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[ASAP] One-Pot C–H Arylation/Lactamization Cascade Reaction of Free Benzylamines

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00542




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[ASAP] Regiodivergent Synthesis of Penta-Substituted Pyrroles through a Cascade [3 + 2] Cyclization of C-Acylimines with Activated Alkynes and Aromatic Nucleophiles

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00712




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[ASAP] Palladium-Catalyzed Cascade Cyclization/Dearomatization/Arylation of Alkyne-Containing Phenol-Based Biaryls with Aryl Halides: An Entry to Diversely Functionalized Spirocyclohexadienones

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00710




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A signal cascade amplification strategy based on RT-PCR triggering of G-quadruplex DNAzyme for a novel electrochemical detection of viable Cronobacter sakazakii

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00270D, Paper
Yuanyuan Yuan, Xianyong Wu, Zhanmin Liu, QIqi Ning, Liqiang Fu, Sujuan Wu
Cronobacter sakazakii is an important opportunistic food-borne pathogen, and it can cause severe diseases with main symptoms including neonatal meningitis, necrotizing enterocolitis, and sepsis. For the achievement of practical and...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Paper-based platforms with coulometric readout for ascorbic acid determination in fruit juices

Analyst, 2020, 145,3431-3439
DOI: 10.1039/D0AN00477D, Paper
Estefanía Nunez-Bajo, M. Teresa Fernández-Abedul
Paper-based electrochemical platforms with coulometric readout are employed for fast and low cost determination of ascorbic acid in commercial juice samples.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Art beyond borders: artistic exchange in communist Europe (1945-1989) / edited by Jérôme Bazin, Pascal Dubourg Glatigny, and Piotr Piotrowski

Online Resource




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Out in the open / Jesús Carrasco ; translated by Margaret Jull Costa

Hayden Library - PQ6703.A755 I4813 2017




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Escribir la infancia: narradoras mexicanas contemporáneas / Nora Pasternac, Ana Rosa Domenella, Luzelena Gutiérrez de Velasco, coordinadoras

Online Resource




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Entre la tradicion y el canon: homenaje a Yvette Jiménez de Báez / Ana Rosa Domenella, Luzelena Gutiérrez de Velasco y Edith Negrín, editoras

Online Resource




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Homenaje a Tomás Segovia: maestro, ensayista, traductor y sobre todo poeta / Luzelena Gutiérrez de Velasco [and thirteen others]

Online Resource




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Mais qui fait tout ce bruit? / Céline Claire et Pascale Bonenfant

Claire, Céline, author




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A radical-mediated 1,3,4-trifunctionalization cascade of 1,3-enynes with sulfinates and tert-butyl nitrite: facile access to sulfonyl isoxazoles

Chem. Commun., 2020, Advance Article
DOI: 10.1039/D0CC01659D, Communication
Xin Yue, Ming Hu, Xingyi He, Shuang Wu, Jin-Heng Li
An unprecedented indium-promoted three-component 1,3,4-trifunctionalization cascade of 1,3-enynes with sulfinates and tert-butyl nitrite for producing 5-sulfonylisoxazoles via [3+2] annulation is reported.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of functionalized tetrahydropyrans via cascade cycloaddition involving silyloxyallyl cation intermediates

Chem. Commun., 2020, 56,5034-5037
DOI: 10.1039/D0CC01796E, Communication
Fatimat O. Badmus, Joshua A. Malone, Frank R. Fronczek, Rendy Kartika
An expedient synthesis of highly substituted tetrahydrobenzofuran via an unsymmetrical silyloxyallyl cation is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Learn HTML5 and Javascript for iOS / Scott Preston

Preston, Scott, 1969-




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Exam ref 70-480 : programming in HTML5 with Javascript and CSS3 / Rick Delorme

Delorme, Rick, author




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Une famille spirituelle de penseurs : Plotin, Pascal, Maine de Biran, Bergson / Edouard Krakowski

Krakowski, Edouard, 1896- author




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Emergent masculinities: gendered power and social change in the Biafran Atlantic age / Ndubueze L. Mbah

Hayden Library - HQ1075.5.N6 M33 2019




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Young men navigating contemporary masculinities / Karla Elliott

Online Resource




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Plato and the body: reconsidering socratic asceticism / Coleen P. Zoller

Hayden Library - B398.A8 Z65 2018




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Construction and application of nonenzymatic ascorbic acid sensor based on NiO1.0/polyaniline3.0 hybrid

New J. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0NJ00696C, Paper
shichao Zhu, Aijuan Xie, Bingyan Wei, Xiang Tao, Jianghui Zhang, Wenhao Peng, Chenyang Liu, Linyang Gu, Chenfei Xu, Shiping Luo
NiO1.0/PANI3.0 was prepared by in-situ polymerization method in one-pot and applied in detection of ascorbic acid (AA). Cyclic voltammetry (CV) and Differential pulse voltammetry (DPV) were used to optimize the...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Collection of procedural decisions in ICC arbitration 1993-1996 = Recueil des décisions de procédure dans l'arbitrage CCI / Dominique Hascher

Hascher, Dominique




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Energy follies: missteps, fiascos, and successes of America's energy policy / Robert R. Nordhaus, Sam Kalen

Dewey Library - HD9502.U52 N674 2018




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Web Directions Code ’20 session spotlight–JavaScript debugging the hard way

JavaScript debugging the hard way Marcin Szczepanski, Principal Developer Atlassian Error on line 1, column 6532112 of bundle.js? Out of memory error trying to load a CPU profile into the Chrome debugger? Two minutes to see wait and see if a change you made fixed a bug? While upgrading our complex web application from Webpack […]

The post Web Directions Code ’20 session spotlight–JavaScript debugging the hard way appeared first on Web Directions.




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Paying outsourced labor [electronic resource] : direct evidence from linked temp agency-worker-client data / Andres Drenik, Simon Jäger, Pascuel Plotkin, Benjamin Schoefer

Cambridge, Mass. : National Bureau of Economic Research, 2020




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Emotion-focused therapy for complex trauma : an integrative approach / Sandra C. Paivio, Antonio Pascual-Leone

Paivio, Sandra C




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General and vascular ultrasound : case review / John McGahan, Sharlene A. Teefey, Laurence Needleman

McGahan, John P., author




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Vascular smooth muscle (Hai)




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Clinical immunology and serology : a laboratory perspective / Christine Dorresteyn Stevens, EdD, MT(ASCP), Professor Emeritus of Clinical Laboratory Science, Western Carolina University, Cullowhee, North Carolina, Linda E. Miller, PhD, I, ḾBCM(ASCP)Si, P

Stevens, Christine Dorresteyn, author




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Clinical chemistry : principles, techniques, and correlations / [edited by] Michael L. Bishop, MS, MLS (ASCP) (Campus Department Chair, Medical Laboratory Science, Keiser University, Orlando, Florida), Edward P. Fody, MD (Clinical Professor, Department of




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Phlebotomy handbook : blood specimen collection from basic to advanced / Diana Garza, EdD, MLS (ASCP) (Medical Writer/Editor, Health Care Consultant, Houston, Texas), Kathleen Becan-McBride, EdD, MASCP, MLS (ASCP) (Health Care Consultant, Medical Writer/E

Garza, Diana, author




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Processes of urbanism [electronic resource] : a multidisciplinary approach / [edited by] Joyce Aschenbrenner [and] Lloyd R. Collins




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Unlike us reader : social media monopolies and their alternatives / edited by Geert Lovink and Miriam Rasch




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​Debt, hybrid mutual funds see large outflows in April; advisors blame Franklin fiasco

Most debt mutual fund categories have witnessed outflows in the last month, data shows.




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The joy of pixeling and building pixel tools with HTML5 canvas and JavaScript

Some people knit, others do puzzles, and yet others find calm by colouring. Me, I love pixeling. My computer career started with a super basic computer. It didn’t even have a way to store what I programmed. So, every day, I would write myself a small program that allows me to paint on the screen […]




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JavaScript Picture-in-Picture API

As a huge fan of media on the web, I’m always excited about enhancements to how we can control our media. Maybe I get excited about simple things like the <video> tag and its associated elements and attributes because media on the web started with custom codecs, browser extensions, and Flash. The latest awesome media […]

The post JavaScript Picture-in-Picture API appeared first on David Walsh Blog.




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Drama & theatre : key terms & concepts / Robin Pascoe, Hannah Pascoe

Pascoe, Robin, author




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Coronavirus threatens Indian banks’ nascent recovery

Work to reduce bad corporate loans at risk of setback as fears grow for consumers




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Real-Time Search in JavaScript

What I meant was scanning the DOM of a page for text equivalents and showing the actual parts of the page, as well as hiding the irrelevant ones. I came up with the technique when I was designing Readerrr’s FAQ page. Take a look at the example:

I have also implemented the solution here on my blog.

How it works

All simple. Let’s take the FAQ page as an example. Here’s a typical markup:

<h1>FAQ</h1>
<div class="faq">
	<input type="search" value="" placeholder="Type some keywords (e.g. giza, babylon, colossus)" />
	<ul>
		<li id="faq-1">
			<h2><a href="#faq-1">Great Pyramid of Giza</a></h2>
			<div>
				<p>The Great Pyramid of Giza <!-- ... --></p>
				<!-- ... -->
			</div>
		</li>
		<li id="faq-2">
			<h2><a href="#faq-2">Hanging Gardens of Babylon</a></h2>
			<div>
				<p>The Hanging Gardens of Babylon <!-- ... --></p>
				<!-- ... -->
			</div>
		</li>
		<!-- ... -->
	</ul>
	<div class="faq__notfound"><p>No matches were found.</p></div>
</div>

I wrote a tiny piece of JavaScript code to handle the interaction and this is how it works:

  1. When the page loads, the script indexes the content of all li’s into browser’s memory.
  2. When a user types text into the search field, the script searches for equivalents among the indexed data and hides the corresponding li’s where no equivalents were found. If nothing found, a message is shown.
  3. The script highlights the text equivalents by replacing phases, for example, babylon becomes <span class="highlight">babylon</span>.

Now, try it yourself:

Demo

Taking it further

Since I chose FAQ page as an example, there are some issues to deal with.

Toggling the answers

It is a good practice to hide the answers by default and show them only when user needs them, that is to say when they press the question:

.faq > ul > li:not( .is-active ) > div
{
	display: none;
}
$( document ).on( 'click', '.faq h2 a', function( e )
{
	e.preventDefault();
	$( this ).parents( 'li' ).toggleClass( 'is-active' );
});

In the CSS part I use child combinator selector > because I don’t want to select and, therefore, to hide the elements of an answer, which may contain lists and div’s.

What if JavaScript is disabled

The user won’t be able to see the answers. Unless you show them by default or develop a JavaScript-less solution. To do this, take a closer look at these fragments of the markup:

  • <li id="faq-1">
  • <a href="#faq-1">

The usage of fragment identifiers enables us to take the advantage of CSS’s pseudo selector :target:

.faq > ul > li:not( :target ) > div
{
	display: none;
}

Furthermore, the real-time search is not possible as well. But you can either provide a sever-side search possibility or hide the search field and so as not to confuse the user:

<html class="no-js">
	<head>
		<!-- remove this if you use Modernizr -->
		<script>(function(e,t,n){var r=e.querySelectorAll("html")[0];r.className=r.className.replace(/(^|s)no-js(s|$)/,"$1$2")})(document,window,0);</script>
	</head>
</html>

I added a class name no-js to <html> element. The <script> part removes that class name. If JavaScript support is disabled in a browser, the class name won’t be removed; therefore:

.no-js .faq input
{
	display: none;
}

The no-js is a very handy technique, you can use it site-wide.

Improving UX

If there is only one list item that matches user’s query, it is a good practice to automatically show the content of that item, without requiring to press the title. To see what I mean, head over the GIF at the beginning of the post.

Hidden keywords

Here on my blog I have a filterable list of blog post titles only. Each post has some related keywords assigned. So, during the search, how do I make an item discoverable even if the title does not consist of a particular keyword? For example, how can I make the entry “Real-Time Search in JavaScript” visible if a user entered “jquery”? Yes, exactly, that is adding keywords and hiding them with CSS:

<li>
	<h2><a href="/real-time-search-in-javascript">Real-Time Search in JavaScript</a></h2>
	<p class="hidden-keywords" aria-hidden="true">jquery filter input html css</p>
</li>
.hidden-keywords
{
	display: none;
}

A simple trick but not always that obvious.


You will find two versions of the code in the source of the demo: without dependencies and jQuery-dependent. These versions are also divided into three groups of code so you can adapt only what your project needs.

Demo




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Diversity oriented multi-component reaction (DOS–MCR) approach to access natural product analogues: regio- and chemo-selective synthesis of polyheterocyclic scaffolds via one-pot cascade reactions

Org. Biomol. Chem., 2020, 18,3082-3092
DOI: 10.1039/D0OB00368A, Paper
Lakshmanan Palanivel, Vasuki Gnanasambandam
Skeletally diverse and complex polyheterocyclic hybrid scaffolds have been accessed via one-pot three-component reaction by exploiting the build/couple/pair strategy of diversity oriented synthesis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Metal-free cascade reactions of aziridines with arylalkynes and aryldiazoniums: facile access to arylazopyrrolines

Org. Biomol. Chem., 2020, 18,3149-3157
DOI: 10.1039/D0OB00346H, Paper
Jing Rong, Hao Jiang, Sijing Wang, Zhenni Su, Huiyan Wang, Chuanzhou Tao
A novel and facile approach to synthesize arylazopyrroline scaffolds via metal-free cascade reactions of aziridines with arylalkynes and aryldiazoniums has been developed, providing access to a variety of 4-arylazo-2-pyrrolines in a highly concise fashion.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Gold(III)-catalyzed azide-yne cyclization/O–H insertion cascade reaction for the expeditious construction of 3-alkoxy-4-quinolinone frameworks

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00745E, Paper
Jingjing Huang, Han Su, Ming Bao, Lihua Qiu, Yuanqing Zhang, Xinfang Xu
A gold-catalyzed cascade reaction has been developed, and it provides an expeditious access to 3-alkoxy-4-quinolines and applications in alkaloid synthesis.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Efficient synthesis of a galectin inhibitor clinical candidate (TD139) using a Payne rearrangement/azidation reaction cascade

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00910E, Paper
Jacob St-Gelais, Vincent Denavit, Denis Giguère
Selective galectin inhibitors are valuable research tools and could also be used as drug candidates. In that context, TD139, a thiodigalactoside galectin-3 inhibitor, is currently being evaluated clinically for the...
The content of this RSS Feed (c) The Royal Society of Chemistry




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How to Add a CSS and JavaScript Sticky Menu to Your Site

See the two ways to add a sticky horizontal menu to your site, plus 7 beautiful examples of this pattern out in the wild.




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Smooth Scrolling HTML Bookmarks using JavaScript

See how to use native JavaScript to create smooth scrolling HTML bookmark links inside the page, and for those that need legacy browser support, using jQuery instead.




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Design FX - Godzilla: Creating the Animalistic and Masculine Kaiju Monster

After Roland Emmerich missed the mark with Godzilla in 1998, we had reason to be skeptical of Gareth Edwards’ new remake. Fxguide’s Mike Seymour goes inside the special effects behind the latest incarnation, in which effects company MPC designed the largest Godzilla yet, featuring an animalistic appearance with anthropomorphized traits.




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Angry Nerd - "Penguins of Madagascar" & Animated Spin-offs that Rock

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Angry Nerd - Channing Tatum as a Douchey Elf? No Thanks, “Jupiter Ascending”

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The Fascinating Math Behind Why You Won't Win The Powerball

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The Fascinating Robot That Teaches Itself How to Grab New Objects

Researchers have loaded a robot with AI that lets it scan an object and determine how best to grab it.




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Hexa: the Fascinating Yet Unsettling Six-Legged Robot

Hexa isn’t just an extremely entertaining robot. Its maker hopes to turn it into a full-fledged robotics platform.