Three portraits from yesterday's Blackpool Pride Festival in Blackpool, all of which were shot with the Fujifilm X-T1 and 90mm f/2 (my new favourite lens). As always, it was a great event, with lots of great characters.

While pretty much everyone enjoyed the Blackpool Pride Festival there were a handful of slightly less cheerful folk.

Gentle Readers, here is another treat for us while we are confined to our homes. We may even be able to lure Dorothy away from her garret for this one. Streaming Musicals will present a free streaming event of Paul Gordon’s musical adaptation of Pride and Prejudice on Friday, April 10, 2020 at 6:30 p.m.…

IBM (NYSE: IBM) et Boursorama, filiale du groupe Société Générale, renouvellent leur accord par la signature d’un contrat de Cloud hybride d’une durée de 5 ans afin d’enrichir l'offre de nouveaux produits et services proposés par la banque.

A l’occasion de VMworld® 2016, VMware, Inc. (NYSE : VMW) et IBM (NYSE : IBM) annoncent la disponibilité de services Cloud d’un genre nouveau, permettant aux entreprises de migrer rapidement et simplement des ressources informatiques d’entreprise vers le Cloud. Avec déjà plus de 500 clients concernés, le partenariat mondial entre IBM et VMware aide de plus en plus d’organisations à étendre leurs ressources informatiques existantes vers le Cloud en quelques minutes au lieu de plusieurs semaines ou mois.

IBM Australia partners with Australia’s first Pride Centre to connect LGBTIQ community in Australia

Ride like the wind! This song reminds me of taking a long trip on a big V4 motorcycle, V-Max, it stands up on it’s center stand chrome sparkling in the street lights, it has a physical presence almost deadly, it radiates power, four chromed exhausts a huge 1800cc V4 just waiting for you to climb...

After finding out about their co-worker’s secret on-the-job fuck spot, Riley Mitchel and Jack Andy sneak away the first chance they can get to check it out for themselves. They agree it’s a perfect spot where no one else would think to look for them, and not wanting to be outdone by their co-worker, they... View Article

The post PrideStudios: Jack Andy and Riley Mitchel appeared first on QueerClick.

Never scoff at the hint option!

Today our last in Goa finds us up early and waiting outside for our driver at 6.30am as we're heading to Dudhsager Falls. These falls form part of the border between Goa and Karnataka and are India's 5th highest waterfall.At around 120klm for the re

I decided to introduce my son to video games. We soon found one he liked … and I mean really, really liked

So I decided to introduce my two-year-old son to the world of video games. Before you accuse me of hobbling my offspring's mind, I'd like to point out that a) television is 2,000 times worse, so shove that up your Night Garden and b) I also decided to counterbalance the gaming with exposure to high culture. For every 10 minutes of Fruit Ninja during daylight hours, he'd get 10 pages of a critically acclaimed novel at bedtime. We're currently halfway through The Magus by John Fowles, which he's enjoying immensely. He finds some passages so moving that his protracted sobs drown out my reading completely, and when I return to the beginning of the chapter to start again, he leaps up screaming, trying to snatch the book out of my hands with delight.

Like any self-respecting 2014 toddler, he can swipe, pat and jab at games on a smartphone or tablet, but smartphone games aren't real games. They're interactive dumbshows designed to sedate suicidal commuters. And they're not just basic but insulting, often introducing themselves as free-to-play simply so they can extort money from you later in exchange for more levels or less terrible gameplay. Either that or they fund themselves with pop-up adverts that defile the screen like streaks on a toilet bowl.

We estimate valuations of time using detailed consumer choice data from a large European ride hail platform, where drivers bid on trips and consumers choose between a set of potential rides with different prices and waiting times. We estimate consumer demand as a function of prices and waiting times. While demand is responsive to both, price elasticities are on average four times higher than waiting-time elasticities. We show how these estimates can be mapped into values of time that vary by place, person, and time of day. Regarding variation within a day, the value of time during non-work hours is 16% lower than during work hours. Regarding the spatial dimension, our value of time measures are highly correlated both with real estate prices and urban GPS travel flows. A variance decomposition reveals that most of the substantial heterogeneity in the value of time is explained by individual differences as opposed to place or time of day. In contrast with other studies that focus on long run choices we do not find evidence of spatial sorting. We apply our measures to quantify the opportunity cost of traffic congestion in Prague, which we estimate at $483,000 per day.

Australian jockey Luke Tarrant has been given a six-month ban after head-butting fellow rider Larry Cassidy during an altercation at Doomben.

Experiments in Chile’s Atacama Desert point to a potential method of transportation for microbes on Mars—whether they exist there already, or we introduce them.

Best known for their aluminum products, Newmen's new carbon fiber wheelset is aimed at enduro riders.
( Photos: 10, Comments: 96 )

Isaiah Mobley has learned to deal with adversity since arriving at USC as one of the top college basketball recruits in the nation.

Stuck in coronavirus lockdown, all I wanted to do was sleep in and eat toast. And then I rediscovered my bike.

Pae White's art installations at the Beverly Center have taken over the walls along the five-story escalators.

I would make the drive nearly every weekend, braving the Friday traffic and returning late Sunday night. I did this willingly and savored the time in L.A. with him. But how did he feel? Was I just an easy ride?

Disneyland is closed -- but that hasn't stopped fans from building their own theme park rides and attractions in their homes and backyards.

Kathy Valentine's hair-raising memoir recounts life before, during and shortly after the Go-Go's ascended to become the darlings of the MTV generation.

"I joined ICA to fulfil my biggest dream: Racing in the World Tour and Tour De France!" 23-year-old Chokri Elmehdi from Morocco said.

Transportation options for wheelchair users, especially those riders who use a fixed-frame wheelchair, have grown but are still limited.

The Fiat 500X offers a much sportier driving experience than the Fiat 500 thanks to an all-new 1.3-liter turbocharged engine.

Lowrider magazine was once among the bestselling newsstand automotive periodicals in the country. After 42 years, it will cease to print this year.

Rogosin's longest-running success was the classic TV western 'The Virginian'

The Virtual Grand National takes place today and Express Sport is on hand with the full list of runners and riders.

THE QUEEN's powerful VE Day speech touched the hearts of Britons around the country as she reflected on her personal memories of World War 2 and sent her "warmest good wishes" to everyone celebrating in lockdown.

In IndyCar Series history, driver Helio Castroneves ranks second in second-place race finishes. His legacy, beyond being a three-time Indianapolis 500 winner, might be that of being this era's bridesmaid.

The Hoosiers' offensive line loses key leaders, with graduation of Simon Stepaniak and Hunter Littlejohn and transfer of Coy Cronk.

We hear about the book that is 85% classic literature, 15% zombie horror. How did Jane Austen get so mashed-up?

As COVID-19 continues to shut down sporting events across the globe, a former Roughriders’ CEO says it could be the greatest threat the CFL has ever faced.

The game is a beautiful marriage of aesthetics and gameplay. It has the makings of a minor classic.

A Chicago cyclist was injured by an electric scooter rider who fled the scene. Now he's gone to court to get the city's scooter companies to turn over personal information about their riders and their history.

Zum announced that it is expanding to a half dozen other cities around the county, including San Diego, Miami, Phoenix, Dallas, Chicago and the D.C. area.

• While ride-hailing has suffered from the impact of COVID-19, Uber is in a good position to survive the crisis, three analysts who cover the company told Business Insider.
• Uber is in no danger of running of out money anytime soon, said Mark Mahaney, a managing director at RBC Capital Markets.
• And a series of cost-cutting moves should make the company profitable by next year, said Dan Ives, a managing director of equity research at Wedbush Securities.
• Uber's food-delivery service, Uber Eats, gives the company an advantage over ride-hailing competitors, since it allows homebound consumers to keep using its app, said Tom White, a senior research analyst at DA Davidson.
• Are you a current or former Uber employee? Do you have an opinion about what it's like to work there? Contact this reporter at mmatousek@businessinsider.com. You can also reach out on Signal at 646-768-4712 or email this reporter's encrypted address at mmatousek@protonmail.com.
• Visit Business Insider's homepage for more stories.

The ride-hailing industry has taken a major hit from COVID-19 as potential customers remain confined to their homes, but Uber is in a good position to survive the crisis, three analysts who cover the company said.

"Their business model will be intact on the other side of this," said Dan Ives, a managing director of equity research at Wedbush Securities.

A strong cash reserve will help. After ending the first quarter with $9 billion in cash and short-term investments, Uber has the resources to survive a scenario in which the prevalence of COVID-19 and its effect on consumer behavior last for the next two years, said Mark Mahaney, a managing director at RBC Capital Markets.

On Thursday, Uber disclosed its first-quarter financial results, reporting an adjusted loss of $2.9 billion on revenue of $3.5 billion during the first three months of this year. Uber CEO Dara Khosrowshahi said on a call with analysts that the ride-hailing company would cut $1 billion in fixed costs. The company has recently removed its food-delivery service — Uber Eats — from eight unprofitable markets, folded its electric bike and scooter business into Lime (Uber recently led a $170 million investment round in the company), and announced it will lay off about 14% of its workforce.

Those moves should help Uber become profitable in 2021 (the company predicted in February that it would turn a profit by the end of this year), Ives said. Uber's management, which had struggled in the wake of the company's 2019 IPO, has performed well in the current crisis by being transparent with investors and quickly moving to reduce expenses, Ives said. Investors signaled their approval of the company's strategy by sending shares up as much as 8% in after-hours trading on Thursday.

Uber Eats was one of the highlights of the company's first-quarter results, said Tom White, a senior research analyst at DA Davidson, as gross bookings grew 52% from the first quarter of 2019 to $4.7 billion. Eats gives Uber an advantage over ride-hailing competitors that don't have a similar service, as it allows the company to keep homebound consumers using its app, White said. Even after the toll of COVID-19 begins to subside, demand for online food delivery could see continued growth, he added.

But there are still challenges ahead for Uber. The company said rides fell by as much as 80% in April, and Ives projects that 30% of the customers for gig-economy companies like Uber, Airbnb, and Lyft won't use a ride-hailing service until there's a vaccine for COVID-19. Yet the pandemic could leave Uber better off in the long run, White said.

"I saw and heard enough [during Uber's first-quarter earnings call] that makes it harder and harder for me to think that these guys don't emerge from this pandemic probably in a stronger competitive position and a healthier and leaner operating position," he said.

Are you a current or former Uber employee? Do you have an opinion about what it's like to work there? Contact this reporter at mmatousek@businessinsider.com. You can also reach out on Signal at 646-768-4712 or email this reporter's encrypted address at mmatousek@protonmail.com.

• Read more:
• Uber CEO Dara Khosrowshahi says drivers should receive tiered healthcare benefits based on how many hours they work, and that the company would pay for it
• SoftBank-backed companies laid off more than 3,700 people in 2020 and more than 7,000 in the past year
• Uber reveals first-quarter losses of $2.9 billion because of the coronavirus — but says business is starting to pick up again
• Lyft surges 17% after posting a narrower-than-expected quarterly loss as coronavirus hit the ride-hailing industry

SEE ALSO: Elon Musk's theater of the absurd is a sign of the times for tech

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NOW WATCH: Why Pikes Peak is the most dangerous racetrack in America

Hear about travel to The Hebrides as the Amateur Traveler talks to Matt Higgs about his trip to these remote islands in Scotland.

The following article, Donald Trump Jr. Offers To Walk Bride-to-Be Down The Aisle After Liberal Parents Refuse To Attend Her Wedding Because Fiance Is A Conservative, was first published on 100PercentFedUp.com.

TDS or Trump Derangement Syndrome brings out the worst in a lot of people. One young Texan girl’s story of her intolerant parents who refuse to attend her wedding because she’s marrying a conservative, however, is a new low. Lawyer and conservative civil rights activist, Rogan O’Handley tweeted a Tik Tok video of a Texan […]

Continue reading: Donald Trump Jr. Offers To Walk Bride-to-Be Down The Aisle After Liberal Parents Refuse To Attend Her Wedding Because Fiance Is A Conservative ...

Although a robust inflammatory response is needed to combat infection, this response must ultimately be terminated to prevent chronic inflammation. One mechanism that terminates inflammatory signaling is the production of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway. Whereas most genes in the TLR pathway encode positive mediators of inflammatory signaling, several, including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms that encode dominant-negative inhibitors of the response. Production of these negatively acting alternatively spliced isoforms is induced by stimulation with the TLR4 agonist lipopolysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents chronic inflammation. In the current study, we investigated the mechanisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macrophages. We found that 1) the induction of the alternatively spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulatory mechanism, 2) MyD88 splicing is regulated by both the MyD88- and TRIF-dependent arms of the TLR signaling pathway, 3) MyD88 splicing is regulated by the NF-κB transcription factor, and 4) NF-κB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing indirectly by altering MyD88 transcription. We conclude that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.