The Swedish automaker has added an entry-level version of the Polestar 3.

A 10-year-old autistic boy from California who was slapped by an irate Mercedes driver a few months ago received the surprise of his life recently when he was given an SUV.

A 10-year-old autistic boy from California who was slapped by an irate Mercedes driver a few months ago received the surprise of his life recently when he was given an SUV.

The Hyundai Ioniq 9 will debut at the LA auto show on Nov. 21 The Ioniq 9 will be an electric three-row crossover SUV built in Georgia The Ioniq 9 will share its underpinnings with the Kia EV9 and arrive in 2025 Hyundai on Wednesday released the another teaser for the Ioniq 9, a three-row electric SUV the automaker will unveil at the 2024 Los...

The Polestar 3 has been given a price cut for 2025, while the Polestar 2 is a lot more expensive The 2025 Polestar 3 now starts at $68,900 The 2025 Polestar 2 now starts at $66,200 Swedish performance EV brand Polestar is bringing down the starting price of some of its models in the U.S. while raising it on others. The U.S.-built Polestar 3...

In October 2024, both Dussehra and Diwali fell in the same month, traditionally boosting consumer demand and driving significant gains for the auto industry

Autor: knjizaraNOVA Naslov: Predstavljanje knjiga "Suvremeni hrvatski haiku - Nova antologija" i "Dosje i druge p
Postano: 13.11.2024. 14:09 (GMT 1) Društvo hrvatskih književnika i Klub knjižare Nova pozivaju Vas na predstavljanje knjiga "Suvremeni hrvatski haiku - Nova antologija" i "Dosje i druge priče".

Na predstavljanju sudjeluju: Nikola Đuretić, Tomislav Maretić i Mirko Ćurić.

Predstavljanje će se održati u Klubu knjižare Nova (Trg Ante Starčevića 4, Osijek) u subotu, 16. studenoga u 11 sati.

Radujemo se Vašem dolasku!

Senior Technician Bill McMillan works a bank of Magnecorders in the main control room of the new Broadcasting House, Fiji Broadcasting Commission, Suva, Fiji in 1954...

Isareli Racule was the first head of the Fiji section, Fiji Broadcasting Commision in 1954...

I am confused whether I should buy an Audi Q3 Premium Plus or a BYD Atto 3 Dynamic.

Lavya Garg, Gurugram

Autocar India says: Both are very different cars; one is combustion-engined, and the other an EV. The Audi is the safer choice as it feels more premium and can be taken anywhere without worrying about fuelling up. The Atto 3 doesn’t feel as premium but has a lot more tech that makes the Q3 look outdated. Being an EV, the Atto 3 is much easier to drive and has negligible running costs, but it will have poorer resale value.

Also See:

2022 Audi Q3 India review: Back with a bang

2022 Audi Q3 India video review

Audi Q3 Sportback review: The downsized Q8

BYD Atto 3 review: Characterful and slick to drive

BYD Atto 3 real world range test video

I am confused between the Mahindra XUV700 and the Mahindra Thar Roxx. We’re a family of six, and I need a powerful vehicle with ADAS.

Kaustubh Satish, Bengaluru

Autocar India says: As a family car, the XUV700 is a better choice as it is more spacious than the Thar Roxx, especially since you have six family members. The XU700’s second row is wider than the Roxx, so sitting three abreast isn’t as comfortable on the latter. Also, the XUV700 has a third row, which the Roxx doesn’t, and this is crucial for accommodating the sixth passenger. The XUV700 is also more powerful than the Roxx and comes with ADAS. The Roxx is meant for adventure seekers who also want an everyday car, but for your requirements, the XUV700 is the better choice.

Also See:

Mahindra Thar Roxx review: An SUV that does it all?

Mahindra Thar Roxx video review

2021 Mahindra XUV700 review, test drive

2021 Mahindra XUV700 video review

I currently drive a BMW X5, and I’m looking to upgrade to the Mercedes-Benz EQS SUV or the Range Rover Sport. What would you recommend?

Suraj M, Gurugram

Autocar India says: If you mainly drive within the city with the odd weekend outing, the EQS SUV is a good choice. It’s smoother and faster, has a futuristic interior and is far more refined than the Range Rover Sport. If you are planning to do a lot of highway driving, then the RR Sport is better. It also has a better back seat and more legroom than the EQS SUV. 

Also See:

New Range Rover Sport video review

New Range Rover Sport review: More than just good looks

Mercedes EQS SUV review: High on EQ

Mercedes EQS SUV video review

I am looking for a luxurious family car between Rs 1 crore and Rs 1.5 crore. We’re a family of five – three adults and two kids – so my priority is comfort. It needs to be a recognisable brand, have a decent road presence and have updated technology. I will be driving the car, but my usage will be very low. I can extend my budget slightly if you strongly recommend a car. I am not in favour of EVs and would prefer petrol.

Mohit Sarin, New Delhi

Autocar India says: There’s a fair bit of choice for your budget, but we would suggest you look at the Mercedes-Benz GLE. It has a good road presence, is a very strong brand, the back seat is spacious, the MBUX infotainment system has the best on-board tech, and it is fairly reliable.

Also See:

Mercedes Benz GLE facelift review: Small updates for big Merc SUV

Mercedes Benz GLE facelift video review

Mercedes-AMG GLE 53 Coupe review: The everyday AMG

I am looking for a luxurious family car between Rs 1 crore and Rs 1.5 crore. We’re a family of five – three adults and two kids – so my priority is comfort. It needs to be a recognisable brand, have a decent road presence and have updated technology. I will be driving the car, but my usage will be very low. I can extend my budget slightly if you strongly recommend a car. I am not in favour of EVs and would prefer petrol.

Mohit Sarin, New Delhi

Autocar India says: There’s a fair bit of choice for your budget, but we would suggest you look at the Mercedes-Benz GLE. It has a good road presence, is a very strong brand, the back seat is spacious, the MBUX infotainment system has the best on-board tech, and it is fairly reliable.

Also See:

Mercedes Benz GLE facelift review: Small updates for big Merc SUV

Mercedes Benz GLE facelift video review

Mercedes-AMG GLE 53 Coupe review: The everyday AMG

It was one of those perfect drives, a rare window of relative emptiness on India’s busiest highway. A mid-morning dash to the BU Bhandari showroom for the launch of the Mercedes-AMG GLC 43 was the easiest Mumbai-Pune trip I’ve done in a long time. Making the drive particularly relaxing was the new addition to Autocar India’s fleet, the all-electric Mercedes EQE SUV, which got its first highway outing.

It took just two hours and six minutes in the ultra-smooth (and quick) EQE SUV to go from the Autocar HQ to the BU Bhandari Showroom on the Pune bypass. That’s less than what many office folks take to get home on a typical working day in Mumbai. It does help that the AtalSetu has brought our office closer to the edge of Mumbai, and a 10:15am departure was a sweet spot (or time). The early-morning highway rush was over, the toll plazas had no long queues, and even the Lonavala Ghat, which is choked most of the day (and night) on Google Maps, was surprisingly ‘blue’. Traffic flowed without holdups, even on the steepest sections where trucks otherwise block all lanes while trying to ‘overtake’ at a crawl.

The Atal Setu is always a great place to try out the ADAS system on any car. The wide and perfectly marked lanes and the gentle curves on this 21km sea bridge were perfect for checking out the EQE SUV’s ‘Level 2’ ADAS capability. That meant letting the Adaptive Cruise Control (ACC), which I have set at 99kph (just below the 100kph speed limit), and the Lane Keep Assist do the work while I sat back and relaxed with just a light hand on the wheel, enjoying the harbour’s breathtaking views.

The Lane Keep Assist worked brilliantly, keeping the big Merc centred nicely in the fast lane. When changing lanes, I was impressed with how the ACC reacted smoothly. When you signal and shift into the overtaking lane, the ACC provides strong and linear acceleration without abrupt power surges to match the new lane’s speed.

While the ADAS in the Mercedes EQE SUV is highly advanced, it has some limitations, especially when dealing with erratic drivers who slice across lanes like it’s a normal thing to do. If some idiot abruptly cuts into your lane from a sharp angle, the ADAS can struggle to react promptly. This is not the case with just the EQE SUV – no ADAS is fully capable of handling such unpredictable events, which is a reminder of why the tech can only assist and not replace the driver.

Mercedes’ Active Brake Assist, while a great safety feature on paper, can become a nuisance – and even a potential hazard – in Mumbai’s chaotic traffic. Designed for controlled environments, it doesn’t quite account for the unpredictability of pedestrians darting across roads or scooters weaving through tight gaps. The system often triggers unnecessarily, slamming on the brakes at the slightest hint of an obstacle. In such congested conditions, this overly sensitive response can be more dangerous than helpful. These fierce and abrupt stops are hugely unnerving for the passengers and could catch a driver behind you off guard, increasing the risk of rear-end collisions. It’s best to switch the Brake Assist off, which you have to do every time you start the car.

The monsoons have made mincemeat of the Nhava Sheva road, which connects the Atal Setu to the Mumbai-Pune Expressway, and on such surfaces, the EQE SUV is out of its comfort zone. To be honest, it doesn’t quite live up to its SUV credentials and isn’t comfortable dropping in and out of potholes like its IC engine brethren. That’s because the softly sprung EQE SUV uses up its suspension travel quite easily, and deep ruts and craters crash through. In fact, it’s best to use ‘Sport’ drive mode as the default setting. The suspension feels overtly soft in Comfort and Normal modes, which is fine when you are crawling in rush hour, but up the pace a bit on even a slightly smooth road, and you’ll find the EQE SUV tends to wallow and feel floaty. In Sport mode, the suspension tightens nicely to give a more settled ride, which is what you want on the highway.

Two areas where the EQE SUV stands out are performance and range, and both are interlinked because, with great range, you can enjoy the performance without keeping an eye on the SOC meter.

Plant your foot down, and this big and heavy SUV lunges forward with an intensity that can take you aback but in a very pleasing way. The EQE SUV gathers with velvet smoothness, and before you know it, you’ve sailed past the speed limit. On the Mumbai-Pune expressway, which is now infested with speed cameras, it is hard not to get a speeding ticket. To stay out of trouble, I limit my indulgence to short jabs of the accelerator pedal just to enjoy all the 408hp and 858Nm of torque that puts most IC engine SUVs to shame.

I averaged 66kph on the 140km drive to BU Bhandari, which is pretty good if you consider that this included slow, non-expressway sections. Not that the expressway raises your average speed dramatically because with so many cameras staring at you, I’m forced to show a lot of restraint! With 332km range left, I didn’t need to use the Pune Mercedes dealers’ on-site 180kW fast charger, but it’s good to know that it’s there and that the dealership is happy to let non-Merc owners plug in as well. Located just off the Pune bypass, it’s an incredibly convenient place for EVs on a long-distance trip to Mahabaleshwar or beyond to quickly top up their batteries.

The return journey was equally uneventful. Using the regen down the Lonavala Ghat, I could extend the range even further, which, on this round trip, I calculated to be 504km. That is a truly impressive figure, considering how hard I was driving the EQE SUV. In fact, there was enough charge left in the battery (36 percent) for me to make another trip to Pune!

The other area where the EQE SUV shines is refinement. The EQE SUV is not just quiet; it’s like being inside a luxury vault on wheels. The adaptive air suspension noiselessly glides over any surface, and then there’s the acoustic insulation, which Mercedes has absolutely nailed. Road, tyre and wind noises, even the electric motor’s faint whir, are gone. The cabin is like a calm oasis, and that’s what makes the EQE SUV special. It is luxury in its most serene form.

Also see:

Mercedes EQE SUV vs Audi Q8 e tron vs BMW iX vs Jaguar I Pace comparison video

Mercedes CLE review: Breezy cruiser

New Mercedes-AMG C 63 S E Performance to launch on November 12

At a time when most passenger vehicle brands are shifting focus towards SUVs, Maruti believes it's crucial to have a strong product line-up across all mass-market segments, including sedans, for a high market share.

“Although the SUV segment is growing, all other segments are equally important for us; Because, to retain our high market share, we have to have a presence in each segment. Especially in the sedan segment, which is traditionally very important,” MD and CEO Hisashi Takeuchi said on the sidelines of the new Dzire launch.

1. Maruti has spent Rs 1,000 crore on developing the fourth-gen Dzire
2. Sedans currently account for around 8 percent of the total PV volume
3. Maruti aims to increase sedan market to 10 percent with the new Dzire

New Dzire to rejuvinate compact sedan segment 

Hatchbacks or small cars and sedans have seen a significant decline in sales over the past decade, leading automakers to put their major focus on SUVs, with several even vacating the small car space altogether. The sedan segment has also been missing major product action for some time now. For Maruti, however, things are slightly different, as the brand continues to focus on popular models like the Dzire, with timely updates and model changes.

“The compact sedan is a very reliable and stable segment. We can count on stable numbers all the time,” Takeuchi said. The automaker spent Rs 1,000 crore on the design, development, and production of the new 4th-generation Dzire, which comes with the Swift’s 1.2-litre three-cylinder Z12E engine and a slew of new features, including added safety tech.

With the new Dzire, the automaker expects to re-energise the segment. “Taking a long perspective, by 2030, we feel the passenger vehicle market will be around 60 lakh units and sedans will still have a reasonable pie of close to 10 percent,” said senior executive officer for Marketing and Sales Partho Banerjee.

Sedans currently account for around 8 percent of the total passenger vehicle volume and compact sub-4 meter models contribute to approximately 70 percent of that segment. Maruti Suzuki is the market leader in the compact sedan space with a share of around 60 percent. Last year, it sold around 1.6 lakh units of the Dzire.

The Dzire generates a significant part of its sales from the fleet segment, where it is exclusively sold as the low-frills 'Tour S' variant for fleet operators. Around 65-70 percent of the Dzire sales come from the personal segment, while the rest account for the fleet segment.

“With the previous-generation Dzire, there was a challenge to meet the different requirements of personal and fleet customer segments. So, we used to keep a balance to serve both segments,” Banerjee said.

However, in a bid to prioritise the requirement of private buyers, Maruti is offering the fourth-generation Dzire only for personal mobility. For fleet users, the automaker will continue with the previous-generation Dzire, branded as Maruti Tour S. Apart from the Dzire, the Tata Tigor, Honda Amaze, and Hyundai Aura are other models in the compact sedan space. 

With inputs from Yukta Mudgal

Also see:

2024 Maruti Suzuki Dzire review: India's favourite sedan massively updated

2024 Maruti Dzire image gallery

New Maruti Dzire video review 

It was one of those perfect drives, a rare window of relative emptiness on India’s busiest highway. A mid-morning dash to the BU Bhandari showroom for the launch of the Mercedes-AMG GLC 43 was the easiest Mumbai-Pune trip I’ve done in a long time. Making the drive particularly relaxing was the new addition to Autocar India’s fleet, the all-electric Mercedes EQE SUV, which got its first highway outing.

It took just two hours and six minutes in the ultra-smooth (and quick) EQE SUV to go from the Autocar HQ to the BU Bhandari Showroom on the Pune bypass. That’s less than what many office folks take to get home on a typical working day in Mumbai. It does help that the AtalSetu has brought our office closer to the edge of Mumbai, and a 10:15am departure was a sweet spot (or time). The early-morning highway rush was over, the toll plazas had no long queues, and even the Lonavala Ghat, which is choked most of the day (and night) on Google Maps, was surprisingly ‘blue’. Traffic flowed without holdups, even on the steepest sections where trucks otherwise block all lanes while trying to ‘overtake’ at a crawl.

The Atal Setu is always a great place to try out the ADAS system on any car. The wide and perfectly marked lanes and the gentle curves on this 21km sea bridge were perfect for checking out the EQE SUV’s ‘Level 2’ ADAS capability. That meant letting the Adaptive Cruise Control (ACC), which I have set at 99kph (just below the 100kph speed limit), and the Lane Keep Assist do the work while I sat back and relaxed with just a light hand on the wheel, enjoying the harbour’s breathtaking views.

The Lane Keep Assist worked brilliantly, keeping the big Merc centred nicely in the fast lane. When changing lanes, I was impressed with how the ACC reacted smoothly. When you signal and shift into the overtaking lane, the ACC provides strong and linear acceleration without abrupt power surges to match the new lane’s speed.

While the ADAS in the Mercedes EQE SUV is highly advanced, it has some limitations, especially when dealing with erratic drivers who slice across lanes like it’s a normal thing to do. If some idiot abruptly cuts into your lane from a sharp angle, the ADAS can struggle to react promptly. This is not the case with just the EQE SUV – no ADAS is fully capable of handling such unpredictable events, which is a reminder of why the tech can only assist and not replace the driver.

Mercedes’ Active Brake Assist, while a great safety feature on paper, can become a nuisance – and even a potential hazard – in Mumbai’s chaotic traffic. Designed for controlled environments, it doesn’t quite account for the unpredictability of pedestrians darting across roads or scooters weaving through tight gaps. The system often triggers unnecessarily, slamming on the brakes at the slightest hint of an obstacle. In such congested conditions, this overly sensitive response can be more dangerous than helpful. These fierce and abrupt stops are hugely unnerving for the passengers and could catch a driver behind you off guard, increasing the risk of rear-end collisions. It’s best to switch the Brake Assist off, which you have to do every time you start the car.

The monsoons have made mincemeat of the Nhava Sheva road, which connects the Atal Setu to the Mumbai-Pune Expressway, and on such surfaces, the EQE SUV is out of its comfort zone. To be honest, it doesn’t quite live up to its SUV credentials and isn’t comfortable dropping in and out of potholes like its IC engine brethren. That’s because the softly sprung EQE SUV uses up its suspension travel quite easily, and deep ruts and craters crash through. In fact, it’s best to use ‘Sport’ drive mode as the default setting. The suspension feels overtly soft in Comfort and Normal modes, which is fine when you are crawling in rush hour, but up the pace a bit on even a slightly smooth road, and you’ll find the EQE SUV tends to wallow and feel floaty. In Sport mode, the suspension tightens nicely to give a more settled ride, which is what you want on the highway.

Two areas where the EQE SUV stands out are performance and range, and both are interlinked because, with great range, you can enjoy the performance without keeping an eye on the SOC meter.

Plant your foot down, and this big and heavy SUV lunges forward with an intensity that can take you aback but in a very pleasing way. The EQE SUV gathers with velvet smoothness, and before you know it, you’ve sailed past the speed limit. On the Mumbai-Pune expressway, which is now infested with speed cameras, it is hard not to get a speeding ticket. To stay out of trouble, I limit my indulgence to short jabs of the accelerator pedal just to enjoy all the 408hp and 858Nm of torque that puts most IC engine SUVs to shame.

I averaged 66kph on the 140km drive to BU Bhandari, which is pretty good if you consider that this included slow, non-expressway sections. Not that the expressway raises your average speed dramatically because with so many cameras staring at you, I’m forced to show a lot of restraint! With 332km range left, I didn’t need to use the Pune Mercedes dealers’ on-site 180kW fast charger, but it’s good to know that it’s there and that the dealership is happy to let non-Merc owners plug in as well. Located just off the Pune bypass, it’s an incredibly convenient place for EVs on a long-distance trip to Mahabaleshwar or beyond to quickly top up their batteries.

The return journey was equally uneventful. Using the regen down the Lonavala Ghat, I could extend the range even further, which, on this round trip, I calculated to be 504km. That is a truly impressive figure, considering how hard I was driving the EQE SUV. In fact, there was enough charge left in the battery (36 percent) for me to make another trip to Pune!

The other area where the EQE SUV shines is refinement. The EQE SUV is not just quiet; it’s like being inside a luxury vault on wheels. The adaptive air suspension noiselessly glides over any surface, and then there’s the acoustic insulation, which Mercedes has absolutely nailed. Road, tyre and wind noises, even the electric motor’s faint whir, are gone. The cabin is like a calm oasis, and that’s what makes the EQE SUV special. It is luxury in its most serene form.

Also see:

Mercedes EQE SUV vs Audi Q8 e tron vs BMW iX vs Jaguar I Pace comparison video

Mercedes CLE review: Breezy cruiser

New Mercedes-AMG C 63 S E Performance to launch on November 12

The new Honda Elevate will make its global debut in India on June 6, followed by a market launch in August, this year

These updates have been released ahead of the October 2023 deadline that requires all cars and SUVs to come with six airbags and three-point seatbelts as standard

Production of C3 Aircross SUV has commenced at the Tiruvallur plant. Bookings will begin by September and deliveries by October. The price will be announced closer to that date.

Tata Motors has finally taken the wraps off the Curvv, a bold looking SUV coupe that is available with petrol, diesel and electric powertrains

Both Cadillac and Mercedes plan to expand their electric car offerings to the SUV market segment in the near future.

The post Large Electric SUV Models Coming From Cadillac & Mercedes appeared first on CleanTechnica.

STELLANTIS MALAYSIA is introducing the Leapmotor C10, its latest new energy SUV, through an exciting nationwide Leapmotor C10 Experience Roadshow. Attendees can get up close and personal with this innovative electric vehicle (EV), renowned for its award-winning design, advanced technology, and driving ease.

The roadshow will take place at the following locations:

Roadshow Highlights

Interactive Showroom: Experience the Leapmotor C10’s state-of-the-art features focused on comfort, intelligence, and spacious design.

Family-Friendly Area: The Publika roadshow will feature a Play Cabin for kids, while parents can explore the vehicle’s child-friendly interior.

Virtual Reality (VR): Immerse yourself in a VR experience for an in-depth look at the C10’s innovative technology.

Test Drive & Exclusive Merchandise

Visitors can test drive the Leapmotor C10 and experience its performance, powered by a Qualcomm® Snapdragon™ 8155 chip with driving optimization by Maserati for a seamless experience. Test drivers will receive exclusive Leapmotor merchandise, and all visitors can redeem a limited-edition Leapmotor tote bag and enamel pin set.

Special Booking Offer

Prospective buyers can enjoy a limited-time offer by booking the Leapmotor C10 at the roadshow before 30 November 2024 for an introductory price of RM149,000 on the road without insurance (RM10,000 off the original RM159,000 price).

BENTLEY is accelerating toward its electric future, building on a path that began with the introduction of the Bentayga Hybrid in 2018. With plug-in hybrid versions of the Continental GT and Flying Spur now available, the luxury automaker has officially announced plans for its first fully electric vehicle (EV), set to debut in 2026.

This new EV will be a luxury urban crossover SUV, described by Bentley’s new CEO, Frank-Steffen Walliser, as “compact” — a term that is relative in Bentley’s world. Measuring under 5003mm in length, it is expected to be similar in size to the Porsche Cayenne or Audi Q7 and will likely share its platform with the forthcoming Porsche Cayenne EV.

While Bentley has withheld technical details, Walliser emphasised that the upcoming model will prioritise usable range and charging speed to meet the demands of modern luxury car buyers. Addressing concerns about the transition to electric power, he assured, “We don’t want to make just any electric car; we want to make a Bentley.” The brand remains committed to preserving the unique qualities that define a Bentley, even without the traditional engine sound. Bentley board member Matthias Rabe hinted at innovative solutions to replicate the emotional experience of a combustion engine without merely copying conventional engine notes.

Bentley’s electrification strategy, initially called Beyond 100, has been rebranded as Beyond 100 Plus, reflecting an adjusted timeline for full carbon neutrality, extended from 2030 to 2035. The shift is driven by both regulatory pressures and growing customer interest, though Walliser acknowledged that the transition will vary across different markets.

This announcement underscores Bentley’s ambition to balance modern sustainability with its storied heritage of opulence and performance. As the brand embraces its electric transformation, it aims to redefine luxury mobility for the next generation.

Plus: Lots of other fun iron from Frankfurt and Ford's bold new infotainment venture.

General Motors is recalling nearly 462,000 pickup trucks and big SUVs with diesel engines because the rear wheels can lock up, increasing the risk of a crash.

In the Chinese city of Zhuhai, a car rammed into a crowd of people near a sports center. The 62-year-old driver fled the scene of the accident but was later detained. The victims were hospitalized, China Daily said with reference to local authorities. WARNING: The videos are extremely graphic! Click here to see more photos and videos from the scene.

Up till now, the automaker reportedly maintained that low demand for 4x4 cars has led to the absence of off-road tech in its products. In a recent conversation with TOI Auto, Shailesh Chandra, Managing Director, Tata Motors Passenger Vehicles Limited, shed some light on the future of the company’s SUV portfolio and if the 4x4 drivetrain will make a comeback.

Global Limos' sales website will showcase limo, party bus, shuttle and charter bus, luxury cars and SUV deals to general public and the luxury transportation operators. From Rolls Royce to bus brands like MCI, the site will features 1000s of vehicles

Con 4,5 metros de largo, se vende ya con motor de gasolina de 145 CV y a finales de año lo hará con un grupo híbrido enchufable con 340 CV y 90 kms de alcance eléctrico. Parte de 33.900 euros. Leer

La marca premium de Toyota nunca tuvo un modelo tan campero como este todocamino híbrido, igualmente exclusivo por su precio: 71.100 euros. Leer

La japonesa refuerza su apuesta por Europa y en 2025 llegana las primeras unidades de su 'buque insignia', el Outlander PHEV. Parte de los 39.700 euros pero hay que cumplir varias condiciones Leer

The Tucson Hybrid is a gem and should please buyers looking for a mid-size SUV.

The molecular mechanisms of reduced frataxin (FXN) expression in Friedreich's ataxia (FRDA) are linked to epigenetic modification of the FXN locus caused by the disease-associated GAA expansion. Here, we identify that SUV4-20 histone methyltransferases, specifically SUV4-20 H1, play an important role in the regulation of FXN expression and represent a novel therapeutic target. Using a human FXN–GAA–Luciferase repeat expansion genomic DNA reporter model of FRDA, we screened the Structural Genomics Consortium epigenetic probe collection. We found that pharmacological inhibition of the SUV4-20 methyltransferases by the tool compound A-196 increased the expression of FXN by ∼1.5-fold in the reporter cell line. In several FRDA cell lines and patient-derived primary peripheral blood mononuclear cells, A-196 increased FXN expression by up to 2-fold, an effect not seen in WT cells. SUV4-20 inhibition was accompanied by a reduction in H4K20me2 and H4K20me3 and an increase in H4K20me1, but only modest (1.4–7.8%) perturbation in genome-wide expression was observed. Finally, based on the structural activity relationship and crystal structure of A-196, novel small molecule A-196 analogs were synthesized and shown to give a 20-fold increase in potency for increasing FXN expression. Overall, our results suggest that histone methylation is important in the regulation of FXN expression and highlight SUV4-20 H1 as a potential novel therapeutic target for FRDA.

An 18-year-old man is scheduled to make a court appearance on Tuesday, after being charged by the OPP with attempted murder and aggravated assault on a 16-year-old female victim. The charges follow a violent incident in Cobalt, Ont., on Nov 3.

A Saskatoon woman is accused of damaging multiple vehicles and assaulting a man with a baseball bat on Nov. 11.

"It's just like a big blur. It doesn't seem real," says the mother of 16-year-old Kaylie Smith.

One person is dead after a motorcycle and an SUV collided in Mount Albert, Ont., on Monday, Ontario Provincial Police say.

A man was on Monday arrested for driving his car, a Mahindra Thar, on a railway track in Rajasthan's Jaipur. The man, said to be drunk, had taken his SUV on to railway tracks to shoot a reel for social media.

Jeep Wrangler sets the bar for off-roading capability Larger Ford Bronco has a more modern suspension Both SUVs have removable doors and tops When Ford relaunched the Bronco for the 2021 model year, it had one target in its sights: The Jeep Wrangler. The Wrangler has been the American benchmark for off-roading capability in the 80-plus years since...

The XT4 compact crossover ends production in January after one generation The Cadillac Optiq electric crossover will take the place as the entry point into the Cadillac brand Production of the XT4 ends not longer after it ended on the Chevy Malibu as GM retools its Fairfax Assembly for the next Bolt EV A year after an interior glow-up, Cadillac...

What kind of vehicle is the 2025 Mercedes-Benz EQS SUV? What does it compare to? The EQS is Mercedes-Benz’s biggest all-electric SUV. Shop it against the Rivian R1S, Audi Q8 E-Tron, BMW iX, and Tesla Model X. Is the 2025 Mercedes-Benz EQS SUV a good car/SUV? The EQS has attractive styling and lots of features, though it is very expensive...

Cadillac Vistiq revealed as brand's “globally sized” electric three-row SUV Vistiq comes standard with 615 hp and 102 kwh Pricing starts at $78,790, including destination Cadillac's expansion of its electric vehicle lineup continues with the arrival of the 2026 Vistiq, a midsize SUV with third-row seats designed to fill the gap between...

Santa Fe Hybrid makes 231 hp and 271 lb-ft of torque Santa Fe Hybrid averaged 31 mpg combined over mostly highway miles Comfy seats, clever storage, and a spacious cargo area with the third-row folded make it a good family hauler My teen daughter’s a videographer. Whenever I test a big car, fast car, cool car, anything that’s not...

Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer disease (AD). We validated a simplified tissue-to-reference ratio method using SUV ratios (SUVRs) for estimating synaptic density with [¹¹C]UCB-J PET. Methods: Participants included 31 older adults with AD and 16 with normal cognition. The distribution volume ratio (DVR) using simplified reference tissue model 2 was compared with SUVR at short scan windows using a whole-cerebellum reference region. Results: Synaptic density was reduced in AD participants using DVR or SUVR. SUVR using later scan windows (60–90 or 70–90 min) was minimally biased, with the strongest correlation with DVR. Effect sizes using SUVR at these late time windows were minimally reduced compared with effect sizes with DVR. Conclusion: A simplified tissue-to-reference method may be useful for multicenter and longitudinal studies seeking to measure synaptic density in AD.