asc

Yamaha Fascino 125 gets first price hike since launch: Here’s how much!

Yamaha marked its entry in the 125cc scooter segment with the Fascino 125 and Ray ZR 125 late last year.




asc

Relief for celebrities, guidelines to check veracity of ad claims now possible; Srinivasan Swamy, Chairman, ASCI explains how

Advertising Standards Council of India (ASCI) recently announced a set of guidelines that will help celebrities to perform due diligence on a product or brand they wish to endorse.




asc

Tanzania to subject Madagascar Covid-19 medicine to clinical trials

The rush to get the medicine was a quick one and the minister's phone has not stopped ringing since he returned




asc

Some Actual Good News After Trump's Paris Agreement Fiasco

Just hours after President Donald Trump announced that he intends to withdraw the United States from Paris Climate Agreement, three state governors announced the formation of the United States Climate Alliance, a union that will work to reduce greenhouse gas emissions, even as national leadership on climate change falters.

For now, the alliance includes California, New York and Washington State. The governors of those states, Jerry Brown, Andrew Cuomo, and Jay Inslee, respectively, released a statement on Thursday describing how the new alliance will build state-level partnerships to continue aggressive American action on climate change and uphold the goals and standards of the Paris Agreement.

"The president has already said climate change is a hoax, which is the exact opposite of virtually all scientific and worldwide opinion," said Governor Brown in the statement. "I don't believe fighting reality is a good strategy—not for America, not for anybody. If the president is going to be AWOL in this profoundly important human endeavor, then California and other states will step up."

Governor Cuomo echoed that sentiment. Trump's "reckless decision to withdraw from the Paris Climate Agreement has devastating repercussions not only for the United States, but for our planet," he said. "This administration is abdicating its leadership and taking a backseat to other countries in the global fight against climate change."

California, New York, and Washington combined are home nearly 70 million people, about 20 percent of the US population. And their governments have already begun to take action. For example, the California State Senate passed legislation on Wednesday that mandates California to develop 100 percent of its electricity from renewable resources by 2045.

So far, no other states have signed on to the alliance, though 61 American mayors also pledged on Thursday that their cities will uphold the tenets of the Paris Climate Agreement.




asc

Live American Sports Return to ESPN with Cornhole Competition, NASCAR Goes Live Next Week

The Cornhole Mania 2020 doubles tournament broadcasted on ESPN noon, and the singles event will take place at 6 p.m. as some live sports begin making a comeback.





asc

Mike Gascoyne hails big step forward for Lotus

Lotus technical chief Mike Gascoyne said his team's performance in Canada was a 'massive step forward'




asc

Business brief: The ascendancy of digital trade: A new world order?

We are so used to all things digital that we can sometimes lose sight of just how enormous the phenomenon has become, and how disruptive it can be.




asc

Delhi, Agra and Jaipur – Fascinating Cities of India

The 28 States and 7 Union Territories of India are favorite tourist destinations for globetrotters. Each region offers a distinctive taste of travel experience. Thousands of travelers visit every day to the land to explore its...




asc

Cardiovascular Disease and Diabetes: Germany

Germany has reduced the mortality due to cardiovascular diseases (CVD) in line with other OECD countries




asc

Chandrakant Himatlal Kampani & ... vs Ascon Agro Products Exporters And on 28 April, 2020

VERSUS ASCON AGRO PRODUCTS EXPORTERS AND BUILDERS PRIVATE LIMITED BEFORE The Hon'ble Justice SHAMPA SARKAR Date: 28th April, 2020 Apperance Mr. Saunak Ghosh, Adv. with Mr. Rajib Mullick, Adv.

..for the decree holder Mr. Dipanjan Roy, Adv (in person) ..for the judgment debtor The Court: GA No.803 of 2020 is an application filed by the decree holder for non-prosecution of the Execution Case no.302 of 2019 arising out of a judgment and decree dated July 26, 2017 passed in CS No.115 of 2013, in view of settlement arrived at by and between the parties.




asc

U.S. Soccer star Alex Morgan announces she has given birth to daughter Charlie Elena Carrasco

Alex Morgan welcomed her first child with husband Servando Carrasco, 31, a daughter named Charlie, on Thursday.




asc

Profesorii și elevii din ultimii ani vor fi obligați să poarte mască începând cu 15 mai (propunere)

Profesorii și elevii din ultimii ani de gimnaziu și liceu care revin la școală pentru pregătirea examenelor naționale sunt obligați să poarte mască, potrivit regulilor elaborate de Institutul Național de Sănătate Publică pentru perioada de după 15 mai, informează Radio România Actualități.

The post Profesorii și elevii din ultimii ani vor fi obligați să poarte mască începând cu 15 mai (propunere) appeared first on Forbes.ro.




asc

How the gentle ascetic figure of Bharat Mata morphed into an ultra-nationalist warrior

Historian Sumathi Ramaswamy’s seminal book The Goddess and the Nation, Mapping Mother India shows how Bharat Mata has been reimagined over the years, going from a benign, giving figure or a tragedienne to a martyr and often an ultra-nationalist warrior.




asc

Die elektrischen Einrichtungen der Eisenbahnen: eine Anleitung zum Selbststudium der Telegraphen-, Telephon- und elektrischen Signal-Einrichtungen / von R. Bauer, A. Prasch, O. Wehr

Archives, Room Use Only - TF615.B38 1913




asc

Bulletproof JavaScript benchmarks

The following article, written by John-David Dalton and yours truly, was published as part of the Performance Calendar series in 2010.




asc

How I detect and use `localStorage`: a simple JavaScript pattern

By now, everyone knows how to detect and use localStorage. However, I’ve been using a seemingly unconventional (but slightly more efficient) technique to do so. Since I haven’t seen it documented anywhere else, here goes!




asc

JavaScript `foo.prototype.bar` notation

As a follow-up to the post documenting a few popular HTML element + attribute notations, here’s a similar one about JavaScript.




asc

JavaScript character escape sequences

Having recently written about character references in HTML, I figured it would be interesting to look into JavaScript character escapes as well.




asc

JavaScript’s internal character encoding: UCS-2 or UTF-16?

Does JavaScript use UCS-2 or UTF-16 encoding? Since I couldn’t find a definitive answer to this question anywhere, I decided to look into it. The answer depends on what you’re referring to: the JavaScript engine, or JavaScript at the language level.




asc

Valid JavaScript variable names in ES5

Did you know var π = Math.PI; is syntactically valid JavaScript? I thought this was pretty cool, so I decided to look into which Unicode glyphs are allowed in JavaScript variable names, or identifiers as the ECMAScript specification calls them.




asc

Unquoted property names / object keys in JavaScript

Fun fact: var foo = { H̹̙̦̮͉̩̗̗ͧ̇̏̊̾Eͨ͆͒̆ͮ̃͏̷̮̣̫̤̣Cͯ̂͐͏̨̛͔̦̟͈̻O̜͎͍͙͚̬̝̣̽ͮ͐͗̀ͤ̍̀͢M̴̡̲̭͍͇̼̟̯̦̉̒͠Ḛ̛̙̞̪̗ͥͤͩ̾͑̔͐ͅṮ̴̷̷̗̼͍̿̿̓̽͐H̙̙̔̄͜: 42 }; is valid JavaScript. It may not be immediately obvious, but the real surprise here is that the Cthulhu-esque property name is not surrounded by quotes. Intrigued by this, and having written about the similar topic of JavaScript identifiers before, I decided to look into valid property names in JavaScript. When do they need to be quoted? When can the quotes be omitted? And in which cases can dot notation be used instead of bracket notation to get or set a property based on its name?




asc

Reserved keywords in JavaScript

Looking for a list of all reserved words in JavaScript? You’ve come to the right place. I recently needed such a list myself, but ended up comparing the reserved keywords in all ECMAScript versions as well. The result is listed below, for future reference.




asc

JavaScript has a Unicode problem

The way JavaScript handles Unicode is… surprising, to say the least. This write-up explains the pain points associated with Unicode in JavaScript, provides solutions for common problems, and explains how the ECMAScript 6 standard improves the situation.




asc

Valid JavaScript variable names in ES2015

ES2015 updates the grammar for identifiers. This affects a number of things, but most importantly, identifiers can be used as variable names, and identifier names are valid unquoted property names. This post describes the observable changes compared to the old ES5 behavior.




asc

Unicode property escapes in JavaScript regular expressions

ES2018 adds support for Unicode property escapes of the form p{…} and P{…} to JavaScript regular expressions. This article explains what Unicode property escapes are, how they work, and why they’re useful.




asc

ECMAScript regular expressions are getting better!

This article highlights what’s happening in the world of JavaScript regular expressions right now. Spoiler: it’s quite a lot — there are more RegExp-related proposals currently advancing through the TC39 standardization process than there have been updates to RegExp in the history of ECMAScript!




asc

JavaScript engine fundamentals: Shapes and Inline Caches

This article describes some key fundamentals that are common to all JavaScript engines — and not just V8, the engine the authors work on. As a JavaScript developer, having a deeper understanding of how JavaScript engines work helps you reason about the performance characteristics of your code.




asc

JavaScript engine fundamentals: optimizing prototypes

This article explains JavaScript engine optimization pipeline trade-offs, and describes how engines such as V8 speed up accesses to prototype properties. As a JavaScript developer, having a deeper understanding of how JavaScript engines work helps you reason about the performance characteristics of your code.




asc

A horrifying `globalThis` polyfill in universal JavaScript

The globalThis proposal introduces a unified mechanism to access the so-called “global object” a.k.a. “the global” in any JavaScript environment. It sounds like a simple thing to polyfill, but it turns out it’s pretty hard to get right.




asc

Cascading transitions toward unconventional charge density wave states in the quasi-two-dimensional monophosphate tungsten bronze P4W16O56

Single crystals of the m = 8 member of the low-dimensional monophosphate tungsten bronzes (PO2)4(WO3)2m family were grown by chemical vapour transport technique and the high crystalline quality obtained allowed a reinvestigation of the physical and structural properties. Resistivity measurements revealed three anomalies at TC1 = 258 K, TC2 = 245 K and TC3 = 140 K, never observed until now. Parallel X-ray diffraction investigations showed a specific signature associated with three structural transitions, i.e. the appearance of different sets of satellite reflections below TC1, TC2 and TC3. Several harmonics of intense satellite reflections were observed, reflecting the non-sinusoidal nature of the structural modulations and a strong electron–phonon coupling in the material. These transitions could be associated with the formation of three successive unconventional charge density wave states.




asc

Newly discovered Madagascar spider spins largest, toughest webs on record

Darwin's bark spider cast giant webs across streams, rivers and lakes, suspending the web’s orb above water and attaching it to plants on each riverbank. Bridgelines of these water-spanning webs have been measured as long as 25 meters.

The post Newly discovered Madagascar spider spins largest, toughest webs on record appeared first on Smithsonian Insider.




asc

Five fascinating species discovered by Smithsonian scientists in 2014

While it seems that we can find just about anything on the Internet, it doesn’t mean we know everything yet. Every year, Smithsonian scientists discover […]

The post Five fascinating species discovered by Smithsonian scientists in 2014 appeared first on Smithsonian Insider.




asc

These newly discovered pelican spiders will make you want to visit Madagascar

In 1854, a curious-looking spider was found preserved in 50 million-year-old amber. With an elongated neck-like structure and long mouthparts that protruded from the “head” […]

The post These newly discovered pelican spiders will make you want to visit Madagascar appeared first on Smithsonian Insider.



  • Animals
  • Science & Nature
  • National Museum of Natural History

asc

Bosutinib prevents vascular leakage by reducing focal adhesion turnover and reinforcing junctional integrity [RESEARCH ARTICLE]

Liza Botros MD., Manon C. A. Pronk PhD., Jenny Juschten MD., John Liddle, Sofia K. S. H. Morsing, Jaap D. van Buul PhD., Robert H. Bates, Pieter R. Tuinman MD. PhD., Jan S. M. van Bezu, Stephan Huveneers PhD., Harm Jan Bogaard MD. PhD., Victor W. M. van Hinsbergh PhD., Peter L. Hordijk PhD., and Jurjan Aman MD. PhD.

Aims: Endothelial barrier dysfunction leads to edema and vascular leak, carrying high morbidity and mortality. Previously, Abl kinase inhibition was shown to protect against vascular leak. Using the distinct inhibitory profiles of clinically available Abl kinase inhibitors, we aimed to provide a mechanistic basis for novel treatment strategies against vascular leakage syndromes.

Methods & Results: Bosutinib most potently protected against inflammation-induced endothelial barrier disruption. In vivo, bosutinib prevented LPS-induced alveolar protein extravasation in an acute lung injury mice model. Mechanistically, Mitogen-activated Protein 4 Kinase 4 (MAP4K4) was identified as important novel mediator of endothelial permeability, which signals via ezrin, radixin and moesin proteins to increase turnover of integrin-based focal adhesions. The combined inhibition of MAP4K4 and Arg by bosutinib preserved adherens junction integrity and reduced turnover of focal adhesions, which synergistically act to stabilize the endothelial barrier during inflammation.

Conclusion: MAP4K4 was identified as important regulator of endothelial barrier integrity, increasing focal adhesion turnover and disruption of cell-cell junctions during inflammation. Inhibiting both Arg and MAP4K4, the clinically available drug bosutinib may form a viable strategy against vascular leakage syndromes.




asc

How to use Telnet Client to view Starwars ASCIIMation




asc

Honeybees fascinate visitors at the National Zoological Park

Visits to the Smithsonian's National Zoo just became a little bit sweeter with the arrival of a new honeybee colony. With a hive made of glass in the Zoo's Pollinarium and full access to the outdoors, these bees are showing off the wondrous ways of their world.

The post Honeybees fascinate visitors at the National Zoological Park appeared first on Smithsonian Insider.




asc

With 800 color photographs, new book takes a fascinating look inside palms

The chief appeal of The Anatomy of Palms is some 800 color photographs that document the extent of palm anatomical diversity.

The post With 800 color photographs, new book takes a fascinating look inside palms appeared first on Smithsonian Insider.




asc

???Seascape???: a key influence on marine protected areas

New research has shed light on how fish respond to marine protected areas (MPAs). It suggests that seascape structure ??? the range of sea depths and habitat types included inside and outside the MPA ??? has a larger influence on changes in the abundance of fish than protection itself.




asc

Mediterranean diet associated with lower risk of death in cardiovascular disease patients

28 Aug 2016: The Mediterranean diet is associated with a reduced risk of death in patients with a history of cardiovascular disease, according to results from the observational Moli-sani study presented at ESC Congress 2016 today.1

read more



  • Health & Medicine

asc

Aircraft noise at night can result in dysfunction of blood vessels and cause long-term cardiovascular disease

Recent research into the impact of different levels of noise on 75 volunteers reveals that disturbed sleep caused by night-time aircraft noise can damage blood vessels and increase the levels of stress hormones. As these physical changes are potential pathways to high blood pressure, heart and circulatory disease over the long term, reducing night-time aircraft noise is important for preventing cardiovascular disease in people living near airports.




asc

Project #1170: New Gutters and fascia




asc

Locust swarms wreak havoc on Madagascar's farmlands

The island country is currently experiencing a harrowing seasonal infestation of the Malagasy migratory locust.



  • Wilderness & Resources

asc

11 fascinating farm blogs

From backyard chicken keepers to serious sheep shearers, these online storytellers live up the rural life.



  • Organic Farming & Gardening

asc

5 fascinating folk vocal traditions

From the Haka in New Zealand to the Klapa in Croatia, the earliest music traditions relied on the human voice alone.



  • Arts & Culture

asc

Help Cascadian Farm 'Bee Friendlier' to pollinators

Donating money to help the bees is as easy as adding a mustache to your cat's (or your friend's) photo.




asc

What is cascara tea?

Cascara tea is a brewed beverage made from the dried husks of the coffee berry isn't technically a tea, but it's not coffee, either.




asc

Whole Foods' John Mackey on Obamacare, fascism and capitalism's moral code

The granola guru John Mackey has a new book and is once again making waves with his outspoken views.



  • Sustainable Business Practices

asc

9 fascinating facts about the founder of Mother's Day

Anna Jarvis created Mother's Day, then was dismayed how quickly the holiday became commercialized.




asc

Is the Tabasco family responsible for an infestation of nutria?

The creator of Tabasco sauce is often credited with a proliferation of large rodents called nutria in the swamps of Louisiana.