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I awake in my small room and slip out under the mosquito net that cocoons my bed. I know the layout so don't need to light a candle. My pack is ready where I left it last night I sling it over my shoulder and disappear into the equal darkness outside. Th

The prime minister has refused to go head-to-head with Ed Miliband – and the multi-party debate we are getting will be a 90-minute cry for help on behalf of the democratic system

Last week, Germany chose its entry for this year’s Eurovision: Heart of Stone, performed by Andreas Kümmert, former winner of the German version of The Voice (which is known as The Voice of Germany in its native country, rather than Die Stimme von Deutschland. Presumably the producers didn’t want to put viewers off by making it sound too German).

After wailing his guts out and winning the public vote, Kümmert abruptly announced, on live TV, that he didn’t actually want to “do” Eurovision after all, and awarded his “prize” to the runner-up instead. A chorus of boos broke out. German boos. Buhen.

Leitrim's historic 1994 Connacht championship success was the culmination of a building process initiated five years earlier

George Gascón pushed L.A. County Dist. Atty. Jackie Lacey into a runoff. His challenge is to show how his progressive policies can keep us safer.

If one game could decide the NBA MVP, it was Lakers vs. Bucks, and LeBron James came out on top against Giannis Antetokounmpo.

LeBron James and the Lakers proved on Sunday that the team is capable of beating their crosstown rivals in the playoffs this season.

The sports world has stopped, but the late Kobe Bryant was with us again as he was chosen for entrance to the Hall of Fame.

Lakers star LeBron James was overwhelmingly voted as the favorite local athlete in a new survey, only a year after he was booed in Staples Center.

LeBron James and Anthony Davis enjoyed a magical season together. In a summer lost to the coronavirus, no team loses more than the Lakers.

Times columnist Bill Plaschke is joining the airwaves with a morning show that kicks off this week on all-sports radio station the Beast 980 AM.

Legendary Dodgers announcer Vin Scully says the coronavirus outbreak is unlike anything he's ever seen, but he finds hope in a time of despair.

There was something missing at Dodger Stadium on a day that was suppose to be Opening day in MLB.

After six years of the Dodgers willingly allowing more than half of Los Angeles to sit in the dark, Spectrum Networks has reached a deal to end the blackout.

Dieter Ruehle, the organist for the Dodgers and Kings, is having a tough time living through the sports famine, but he has a secret coping mechanism.

When the Dodgers were unable to honor military hero Ken Mallory, he Zoomed in by computer.

Paul Martinez loved his L.A. sports teams. His death due to complications related to coronavirus is a loss that extends beyond his family and friends.

'To end it this way, you can't really ask for anything else,' USC's Jonah Mathews said of his game-winning three-pointer against UCLA on Senior Day.

Kaitlyn Dever, Léa Seydoux and Oscar-winning director Elena Andreicheva are this year's ambassadors for Suzy Amis Cameron's Red Carpet Green Dress initiative.

With auto sales slammed by COVID-19, Musk sticks to his vision of a beautiful future for Tesla. But what about cash?

The second installment of ESPN's Michael Jordan documentary series tells the story of the birth of the Chicago Bulls' dynasty and its two star rebels.

Daily Express Chief Sports Writer Neil Squires urges the EFL and its clubs to protect their long-term future once the coronavirus crisis ends.

Kyle Larson's derogatory comments, which appeared meant for a private channel, went public Sunday night, and he's been suspended by his team and the series.

The president of Texas Motor Speedway is still hoping to run the Genesys 600 with fans in June. But if they're turned away, he'll need NASCAR's help.

Watch highlights as Pascal Wehrlein takes a lights-to-flag win in the third Formula E Race At Home Challenge at Monaco which saw a "shunt that never ends" on the opening lap.

A chronology of key events

Key facts for St Helena, Ascension Island and Tristan da Cunha

Key facts, figures and dates

Madagascar's President Andry Rajoelina has promised to release a prominent journalist who was detained after criticising his handling of the coronavirus pandemic.

Tanzania says it has received its first shipment of Madagascar's self-proclaimed, plant-based "cure" for coronavirus, despite warnings from the World Health Organisation that its efficacy is unproven.

velocityconf: New #velocityconf speaker interview w/ @sascha_d http://t.co/zg4tzDzIlH Config Management: It's Not About the Tool

Madagascar

Chihuahua is also known for the beautiful Cooper Canyon which is best seen from the train that transverses it. Copper Canyon is a popular tourist destination with Mexicans. Copper Canyon is larger and portions are deeper than the Grande Canyon.

Hear about travel to Madagascar as the Amateur Traveler talks to Corinne Vale from reflectionsenroute.com about her travel to this island nation off southern Africa.

7 May 2020 , Volume 96, Number 3

7 May 2020 , Volume 96, Number 3

Lipid rafts are highly ordered regions of the plasma membrane that are enriched in cholesterol and sphingolipids and play important roles in many cells. In hematopoietic stem and progenitor cells (HSPCs), lipid rafts house receptors critical for normal hematopoiesis. Lipid rafts also can bind and sequester kinases that induce negative feedback pathways to limit proliferative cytokine receptor cycling back to the cell membrane. Modulation of lipid rafts occurs through an array of mechanisms, with optimal cholesterol efflux one of the major regulators. As such, cholesterol homeostasis also regulates hematopoiesis. Increased lipid raft content, which occurs in response to changes in cholesterol efflux in the membrane, can result in prolonged receptor occupancy in the cell membrane and enhanced signaling. In addition, certain diseases, like diabetes, may contribute to lipid raft formation and affect cholesterol retention in rafts. In this review, we explore the role of lipid raft-related mechanisms in hematopoiesis and CVD (specifically, atherosclerosis) and discuss how defective cholesterol efflux pathways in HSPCs contribute to expansion of lipid rafts, thereby promoting myelopoiesis and thrombopoiesis. We also discuss the utility of cholesterol acceptors in contributing to lipid raft regulation and disruption, and highlight the potential to manipulate these pathways for therapeutic gain in CVD as well as other disorders with aberrant hematopoiesis.

Site-specific arrest of RNA polymerases (RNAPs) is fundamental to several technologies that assess RNA structure and function. Current in vitro transcription “roadblocking” approaches inhibit transcription elongation by blocking RNAP with a protein bound to the DNA template. One limitation of protein-mediated transcription roadblocking is that it requires inclusion of a protein factor extrinsic to the minimal in vitro transcription reaction. In this work, we developed a chemical approach for halting transcription by Escherichia coli RNAP. We first established a sequence-independent method for site-specific incorporation of chemical lesions into dsDNA templates by sequential PCR and translesion synthesis. We then show that interrupting the transcribed DNA strand with an internal desthiobiotin-triethylene glycol modification or 1,N6-etheno-2'-deoxyadenosine base efficiently and stably halts Escherichia coli RNAP transcription. By encoding an intrinsic stall site within the template DNA, our chemical transcription roadblocking approach enables display of nascent RNA molecules from RNAP in a minimal in vitro transcription reaction.