title: Exercise Plus Computer Time May Boost Seniors' Brains
Category: Health News
Created: 5/1/2012 6:05:00 PM
Last Editorial Review: 5/2/2012 12:00:00 AM

Title: Young Brains May Gain Skills When Parents Read to Kids
Category: Health News
Created: 4/25/2015 12:00:00 AM
Last Editorial Review: 4/27/2015 12:00:00 AM

Title: Women's Brains May Have Tougher Time Recovering From Concussion
Category: Health News
Created: 4/28/2015 12:00:00 AM
Last Editorial Review: 4/28/2015 12:00:00 AM

Title: Breast Milk Has Biggest Benefit for Preemies' Brains: Study
Category: Health News
Created: 4/27/2019 12:00:00 AM
Last Editorial Review: 4/29/2019 12:00:00 AM

Title: Morning Exercise Kick-Starts Seniors' Brains
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/2/2019 12:00:00 AM

Title: Long Periods in Space Alter Astronauts' Brains
Category: Health News
Created: 4/14/2020 12:00:00 AM
Last Editorial Review: 4/15/2020 12:00:00 AM

Samantha M. Logan, Kama E. Szereszewski, Nigel C. Bennett, Daniel W. Hart, Barry van Jaarsveld, Matthew E. Pamenter, and Kenneth B. Storey

Mole-rats are champions of self-preservation, with increased longevity compared to other rodents their size, strong antioxidant capabilities, and specialized defenses against endogenous oxidative stress. However, how the brains of these subterranean mammals handle acute in vivo hypoxia is poorly understood. This study is the first to examine the molecular response to low oxygen in six different species of hypoxia-tolerant mole-rats from sub-Saharan Africa. Protein carbonylation, a known marker of DNA damage (hydroxy-2’-deoxyguanosine), and antioxidant capacity did not change following hypoxia but HIF-1 protein levels increased significantly in the brains of two species. Nearly 30 miRNAs known to play roles in hypoxia-tolerance were differentially regulated in a species-specific manner. The miRNAs exhibiting the strongest response to low oxygen stress inhibit apoptosis and regulate neuroinflammation, likely providing neuroprotection. A principal component analysis using a subset of the molecular targets assessed herein revealed differences between control and hypoxic groups for two solitary species (Georychus capensis and Bathyergus suillus), which are ecologically adapted to a normoxic environment, suggesting a heightened sensitivity to hypoxia relative to species that may experience hypoxia more regularly in nature. By contrast, all molecular data were included in the PCA to detect a difference between control and hypoxic populations of eusocial Heterocephalus glaber, indicating they may require many lower-fold changes in signaling pathways to adapt to low oxygen settings. Finally, none of the Cryptomys hottentotus subspecies showed a statistical difference between control and hypoxic groups, presumably due to hypoxia-tolerance derived from environmental pressures associated with a subterranean and social lifestyle.

Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of α-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient centrifugation and transiently transfected HEK 293T cells to identify the species of α-synuclein from the brains of homozygous, symptomatic mice transgenic for human mutant A53T α-synuclein (line M83) that seed aggregation. The most potent fractions contained Sarkosyl-insoluble assemblies enriched in filaments. We also analyzed six cases of idiopathic Parkinson's disease (PD), one case of familial PD, and six cases of multiple system atrophy (MSA) for their ability to induce α-synuclein aggregation. The MSA samples were more potent than those of idiopathic PD in seeding aggregation. We found that following sucrose gradient centrifugation, the most seed-competent fractions from PD and MSA brains are those that contain Sarkosyl-insoluble α-synuclein. The fractions differed between PD and MSA, consistent with the presence of distinct conformers of assembled α-synuclein in these different samples. We conclude that α-synuclein filaments are the main driving force for amplification and propagation of pathology in synucleinopathies.

Spending at least six months in microgravity can cause astronauts’ brain volumes to increase, causing pressure to build up in their heads and creating vision problems

BrainStorm Cell Therapeutics, a firm developing cellular therapies to tackle neurodegenerative diseases, has named industry Big Pharma veteran Dr David Setboun as its new Executive Vice President and Chief Operating Officer.

Dr Setboun has served for two decades at some of the biggest names in pharma. His most recent role was Vice President of Corporate Development, Strategy & Business at Life Biosciences, where he helped drive development of a range of vital commercial, operating and funding milestones.

read more

New study says there's no safe level of exposure to organophosphates, a main ingredient in pesticides.

Is it doing the same for people?

Overprotective parenting is more than an annoyance; it's an evolutionary aberration.

Man, just imagine walking around and seeing one of these mannequins in one of these bizarre positions, and the reality trip that that'd throw you for? A definite double take would be in order. Can imagine the cops being called on some of these. Mannequins are already eerie enough as it is. 

Two-person-together MRI scans on couples were used to investigate how touching is perceived in the brain. The study was carried out by Aalto University and Turku PET Centre researchers.

A new technique using artificial intelligence to better define the different sections of the brain in newborns during a magnetic resonance imaging (MRI) exam has been developed by Canadian scientists.

With sound framework conditions, fine universities, good infrastructure and policies friendly towards foreign direct investment, Ireland scores high in international innovation scoreboards. Overall, policies to boost innovation and entrepreneurship are on the right track, but investment in knowledge-based capital could be made a more dynamic source of growth and jobs.

During this pandemic, many organizations are offering free or drastically cheaper courses to help people skill-up for when we eventually get out of lock-down. There are numerous outlets if you want to learn to code from, for instance, Freecodecamp or the Free Fridays scheme from General Assembly. And for gamers, Gamedev.tv has taken 80% off […]

During this pandemic, many organizations are offering free or drastically cheaper courses to help people skill-up for when we eventually get out of lock-down. There are numerous outlets if you want to learn to code from, for instance, Freecodecamp or the Free Fridays scheme from General Assembly. And for gamers, Gamedev.tv has taken 80% off […]

Iggy Azalea has defended her 'sickening' In My Defense album artwork.

The Today show reported that the Duke and Duchess of Sussex visited Stanford in Palo Alto, California, on Tuesday to attend a 'brainstorming session'.

Mark Roe, the CEO of Adelaide based company Fusetec, said the brains have the potential to save lives as surgeons are able to practice high risk surgeries before they treat patients.