Although common ‘disorders’ (e.g., eating disorders, anxiety, and depression) look different on the surface, there are some common underlying mechanisms. One of these is checking. I’m going to go explain the role of checking in a selection of common mental health problems. Checking in Health Anxiety Examples: – Person goes to the Dr for blood […]

The post CBT: How Checking Contributes to Mental Health Problems (Eating Disorders, Depression, Anxiety) appeared first on Dr Alice Boyes.

The extensions will let schools and community groups continue feeding students with fewer restrictions than typical under the National School Lunch and Breakfast Programs.

Parents Unified for Local School Education New Jersey is calling for community-driven schools and opposes the One Newark reorganization plan.

Abnormal neuronal morphological features, such as dendrite branching, axonal branching, and spine density, are thought to contribute to the symptoms of depression and anxiety. However, the role and molecular mechanisms of aberrant neuronal morphology in the regulation of mood disorders remain poorly characterized. Here, we show that neuritin, an activity-dependent protein, regulates the axonal morphology of serotonin neurons. Male neuritin knock-out (KO) mice harbored impaired axonal branches of serotonin neurons in the medial prefrontal cortex and basolateral region of the amygdala (BLA), and male neuritin KO mice exhibited depressive and anxiety-like behaviors. We also observed that the expression of neuritin was decreased by unpredictable chronic stress in the male mouse brain and that decreased expression of neuritin was associated with reduced axonal branching of serotonin neurons in the brain and with depressive and anxiety behaviors in mice. Furthermore, the stress-mediated impairments in axonal branching and depressive behaviors were reversed by the overexpression of neuritin in the BLA. The ability of neuritin to increase axonal branching in serotonin neurons involves fibroblast growth factor (FGF) signaling, and neuritin contributes to FGF-2-mediated axonal branching regulation in vitro. Finally, the oral administration of an FGF inhibitor reduced the axonal branching of serotonin neurons in the brain and caused depressive and anxiety behaviors in male mice. Our results support the involvement of neuritin in models of stress-induced depression and suggest that neuronal morphological plasticity may play a role in controlling animal behavior.

Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer's disease (AD) facilitates the identification of new targets for effective treatments. Recently available large-scale multiomics datasets provide opportunities to use computational approaches for such studies. Here, we devised a novel disease gene identification (digID) computational framework that consists of a semi-supervised deep learning classifier to predict AD-associated genes and a protein–protein interaction (PPI) network-based analysis to prioritize the importance of these predicted genes in AD. digID predicted 1,529 AD-associated genes and revealed potentially new AD molecular mechanisms and therapeutic targets including GNAI1 and GNB1, two G-protein subunits that regulate cell signaling, and KNG1, an upstream modulator of CDC42 small G-protein signaling and mediator of inflammation and candidate coregulator of amyloid precursor protein (APP). Analysis of mRNA expression validated their dysregulation in AD brains but further revealed the significant spatial patterns in different brain regions as well as among different subregions of the frontal cortex and hippocampi. Super-resolution STochastic Optical Reconstruction Microscopy (STORM) further demonstrated their subcellular colocalization and molecular interactions with APP in a transgenic mouse model of both sexes with AD-like mutations. These studies support the predictions made by digID while highlighting the importance of concurrent biological validation of computationally identified gene clusters as potential new AD therapeutic targets.

Experience- and activity-dependent transcription is a candidate mechanism to mediate development and refinement of specific cortical circuits. Here, we demonstrate that the activity-dependent transcription factor myocyte enhancer factor 2C (MEF2C) is required in both presynaptic layer (L) 4 and postsynaptic L2/3 mouse (male and female) somatosensory (S1) cortical neurons for development of this specific synaptic connection. While postsynaptic deletion of Mef2c weakens L4 synaptic inputs, it has no effect on inputs from local L2/3, contralateral S1, or the ipsilateral frontal/motor cortex. Similarly, homozygous or heterozygous deletion of Mef2c in presynaptic L4 neurons weakens L4 to L2/3 excitatory synaptic inputs by decreasing presynaptic release probability. Postsynaptic MEF2C is specifically required during an early postnatal, experience-dependent, period for L4 to L2/3 synapse function, and expression of transcriptionally active MEF2C (MEF2C-VP16) rescues weak L4 to L2/3 synaptic strength in sensory-deprived mice. Together, these results suggest that experience- and/or activity-dependent transcriptional activation of MEF2C promotes development of L4 to L2/3 synapses. Additionally, MEF2C regulates the expression of many pre- and postsynaptic genes in postnatal cortical neurons. Interestingly, MEF2C was necessary for activity-dependent expression of many presynaptic genes, including those that function in transsynaptic adhesion and neurotransmitter release. This work provides mechanistic insight into the experience-dependent development of specific cortical circuits.

By 1953, six years after the Bell X-1 first went supersonic, that airplane and others were routinely flying at more than twice the speed of sound. On December 17, 1953the 50th anniversary of the Wright brothers first powered flight at Kitty HawkMajor Yeager sat down at the Pentagon for an informal press briefing to discuss his own Mach 2.43 flight in the X-1 five days earlier. Video: Department of Defense, Courtesy National Archives and Records Administration

The wild canines have the same muscles used by domestic dogs to create the wide-eyed, pleading look that captures humans' hearts

Babies who were conceived and born during the period of rationing in the United Kingdom were less likely to develop certain diseases as adults, a new study finds

Hospice Northwest Services is inviting people to visit its third annual photography exhibit, "A Personal Lens on Grief." Here's what the project in Thunder Bay, Ont., entails, and why staff say it's important to find creative ways to express loss.

A group of residential school survivors and their supporters are asking the federal government to reverse what they're calling a funding cut and come up with more money to help find the unmarked graves of students who went to these institutions.

People who experience depression and concussions simultaneously have significantly worse symptoms for both conditions and disruptions to brain connectivity, according to a study by researchers at Penn State.

Apple's decision to place the power button of the M4 Mac mini underneath has been questioned by users. In some cases, they've come up with their own "solutions" to the problem.

The Freedom Climbers remain encouraged through increasing altitudes and dropping temperatures as they continue upward to Mt. Everest Base Camp and Kala Patthar Peak.

Congress grilled the CEOs of Amazon, Apple, Facebook, and Google about "pandemic profiteering," anti-competitive practices, and the flow of misinformation about COVID-19.

The effectiveness of national voluntary programs asking companies to pledge to lower their pollution and greenhouse gas emissions depends on pressure from the public, according to a new study led by a Penn State researcher.

Penn State Greater Allegheny student journalists earned Golden Quill Awards from the Press Club of Western Pennsylvania for their exceptional writing and multimedia work in the campus newspaper, the GA-Zette.

The requests put the nation's special education administrators in conflict with disability rights advocates who fear waivers will place millions of special education students at risk.

Virtual reality goggles with a choice of soothing environments or guided meditations, a color-changing bubble wall, a prayer area, Zen garden and massage chair: These are all options provided by Penn State Wilkes-Barre’s Counseling Services to help students relax and stay calm.

Delaware Affordable Housing Developers Facing Cost Increases Encouraged To Apply   Dover, Del., February 1, 2023 – The Delaware State Housing Authority (DSHA) is extending the submission deadline for the Market Pressure Relief Fund (MPRF) to 3:00 p.m. on Friday, February 3, 2023. Application materials can be found here: http://destatehousing.com/Developers/Developers.php. MPRF was announced in July […]

Ricky Ponting didn't hold back on Gautam Gambhir's criticism, calling the India head coach a 'prickly character'.

Shraddha dropped a string of sweaty face and head slamming emojis

Malai Roti In Jodhpur: A clip showing a unique delicacy called "malai roti" has received a lot of attention on Instagram. Find out more about it below.

The video of dosa served with aloo masala and tomato chutney has clocked 5.7 million views

Dover, Del. (July 15, 2021) – The Delaware Division of Small Business and Office of Management and Budget (OMB) announced today the launch of a Market Pressure Relief Fund designed to assist state contractors facing increased costs for construction materials due to the pandemic. The fund will provide adjustment reimbursements for non-transportation construction materials purchased […]

DOVER, DE (OCT. 28, 2022) – The Delaware Division of Public Health (DPH) is concerned about increases in respiratory viruses in the state, particularly influenza (flu) and respiratory syncytial virus (RSV). For the week of Oct. 16, 2022, through Oct. 22, 2022, there were 44 laboratory-confirmed cases of the flu, compared to 19 cases the week […]

At least five people were killed this morning after their speeding car rammed a truck that had broken down and was parked on the roadside in Noida.

1. Inflation in nearly half of major states outgrows India's Oct CPI; price pressure steepest in Chhattisgarh  Moneycontrol
2. Retail inflation surges to a 14-month high of 6.2% in October  The Times of India
3. If we exclude vegetable prices, CPI inflation remains in RBI's range: UBI research  The Economic Times
4. Rising food prices are likely to push back beginning of rate cutting cycle  The Indian Express
5. India confident of reaching USD 100 billion trade volume with Russia ahead of 2030 timeline: S Jaishankar  Telegraph India

The iPad Mini 7 is an impressive tablet, but there are some compromises that might be a deterrent for potential buyers.

The post iPad Mini (2024) Review: Imperfect, but Impressive appeared first on Phandroid.

Display Stream Compression (DSC) is a lossless or near-lossless image compression standard developed by the Video Electronics Standards Association (VESA) for reducing the bandwidth required to transmit high-resolution video and images. DSC compresses video streams in real-time, allowing for higher resolutions, refresh rates, and color depths while minimizing the data load on transmission interfaces such as DisplayPort, HDMI, and embedded display interfaces.

Why Is DSC Needed?

In the ever-evolving landscape of display technology, the pursuit of higher resolutions and better visual quality is relentless. As display capabilities advance, so do the challenges of managing the immense amounts of data required to drive these high-performance screens. This is where DSC steps in. DSC is designed to address the challenges of transmitting ultra-high-definition content without sacrificing quality or performance. As displays grow in resolution and capability, the amount of data they need to transmit increases exponentially. DSC addresses these issues by compressing video streams in real-time, significantly reducing the bandwidth needed while preserving image quality.
 

DSC Use in End-to-end System

DSC Key Features

• Encoding tools:
  • Modified Median-Adaptive Prediction (MMAP)
  • Block Prediction (BP)
  • Midpoint Prediction (MPP)
  • Indexed color history (ICH)
  • Entropy coding using delta size unit-variable length coding (DSU-VLC)

• The DSC bitstream and decoding process are designed to facilitate the decoding of 3 pixels/clock in practical hardware decoder implementations. Hardware encoder implementations are possible at 1 pixel/clock.
• DSC uses an intra-frame, line-based coding algorithm, which results in very low latency for encoding and decoding.

DSC encoding algorithm
 

• Compression can be done to a fractional bpp. The compressed bits per pixel ranges from 6 to 63.9375.
• For validation/compliance certification of DSC compression and decompression engines, cyclic redundancy checks (CRCs) are used to verify the correctness of the bitstream and the reconstructed image.
• DSC supports more color bit depths, including 8, 10, 12, 14, and 16 bpc.
• DSC supports RGB and YCbCr input format, supporting 4:4:4, 4:2:2, and 4:2:0 sampling.
• Maximum decompressor-supported bits/pixel values are as listed in the Maximum Allowed Bit Rate column in the table below

• DP DSC Source device shall program the bit rate within the range of Minimum Allowed Bit Rate column in the table:

Summary

Display Stream Compression (DSC) is a technology used in DisplayPort to enable higher resolutions and refresh rates while maintaining high image quality. It works by compressing the video data transmitted from the source to the display, effectively reducing the bandwidth required. DSC uses a visually lossless algorithm, meaning that the compression is designed to be imperceptible to the human eye, preserving the fidelity of the image. This technology allows for smoother, more detailed visuals at higher resolutions, such as 4K or 8K, without requiring a significant increase in data bandwidth.

More Information

• Cadence has a very mature Verification IP solution. Verification over many different configurations can be used with DisplayPort 2.1 and DisplayPort 1.4 designs, so you can choose the best version for your specific needs.
• The DisplayPort VIP provides a full-stack solution for Sink and Source devices with a comprehensive coverage model, protocol checkers, and an extensive test suite.
• More details are available on the DisplayPort Verification IP product page, Simulation VIP pages.
• If you have any queries, feel free to contact us at talk_to_vip_expert@cadence.com

Hi,

I have a question about printing noise summary via maestro output expressions.

How can I print noise data using output expressions, for multiple levels of the hierarchy?

I have found this article which describe the procedure using ocnGenNoiseSummary() function: https://support.cadence.com/apex/ArticleAttachmentPortal?id=a1Od0000007MViHEAW&pageName=ArticleContent

I see also Andrew Beckett referring to the above mentioned article as a solution to a similar question: community.cadence.com/.../noise-summary-per-instance

However, this seems to work only if I'm to extract noise data from a single level of hierarchy.

If I have the output expression "ocnGenNoiseSummary(2 ?result 'hbnoise)", it will generate a "noisesummary" directory under results directory for a hierarchy level of 2.

If I am to extract data from various hierarchy levels, I should be able to generate multiple noise summary directories, such as noisesummary1, noisesummary2 where they correspond to "ocnGenNoiseSummary(1 ?result 'hbnoise)" & "ocnGenNoiseSummary(2 ?result 'hbnoise)", respectively. However this does not seem to be possible.

Can you please advice? Thanks.

My Cadence version: IC23.1-64b.ISR7.27

BR,

Denizhan Karaca

Hi,

My Virtuoso and Spectre Version: ICADVM20.1-64b.NYISR30.2

I have an expression where the EvalType is "sweeps". Here is the expression (I also attached the snapshot):

(peakToPeak(leafValue(swapSweep(delay(?wf1 clip((VT("/clk0") - VT("/clk180")) (VAR("mt_stop") - (4.0 / VAR("datarate"))) VAR("mt_stop")) ?value1 0 ?edge1 "rising" ?nth1 1 ?td1 0 ?tol1 nil ?wf2 clip((VT("/tx_padp") - VT("/tx_padn")) (VAR("mt_stop") - (4.0 / VAR("datarate"))) VAR("mt_stop")) ?value2 0 ?edge2 "rising" ?nth2 1 ?tol2 nil ?td2 nil ?stop nil ?multiple nil) "VDD_FIXED_NOISE") "VREGLN_cmode" 0.85 "VREGDRV_novn" 0.4 "datarate" 1.658e+10) ?overall t) / 10.0)

What this expression does is that it compares the delay between the output data with respect to a reference clock. I then get this information for two conditions (VDD_FIXED_NOISE = 0 or 10mV) to get the effect of the supply-induced jitter. In the expression, I need to give the value of each parameter in different modes to distinguish them from each other. Now I want to sweep the base supply values and see the supply variation effects. For example, I want to change VREGLN_cmode from 0.85 to 0.81 and see how my supply-induced jitter changes. For that, the hard way is to copy the expression and change that value accordingly (e.g. "VREGLN_cmode" 0.81). I'm looking for an easier way to use a variable in the expression. Something like VAR("VREGLN_Sweep"). But I see it doesn't work in my expression and it gives an eVal error. I tested this before in other expressions (not sweep type) and it always worked. I have only one test and these variables are all Design Variables and not Global variables.
I want to know what mistake am I doing here and is there a way to make this work. Sorry that if I could not explain better my inquiry. Thank you.

Starting at noon ET on Nov. 11, Walmart+ members can buy a Keurig K-Express Essentials single-serve coffee maker for just $29.88.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Following the keenly contested war of ballots in the recent presidential election between the incumbent President Goodluck Ebele Jonathan — who represented the ruling People’s Democratic Party (PDP) and retired General Muhammadu Buhari of the All Progressives Congress (APC) — which ended in favour of the retired General, Nigerians have barred their minds on their expectations from the incoming administration as they say, “to whom much is given, much more is expected.” Foremost amongst the challenges Nigerians are confronted with are economic instability, insecurity and terrorism, provision of shelter, social and infrastructural amenities, qualitative education, employment generation, and more. Proffering […]

LONDON — The head of the Church of England, spiritual leader of the global Anglican Communion, is under pressure to resign after an investigation found that he failed to inform police about serial physical and sexual abuse by a volunteer at Christian summer camps as soon as he became aware of it. Some members of the General Synod, the church's national assembly, have started a petition calling on Archbishop of Canterbury Justin Welby to step down, saying he had "lost the confidence of his clergy." The petition had garnered more than 1,800 signatures on Change.org by late morning London time on Monday. Compounding the pressure, a senior cleric added her voice to those who believe he should resign. Helen-Ann Hartley, the bishop of Newcastle, told the BBC that Welby's position is "untenable.'' Calls for Welby's resignation have grown since Thursday, when the church released the results of an independent review into John Smyth, who sexually, psychologically and physically abused about 30 boys and young men in the United Kingdom and 85 in Africa over five decades. The 251-page report concluded that Welby failed to report Smyth to authorities when he was informed of the abuse in August 2013, soon after he became Archbishop of Canterbury. Welby last week took responsibility for not ensuring that the allegations were pursued as "energetically" as they should have been after he learned of the abuse but said he had decided not to resign. On Monday, his office issued a statement reiterating Welby's "horror at the scale of John Smyth's egregious abuse." "As he has said, he had no awareness or suspicion of the allegations before he was told in 2013 — and therefore, having reflected, he does not intend to resign," the statement said. "He hopes the Makin Review supports the ongoing work of building a safer church here and around the world." Church officials were first made aware of the abuse in 1982, when they received the results of an internal investigation into Smyth. The recipients of that report "participated in an active cover-up" to prevent its findings from coming to light, the Makin Review found. Between 1984 and 2001, Smyth moved to Zimbabwe and subsequently relocated to South Africa. He continued to abuse boys and young men in Zimbabwe and there is evidence that the abuse continued in South Africa until he died in August 2018. Smyth's abuse wasn't made public until a 2017 investigation by Britain's Channel 4 television, which led Hampshire Police to start an investigation. Police were planning to question Smyth at the time of his death and had been preparing to extradite him. The Makin Review found that if Smyth had been reported to police in 2013, it could have helped to uncover the truth, prevented further abuse and led to a possible criminal conviction. "In effect, three and a half years was lost, a time within which John Smyth could have been brought to justice and any abuse he was committing in South Africa discovered and stopped," the review found. The Archbishop of Canterbury is the head of the Church of England and is seen as the spiritual leader of the Anglican Communion, which has more than 85 million members in 165 countries. He is considered first among equals with respect to the communion's other primates.

[Addis Standard] Addis Abeba -- The Committee to Protect Journalists (CPJ) presented to the UN's Human Rights Council a five-year review of press freedom in Ethiopia ahead of the United Nations Universal Periodic Review (UPR) of Ethiopia at the 47th Session taking place today by the UN's Human Rights Council.

Anyone interested in unsolved murders and disappearances will find much to study in Sri Lanka. Fifteen to twenty years ago, the country made global headlines, not only for the government’s military offensive against the Liberation Tigers of Tamil Eelam (LTTE) guerrillas but also for the numerous murders of journalists. The newly elected president, Anura Kumara […]

Information manipulation and misinformation are not new phenomena, but they have taken on exaggerated importance, especially with the massive use of social media. Hostile and stigmatizing narratives against civil society and civic activism, whether intentional or not, especially when propagated by authorities, create undue restrictions and hinder the exercise of the rights to freedom of […]

Violence in the Middle East has escalated dramatically since the Hamas terrorist attack in October 2023 and the fallout that has since followed. There is tension, if not a state of war, between all the major opponents on the ground. Israel is directly facing off with mainly non-state actors from other countries, who have more […]

A weekly selection of opinions and analyses from the Arab media around the world.

Sullivan laid the blame squarely on Hamas, clarifying that the issue was that the group simply didn’t want to make a deal under any terms.

You have undoubtedly heard people say things like, “God is calling me to the mission field,” or “God led me to attend this college,” or “We feel God wants us to get married.” Perhaps you have even said such things yourself. Christians who use expressions like those often mean they have had an impression or a strong feeling that they interpret as a disclosure of the divine will.

We often skim quickly over the introductory parts of Paul’s epistles, but they are usually pregnant with meaning—and in the case of his letter to Titus, profoundly so. In his seemingly simple salutation, Paul gives us some vivid insight into how the plan of redemption started.