Dan Shappir takes the lead and walks the panel through the history of JavaScript and a discussion on ES6, TypeScript, the direction and future of JavaScript, and what features to be looking at and looking for in the current iteration of JavaScript.

Panel

• AJ O’Neal
• Aimee Knight
• Charles Max Wood
• Steve Edwards
• Dan Shappir

Sponsors

• Taiko - free and open source browser test automation
• Split

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"The MaxCoders Guide to Finding Your Dream Developer Job" by Charles Max Wood is now available on Amazon. Get Your Copy Today!

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Links

• The TC39 Process
• Le Creuset Star Wars™ Han Solo Roaster | Williams Sonoma
• 124 JSJ The Origin of Javascript with Brendan Eich
• Crockford on JavaScript
• Le Creuset Turkey
• MJS 108: Dan Shappir
• MJS 132: Douglas Crockford
• JSJ 392: The Murky Past and Misty Future of JavaScript with Douglas Crockford
• "Things You Can Do In ES6 That Can't Be Done In ES5" - View Source talk by Dan Shappir
• Object Property Value Shorthand in JavaScript with ES6
• Spread syntax - JavaScript | MDN
• JavaScript for-loops are… complicated - HTTP203
• Optional chaining - JavaScript | MDN
• Breaking Chains with Pipelines in Modern JavaScript

Picks

AJ O’Neal:

• Expert Secrets
• Course Creator Pro
• Braun Series 7

Aimee Knight:

• Kickstarter Employees Win Historic Union Election
• Broccoli Sprouts Nutrition And Benefits Of Sulforaphane

Charles Max Wood:

• The Expanse
• The Masked Singer
• LEGO Masters

Steve Edwards:

• Beano
• Steve Wright HBO special

Dan Shappir:

• CC 001: Clean Agile with Robert "Uncle Bob" Martin
• .NET 019: The History of .NET with Richard Campbell
• RRU 097: State Management and React Component Design with Becca Bailey

Follow JavaScript Jabber on Twitter > @JSJabber

JavaScript Remote Conf 2020

May 13th to 15th - register now!

Matt Crook joins the conversation to talk with the JavaScript Jabber panel to talk about his experience going through Nashville Software School. The panel discusses and asks questions about getting into programming, working through the bootcamp, and what prospects are for bootcamp graduates.

Panel

• AJ O’Neal
• Aimee Knight
• Charles Max Wood
• Steve Edwards
• Dan Shappir

Guest

• Matt Crook

Sponsors

• Taiko
• Educative.io | Click here for 10% discount

"The MaxCoders Guide to Finding Your Dream Developer Job" by Charles Max Wood is now available on Amazon. Get Your Copy Today!

Picks

AJ O’Neal:

• PostgREST
• The Way of Kings
• VirtualBox
• Bootable Installers for MacOS, Windows, and more

Aimee Knight:

• State of Microservices 2020 Report
• Peloton Bike

Charles Max Wood:

• The Hobbit
• D&D Starter Set
• JavaScript Weekly
• Devchat.tv Remote Meetups
• Devchat.tv Remote Conferences
• Reading to Kids

Steve Edwards:

• It Is Well With My Soul
• Pitbull Gold PRO Skull Shaver
• Brad Balfour

Dan Shappir:

• Gödel, Escher, Bach
• Translating "The Hobbit" in Captivity

Matt Crook:

• Follow Matt on Twitter > @mgcrook, Instagram, LinkedIn
• Swolenormous
• Fireship
• Static Headz
• Yugen

Follow JavaScript Jabber on Twitter > @JSJabber

Young, Vershawn Ashanti

This cohort study assesses whether long-term variability and rate of change of blood pressure from young adulthood to midlife are associated with cardiovascular disease and all-cause mortality by middle age.

In this issue of JAMA Cardiology, Lim and colleagues report on cardiovascular functional reserve in people with end-stage renal disease before and after kidney transplant. They performed a 3-arm, prospective, concurrent cohort study to assess change in cardiovascular functional reserve after kidney transplant using state-of-the-art cardiopulmonary exercise testing (CPET). They also assessed left ventricular morphologic findings 1 year after transplant. They enrolled 81 participants with stage 5 chronic kidney disease (CKD) who underwent kidney transplant, 85 wait-listed participants with stage 5 CKD who had not undergone transplant, and 87 controls treated for hypertension only. The authors quantified cardiovascular functional reserve using CPET in parallel with transthoracic echocardiography. One year after transplant, a significant improvement in maximum oxygen consumption was found in the transplant group compared with the nontransplant group. Moreover, left ventricular function improved but not the body mass index.

To the Editor We read the recent article by Klauser et al with great interest. While the potential implications of the findings are exciting, we have several concerns. First, the authors do not explicitly state whether electrocardiogram gating was used in their study. This is an important detail because cardiac motion artifact is a source of artifactual coloration with dual-energy computed tomography (DECT), particularly with dual-source scanners given the approximately 80-millisecond temporal difference between the 2 radiography beams. Furthermore, beam hardening artifact from calcified atheromas and partial volume effect, known sources of artifacts in the 2-material decomposition algorithm of DECT, may largely explain the findings. While patients with gout had higher prevalence of coronary calcification (55 of 59 patients [93%]) and cardiovascular monosodium urate (MSU) deposition (51 of 59 patients [86%]) than controls, the authors do not report whether the 4 patients with gout without coronary calcifications exhibited MSU deposition nor the number of controls or cadaveric hearts with coronary calcification. The images from the article show areas of green pixelization occurring adjacent to calcified plaques on grayscale computed tomography images (eg, Figure 2A and D, left anterior descending artery [yellow arrowhead]), which would favor this artifact hypothesis without additional data.

In Reply We appreciate the valuable comments of Becce et al on our article. We applied prospective electrocardiography gating using a thin-slice cardiac protocol to ensure highest spatial resolution with minimal motion artifact. A noncontrast electrocardiography-gated computed tomography (CT) examination with standardized scan parameters was performed using a 128-slice dual-source CT (SOMATOM Definition Flash; Siemens) with a detector collimation of 2 × 64 × 0.6 mm, rotation time of 0.28 seconds, and prospective electrocardiography triggering for heart rates less than 65 beats per minute (diastolic padding, 70% of RR interval) and more than 65 beats per minute (systolic padding, 40% of RR interval). Axial images were reconstructed with 0.75-mm slice width, increment of 0.5, and a medium-smooth convolution kernel (B26f). When motion artifact was present, it was distinguished by visual analysis of an experienced observer and colorized pixels related to motion were excluded.

This cohort study assesses cardiovascular functional reserve before and after kidney transplant in patients with end-stage renal disease.

Lowering low-density lipoprotein cholesterol (LDL-C) levels remains a mainstay of cardiovascular disease prevention, but gaps in treatment remain, even in persons with hypercholesterolemia and greatly elevated LDL-C levels. Although well-described gene variants in the apolipoprotein B (APOB), low-density lipoprotein receptor (LDLR), and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes explain small but important fractions of monogenic hypercholesterolemia, recent attention has turned to prognostication of cardiovascular disease using polygenic risk scores (PRS) that incorporate common genetic variants derived from large-scale genome-wide association studies of lipid subfractions. Earlier PRS considered only variants with genome-wide significance, and newer studies have focused on methods that better capture the variance conferred by millions of variants, suggesting an ability to identify risk equivalent to monogenic mutations. There remains a gap in evidence from prospective observational studies or treatment trials regarding the appropriate placement of PRS in risk assessment and lipid treatment decisions relative to information on rare monogenic gene variants, particularly in multiethnic populations.

This cohort study uses the UK Biobank cohort data to compare the association of monogenic vs polygenic hypercholesterolemia with the risk of atherosclerotic cardiovascular disease among individuals with comparable levels of low-density lipoprotein cholesterol.

What is the cascade?

The cascade is a mechanism for determining which styles should be applied to a given element, based on the rules that have cascaded down from various sources.

The cascade takes importance, origin, specificity, and source order of style rules into account. It assigns a weight to each rule. When multiple rules apply to a given element, the rule with the greatest weight takes precedence. The result is an unambiguous way to determine the value of a given element/property combination.

Browsers apply the following sorting logic:

• Find all declarations that apply to a given element/property combination, for the target media type.

• Sort declarations according to their importance (normal or important) and origin (author, user, or user agent). From highest to lowest precedence:

  1. user !important declarations
     
  2. author !important declarations
     
  3. author normal declarations
     
  4. user normal declarations
     
  5. user agent declarations

• If declarations have the same importance and source, sort them by selector specificity.

• Finally, if declarations have the same importance, source, and specificity, sort them by the order they are specified in the CSS. The last declaration wins.

What is specificity?

Specificity is a method of conflict resolution within the cascade.

Specificity is calculated in a very particular way, based on the values of 4 distinct categories. For explanatory purposes, the CSS2 spec represents these categories using the letters a, b, c, and d. Each has a value of 0 by default.

• a is equal to 1 if the declaration comes from a style attribute in the HTML (“inline styles”) rather than a CSS rule with a selector.
• b is equal to the number of ID attributes in a selector.
• c is equal to the number of other attributes and pseudo-classes in a selector.
• d is equal to the number of elements and pseudo-elements in a selector.

The specificity is given by concatenating all 4 resulting numbers. More specific selectors take precedence over less specific ones.

For example, the selector #id .class[href] element:hover contains:

• 1 ID (b is 1)
• 1 class, 1 attribute selector, and 1 pseudo-class (c is 3)
• 1 element (d is 1)

Therefore, it has a specificity of 0,1,3,1. Note that a selector containing a single ID (0,1,0,0) will have a higher specificity than one containing any number of other attributes or elements (e.g., 0,0,10,20). This is one of the reasons why many modern CSS architectural patterns avoid using IDs for styling purposes.

What is inheritance?

Inheritance is distinct from the cascade and involves the DOM tree.

Inheritance is the process by which elements inherit the the values of properties from their ancestors in the DOM tree. Some properties, e.g. color, are automatically inherited by the children of the element to which they are applied. Each property defines whether it will be automatically inherited.

The inherit value can be set for any property and will force a given element to inherit its parent element’s property value, even if the property is not normally inherited.

About !important

The above should make it apparent that !important is a separate concept to specificity. It has no effect on the specificity of a rule’s selector.

An !important declaration has a greater precedence than a normal declaration (see the previously mentioned cascade sorting logic), even declarations contained in an element’s style attribute.

[CSS terminology reference]

Translations

• CSS: каскад, специфика и наследование

Interview with Nehal N. Mehta, MD, MSCE, author of Association Between Aortic Vascular Inflammation and Coronary Artery Plaque Characteristics in Psoriasis, and Jagat Narula, MD, PhD, author of Inflammation, Superadded Inflammation, and Out-of-Proportion Inflammation in Atherosclerosis

Interview with Paul A Heidenreich, MD, MS, author of Association of Statin Adherence With Mortality in Patients With Atherosclerotic Cardiovascular Disease

Interview with Peter Rhee, MD, MPH, and Bellal Joseph, MD, authors of Nationwide Analysis of Resuscitative Endovascular Balloon Occlusion of the Aorta in Civilian Trauma

Interview with Stephen W. Waldo, MD, author of Association of Coronary Anatomical Complexity With Clinical Outcomes After Percutaneous or Surgical Revascularization in the Veterans Affairs Clinical Assessment Reporting and Tracking Program

Interview with Scott David Solomon, MD, and Stephen Yishu Wang, BS, authors of Longitudinal Associations Between Income Changes and Incident Cardiovascular Disease: The Atherosclerosis Risk in Communities Study, and Edward P. Havranek, MD, author of The Influence of Social and Economic Factors on Heart Disease

Interview with Alexia Mattei, MD, author of Feasibility of First Injection of Autologous Adipose Tissue–Derived Stromal Vascular Fraction in Human Scarred Vocal Folds: A Nonrandomized Controlled Trial

Interview with Aaron L. Baggish, MD, author of Association of Ascending Aortic Dilatation and Long-term Endurance Exercise Among Older Masters-Level Athletes

Jennings, Eric, author

The complex mineral collection beneath northern New Jersey may offer clues to how Earth formed and how soil affects water purity and plant growth

Darmstadt : Steinkopff Verlag Darmstadt, 2006

Milano : Springer, 2007

Online Resource

Wang, You Zhi

Berthier, Jean, 1952-

Buchholz, Klaus, 1941-

Kessie, Francis K

NASCAR's empty-oval return means lost races at three tracks

Interview with Bimal R. Shah, MD, MB, author of Association Between Physician Billing and Cardiac Stress Testing Patterns Following Coronary Revascularization

Interview with Martin J. O'Donnell, MB, PhD, author of Urinary Sodium and Potassium Excretion and Risk of Cardiovascular Events