[Manchester] : [James Mudd], [between 1800 and 1899]

[The Netherlands] : [publisher not identified], [1688]

Rockville, Maryland : National Institute on Drug Abuse, 1985.

Rockville, Maryland : National Institute on Drug Abuse, 1985.

All-Pac-12 talent Mikayla Pivec's career in Corvallis has been memorable to say the least. While it's difficult to choose just three, her top moments include a career-high 19 rebounds against Washington, a buzzer-beating layup against ASU, and breaking Ruth Hamblin's Oregon State rebounding record this year against Stanford.

The news comes shortly after a valet who served meals to President Trump also tested positive for the virus.

Zhixiang Lin, Mahdi Zamanighomi, Timothy Daley, Shining Ma, Wing Hung Wong.

Source: Statistical Science, Volume 35, Number 1, 2--13.

Abstract:
Unsupervised methods, including clustering methods, are essential to the analysis of single-cell genomic data. Model-based clustering methods are under-explored in the area of single-cell genomics, and have the advantage of quantifying the uncertainty of the clustering result. Here we develop a model-based approach for the integrative analysis of single-cell chromatin accessibility and gene expression data. We show that combining these two types of data, we can achieve a better separation of the underlying cell types. An efficient Markov chain Monte Carlo algorithm is also developed.

Chris Englund
Jan 5, 2005; 25:247-251
BRIEF COMMUNICATION

Jessica A. Gorski
Aug 1, 2002; 22:6309-6314
BRIEF COMMUNICATION

Lennart Mucke
Jun 1, 2000; 20:4050-4058
Cellular

Microsoft has introduced a slew of new products, including the Surface Go 2, the Surface Book 3, Surface Headphones 2 and Surface Earbuds. Both the Surface Go 2 and the Surface Book 3 come in consumer and corporate versions. "The two products are very different," noted Rob Enderle, principal analyst at the Enderle Group. "The Go 2 is a high-value product -- the Surface Book 3 high innovation."

Sensory systems integrate multiple stimulus features to generate coherent percepts. Spectral surround suppression, the phenomenon by which sound-evoked responses of auditory neurons are suppressed by stimuli outside their receptive field, is an example of this integration taking place in the auditory system. While this form of global integration is commonly observed in auditory cortical neurons, and potentially used by the nervous system to separate signals from noise, the mechanisms that underlie this suppression of activity are not well understood. We evaluated the contributions to spectral surround suppression of the two most common inhibitory cell types in the cortex, parvalbumin-expressing (PV+) and somatostatin-expressing (SOM⁺) interneurons, in mice of both sexes. We found that inactivating SOM⁺ cells, but not PV+ cells, significantly reduces sustained spectral surround suppression in excitatory cells, indicating a dominant causal role for SOM⁺ cells in the integration of information across multiple frequencies. The similarity of these results to those from other sensory cortices provides evidence of common mechanisms across the cerebral cortex for generating global percepts from separate features.

SIGNIFICANCE STATEMENT To generate coherent percepts, sensory systems integrate simultaneously occurring features of a stimulus, yet the mechanisms by which this integration occurs are not fully understood. Our results show that neurochemically distinct neuronal subtypes in the primary auditory cortex have different contributions to the integration of different frequency components of an acoustic stimulus. Together with findings from other sensory cortices, our results provide evidence of a common mechanism for cortical computations used for global integration of stimulus features.

Hydrocephalus is a pathologic condition associated with various brain diseases, including Alzheimer's disease (AD). Dysfunctional ependymal cells (EpCs) are believed to contribute to the development of hydrocephalus. It is thus of interest to investigate EpCs' development and function. Here, we report that vacuolar protein sorting-associated protein 35 (VPS35) is critical for EpC differentiation, ciliogenesis, and survival, and thus preventing neonatal hydrocephalus. VPS35 is abundantly expressed in EpCs. Mice with conditional knock-out (cKO) of Vps35 in embryonic (Vps35^GFAP-Cre and Vps35^Emx1-Cre) or postnatal (Vps35^Foxj1-CreER) EpC progenitors exhibit enlarged lateral ventricles (LVs) and hydrocephalus-like pathology. Further studies reveal marked reductions in EpCs and their cilia in both Vps35^GFAP-Cre and Vps35^Foxj1-CreER mutant mice. The reduced EpCs appear to be due to impairments in EpC differentiation and survival. Additionally, both Vps35^GFAP-Cre and Vps35^Foxj1-CreER neonatal pups exhibit increased cell proliferation and death largely in a region close to LV-EpCs. Many microglia close to the mutant LV-EpC region become activated. Depletion of the microglia by PLX3397, an antagonist of colony-stimulating factor 1 receptor (CSF1R), restores LV-EpCs and diminishes the pathology of neonatal hydrocephalus in Vps35^Foxj1-CreER mice. Taken together, these observations suggest unrecognized functions of Vps35 in EpC differentiation, ciliogenesis, and survival in neonatal LV, and reveal pathologic roles of locally activated microglia in EpC homeostasis and hydrocephalus development.

SIGNIFICANCE STATEMENT This study reports critical functions of vacuolar protein sorting-associated protein 35 (VPS35) not only in promoting ependymal cell (EpC) differentiation, ciliogenesis, and survival, but also in preventing local microglial activation. The dysfunctional EpCs and activated microglia are likely to induce hydrocephalus.

A planned exhibition at the Portland Art Museum highlights the boldness of their work

Green Depots will begin to reopen across the province on Monday, according to the Multi-Materials Stewardship Board, though dates and hours of operation may vary between sites. 

Over many years, the Xenopus laevis embryo has provided a powerful model system to investigate how mechanical forces regulate cellular function. Here, we describe a system to apply reproducible tensile and compressive force to X. laevis animal cap tissue explants and to simultaneously assess cellular behavior using live confocal imaging.

Press release "Saudi G20 Presidency and the Bank for International Settlements (BIS) Innovation Hub invite global innovators to solve RegTech and SupTech challenges", 27 April 2020

Interview with Mr Luis de Guindos, Vice-President of the European Central Bank, and Expresso, conducted by Mr João Silvestre on 15 April 2020.

'Creative Music Making' Documentary to Air on Nine Network - MPress  Maryville University News

Happy birthday Vijay Deverakonda: Tollywood's 'Dear Comrade' who auctioned his first Filmfare Award for charity  The New Indian Express

Sound of hope  The New Indian Express

The White House says it is conducting contact tracing after the U.S. vice-president's press secretary, Katie Miller, tested positive for coronavirus.

Introductory statement by Ms Christine Lagarde, President of the European Central Bank, and Mr Luis de Guindos, Vice-President of the European Central Bank, Frankfurt am Main, 30 April 2020.

Anti-government ideology is crippling pandemic policy.

DFMXpress is the smaller brother of the full blown version DFMPro by HCL Technologies, LTD and is included in each level of SOLIDWORKS. DFM stands for Design For Manufacturability. This is a tool we can use to improve our designs

Author information

The post SOLIDWORKS Tech Tip – Using DFMXpress appeared first on SOLIDWORKS Tech Blog.

Denver Newsroom, Apr 24, 2020 / 03:32 pm (CNA).- A Catholic lawyer says his arrest last Saturday is part of mainland China’s wide-ranging efforts to tighten control over Hong Kong.

His ordeal follows his participation in months of pro-democracy protests on the island, which have been slowed by the coronavirus pandemic.

Hong Kong police arrested 81-year-old Martin Lee, along with 14 other pro-democracy protestors, on April 18. Lee has been demonstrating for universal suffrage in Hong Kong for nearly 40 years, and this is his first arrest, the Washington Post reports.

CNA spoke with one of Lee’s close friends, who said Lee and those arrested with him are currently bailed out of prison, and are safe.

Lee, the founder of Hong Kong’s Democratic Party, wrote in an April 21 column in the Washington Post that he was arrested for taking part in protests last year against an extradition bill— now withdrawn— which would have allowed the Chinese government to extradite alleged criminals from Hong Kong to the mainland to stand trial.

Hong Kong is currently facing two plagues from China, Lee wrote: the coronavirus (COVID-19) and “attacks on our most basic human rights.”

“We can all hope a vaccine is soon developed for the coronavirus. But once Hong Kong’s human rights and rule of law are rolled back, the fatal virus of authoritarian rule will be here to stay,” Lee wrote.

He said that the free press in Hong Kong was vital for alerting the world to the dangers of the coronavirus, even as Chinese state media sought to repress information about the outbreak.

Now, Chinese authorities are attempting to pass legislation to increase their influence over Hong Kong, Lee said.

Hong Kong is a special administrative region of China. Hong Kongers enjoy freedom of worship and evangelization, while in mainland China, there is a long history of persecution for Christians who run afoul of the government.

In January, China appointed Luo Huining as the head of the powerful Central Liaison Office in Hong Kong. Luo last week intensified calls for Communist China to exercise more control in Hong Kong by passing “national security legislation.”

The legislation would outlaw “sedition, subversion and the theft of state secrets,” Lee wrote.

This is not the first time the legislation has been introduced— in 2003, widespread protests against the measure led China to withdraw it.

The passing of such a “subversion” law would give China even more power to quash Hong Kongers’ freedoms, Lee warned.

“These vague standards are designed to protect the Chinese Communist Party and undermine core freedoms of Hong Kong, such as freedoms of religion, assembly and the press — including the reporting of pandemics that embarrass Beijing,” he wrote.

The Justice and Peace Commission of the Diocese of Hong Kong released a statement condemning the arrests April 18, calling for an end to all arrests until an independent commission can be established, and for the police to return the mobile phones of all arrested persons in order to ensure their privacy.

The diocese also reiterated that the government must respond to the demands for which the pro-democracy demonstrators have been calling for months, which include an independent inquiry into police tactics.

A Hong Kong friend of Lee, who declined to be identified for safety, said they believe Sun Li Jun— the deputy public security minister for Hong Kong who oversees the Chinese secret police— wanted to send a message of power ahead of Chinese Workers’ Day celebration on May 1.

The friend believes Sun— who is reportedly under investigation by China for corruption— ordered the arrests to show that the authorities have control of the pro-democracy movement in Hong Kong.

“As the followers of God, we will keep praying for [Hong Kong] and let our Lord lead the way,” Lee’s friend told CNA.

“In HK we all love China and Chinese people but we are against CCP [Chinese Communist Party] for what they did to all of us now and before.”

An estimated 1 million protesters turned out at the first major pro-democracy demonstration in Hong Kong on June 6, 2019.

Catholics have played a major role in the protests, which continued after the extradition bill was revoked. Protestors largely called for the resignation of chief executive Carrie Lam— herself a Catholic— more open elections in the region, and an investigation into police brutality allegations.

In October, the legislature of Hong Kong completed the process of officially withdrawing the controversial extradition bill.

“Had the extradition bill been passed, we could have faced trial already in China instead of Hong Kong,” Lee noted in his column.

The impetus for the bill was a case involving a young Hong Kong man whom Taiwan requested be extradited for an alleged murder. Hong Kong previously has no formal extradition agreements with mainland China or Taiwan.

Christians and advocates widely opposed the bill, fearing that the Chinese government, which already seeks to control and suppress Christianity on the mainland, would use it to further tighten its grip on free exercise of religion in Hong Kong.

 

The Freedom Climbers remain encouraged through increasing altitudes and dropping temperatures as they continue upward to Mt. Everest Base Camp and Kala Patthar Peak.

FRANKLY? The restaurant world is going mad. Consider this: I order a home delivery from Yu-ca-taco early on Friday evening. For Saturday night. By text of course.

The Meadowbank Stadium was one of the shabbier landmarks in east Edinburgh until it was knocked down last year. A new one is rising from the ashes, looking like one of those massive cruise liners that appear in the Forth.

The evidence that culturally responsive teaching can fix the nation's schools for children of color is promising, but woefully incomplete, writes Heather C. Hill.

Conduct problems, substance use, substance use problems, and depressive symptoms increase as black adolescents enter high school. Although family-centered prevention programs deter these problems during middle school, no such programs have been developed and evaluated for black high school students.

This study demonstrates that participation in a family-centered preventive intervention reduces conduct problems, substance use, and substance use problems among black adolescents by more than 30% compared with adolescents in an attention control condition across nearly 2 years. (Read the full article)

Nasal continuous positive airway pressure (NCPAP) is a noninvasive ventilatory support that may reduce the need for mechanical ventilation in preterm infants with respiratory distress syndrome. Heliox, a helium-oxygen mixture, has shown positive effects, especially in obstructive diseases.

NCPAP with heliox reduces the need for mechanical ventilation in preterm infants with respiratory distress syndrome in comparison with NCPAP with medical air. (Read the full article)

There are a number of effective interventions designed to prevent childhood/adolescent depression. Such interventions tend to comprise screening and the subsequent provision of psychological therapy. However, the cost-effectiveness of routinely providing such interventions at a population level is not known.

By using economic modeling techniques, this study shows that the population cost-effectiveness of such preventive interventions for childhood/adolescent depression is very favorable, although implementation issues, particularly around the acceptability to providers, need to be addressed before widespread adoption. (Read the full article)

Subjects born preterm have higher blood pressure (BP) in childhood and adolescence. Little is known about at what age the deviation from normal BP starts, and data are especially scarce for the new generation of survivors after extremely preterm birth.

In a population-based study, we found that BP was higher in 2.5-year-old children born extremely preterm compared with controls. This finding might have implications for follow-up programs after preterm birth, with the goal of improving later cardiovascular health. (Read the full article)

As a result of safety and environmental concerns about mercury, aneroid sphygmomanometers have replaced mercury-filled devices for blood pressure measurements. Despite this change, few studies have compared the 2 devices.

Little clinical variation exists between blood pressure measurements obtained from an aneroid or mercury device, suggesting that either device could be used in a research or clinical setting. (Read the full article)

Although obesity is correlated with levels of systolic and diastolic blood pressure, there is little evidence if the increases in obesity over the last 40 years have resulted in increased blood pressure levels.

Despite increases in obesity in Bogalusa, Louisiana between 1974 and 1993, there was no increase in systolic or diastolic blood pressure levels. It should not be assumed that trends in high blood pressure have paralleled those for obesity. (Read the full article)

Few longitudinal studies from developing countries have assessed the relation between early maternal depressive symptoms and child growth beyond age 2. The results of these studies have been inconclusive.

Early maternal depressive symptoms were related to higher odds of deficits in stature but not to deficits in weight among preschool- and school-aged children. Well-child care provides opportunities to identify maternal depressive symptoms to prevent future child growth delays. (Read the full article)

High blood pressure in childhood predisposes people to hypertension in adulthood and is associated with early development of cardiovascular disease and risk for premature death. High sodium intake and overweight/obesity are recognized as risk factors for hypertension in children.

These results show that usual sodium intake was positively associated with systolic blood pressure and risk for pre-high blood pressure and high blood pressure among US children. The data indicate a synergistic interaction between sodium intake and weight status on risk for high blood pressure. (Read the full article)

Most studies on corticoid treatment of respiratory syncytial virus (RSV) respiratory diseases have revealed no beneficial effect. The mechanism by which RSV respiratory-infected patients are insensitive to the antiinflammatory effect of corticosteroids is unknown.

This study helps to understand how a respiratory syncytial viral infection may alter the normal antiinflammatory response to cortisol and the insensitivity to glucocorticoid treatment. The increase expression of β glucocorticoid receptor could be a marker of disease severity. (Read the full article)

Adult patients with neurocardiogenic syncope have shown high rates of depression. Patients with more severe depressive symptoms have higher rates of syncope recurrence. Psychiatric interventions improve quality of life and decrease syncope recurrence rates.

Children with neurocargiogenic syncope presented a 2.6-fold higher rate of clinically significant depressive symptoms compared to healthy controls. No recurrent syncope was noted during follow-up which along with improvement in family functioning predicted depressive symptoms improvement. (Read the full article)

Nasal continuous positive airway pressure (NCPAP) is commonly given to premature infants with nasal prongs and nasal masks. Prongs and masks appear to injure the nose of preterm infants with equal frequency.

Nasal masks are more effective than nasal prongs for preventing intubation and mechanical ventilation in premature infants within 72 hours of starting NCPAP. (Read the full article)

Hypothalamic-pituitary-adrenal axis suppression caused by inhaled corticosteroids is considered rare. Adrenal crisis has been described in children treated with high doses of inhaled fluticasone propionate. It was recommended that doses licensed for children should not be exceeded.

Biochemically confirmed hypothalamic-pituitary-adrenal axis dysfunction may occur in two-thirds of children treated with corticosteroids. Suppression may occur at low doses and especially with concomitant nasal steroids. Children with poor adherence or obesity may be less prone to adrenal crisis. (Read the full article)