asc Nikki Bascome To Fight Rashad Kilpatrick By bernews.com Published On :: Fri, 08 Mar 2024 13:54:45 +0000 [Written by Stephen Wright] Boxer Nikki Bascome will face American Rashad Kilpatrick in the co-main event at The Shed in Dockyard on March 30. Kilpatrick, who has lost two of his nine professional contests, defeated Juan de la Cruz Rodriguez [11-22-1], of El Salvador, by unanimous decision in Baltimore in September last year in his […] Full Article All News Sports #Boxing #NikkiBascome #StephenWrightReports
asc Nikki Bascome On Fight Against Kilpatrick By bernews.com Published On :: Sun, 19 May 2024 09:56:23 +0000 [Written by Stephen Wright] Boxer Nikki Bascome insists he is still as hungry as ever as he gears up for his professional bout against American Rashad Kilpatrick at The Shed in Dockyard next Saturday [May 25]. Bascome, who will face Rashad in an eight-round welterweight contest, has not fought since defeating Filipino Alvin Lagumbay on […] Full Article All News Sports #Boxing #NikkiBascome #StephenWrightReports
asc Nikki Bascome Defeats Kilpatrick On Points By bernews.com Published On :: Sun, 26 May 2024 23:39:23 +0000 Boxer Nikki Bascome claimed a unanimous points win over American Rashad Kilpatrick in the co-main event at The Shed in Dockyard yesterday [May 25]. Bascome dominated his opponent throughout the eight-round welterweight contest to improve his record in the paid ranks to 14 wins and one defeat. The 33-year-old wrote on Instagram: “Thank you God […] Full Article All Sports #Boxing #GoodNews #NikkiBascome
asc Nikki Bascome Reflects On Points Victory By bernews.com Published On :: Tue, 28 May 2024 12:07:36 +0000 [Written by Stephen Wright] Boxer Nikki Bascome says he has more fights left in the tank after his unanimous points win over American Rashad Kilpatrick in the co-main event at The Shed in Dockyard on Saturday [May 25]. Bascome improved his professional record to 13 wins from 14 bouts after a controlled display in his […] Full Article All Sports #Boxing #NikkiBascome #StephenWrightReports
asc Wiley - The Ascent By www.bbc.co.uk Published On :: Mon, 25 Mar 2013 00:00:00 +0000 An incoherent album from the grime godfather, but one full of loveable eccentricities. Full Article
asc Fascism Rising & the Burning of the Reichstag: February 27, 1933 By corporatejusticeblog.blogspot.com Published On :: Wed, 28 Feb 2024 06:01:00 +0000 Fascism means an extreme concentration of power in one person who thereby rises above the law. Such irrational power concentration always arises from lies, delusions and hatred--such as racism. It always leads to violence, bloodshed and war. From its origins in Italy after World War I through today as manifest in Donald Trump, and his comrades in arms, Vladimir Putin, Kim Jong Un and Xi Jinping, it always fails and leads to destruction and mass death. Human rights violations and oppression universally accompany fascism. Even a cursory review of history reveals that fascism entails pain, misery, and mass murder. Yet, fascism rises across the world and even in America. Tuesday, November 5, 2024, will determine whether fascism will march forward in the world or fail to overcome the freedom, prosperity and determination of the West. I will chronicle this contest here. Along the way we will explore the history of fascism and its manifold failures. Fittingly, today coincides with the 91st anniversary of the Burning of the Reichstag. This event launched Adolph Hitler toward totalitarian dictator. The next day the German President Paul von Hindenburg suspended civil liberties. Opposition to Nazis effectively became a crime. Today, controversy surrounds the Burning of the Reichstag. The new consensus in Berlin holds that the Nazis did it. In any event, it became a Big Lie that supported the onset of fascism in Germany. Things did not end well for the German people nor the wider world--over 8 million Germans perished. Donald Trump already called for the suspension of the Constitution so that he may seize power. He promises to be a "dictator" on day one of his new administration. He claims power to override the Constitution via executive order--the first President to ever make such an outlandish claim. Trump will never concede defeat and acquiesce in the peaceful transition of power as he proved on January 6, 2020 when he led an insurrection rather than concede defeat. Trump proved he will never consent to the peaceful transition of power. Which is why his admission that he seeks to exercise dictatorial power on day one of his new administration should he win the election must be taken seriously:It is hard to imagine a more clear and present danger to our Constitutional Republic than Trump's own admission that he seeks dictatorial power. Full Article
asc FINAL WARNING: Donald Trump seeks a Fascist Dictatorship By corporatejusticeblog.blogspot.com Published On :: Wed, 30 Oct 2024 19:53:00 +0000 No President nor nominee in US history so openly and brazenly pursued a fascist dictatorship like Donald Trump does today. In fact, many of Trump's own handpicked senior advisers from his first term as President issue urgent warnings today about Trump's drive to dictatorship. For example:1) TRUMP'S LONGEST SERVING CHIEF OF STAFF MARINE GENERAL JOHN KELLYJohn Kelly enlisted in the Marine Corps in 1970, and was discharged as a sergeant in 1972. Following college graduation in 1976, he returned to the Marines as an infantry officer. Kelly rose to Brigadier General and served in Iraq for the better part of 2 years. Kelly deployed again to Iraq in 2008 after promotion to Major General. Ultimately, in his last military post, from 2012 to 2016 he served as a four-star general leading the United States Southern Command, the unified combatant command responsible for American military operations in Central America, South America, and the Caribbean.President Trump appointed Kelly the Secretary of Homeland Security in 2017. Trump promoted Kelly to Chief of Staff on July 31, 2017. At the time, Trump called Kelly a "great American" who has "done a spectacular job at Homeland Security" and "been a true star of my administration."The New York Times published an interview with Kelly, on Oct. 22, 2024, available here. According to General Kelly: “Certainly the former president is in the far-right area, he’s certainly an authoritarian, admires people who are dictators — he has said that. So he certainly falls into the general definition of fascist. . . . He certainly prefers the dictator approach to government.” Further, the General said that "a very big surprise for him was that we were — those of us who were former generals and certainly people still on active duty — that the commitment, the loyalty was to the Constitution, without question, without second thought. That was a big surprise to him that the generals were not loyal to the boss, in this case him.” Trump apparently failed middle school history.2) TRUMP'S HANDPICKED CHAIR OF THE JOINT CHIEFS OF STAFF MARK MILLEYFour star General Mark Milley became the Chairman of the Joint Chiefs of Staff on September 30, 2019, and served as the nation's highest ranking military officer for four years until September of 2023. Milley first became a commissioned officer in 1980 after graduating from Princeton University. As chairman, General Milley acted as the principal military advisor to the President of the United States, the Secretary of Defense, the National Security Council and the Homeland Security Council.When Milley took his oath as Chair, Donald Trump said of his appointee: "In his new role as chairman of the Joint Chiefs of Staff, General Milley will serve as my top military advisor. I have absolute confidence that he will fulfill his duty with the same brilliance and fortitude he has shown throughout his long and very distinguished career."Today the retired General says of Trump: “He is the most dangerous person ever. [N]ow I realize he’s a total fascist. He is now the most dangerous person to this country, a fascist to the core.” In his retirement speech Milley stated: "“We don’t take an oath to a king, or queen, or tyrant or a dictator, and we don’t take an oath to a wannabe dictator. We don’t take an oath to an individual. We take an oath to the Constitution, and we take an oath to the idea that is America, and we’re willing to die to protect it.”3) 13 FORMER TRUMP OFFICIALS IN SUPPORT OF THE GENERALSIn the wake of comments from General Kelly (and fully consistent with the comments of General Milley), 13 Trump appointees wrote a letter of support stating:Donald Trump's disdain for the American military and admiration for dictators like Hitler is rooted in his desire for absolute, unchecked power. This is a man who threw his own Vice President – Mike Pence – at a violent mob in a desperate bid to hold on to power. When Donald Trump says he wants to be a "dictator" on "day one" and deploy the military against American citizens he deems “the enemy from within"--he means it. . . . We did not take the decision to come forward lightly. We are all lifelong Republicans who served our country. However, there are moments in history where it becomes necessary to put country over party. This is one of those moments.All of these Trump Administration appointees, including many serving in senior positions, worked day-to-day with Trump and witnessed first hand how he governs and how he seeks to accumulate dictatorial powers.4) FORMER SECRETARY OF DEFENSE JAMES MATTISFour star Marine General James Mattis served as Trump's first handpicked Secretary of Defense, from Trump's inauguration through early 2019. Mattis previously served as a Marine officer starting in 1971, and saw combat in Operation Dessert Storm, Afghanistan and the invasion of Iraq in 2003.General Mattis posits that Donald Trump is unfit because he places himself above the Constitution. More specifically, Mattis issued a statement after the J6 insurrection that said:Today’s violent assault on our Capitol, an effort to subjugate American democracy by mob rule, was fomented by Mr. Trump. His use of the Presidency to destroy trust in our election and to poison our respect for fellow citizens has been enabled by pseudo political leaders whose names will live in infamy as profiles in cowardice. Our Constitution and our Republic will overcome this stain and We the People will come together again in our never-ending effort to form a more perfect Union, while Mr. Trump will deservedly be left a man without a country.Mattis previously levelled serious objections to Trump's fitness as President due to his misconduct in the summer of 2020, in the wake of protests triggered by the police murder of George Floyd. He stated:Donald Trump is the first president in my lifetime who does not try to unite the American people—does not even pretend to try. Instead, he tries to divide us. We are witnessing the consequences of three years of this deliberate effort. We are witnessing the consequences of three years without mature leadership. 5) FORMER SECRETARY OF DEFENSE MARK ESPER After graduating from West Point, Mark Esper joined the United States Army and served during the 1990-91 Gulf War as an officer with the 101st Airborne Division. Former President Trump appointed him as the Secretary of Defense and he assumed office on July 19, 2019.When asked about the former Generals assertions that Trump seeks to impose a dictatorship Esper stated: "It's hard to say that he doesn't. . . .he certainly has those inclinations. And I think it's something we should be wary about." Esper suggests voters look up the term "fascism" and determine on their own if Trump fits the bill. He also praised the Generals for raising the issue and gave them high marks for integrity and honesty.The Esper interview with CNN is available here.6) FORMER VICE PRESIDENT PENCEIn an extraordinary development, Vice President Mike Pence refuses to endorse Donald Trump for President in election 2024. Pence stated that Trump should never sit in the Oval Office again because Trump put himself and his hold on power above the Constitution. The video above explains his position best.CONCLUSIONThe 18 patriots quoted above all say in unison that Donald Trump cannot rule our country again because he cannot adhere to the Constitution. Instead he will seek extra-Constitutional power and try to rule as a dictator. Trump himself promises to rule as a dictator on Day 1. These warnings come from life-long conservatives and from Trump's hand picked officials at the most senior levels of the Trump Administration. They saw Trump at work in the Oval Office daily--they know much more than us. They risk their lives and the lives of their family. We must heed these unprecedented warnings and take Trump at his word. The Constitution today demands that we all follow the distinguished leaders above and act courageously to protect our Great Constitutional Republic. History will judge us on this most important issue. We must not elect a dictator who promises to "terminate" the Constitution for power. Full Article
asc JavaScript dos and donts @ Mu-An Chiou By muan.co Published On :: 2024-11-13T05:47:01+00:00 Full Article
asc What Does It Mean That Donald Trump Is a Fascist? | The New Yorker By www.newyorker.com Published On :: 2024-11-13T05:47:01+00:00 When the Soviets called their enemies “fascists,” they turned the word into a meaningless insult. Putinist Russia has preserved the habit: a “fascist” is anyone who opposes the wishes of a Russian dictator. So Ukrainians defending their country from Russian invaders are “fascists.” This is a trick that Trump has copied. He, like Vladimir Putin, refers to his enemies as “fascists,” with no ideological significance at all. It is simply a term of opprobrium. Putin and Trump are both, in fact, fascists. And their use of the word, though meant to confuse, reminds us of one of fascism’s essential characteristics. A fascist is unconcerned with the connection between words and meanings. He does not serve the language; the language serves him. When a fascist calls a liberal a “fascist,” the term begins to work in a different way, as the servant of a particular person, rather than as a bearer of meaning Full Article
asc Come si mantiene una mente brillante molto a lungo? I comportamenti che fanno nascere nuovi neuroni (e fate attenzione all'udito) | Corriere.it By www.corriere.it Published On :: 2024-11-13T08:30:33+00:00 Full Article
asc Jaegher FL.X ASCENDER PHOENIX By www.jaegher.be Published On :: 2024-11-13T08:43:44+00:00 Full Article
asc MJ Takes on Black Masculinity By www.bet.com Published On :: Tue, 7 Feb 2017 23:00:00 EST She’s going to get this story! Full Article Being Mary Jane Gabrielle Union Valarie Pettiford Michael Ealy Khleo Thomas
asc BMJ Aftershow: Black Masculinity Confronted By www.bet.com Published On :: Wed, 8 Feb 2017 10:20:00 EST MJ confronts the issues attached to Black masculinity. Full Article Being Mary Jane
asc Fan Accused Of Yelling Racial Slur Was Trying To Get Attention Of Rockies Mascot ‘Dinger,’ Team Says By www.bet.com Published On :: Wed, 11 Aug 2021 14:58:55 EDT He was trying to get the attention of a mascot. Full Article Sports News
asc Ascot Appoints Grayson Chief Information Officer By bernews.com Published On :: Wed, 07 Aug 2024 14:31:23 +0000 Ascot announced today the appointment of Ian Grayson as Chief Information Officer for UK/ Bermuda. A spokesperson said, “In this newly created role, Ian is responsible for developing and executing a technology transformation strategy and driving technology-based innovation and growth to support the company’s robust UK and Bermuda platforms. He will report to Owen Williams, […] Full Article All Business #BermudaBusiness #BusinessExecutives
asc Ascot Appoints Kewsong Lee As Chairman By bernews.com Published On :: Sun, 22 Sep 2024 10:00:23 +0000 Ascot Group Limited announced that Kewsong Lee, the Founder and CEO of BellTower Partners [BellTower], will be appointed Chairman of the Ascot Board of Directors. A spokesperson said, “Ascot Group Limited, the Bermuda-based global specialty insurance company, announced that Kewsong Lee, the Founder and CEO of BellTower Partners [BellTower], will be appointed Chairman of the […] Full Article All Business #BermudaBusiness #BusinessExecutives
asc Video: Flora Of Bermuda Places Third At Ascot By bernews.com Published On :: Wed, 23 Oct 2024 12:52:39 +0000 Flora Of Bermuda, owned by Bermuda Racing, claimed a third-place finish at Ascot in the prestigious Group One Qipco British Champions Sprint Stakes in England last weekend. Drawn in stall 20 in the 20-strong field, the three-year-old, who went off a 25-1, ran strongly on the soft ground under jockey Oisin Murphy. Simon Scupham, founder […] Full Article All Sports Videos #Horse #SportsVideos
asc Bascome Earns Boston AIGA Fellows Award By bernews.com Published On :: Tue, 16 Jul 2024 11:55:49 +0000 The Boston AIGA selected Bermudian Daren Bascome, Managing Director of Proverb Agency, as one of three recipients of the 2024 Fellows award for his significant contributions to the local design community. A spokesperson said, “The Boston AIGA [American Institute of Graphic Artists] selects Bermuda native Daren Bascome, Managing Director of award-winning branding and advertising firm […] Full Article All Entertainment #AwardWinners #GoodNews
asc Daren Bascome Receives AIGA Fellow Award By bernews.com Published On :: Mon, 07 Oct 2024 19:45:27 +0000 Bermudian Daren Bascome spoke at the 2024 AIGA Boston Fellow Awards Celebration, with Mr. Bascome himself among the event’s three awardees. A spokesperson said, “‘Being a great designer isn’t about what you know, it’s about what you notice,’ said Daren Bascome, Managing Director of Proverb Agency on Tuesday at the 2024 AIGA Boston Fellow Awards […] Full Article All Business News #AwardWinners #BermudaBusiness #GoodNews
asc Video: Nikki Bascome Releases “Picture Me” By bernews.com Published On :: Mon, 19 Apr 2021 13:22:34 +0000 Nikki Bascome – who is well known for his skills in the boxing ring — is showcasing another one of his talents, this time his musical ability, with Mr Bascome releasing a new music video and song entitled “Picture Me”. Related Stories Video: Performing Arts Camp Cup Match Song Devaune Ratteray Releases ‘Dark & Stormy’ […] Full Article All Entertainment Music Videos #GoodNews #Music #MusicVideos #NikkiBascome
asc Nascent To Acquire Bermuda Compliance By bernews.com Published On :: Thu, 28 Sep 2023 14:04:30 +0000 Nascent Group Ltd. announced that it has signed an agreement to acquire Bermuda Compliance Consultants Ltd, and the acquisition is expected to close in the fourth quarter of 2023. A spokesperson said, “Founded and headquartered in Bermuda, Bermuda Compliance Consultants Ltd. [BCCL] provides compliance advisory services to the insurance and the fund markets. Alison Morrison, […] Full Article All Business #BermudaBusiness #BusinessMergers
asc Antifa and Black Lives Matter are the Democratic Party’s blackshirts and brownshirts to strengthen and protect our totalitarian fascist state By www.cpa-connecticut.com Published On :: Sat, 27 Jun 2020 14:04:58 +0000 Democratic politicians don't fear the mob. Notice that? Why? Because they don't need to. They control the mob. The mob operates with their permission. These are their foot soldiers. This is their militia. Continue reading → Full Article Accountants CPA Hartford Articles Andrew Cuomo Antifa Antifa and Black Lives Matter are the Democratic Party’s blackshirts and brownshirts to strengthen and protect our totalitarian fascist state Black Lives Matter Bubba Wallace Francis Scott Key Jussie Smollett Kill the colonizers Kill whitey Larry Krasner Mayor Bill de Blasio Teddy Roosevelt
asc The mainstream media and the Democratic Party and the intelligence agencies and the tech monopolies are your enemies. Like fascists they are misleading you with propaganda so that you will obey. By www.cpa-connecticut.com Published On :: Sat, 31 Oct 2020 06:17:04 +0000 The real threat is collusion. When journalists strike secret alliances with the very people they're supposed to be holding accountable, we are in deep trouble. Lies go unchallenged. Democracy cannot function. And that's what we're watching right now. Continue reading → Full Article Accountants CPA Hartford Articles China CNN Democratic Party FBI Fox News Hunter Biden's laptop Joe Biden journalists NBC reporters Russia Russian disinformation tech monopolies the Biden family The mainstream media and the Democratic Party and the intelligence agencies and the tech monopolies are your enemies. Like fascists they are misleading you with propaganda so that you will obey Tony Bobulinski Tucker Carlson Tonight Vladimir Putin
asc With Joe Biden we get fascism: the collusion of government and corporatism By www.cpa-connecticut.com Published On :: Sun, 08 Nov 2020 06:06:02 +0000 This ruling class of administrative state, big tech, corporations: all of these people think that they can get rid of Trump and we'll go back to normal. They're wedded to a broken system that has sold out the American people. And now they're going to try to sell out the American people and the middle class especially. They're not going to fix immigration; they're not going to fix trade deals; they're not going to break up big tech; they're not going to do any of these things. Continue reading → Full Article Accountants CPA Hartford Articles American Majority Ben Sasse billionaire class Linsey Graham Liz Cheney media establishment Mitt romney Ned Ryan November 6 2020 permanent bureaucracy Tucker Carlson With Joe Biden we get fascism: the collusion of government and corporatism
asc FBI CIA NSA are not only spying on American citizens but also are illegally unmasking their identities to journalists who support our fascist government By www.cpa-connecticut.com Published On :: Thu, 29 Jul 2021 22:47:31 +0000 FBI CIA NSA are not only spying on American citizens but also are illegally unmasking their identities to journalists who support our fascist government Continue reading → Full Article Accountants CPA Hartford Articles barefoot accountant Erik Wemple FBI CIA NSA are not only spying on American citizens but also are illegally unmasking their identities to journalists who support our fascist government Glenn Greenwald Intelligence Community January 6th July 28 2021 NSA Substack The Record The Washington Post Tucker Carlson Tucker Carlson Tonight william brighenti
asc The new fascism is the woke industrial complex consisting of big US corporations and the big governments of China and the United States By www.cpa-connecticut.com Published On :: Thu, 12 Aug 2021 07:25:10 +0000 And so that is what I call the birth of this woke industrial complex. It is a new leviathan, a new monster, that is far more powerful than what Thomas Hobbes might have envisioned 400 years ago, and it is the biggest threat to individual liberty today. It is not big government alone. Its conservatives are reciting lines that they memorized in 1980, thinking that big government was the threat to individual liberty. Maybe it was in 1980. It's not today. It is this new hybrid of big government and big business and big government not just in the United States but big government in places like China, co-mingled with big business creating the actual threat to our liberty and our prosperity. Continue reading → Full Article Accountants CPA Hartford Articles baizuo big business big government China Chinese nihilism Communist Party of china cpa president of united states cpa-connecticut.com Disney Marriott NBA Nike occupy wall street The new fascism is the woke industrial complex consisting of big US corporations and the big governments of China and the United States Tucker Carlson United States Uyhur human rights crisis Vivek Ramaswamy WOKE INC woke industrial complex wokeness Xi Jinping
asc Great write up by The Oregonian on our new Washington Cascades trail maps... By natgeomaps.blogspot.com Published On :: Wed, 22 Sep 2010 14:20:00 +0000 Five new National Geographic maps complete coverage of Washington CascadesPublished: Tuesday, September 07, 2010, 3:15 AM Terry Richard, The Oregonian Washington's Cacades are covered.With the release of five new maps this summer by National Geographic, the rugged mountains of Washington are covered from the British Columbia border to Oregon.The maps are sold under the Trails Illustrated brand.New titles this year area Mount St. Helens/Mount Adams, Goat Rocks/Norse Peak/William O. Douglas Wilderness Areas, Alpine Lakes Wilderness, Glacier Peak Wilderness and Mount Baker/Boulder River Wilderness Areas.They go along with several other titles already in print to complete the coverage: North Cascades National Park, Mount Rainier National Park and Columbia River Gorge National Scenic Area.The full-color maps are printed on hefty water-proof, tear resistant paper. National Geographic is one of the best mapmakers in the business, so the maps meet the highest standards.The maps are topographical, but they cover such a large area that the contour interval is 50 feet. This is a little too big for serious off-trail mountain navigation, but National Geographic also sells state map series on CD Roms under the Topo brand with 20-foot contour intervals.The new printed maps maps are excellent for hiking and driving. They show most of the trails and most of the roadside amenities, in easy-to-read formats.Your map files may already contain U.S. Forest Service maps of the areas, but these maps often go 15 years or more between updates. The new Nat Geo maps are the best new maps at this time for the areas they cover.Look for them at stores that sell maps, though getting this many new titles in any particular store may be difficult.One place that does have them all is the Nature of the Northwest in Portland, at 800 N.E. Oregon St., Suite 965. Phone number is 971-673-2331.You can also order them from National Geographic. Cover price is $11.95. For more information visit Trails Illustrated Washington maps.-- Terry Richard Full Article
asc Federal Government Boosts Australian Cardiovascular Alliance’s Mission to Combat Cardiovascular Disease and Stroke - News Hub By news.google.com Published On :: Wed, 13 Nov 2024 05:34:31 GMT Federal Government Boosts Australian Cardiovascular Alliance’s Mission to Combat Cardiovascular Disease and Stroke News Hub Full Article
asc Soros-Backed George Gascon Loses Los Angeles DA Race In Landslide By libertyunyielding.com Published On :: Wed, 06 Nov 2024 17:02:59 +0000 By Wallace White Los Angeles County District Attorney George Gascon lost his seat in a landslide to independent challenger Nathan Hochman, The Associated Press and Los Angeles Times reported. Gascon is projected to lose against Hochman in a crucial seat in one of America’s most crime-ridden cities, according to the AP and the LA Times […] The post Soros-Backed George Gascon Loses Los Angeles DA Race In Landslide appeared first on Liberty Unyielding. Full Article Politics
asc Prominent law professor blames Harris loss on ‘white supremacy’ and ‘toxic masculinity’ By libertyunyielding.com Published On :: Wed, 06 Nov 2024 21:51:35 +0000 In the 2024 election, Donald Trump easily carried many predominantly Hispanic rural areas like Hidalgo County, Texas, and some mostly non-white precincts, such as mostly Asian areas of Brooklyn. As journalist Josh Kraushaar noted, “Trump carried PASSAIC County, New Jersey. Majority/Hispanic electorate and home to a sizable Orthodox Jewish constituency. Was a Dem stronghold for […] The post Prominent law professor blames Harris loss on ‘white supremacy’ and ‘toxic masculinity’ appeared first on Liberty Unyielding. Full Article Education
asc velocityconf: New #velocityconf speaker interview w/ @sascha_d http://t.co/zg4tzDzIlH Config Management: It's Not About the Tool By twitter.com Published On :: Wed, 15 May 2013 22:24:51 +0000 velocityconf: New #velocityconf speaker interview w/ @sascha_d http://t.co/zg4tzDzIlH Config Management: It's Not About the Tool Full Article
asc Ascertaining the biochemical function of an essential pectin methylesterase in the gut microbe Bacteroides thetaiotaomicron [Metabolism] By www.jbc.org Published On :: 2020-12-25T00:06:31-08:00 Pectins are a major dietary nutrient source for the human gut microbiota. The prominent gut microbe Bacteroides thetaiotaomicron was recently shown to encode the founding member (BT1017) of a new family of pectin methylesterases essential for the metabolism of the complex pectin rhamnogalacturonan-II (RG-II). However, biochemical and structural knowledge of this family is lacking. Here, we showed that BT1017 is critical for the metabolism of an RG-II–derived oligosaccharide ΔBT1017oligoB generated by a BT1017 deletion mutant (ΔBT1017) during growth on carbohydrate extract from apple juice. Structural analyses of ΔBT1017oligoB using a combination of enzymatic, mass spectrometric, and NMR approaches revealed that it is a bimethylated nonaoligosaccharide (GlcA-β1,4-(2-O-Me-Xyl-α1,3)-Fuc-α1,4-(GalA-β1,3)-Rha-α1,3-Api-β1,2-(Araf-α1,3)-(GalA-α1,4)-GalA) containing components of the RG-II backbone and its side chains. We showed that the catalytic module of BT1017 adopts an α/β-hydrolase fold, consisting of a central twisted 10-stranded β-sheet sandwiched by several α-helices. This constitutes a new fold for pectin methylesterases, which are predominantly right-handed β-helical proteins. Bioinformatic analyses revealed that the family is dominated by sequences from prominent genera of the human gut microbiota, including Bacteroides and Prevotella. Our re-sults not only highlight the critical role played by this family of enzymes in pectin metabolism but also provide new insights into the molecular basis of the adaptation of B. thetaiotaomicron to the human gut. Full Article
asc Citrus Vascular Proteomics Highlights the Role of Peroxidases and Serine Proteases during Huanglongbing Disease Progression By www.mcponline.org Published On :: 2020-12-01 Jessica Y. FrancoDec 1, 2020; 19:1936-1951Research Full Article
asc Citrus Vascular Proteomics Highlights the Role of Peroxidases and Serine Proteases during Huanglongbing Disease Progression [Research] By www.mcponline.org Published On :: 2020-12-01T00:05:33-08:00 Huanglongbing (HLB) is the most devastating and widespread citrus disease. All commercial citrus varieties are susceptible to the HLB-associated bacterium, Candidatus Liberibacter asiaticus (CLas), which resides in the phloem. The phloem is part of the plant vascular system and is involved in sugar transport. To investigate the plant response to CLas, we enriched for proteins surrounding the phloem in an HLB susceptible sweet orange variety, Washington navel (Citrus sinensis (L) Osbeck). Quantitative proteomics revealed global changes in the citrus proteome after CLas inoculation. Plant metabolism and translation were suppressed, whereas defense-related proteins such as peroxidases, proteases and protease inhibitors were induced in the vasculature. Transcript accumulation and enzymatic activity of plant peroxidases in CLas infected sweet orange varieties under greenhouse and field conditions were assessed. Although peroxidase transcript accumulation was induced in CLas infected sweet orange varieties, peroxidase enzymatic activity varied. Specific serine proteases were up-regulated in Washington navel in the presence of CLas based on quantitative proteomics. Subsequent activity-based protein profiling revealed increased activity of two serine proteases, and reduced activity of one protease in two C. sinensis sweet orange varieties under greenhouse and field conditions. The observations in the current study highlight global reprogramming of the citrus vascular proteome and differential regulation of enzyme classes in response to CLas infection. These results open an avenue for further investigation of diverse responses to HLB across different environmental conditions and citrus genotypes. Full Article
asc Business Development in Madagascar: How to Enable Entrepreneurialism By www.chathamhouse.org Published On :: Thu, 09 Nov 2017 10:30:00 +0000 Business Development in Madagascar: How to Enable Entrepreneurialism 15 November 2017 — 12:00PM TO 1:00PM Anonymous (not verified) 9 November 2017 Chatham House, London Madagascar’s business environment has improved in a period of stability ushered in with elections in 2013, which brought an end to the political crisis that had started in 2009. SME development has been constrained by poor access to credit and financial services, weak definition of property titles, and skills gaps and human capital shortfalls that have impeded the development of a managerial talent pool. However, the government has prioritized reform for company creation, granting construction permits and cross-border trade, in support of entrepreneurialism and business development. At this event, Erick Rajaonary, the CEO of the GuanoMad Group and president of the association of the Madagascar entrepreneurs, will discuss the how to create space for entrepreneurialism and prospects for broad based business development in Madagascar. Full Article
asc Association between prediabetes and risk of cardiovascular disease and all cause mortality: systematic review and meta-analysis By www.bmj.com Published On :: Wednesday, November 23, 2016 - 23:30 Full Article
asc Swimming, aerobics, and racquet sports are linked to lowest risk of cardiovascular death By www.bmj.com Published On :: Wednesday, November 30, 2016 - 06:30 Full Article
asc Endovascular treatment for acute ischaemic stroke in routine clinical practice: prospective, observational cohort study (MR CLEAN Registry) By www.bmj.com Published On :: Friday, March 9, 2018 - 14:16 Full Article
asc Ukraine crisis could trigger cascading risks globally By www.chathamhouse.org Published On :: Wed, 16 Mar 2022 13:14:07 +0000 Ukraine crisis could trigger cascading risks globally Expert comment NCapeling 16 March 2022 The effects on the wider world from the Ukraine invasion go far beyond the waves of shock and horror being felt from this escalating conflict. Russia and Ukraine rank 11th and 55th respectively in terms of their national economies but, for the global supply of critical resources such as energy, food, and minerals, these two countries together are far bigger hitters – and both the threat and reality of resource flows from them being reduced have already driven up global prices. The world is already facing a cost-of-living squeeze coming out of the COVID-19 pandemic, so further price spikes or supply constraints have the potential to seriously undermine food and energy security, equitable access to basic goods and services, and social stability around the world – which can then potentially create systemic risks for economies and societies. The global implications of the Ukraine conflict are only just beginning to be explored fully but the immediate impacts of the crisis on global markets are already well-documented. In the first few days after Russia’s invasion, energy prices spiked, triggering further fertilizer price rises – as fertilizer production is highly energy intensive – which in turn is contributing to food price rises because fertilizer costs are an important factor in food production. Further price spikes or supply constraints have the potential to seriously undermine food and energy security, equitable access to basic goods and services, and social stability around the world Interruptions to shipping in the region around Ukraine – as well as globally – have impeded the flow of goods which pushed prices up even further, while economic sanctions on cross-border flows of goods and finance are further adding to market pressures. But this is just the start – these impacts will bring ripple effects which propagate far beyond their point of origin, known as ‘cascading risks’. Risk is a combination of hazard, exposure, and vulnerability – in terms of the Ukraine invasion, the hazard is the conflict and its immediate impacts on the societies and economies of Ukraine and Russia, while exposure relates to the degree to which other countries are likely to be affected depending on how much they are integrated into the global economy or the ‘just in time’ nature of their supply chains. Vulnerability relates to a society’s capacity to mitigate the harmful impacts of the conflict, such as controlling borders, sourcing alternative goods from suppliers, or protecting against price or supply shocks. Risk cascades – the second- and third-order impacts of the original hazard and of responses to that hazard – can interact across sectoral boundaries – as with energy and food, for example – and their compound effect can lead to overall systemic risks for society. Anticipating this potential is essential to understanding the nature and scale of the global ramifications being felt from the Ukraine conflict. Recent work in the UK to assess levels of cascading risks resulting from a changing climate – the UK Climate Change Risk Assessment – provides a valuable framework for thinking about this area. It examines key pathways for risk to cascade through global systems – when applied to the situation in Ukraine, these pathways and their interactions offer an indication of the scale of crisis that citizens face far beyond Ukraine’s and Russia’s borders. Interruptions to the flows of goods and energy In globalized trade networks, localized disruption to supply chains rapidly yields widespread international impacts – of particular concern is the immediate supply of food because most countries rely on lean supply chains and some may only have a few days food within their own borders. Experience from previous food price crises indicate even small interruptions to trade can result in runs on the market and rapid price inflation. In the case of this conflict, the trade interruption will be far from small because, between them, Russia and Ukraine export around one-quarter of all traded wheat, more than three-quarters of traded sunflower oil, and one-sixth of traded maize. Given many people are understandably fleeing this conflict, other countries may struggle to cope as the cost-of-living crisis and urgent efforts to bolster national security infrastructure may squeeze available public funds Energy markets are also a concern because many countries use more energy than they produce and therefore rely on imports of energy or fuel for domestic use. Russia produces around ten per cent of the world’s commercial energy with a concentration of sales in major regions such as the European Union (EU) and China. As with food, a shortfall in energy provision leads to market runs and rapid inflation as actors compete in a tightening space, while poorly designed policy interventions by nations trying to ensure their own security add further pressure to global supply and worsen price rises. In addition, the closely interconnected nature of energy markets means disruption to one fuel – such as gas in this case – affects global prices for other forms of energy. The impact of moving people and money As the last decade richly illustrates, the cross-border flows of people impact those societies absorbing them – for example, contributing to a rise in nationalism – as well as increase the costs of supplying essential resources. Given many people are understandably fleeing this conflict, other countries may struggle to cope as the cost-of-living crisis and urgent efforts to bolster national security infrastructure may squeeze available public funds. Financial flows are crucial to the functioning of global economies, whether for inward investment or insurance and – as Russian citizens may be about to discover – restricting the global flow of money has a serious impact on households. Beyond Russia, the outflow of money from major financial centres such as London to meet insurance claims or to enable infrastructure reinvestment post-conflict may also have severe knock-on economic impacts. The impact on governance and health The global spikes in energy and food prices resulting from these supply chain disruptions will see many countries struggle with rising food and energy insecurity as well as increased inequality. Taken together these conditions create many issues beyond immigration pressures and the associated politics, including increased inequality and civil unrest. This potentially destabilizes governments which has consequences for the stability of an entire region such as interrupted supply chains, the need to deploy peacekeeping forces, or significant flows of aid – all with global consequences far beyond the countries in question. Populations may suffer mental health impacts arising from the Ukraine invasion, whether from the trauma of being forced to leave home to escape conflict, anxiety for the wellbeing and safety of families and friends caught up in it, or a more general anxiety arising from the perception of living in an unstable world. Full Article
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asc TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not Axon Specification or Axon Initial Segment Formation By www.jneurosci.org Published On :: 2024-10-16T09:30:18-07:00 Vertebrate nervous systems use the axon initial segment (AIS) to initiate action potentials and maintain neuronal polarity. The microtubule-associated protein tripartite motif containing 46 (TRIM46) was reported to regulate axon specification, AIS assembly, and neuronal polarity through the bundling, or fasciculation, of microtubules in the proximal axon. However, these claims are based on TRIM46 knockdown in cultured neurons. To investigate TRIM46 function in vivo, we examined male and female TRIM46 knock-out mice. Contrary to previous reports, we find that TRIM46 is dispensable for axon specification and AIS formation. TRIM46 knock-out mice are viable, have normal behavior, and have normal brain structure. Thus, TRIM46 is not required for AIS formation, axon specification, or nervous system function. However, we confirm that TRIM46 is required for microtubule fasciculation. We also show TRIM46 enrichment in the first ~100 μm of axon occurs independently of ankyrinG (AnkG) in vivo, although AnkG is required to restrict TRIM46 only to the AIS. Our results highlight the need for further investigation of the mechanisms by which the AIS and microtubules interact to shape neuronal structure and function. Full Article
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