On June 25, 2018 I woke up to yet another social media trend – a news story with the bold and quite salacious headline “How Safe Are Customer Deposits At FCMB?” had taken over the digital airwaves. Between the shares and likes and comments, a storm in a cup had brewed to great proportions in […]

The Worrisome Trend of Sensational Social Media “Journalism” and the Impact On Legitimate Business Concerns: Recent Travails of FCMB, GTBank and First Bank

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

A ruling upholding the constitutionality of the Bangsamoro Organic Law but excluding Sulu from the Bangsamoro Autonomous Region in Muslim Mindanao is immediately executory, according to the Supreme Court.

Huge crowds of antigovernment protesters Saturday encircled the Serbian state television building in downtown Belgrade to press their demand for autocratic President Aleksandar Vucic to ease his tight grip on the mainstream media and allow alternative voices. Tens of thousands of opposition supporters, some chanting slogans urging Vucic's resignation, streamed into the rain-drenched streets a day after the president's followers staged an equally big rally in the capital. Most of his supporters were bused into the capital from all over Serbia and some neighboring states. Outside the RTS TV headquarters, the crowds blew whistles and booed loudly. They say that according to the laws, state TV should be unbiased as a public broadcaster, but that it has been openly pro-government. Held for the fourth time since the early May shootings, the opposition-led protests appear to be shaping up into the biggest revolt against Vucic's autocratic rule during his over 10 years in power. The rallies initially erupted in response to two back-to-back mass shootings earlier this month that left 18 people dead and 20 wounded, many of them children from an elementary school. Other protest demands include the resignations of top officials and the revoking of licenses for pro-government media that air violent content and host crime figures and war criminals. Vucic has accused the opposition of abusing the shooting tragedy for political ends. Earlier Saturday, he stepped down from the helm of his populist party amid plans to form a wider political movement. Vucic named his close ally, Milos Vucevic, the current defense minister, as his successor. Holding umbrellas amid heavy rain Saturday, the protesters walked slowly around the RTS television building in central Belgrade, completely covering the streets in the entire area. Many held flowers in memory of the slain children and wore badges reading "vulture" or "hyena," mocking the expressions that officials used to describe the protesters. Vucic has said the new, national movement will be formed in June to include other parties, experts and prominent individuals and promote unity. Analysts say it is a bid to regroup amid mounting public pressure. Critics say the movement could lead to single-party rule, more or less as the case in Vladimir Putin's Russia, which Vucic supports. During the rally Friday, Vucic offered dialogue as he seeks ways to ease mounting public pressure. Opposition parties have pledged to press on with the demonstrations until their demands are fulfilled. They include the ouster of the interior minister and the intelligence chief; the revocation of nationwide broadcast licenses for two pro-government TV stations; and the dismissal of a media-monitoring body. "If they don't fulfill (the demands) we are not leaving from here," said Milica Tomic, a Belgrade resident. "We will be here, if it need be, every day, every week, whenever."

At a recent media briefing, Maria Zakharova, the spokesperson for Russia’s Foreign Ministry, criticized the United States for its support of educational programs, media and NGOs in Africa. Zakharova argued that these efforts are part of a broader attempt by the U.S. to impose Western values and governance models on sovereign African states, framing it […]

MANILA, Philippines — Former President Rodrigo Duterte has challenged the International Criminal Court (ICC) to immediately begin its investigation into alleged crimes against humanity committed during his administration’s anti-drug campaign, saying he might die before the probe even begins. During a House quad committee hearing on Wednesday, Gabriela Party-list Rep. Arlene Brosas asked Duterte if he would cooperate with the investigation, including that of the ICC. In response, Duterte said the ICC is welcome to start its probe as soon as tomorrow (Thursday). “ICC, Ma’am?  I am asking the ICC to hurry up, and if possible, they can come here […]...

Keep on reading: Duterte dares ICC to begin probe immediately: 'Baka mamatay na ako'

Qatar is arguing that it won’t act as a mediator any longer, threatening the fate of the hostages because a deal would be harder without Doha in the middle.

Russian warship armed with hypersonic missiles trains in English Channel, state media reports

The Asian Development Bank (ADB) has provided loans to financial intermediaries to support projects “whose individual financing requirements are not large enough to warrant the direct supervision of ADB.”

we profit from social media a social strategy

There are many scary claims about excess time on digital devices for children and teenagers. Here’s a guide to the real risks - and what to do about them

Title: Chronic Media Multi-Tasking Makes It Harder to Focus
Category: Health News
Created: 8/24/2009 4:10:00 PM
Last Editorial Review: 8/25/2009 12:00:00 AM

Title: ALS Ice Bucket Challenge Blows Up Social Media
Category: Health News
Created: 8/23/2014 11:01:00 AM
Last Editorial Review: 8/25/2014 12:00:00 AM

Respiratory syncytial virus (RSV) is a major global pathogen, causing lower respiratory tract disease in at-risk populations including young children. Antibodies form a crucial layer of protection from RSV disease, particularly in immunologically naïve infants. Such antibodies are derived from the mother via transplacental transfer and breast milk, but may be particularly low in high-risk infants such as those born preterm. Maternally derived antibodies can now be supplemented by the administration of anti-RSV monoclonal antibodies, while a rising wave of maternal and paediatric vaccine strategies are approaching. The implementation of these prophylactics may profoundly decrease the healthcare burden of RSV. In this article, we review the role of antibody-mediated immunity in protecting children from RSV. We focus on maternally derived antibodies as the main source of protection against RSV and study factors that influence the scale of this transfer. The role of passive and active prophylactic approaches in protecting infants against RSV are discussed and knowledge gaps in our understanding of antibody-mediated protection against RSV are identified.

The dorsal vagal complex contains three structures: the area postrema, the nucleus tractus solitarii, and the dorsal motor nucleus of the vagus. These structures are tightly linked, both anatomically and functionally, and have important yet distinct roles in not only conveying peripheral bodily signals to the rest of the brain but in the generation of behavioral and physiological responses. Reports on the new discoveries in these structures were highlights of the symposium. In this outlook, we focus on the roles of the area postrema in mediating brain–body interactions and its potential utility as a therapeutic target, especially in cancer cachexia.

Many RNA-binding proteins (RBPs) contain low-complexity domains (LCDs) with prion-like compositions. These long intrinsically disordered regions regulate their solubility, contributing to their physiological roles in RNA processing and organization. However, this also makes these RBPs prone to pathological misfolding and aggregation that are characteristic of neurodegenerative diseases. For example, TAR DNA-binding protein 43 (TDP-43) forms pathological aggregates associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). While molecular chaperones are well-known suppressors of these aberrant events, we recently reported that highly disordered, hydrophilic, and charged heat-resistant obscure (Hero) proteins may have similar effects. Specifically, Hero proteins can maintain the activity of other proteins from denaturing conditions in vitro, while their overexpression can suppress cellular aggregation and toxicity associated with aggregation-prone proteins. However, it is unclear how these protective effects are achieved. Here, we used single-molecule FRET to monitor the conformations of the aggregation-prone prion-like LCD of TDP-43. While we observed high conformational heterogeneity in wild-type LCD, the ALS-associated mutation A315T promoted collapsed conformations. In contrast, an Hsp40 chaperone, DNAJA2, and a Hero protein, Hero11, stabilized extended states of the LCD, consistent with their ability to suppress the aggregation of TDP-43. Our results link single-molecule effects on conformation to macro effects on bulk aggregation, where a Hero protein, like a chaperone, can maintain the conformational integrity of a client protein to prevent its aggregation.

Organic anion transporting polypeptides (OATP, gene symbol SLCO) are well-recognized key determinants for the absorption, distribution, and excretion of a wide spectrum of endogenous and exogenous compounds including many antineoplastic agents. It was therefore proposed as a potential drug target for cancer therapy. In our previous study, it was found that low-dose X-ray and carbon ion irradiation both upregulated the expression of OATP family member OATP1A2 and in turn, led to a more dramatic killing effect when cancer cells were cotreated with antitumor drugs such as methotrexate. In the present study, the underlying mechanism of the phenomenon was explored in breast cancer cell line MCF-7. It was found that the nonreceptor tyrosine kinase v-YES-1 Yamaguchi sarcoma viral oncogene homolog 1 (YES-1) was temporally coordinated with the change of OATP1A2 after irradiation. The overexpression of YES-1 significantly increased OATP1A2 both at the mRNA and protein level. The signal transducer and activator of transcription 3 (STAT3) pathway is likely the downstream target of YES-1 because phosphorylation and nuclear accumulation of STAT3 were both enhanced after overexpressing YES-1 in MCF-7 cells. Further investigation revealed that there are two possible binding sites of STAT3 localized at the upstream sequence of SLCO1A2, the encoding gene of OATP1A2. Electrophoretic mobility shift assay and chromatin immunoprecipitation analysis suggested that these two sites bound to STAT3 specifically and the overexpression of YES-1 significantly increased the association of the transcription factor with the putative binding sites. Finally, inhibition or knockdown of YES-1 attenuated the induction effect of radiation on the expression of OATP1A2.

Between 2005 and 2021, Facebook, Twitter and YouTube were more likely to make policy changes in the weeks after negative stories in the media

Narratives around addiction often reduce it to a series of poor choices, lack of values and weakness. This has real-world consequences, warns Anna Wolfe

People who went from using social media for at least 2 hours a day to just 30 minutes a day reported no improvement to their sleep or emotional well-being

Social media commentators claimed Jill Biden refused to look at Vice President Harris as they were seated together at Arlington Cemetery for a Veterans' Day Remembrance.

Dallas Mavericks minority owner Mark Cuban returned to the Bluesky social media platform with a post after weeks of contentious X posts.

Brianna Ghey's mother, Esther Ghey, is now campaigning to raise awareness about the dangers of social media and the "toxic" online world which her daughter came to inhabit. She wants tighter regulation on internet access and more parental controls.

If the legislation is passed, social media platforms including X, TikTok, Instagram and Facebook would have one year to work out how to exclude Australian children.

The addition of Discover to LabX’s portfolio strengthens its position as a leading voice in science and research media, bringing one of the most recognized science publications into its family.

A Canada Border Services Agency superintendent is speaking out after being targeted by the Indian government with allegations of murder and terrorism — allegations Canadian authorities say are not backed by any evidence.

Raising deep concern over the partnership between Swiggy Instamart and PharmEasy for a rapid drug delivery model, the All India Organization of Chemists and Druggists (AIOCD) has apprised the Drug Controller

Jardiance is a popular drug used to treat type 2 diabetes and help reduce cardiovascular risk. DTC campaigns […]

In July 2024, internet personality Bobby Saputra posted a video of himself living it up at what appeared to be the star-studded, ultra-lavish wedding of Radhika Merchant and Anant Ambani, the youngest child of Indian billionaire and Asia's richest man, Mukesh Ambani. The video featured clips of Saputra dancing, feasting and soaking up the "completely crazy" celebrations. He gushes in the voiceover: "It was like watching a Bollywood production." The video quickly went viral, racking up 6.6 million views on Instagram, 5.1 million on TikTok, and another 2.2 million on YouTube. Thousands left comments, including some celebrities who claimed they spotted him there. Except… he never set foot in the party. As it turns out, he had pieced together clips from a wedding he attended a few months prior — complete with him in full Indian attire, dancing with friends — and spliced in shots from the Ambani wedding that he found online. The result? Social media magic.

Mar 13, 2024

Social media’s unregulated evolution over the past decade holds a lot of lessons that apply directly to AI companies and technologies.

John Sculley introduces his new multimedia business learning series �How to Build a Successful Business�

Rob Riggle Stars alongside Brice Williams in the newest Easter Seals Dixon Center PSA, directed by Jim Fabio with support from Judd Apatow

Volvo Cars and Ericsson developing intelligent media streaming for self-driving cars

With a Keurig� in every room at Holiday Inn Express� hotels, smart travelers � like actor/comedian Rob Riggle � can get a great cup of coffee with just the push of a button.

EAMF 2016 Highlights

Dr Aluvihare

Eva Longoria :30 English

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