Telugu actor Mohan Babu completed 40 years in film industry, and he celebrated with a grand event at the Indira Priyadarshini grounds in Visakhapatnam city, Andhra Pradesh.

DIY dresses, rainbow-themed make up, and metallic bomber jackets took over Egmore at the 16th edition of the Chennai’s Self-Respect Rainbow Pride March, taking the fashion game up a notch

Gaurav Mehta, the founder-designer of Jaipur Watch Company, talks about his latest collection, watches as storytelling devices, his philosophy of time, and more

Women are more than capable of saving themselves, says Phuphee. They don’t need magic, maybe just a helping hand

Agency commits to action on CH₂Cl₂ in consumer and commercial products

Catalyst spurs insoluble salts into action as nucleophiles for enantioselective reactions

Questions remain about the safety and effectiveness of alternative solvents

The Bentayga can go from a standstill to 100 km/hr in 4.5 seconds, and, if you can keep your foot down, the speedometer will climb all the way to 290 km/hr!

Hyundai Motor India expects its SUV range to gain further traction in the domestic market with demand for personal mobility gaining momentum post the second wave of COVID-19, according to a senior company official.The company, which already leads the SUV space with models like Venue, Creta, Tucson and recently launched Alcazar, is looking to maintain its lead in the segment which is growing with each passing month.

Gayle and de Villiers too join the party in making Kolkata Knight Riders's challenging total seem small

Half of Gujarat Lions worries will be taken care of if the dazzling opening combo of Dwayne Smith and Brendon McCullum fires.

Injuries to key players a concern for both teams; the winner will meet the loser of Qualifier 1 for a place in the final

Bowlers do the trick once again for the Hyderabad team, setting up a meeting with Lions

Iyer has captained Delhi Capitals to their only IPL final in 2020

He is the first Indian to hold that position for the two-time IPL champion

Redi-Go is easy to drive even in cities which are notorious for traffic conditions

Gaurav Siddharth, who is attempting a Guinness World Record for the longest motorcycle journey in a single country, on what drives him

Shravya Varma, the talented niece of film-maker Ram Gopal Varma, and badminton ace Srikanth Kidambi sealed their bond in a grand wedding ceremony in Hyderabad on Saturday.

The BigBasket and Portea Medical promoter expects to see venture debt rising as an asset class in India.

The post Critical to conserve cash and ride out the storm, says GrowthStory’s K Ganesh appeared first on DealStreetAsia.

The Japanese megabank and the Singapore-headquartered superapp get to plug gaps in their businesses.

The post How MUFG’s $700m investment in SoftBank-backed Grab is a three-way shared ride appeared first on DealStreetAsia.

Once the price war is over, we can all collaborate, says Blue Bird president director Noni Purnomo.

The post Taxis can coexist with ride-hailers, says Blue Bird president appeared first on DealStreetAsia.

In recent times, Indian IT industry has been one of the most plausible and impactful success stories, in various ways.

Alia Bhatt's traditional outfits have been aced by a number of brides. Recently, her Sabyasachi saree also inspired a bride-to-be. Sonia Wahlla wore the same Sabyasachi saree for her pre-engagement celebration in Vancouver, Canada. She looked elegant and let's

  Sridevi and Chiranjeevi starrer Telugu film, Jagadeka Veerudu Athiloka Sundari was released on 9 May 1990 and it turned out to be a blockbuster. In the film, veteran actress Sridevi portrayed the role of Indraja, who was a celestial being

K Raghavendra Rao's cult-classic Jagadeka Veerudu Athiloka Sundari starring Chiranjeevi and Sridevi, is all set to complete 30 years on May 9. On the occasion, Vyjayanthi Movies released a set of videos of Nani explaining the story behind the making of

1. This Red Dead Redemption II Mod Lets You Ride A Giant Cougar  Kotaku Australia
2. Red Dead Redemption 2 hog riding mod is even better than it sounds  GamesRadar+ AU
3. Ride tall, handsome hogs in this necessary RDR2 mod  PC Gamer
4. Red Dead Online: How to Enable Autopilot | Screen Rant  Screen Rant
5. This Red Dead Redemption 2 Theory Explains Dutch's Behavior | CBR  CBR - Comic Book Resources
6. View Full coverage on Google News

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The Sensational Grace Hotel, Santorini Islands

Check out travel recommendations at Wanderfly!

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Hucks, cases, mud, roots, and full commitment by all the riders. And tea drinking. Of course.
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The Ride of Your Life is raising money for the construction of a new bike park in Yellowknife.
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Although a robust inflammatory response is needed to combat infection, this response must ultimately be terminated to prevent chronic inflammation. One mechanism that terminates inflammatory signaling is the production of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway. Whereas most genes in the TLR pathway encode positive mediators of inflammatory signaling, several, including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms that encode dominant-negative inhibitors of the response. Production of these negatively acting alternatively spliced isoforms is induced by stimulation with the TLR4 agonist lipopolysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents chronic inflammation. In the current study, we investigated the mechanisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macrophages. We found that 1) the induction of the alternatively spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulatory mechanism, 2) MyD88 splicing is regulated by both the MyD88- and TRIF-dependent arms of the TLR signaling pathway, 3) MyD88 splicing is regulated by the NF-κB transcription factor, and 4) NF-κB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing indirectly by altering MyD88 transcription. We conclude that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.

Actinobacillus pleuropneumoniae (App) is the etiological agent of acute porcine pneumonia and responsible for severe economic losses worldwide. The capsule polymer of App serotype 1 (App1) consists of [4)-GlcNAc-β(1,6)-Gal-α-1-(PO4-] repeating units that are O-acetylated at O-6 of the GlcNAc. It is a major virulence factor and was used in previous studies in the successful generation of an experimental glycoconjugate vaccine. However, the application of glycoconjugate vaccines in the animal health sector is limited, presumably because of the high costs associated with harvesting the polymer from pathogen culture. Consequently, here we exploited the capsule polymerase Cps1B of App1 as an in vitro synthesis tool and an alternative for capsule polymer provision. Cps1B consists of two catalytic domains, as well as a domain rich in tetratricopeptide repeats (TPRs). We compared the elongation mechanism of Cps1B with that of a ΔTPR truncation (Cps1B-ΔTPR). Interestingly, the product profiles displayed by Cps1B suggested processive elongation of the nascent polymer, whereas Cps1B-ΔTPR appeared to work in a more distributive manner. The dispersity of the synthesized products could be reduced by generating single-action transferases and immobilizing them on individual columns, separating the two catalytic activities. Furthermore, we identified the O-acetyltransferase Cps1D of App1 and used it to modify the polymers produced by Cps1B. Two-dimensional NMR analyses of the products revealed O-acetylation levels identical to those of polymer harvested from App1 culture supernatants. In conclusion, we have established a protocol for the pathogen-free in vitro synthesis of tailored, nature-identical App1 capsule polymers.

An OMer learning Turkish was encouraged when she shared the message of the gospel with a taxi driver in a city in Western Turkey.