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Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer disease (AD). We validated a simplified tissue-to-reference ratio method using SUV ratios (SUVRs) for estimating synaptic density with [¹¹C]UCB-J PET. Methods: Participants included 31 older adults with AD and 16 with normal cognition. The distribution volume ratio (DVR) using simplified reference tissue model 2 was compared with SUVR at short scan windows using a whole-cerebellum reference region. Results: Synaptic density was reduced in AD participants using DVR or SUVR. SUVR using later scan windows (60–90 or 70–90 min) was minimally biased, with the strongest correlation with DVR. Effect sizes using SUVR at these late time windows were minimally reduced compared with effect sizes with DVR. Conclusion: A simplified tissue-to-reference method may be useful for multicenter and longitudinal studies seeking to measure synaptic density in AD.

BACKGROUND AND PURPOSE:

Alterations of the basilar artery (BA) anatomy have been suggested as a possible MRA feature of Fabry disease (FD). Nonetheless, no information about their clinical or pathophysiologic correlates is available, limiting our comprehension of the real impact of vessel remodeling in FD.

MATERIALS AND METHODS:

Brain MRIs of 53 subjects with FD (mean age, 40.7 [SD, 12.4] years; male/female ratio = 23:30) were collected in this single-center study. Mean BA diameter and its tortuosity index were calculated on MRA. Possible correlations between these metrics and clinical, laboratory, and advanced imaging variables of the posterior circulation were tested. In a subgroup of 20 subjects, a 2-year clinical and imaging follow-up was available, and possible longitudinal changes of these metrics and their ability to predict clinical scores were also probed.

RESULTS:

No significant association was found between MRA metrics and any clinical, laboratory, or advanced imaging variable (P values ranging from –0.006 to 0.32). At the follow-up examination, no changes were observed with time for the mean BA diameter (P = .84) and the tortuosity index (P = .70). Finally, baseline MRA variables failed to predict the clinical status of patients with FD at follow-up (P = .42 and 0.66, respectively).

CONCLUSIONS:

Alterations of the BA in FD lack of any meaningful association with clinical, laboratory, or advanced imaging findings collected in this study. Furthermore, this lack of correlation seems constant across time, suggesting stability over time. Taken together, these results suggest that the role of BA dolichoectasia in FD should be reconsidered.

Scotland was second out of 12 UK nations and regions on one key measure

Benefit increases, new investment opportunities, and several tax changes are due to come into effect in April.

General relativity teaches us that observing a black hole is all a question of perspective – and technique, says Chanda Prescod-Weinstein

Kurt “CyberGuy" Knutsson says there’s been a rise in cybercriminal services using hacked police and government emails to send subpoenas and data requests to U.S. companies.

By Tom Garry, in Salford

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Red and processed meat, and even poultry, seem to raise the risk of developing type 2 diabetes, according to a study of nearly 2 million adults, but not everyone is convinced

While the 20th century saw rapid rises in average life expectancy at birth, more recent years have seen a slowdown, suggesting we may be reaching the limit of human lifespan

Neuroscientists have been surprised to discover that the human brain is teeming with microbes, and we are beginning to suspect they could play a role in neurodegenerative disorders like Alzheimer's

While many states focused on issues like abortion and immigration throughout this election cycle, voters in California and Colorado approved tougher crime laws.

Yu Shang Food, Inc., a Spartanburg, SC, business, over the weekend recalled 4,589 pounds of ready-to-eat (RTE) meat and poultry products, which may have been adulterated with Listeria monocytogenes, according to the U.S. Department of Agriculture’s Food Safety and Inspection Service (FSIS). The ready-to-eat meat and poultry items were produced from... Continue Reading

Stock and bond markets are already reacting in anticipation of the changes

Jyotsana Jagannathan and Brindha Manikavasagan brought alive the myriad facets of Meenakshi through their refreshing approach

Social distancing, shelter-in-place, lockdown, quarantine:  the global coronavirus outbreak has made these terms part of daily usage. Governments and health organisations across the world are recommending social distancing. It is ...

The post Social distancing need not mean social isolation appeared first on Star Observer.

Moss Agate meaning revolves around growth, emotional healing, and nature's balance. Discover its grounding energy and how it fosters abundance and inner peace.

Apophyllite: Discover the healing powers of apophyllite crystals, known for enhancing clarity, intuition, and spiritual growth. Perfect for meditation and relaxation.

Discover agate meaning: learn how this beautiful crystal supports emotional healing, balance, and grounding energy, making it a must-have for spiritual wellness.

Following a mother and son during the the Blitz, Nazi Germany's bombing campaign on London during the Second World War, director Steve McQueen's new drama understands the war film — perhaps a bit too well.

The federal government ordered an end to TikTok's Canadian operations on Wednesday, citing national security concerns. But its decision to keep the app itself available has privacy experts puzzled.

Supporters say the Supreme Court of Canada's so-called Jordan ruling in 2016 has sped up proceedings and strengthened Charter rights for prompt justice. But some victims say the time limits for trials work in criminals' favour and cases continue to collapse because those limits are breached. 

Raising deep concern over the partnership between Swiggy Instamart and PharmEasy for a rapid drug delivery model, the All India Organization of Chemists and Druggists (AIOCD) has apprised the Drug Controller

The Indian pharmaceutical industry is advocating for enhanced fire safety measures and improved insurance coverage for employees working in pharmaceutical facilities.

A research team at the University of California San Diego have developed a smartphone attachment that can provide information on changes in pupil size, which can be used to assess neurological phenomena, such as traumatic brain injury and Alzheimer’s disease. Such changes in pupil size have been difficult to characterize in the past in those […]

This week, I’m rerunning some popular posts while we put the finishing touches on DCI’s new 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors.

Last week, the Federal Trade Commission (FTC) released the redacted version of administrative complaint against the three largest pharmacy benefit managers (PBMs). The FTC rightly calls out how the gross-to-net bubble can raise patients’ out-of-pocket costs, while also acknowledging how rebates can reduce a plan's (but not the patient’s) costs. Apparently, the FTC believes that PBMs’ customers are pretty dumb, because PBMs are able to prevent plans from “appreciating” such healthcare financing dynamics.

Section V.E. of the complaint (starting on page 23) focuses on the PBMs’ alleged unlawful conduct related to preferring high-list/high-rebate insulin products over versions with lower list prices. I thought it would therefore be fun to take the Wayback Machine to November 2021, when I wrote about this specific topic.

Below, you can review my commentary about the warped incentives behind Viatris’ dual-pricing strategy for its interchangeable biosimilar of Lantus. Much of the FTC’s description of the drug channel aligns with my commentary. But before you fist pump too hard for Ms. Khan’s FTC, you should pause to reflect on the agency’s legal theories in light of plans’ revealed preferences.

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The Food & Drug Administration (FDA) recently approved the first interchangeable biosimilar insulin product: the insulin glargine-yfgn injection from Viatris. Read the FDA’s press release.

Alas, I’m sad to report that the warped incentives baked into the U.S. drug channel will limit the impact of this impressive breakthrough.

Viatris is being forced to launch both a high-priced and a low-priced version of the biosimilar. However, only the high-list/high-rebate, branded version will be available on Express Scripts’ largest commercial formulary. Express Scripts will block both the branded reference product and the lower-priced, unbranded—but also interchangeable—version. Meanwhile, Prime Therapeutics will place both versions on its formularies, leaving the choice up to its plan sponsor clients.

Consequently, many commercial payers will adopt the more expensive product instead of the identical—but cheaper—version. As usual, patients will be the ultimate victims of our current drug pricing system.

Below, I explain the weird economics behind this decision, highlight the negative impact on patients, and speculate on what this all could mean for biosimilars’ future. Until plan sponsors break their addiction to rebates, today’s U.S. drug channel problems will remain.
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President-elect Donald Trump tried unsuccessfully to get rid of the Affordable Care Act during his first term. What action will he take this time around?

Many companies are entering the digital youth mental health space, but it’s important to know which ones are effective, according to a panel of investors at the Behavioral Health Tech conference.

The post Measuring Impact in Digital Youth Mental Health: What Investors Look For appeared first on MedCity News.

Hospitals across the U.S. have significantly restricted the use of pain medications containing narcotics. This shift comes amid […]

The post Pain Management in Crisis: Why Hospitals Are Limiting Pain Medications and What This Means for Patients appeared first on World of DTC Marketing.

The Centers for Medicare and Medicaid Services (CMS) recently announced a 2.9% cut to Medicare physician payments for […]

The post CMS Cuts Medicare Physician Payments: What It Means appeared first on World of DTC Marketing.

Nov 17, 2022

The speakers included Yale Law School professor Harold H. Koh ’75, and Patrick W. Pearsall, Director of the International Claims and Reparations Project at Columbia Law School. Koh and Pearsall discussed their experiences representing Ukraine in legal proceedings against Russia before the International Court of Justice.

Get mortgage help. This is why. MakingHomeAffordable.gov :60

Sabra Launches New Ad Campaign.

Abbott is asking a million people what living fully means to them. See how some people in the U.S. respond.

Kamala Harris is blasting Donald Trump for vowing to protect women whether they “like it or not” at the same time he is calling for Republican Liz Cheney to be shot in the face. We get response from The Nation's abortion access correspondent Amy Littlefield and talk about 10 states with abortion rights on the ballot, including Arizona, Nevada, Florida, South Dakota and Missouri. Trump's remarks are a “succinct and clear definition of patriarchy,” says Littlefield. She argues the 2024 election will be decided in large part by white women and whether they will vote for abortion rights. Trump is “laying out the bargain that white patriarchy has offered for white women in this country,” says Littlefield. “He is saying, 'White women, we will protect you from Brown and Black men.'”

In a major piece for Mother Jones magazine on “Why Ballot Measures Are Democracy’s Last Line of Defense,” voting rights correspondent Ari Berman discusses abortion ballot measures in 10 states, important down-ballot races in Wisconsin and elsewhere, and the movement to abolish or reform the Electoral College.