Commuters can expect long delays heading north from Sydney on the M1, with two lanes closed and traffic stretching back 21 kilometres after a man died in a crash between a ute and semi-trailer at Mt White, north of Sydney.

Director Chris Bolan, producers Alexa L. Fogel and Brendan Mason and subject Pat Henschel talk about the new Netflix documentary "A Secret Love."

"The Hot Zone" author Richard Preston gets candid about a failed 1990s movie adaptation that was once set to star A-listers Robert Redford and Jodie Foster before falling apart.

A surprise digital success story is now sparking a battle between U.S. movie theater chain AMC and the prominent Hollywood studio.

Lemon Slice Records Has Released Speakeasy, The New Album By Luke & The Belleville, A Masterly Integration Between The Swing Of The 1930s And The Most Modern Rhythms And Sounds Of Electronic Music.

The distinguishing factors between the flu and COVID-19, and why it matters. Dr. Carolee Tran discusses her new memoir about her family’s escape from Vietnam 45 years ago, and ‘Socially Distant Saturday’ with CapRadio’s Nick Brunner.

On Saturday, a host of Denver businesses — from clothing stores to hair salons — will open their doors for the first time in nearly two months as Mayor Michael Hancock’s stay-at-home order expires.

On Saturday, a host of Denver businesses — from clothing stores to hair salons — will open their doors for the first time in nearly two months as Mayor Michael Hancock’s stay-at-home order expires.

Recent advancements in Machine Learning (ML) have taught us two main lessons: a large proportion of things that humans do can actually be automated, and that a substantial part of this automation can be done with minimal human supervision. One no longer needs to select features for models to use; in many cases people are … Continue reading Three Paper Thursday: Adversarial Machine Learning, Humans and everything in between →

Hepatocellular carcinoma (HCC) is clearly age-related and represents one of the deadliest cancer types worldwide. As a result of globally increasing risk factors including metabolic disorders, the incidence rates of HCC are still rising. However, the molecular hallmarks of HCC remain poorly understood. Neuropeptide Y (NPY) and NPY receptors represent a highly conserved, stress-activated system involved in diverse cancer-related hallmarks including aging and metabolic alterations, but its impact on liver cancer had been unclear. Here, we observed increased expression of NPY5 receptor (Y5R) in HCC, which correlated with tumor growth and survival. Furthermore, we found that its ligand NPY was secreted by peritumorous hepatocytes. Hepatocyte-derived NPY promoted HCC progression by Y5R activation. TGF-β1 was identified as a regulator of NPY in hepatocytes and induced Y5R in invasive cancer cells. Moreover, NPY conversion by dipeptidylpeptidase 4 (DPP4) augmented Y5R activation and function in liver cancer. The TGF-β/NPY/Y5R axis and DPP4 represent attractive therapeutic targets for controlling liver cancer progression.

Unitec today announced that the number of people employed in two Delivery Centres at its Mount Albert campus now exceeds 500, and continue to drive benefits for Unitec students and the Auckland economy.

The first of two episodes to celebrate the Festival of Residential Child Care 2017.

In this episode Debbie Nolan and Kristina Moodie (Centre for Youth & Criminal Justice) introduce the rationale behind, and findings of their 2016 research 'Between a rock and a hard place': responses to offending in residential childcare.

This enabled discussion with Sheila, Duncan, David and David, all of whom are residential childcare workers, on how far these findings aligned with their experiences of practice.

Key themes discussed:

Complexity in responding to offending in residential child care Supports to staff in doing so The dilemmas and tensions faced The recommendations made in the research to change practice.

Transcript of episode

Music Credit: Something Elated by Broke For Free

The Better Breaks funding programme is focused on improving the range and availability of short break opportunities for disabled children and young people, particularly those with multiple support needs, including short break opportunities that families can enjoy together, or which allow parents and siblings to have time away from their caring responsibilities. This is the summary report.

The Short Breaks Fund helping to make breaks better and brighter for unpaid carers and cared-for people in Scotland. Launched in 2010 for one year, the fund has now been running for five years and has proved to be a lifeline for many carers. During the past five years the Scottish Government, through Shared Cared Scotland has distributed 12,547,409 to 697 projects to deliver innovative, tailor made breaks to groups and individuals.

Amidst great economic and political pressure to reopen in the fall, American colleges and universities must choose between enormous risk and liability if they do open and bankruptcy if they do not. Colleges and universities are among the most vulnerable institutions to disease outbreaks and would serve as efficient grounds the spread of coronavirus as students on campus share close spaces. Students are in close contact in classes, dining halls, clubs, sports, dorms, parties, events, games, assemblies, and meetings. Students could bring the virus to campus upon arrival and bring it home during breaks and holidays. Schools are worried about lawsuits in the case of outbreaks on campus, adding to the risk of reopening in the fall. If schools choose not to reopen this fall, they could lose half of their revenue and ultimately not recover, either filing for bankruptcy or closing permanently. Historically Black colleges and universities (HBCUs) are being hit the hardest by the financial burden of the pandemic and because African Americans are bearing a disproportionate share of the pandemic, school populations of HBCUs are more likely to be impacted by Covid-19. In response to political pressure from the GOP to reopen in the fall, schools are […]

Princeton ecologists Peter and Rosemary Grant led a team of researchers to discover how genetics and hybridization affected the beak shape of finches on the Galápagos Islands.

This article on whether a domain name registrar is the same thing as a web host answers a question I was asked by a visitor.

One of my visitors wanted to know how to change the distance between paragraphs on a web page. This article addresses that question. It also deals with what to do when you change the spacing between lines (eg to double-space it), and the gap between paragraphs becomes too wide.

The butterfly counts not months but moments and has time enough Rabindranath Tagore one of my favourites. I saw the first butterfly of the season today . A Cabbage White the scourge of gardeners who love their cabbages . The pretty white things lays

Did you know that there was a connection between our large 7000 inhabitant village of Wingerworth Randolph Hearst and the a museum across the pond in St Louis No neither did I until I treated our village as if I were a visitor on a first visit . As a v

A week packed with US economic data is likely to provide investors with more evidence of the extent to which the coronavirus pandemic has hit growth, sharpening the debate on whether a rebound in stocks has been justified amid an unprecedented slowdown.

We construct a quantitative model of an economy hit by an epidemic. People differ by age and skill, and choose occupations and whether to commute to work or work from home, to maximize their income and minimize their fear of infection. Occupations differ by wage, infection risk, and the productivity loss when working from home. By setting the model parameters to replicate the progression of COVID-19 in South Korea and the United Kingdom, we obtain three key results. First, government-imposed lock-downs may not present a clear trade-off between GDP and public health, as commonly believed, even though its immediate effect is to reduce GDP and infections by forcing people to work from home. A premature lifting of the lock-down raises GDP temporarily, but infections rise over the next months to a level at which many people choose to work from home, where they are less productive, driven by the fear of infection. A longer lock-down eventually mitigates the GDP loss as well as flattens the infection curve. Second, if the UK had adopted South Korean policies, its GDP loss and infections would have been substantially smaller both in the short and the long run. This is not because Korea implemented policies sooner, but because aggressive testing and tracking more effectively reduce infections and disrupt the economy less than a blanket lock-down. Finally, low-skill workers and self-employed lose the most from the epidemic and also from the government policies. However, the policy of issuing “visas” to those who have antibodies will disproportionately benefit the low-skilled, by relieving them of the fear of infection and also by allowing them to get back to work.

New findings suggest Neanderthals evolved their unusually broad fingers after they split from Denisovans, just 400,000 years ago.

In a new study, brain-like organoids made from human cells were slower to mature than their chimpanzee and macaque counterparts.

L.A. Times Rams beat reporter Gary Klein recalls covering the 2005 BCS national championship game between USC and Texas, which is considered one of the greatest games ever played.

I wasn't going to plead or beg her to stay. I felt my actions of the past week — and during the more than three years we had been together — had done all my talking for me.

Jean Dujardin and Adèle Haenel star in "Deerskin," director Quentin Dupieux's latest darkly absurdist comedy.

Max Verstappen is keeping himself busy by taking part in esports races.

ANDREW LLOYD WEBBER has written some of the greatest musicals of our time with lyricist Tim Rice - but what happened between them?

The worst part of the COVID-19 outbreak for the vast majority of healthy Americans is the uncertainty of the situation, a letter to the editor says.

Two fatal shootings of black men by police and the death of a pregnant pedestrian struck by an officer resurface old scars for Indianapolis.

IT services provider Cognizant said in an earnings call this week that a ransomware incident that took place last month in April 2020 will negatively impact its Q2 revenue. ZDNet reports: "While we anticipate that the revenue impact related to this issue will be largely resolved by the middle of the quarter, we do anticipate the revenue and corresponding margin impact to be in the range of $50 million to $70 million for the quarter," said Karen McLoughlin, Cognizant Chief Financial Officer in an earnings call yesterday. McLoughlin also expects the incident to incur additional and unforeseen legal, consulting, and other costs associated with the investigation, service restoration, and remediation of the breach. The Cognizant CFO says the company has now fully recovered from the ransomware infection and restored the majority of its services. Speaking on the ransomware attack, Cognizant CEO Brian Humphries said the incident only impacted its internal network, but not customer systems. More precisely, Humphries said the ransomware incident impacted (1) Cognizant's select system supporting employees' work from home setups and (2) the provisioning of laptops that Cognizant was using to support its work from home capabilities during the COVID-19 pandemic. Humphries said staff moved quickly to take down all impacted systems, which impacted Cognizant's billing system for a period of time. Some customer services were taken down as a precaution.

Read more of this story at Slashdot.

President Trump has been critical - but what do others think of the "global guardian of public health"?

The Braves' Acuna appears to be a runaway winner right now, but a closer look shows Soto had a tremendous impact on the Nationals.

Even with the Dolphins, Broncos, Bengals and Titans within striking distance, if you are hoping for a dramatic playoff push in the AFC to end the season, bad news: there won’t be any.

What are the main differences between a European canal hotel barge cruise and a river cruise? I think there are 8 key things you need to know that makes a canal cruise different to a river cruise. By understanding how they differ you can better decide is a river cruise or canal hotel barge cruise is best for your next European river cruising vacation

Note: I travelled as a guest of CroisiEurope on a 6-night hotel barge cruise in France before making this video Croisieurope had no input into the opinions or content of this video.

** Buy my Cruise T-shirts: http://bit.ly/TFTStore
** USA cruisers get great cruise deals CRUISEDIRECT.COM: http://bit.ly/TFTBookCruise
** UK Cruisers get great cruise deals with CRUISE.CO.UK: http://bit.ly/BookCruiseUK

Gary Bembridge's Tips For Travellers aims to help you make more of your precious travel time and money on land and when cruising the oceans or rivers of the world. To help you, in every video I draw on my first-hand tips and advice from travelling every month for over 20 years and 60+ cruises.

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- Instagram: http://www.instagram.com/garybembridge
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How would you like to switch AirPods between iPhone, iPad, and Mac? Or what if you’d like to switch AirPods from iPhone to Apple Watch or even Apple TV? If you have a pair of AirPods and multiple Apple devices, you can easily switch AirPods and AirPods Pro between any of your other Apple products, ... Read More

A horror crash involving a truck and a tanker carrying a flammable substance has led to the closure of the N2, near the Mtunzini Toll Plaza on the KwaZulu-Natal north coast.

Manganese (Mn) is an essential micronutrient required for the normal development of many organs, including the brain. Although its roles as a cofactor in several enzymes and in maintaining optimal physiology are well-known, the overall biological functions of Mn are rather poorly understood. Alterations in body Mn status are associated with altered neuronal physiology and cognition in humans, and either overexposure or (more rarely) insufficiency can cause neurological dysfunction. The resultant balancing act can be viewed as a hormetic U-shaped relationship for biological Mn status and optimal brain health, with changes in the brain leading to physiological effects throughout the body and vice versa. This review discusses Mn homeostasis, biomarkers, molecular mechanisms of cellular transport, and neuropathological changes associated with disruptions of Mn homeostasis, especially in its excess, and identifies gaps in our understanding of the molecular and biochemical mechanisms underlying Mn homeostasis and neurotoxicity.

The linear ubiquitin assembly complex (LUBAC) is an essential component of the innate and adaptive immune system. Modification of cellular substrates with linear polyubiquitin chains is a key regulatory step in signal transduction that impacts cell death and inflammatory signaling downstream of various innate immunity receptors. Loss-of-function mutations in the LUBAC components HOIP and HOIL-1 yield a systemic autoinflammatory disease in humans, whereas their genetic ablation is embryonically lethal in mice. Deficiency of the LUBAC adaptor protein Sharpin results in a multi-organ inflammatory disease in mice characterized by chronic proliferative dermatitis (cpdm), which is propagated by TNFR1-induced and RIPK1-mediated keratinocyte cell death. We have previously shown that caspase-1 and -11 promoted the dermatitis pathology of cpdm mice and mediated cell death in the skin. Here, we describe a reciprocal regulation of caspase-1 and LUBAC activities in keratinocytes. We show that LUBAC interacted with caspase-1 via HOIP and modified its CARD domain with linear polyubiquitin and that depletion of HOIP or Sharpin resulted in heightened caspase-1 activation and cell death in response to inflammasome activation, unlike what is observed in macrophages. Reciprocally, caspase-1, as well as caspase-8, regulated LUBAC activity by proteolytically processing HOIP at Asp-348 and Asp-387 during the execution of cell death. HOIP processing impeded substrate ubiquitination in the NF-κB pathway and resulted in enhanced apoptosis. These results highlight a regulatory mechanism underlying efficient apoptosis in keratinocytes and provide further evidence of a cross-talk between inflammatory and cell death pathways.

2 March 2020

8 January 2020 , Volume 96, Number 1

Gijs den Besten
Sep 1, 2013; 54:2325-2340
Reviews

RK Tangirala
Nov 1, 1995; 36:2320-2328
Articles

Invitation Only Research Event

Event participants

Sir Simon Fraser, Managing Partner of Flint Global; Deputy Chairman, Chatham House
Chair: Marianne Schneider-Petsinger, Senior Research Fellow, US and the Americas Programme, Chatham House

Manganese (Mn) is an essential micronutrient required for the normal development of many organs, including the brain. Although its roles as a cofactor in several enzymes and in maintaining optimal physiology are well-known, the overall biological functions of Mn are rather poorly understood. Alterations in body Mn status are associated with altered neuronal physiology and cognition in humans, and either overexposure or (more rarely) insufficiency can cause neurological dysfunction. The resultant balancing act can be viewed as a hormetic U-shaped relationship for biological Mn status and optimal brain health, with changes in the brain leading to physiological effects throughout the body and vice versa. This review discusses Mn homeostasis, biomarkers, molecular mechanisms of cellular transport, and neuropathological changes associated with disruptions of Mn homeostasis, especially in its excess, and identifies gaps in our understanding of the molecular and biochemical mechanisms underlying Mn homeostasis and neurotoxicity.