The value of interim ¹⁸F-fluorodeoxyglucose positron emission tomography (iPET) guided treatment decisions in patients with diffuse large B-cell lymphoma (DLBCL) has been the subject of much debate. This investigation focuses on a comparison of the Deauville score and the deltaSUV_max (SUV_max) approach – two methods to assess early metabolic response to standard chemotherapy in DLBCL. Methods: Of 609 DLBCL patients participating in the Positron Emission Tomography-guided Therapy of Aggressive non-Hodgkin Lymphomas (PETAL) trial, iPET scans of 596 patients originally evaluated using the SUV_max method were available for post-hoc assessment of the Deauville score. A commonly used definition of an unfavorable iPET result according to the Deauville score is an uptake greater than that of the liver, whereas an unfavorable iPET scan with regard to the SUV_max approach is characterized as a relative reduction of the maximum standardized uptake value between baseline and iPET staging of less than or equal to 66%. We investigated the two methods’ correlation and concordance by Spearman’s rank correlation coefficient and the agreement in classification, respectively. We further used Kaplan-Meier curves and Cox regression to assess differences in survival between patient subgroups defined by the pre-specified cut-offs. Time-dependent receiver operating curve analysis provided information on the methods’ respective discrimination performance. Results: Deauville score and SUV_max approach differed in their iPET-based prognosis. The SUV_max approach outperformed the Deauville score in terms of discrimination performance – most likely due to a high number of false-positive decisions by the Deauville score. Cut-off-independent discrimination performance remained low for both methods, but cut-off-related analyses showed promising results. Both favored the SUV_max approach, e.g. for the segregation by iPET response, where the event-free survival hazard ratio was 3.14 (95% confidence interval (CI): 2.22 – 4.46) for SUV_max and 1.70 (95% CI: 1.29 – 2.24) for the Deauville score. Conclusion: When considering treatment intensification, the currently used Deauville score cut-off of an uptake above that of the liver seems to be inappropriate and associated with potential harm for DLBCL patients. The SUV_max criterion of a relative reduction of the maximum standardized uptake value of less than or equal to 66% should be considered as an alternative.

From the ashes of the failed Fisker Karma sports car, automotive designer Henrik Fisker has designed a futuristic battery-powered luxury SUV that won't break the bank.

Witness intimidation sends man to prison A 30-year-old Seaford man who tried to flee from a traffic stop with a state trooper holding on to his moving vehicle pleaded guilty in Superior Court. Deputy Attorney General John Donahue secured the plea to Assault Second Degree, Reckless Endangering, and Resisting Arrest from Brandon Showell. In June […]

Hyundai, the South Korean car manufacturer is currently working on the new generation Tucson SUV, which has been spotted doing rounds on the home soil. The SUV yet again has been spied testing in...

The GLA-Class is expected to be launched in India soon as the German brand has displayed the vehicle on its India website.

The SUVs shown here could be priced as low as Rs 10 lakh while few others might breach the Rs 25 lakh mark.

Touchscreen infotainment systems have become one of the defining characteristics of modern SUVs. Here are five of the largest touchscreens that are available under the Rs 25 lakh bracket.

A fleet of 15 Jaguar F-Pace has been provided to support the UK’s ‘Help NHS Heroes’ initiative delivering food and essentials to NHS frontline staff, carers and their families.

A whole bunch of new sub-4m SUVs mostly below Rs 10 lakh are coming our way this year.

The Enyaq electric SUV has an enviable range, delectable features and should cost as much as the Skoda Kodiaq RS version.

The Venue and the Nexon follow two separate approaches when it comes to tackling the sub-4m SUV space. One has a lot of features and a feel-good factor while the second one is the best its maker churns out and has got better daily usability. Which one is our choice? Lijo finds it out.

The Tata Nexon EV is going to launch in India soon. Its prices are expected to fall in the range of Rs 15 lakh to Rs 17 lakh. Here is out first drive review of what would be India’s first all-electric sub-four-meter SUV.

MG Motor is a British carmaker now owned by SAIC Motor of China. The Hector is its first product for the Indian market—and the company calls it India’s first internet car.

The Seltos has a modern design, and one that the next-generation Creta (likely in 2020) could take some cues from.

Over 300 World of SUVs set up in six months.

Earlier this week, Porsche India gave the Macan SUV a comprehensive upgrade; it launched the new Macan (Rs 69.98 lakh) and the more powerful Macan S (Rs 85.03 lakh). The Macan is a compact SUV made by Porsche.

The Ford Puma is a new SUV-inspired crossover that has been unveiled in Europe with a launch set for later this year

The Audi Q8 now stands as the flagship SUV from the German automaker in India. It will find its place above the Q7 in the brand's product line-up. The competition will include the likes of Mercedes-Benz GLS and the BMW X7.

Three-row crossover SUVs are having their day in the sun. These family haulers provide the spaciousness and safety of a minivan with the style and performance of something less...egg-shaped. Two of the bestselling three-row SUVs, the 2020 Honda Pilot and 2020 Ford Explorer, go about their family business a bit differently. What the Pilot lacks in...

These are halcyon days for fleet-footed crossover SUVs. Saucy ‘utes like the 2020 Mercedes-Benz GLC 43 AMG hardly look like they’re just as quick as their smaller siblings but stopwatches don’t lie. In the example above, Mercedes says the GLC43 crossover takes just 4.7 seconds from 0-60 mph compared to the C43 sedan’s time...

The IIHS reported Thursday that the new Jeep Wrangler, which was last comprehensively updated for the 2018 model year, tipped over onto its passenger side during its driver-side small overlap crash test. The insurance industry-funded safety watchdog said the Wrangler was tested three times, twice by the agency and once by the automaker. The...

MOST150 Technology to Control the Infotainment System on Volvo Cars’ Second-Generation XC60 SUV

देश दुनिया में लगातार बढ़ रहे वायरस के ममाले रुकने का नाम नहीं ले रहे हैं। इससे दुनियाभर के लोगों में एक खौफ भी पैदा हो गया है। खौफ इतना ज्यादा है कि अब कुछ लोग अपने घरों से भी निकलना पसंद नहीं कर रहे हैं।

Skoda कंपनी जल्द ही अपनी इलेक्ट्रिक एसयूवी Skoda Enyaq को बाजार में लेकर आने की तैयारी है। कंपनी अपनी इस इलेक्ट्रिक एसयूवी को तीन बैटरी साइज और पांच पावर वेरिएंट्स में लेकर आ रही है।

A prototype SUV from BMW reportedly gets 62 MPGe, far more than a Toyota Prius. It also comes with some sweet features

Laura Laker of the Guardian describes growing complaints in Germany and the UK.

Mayor says "Such tank-like SUVs do not belong in the city"

Activists everywhere were outraged by their latest public service message.

Forget drones and self-driving cars; this is the future of deliveries, whether goods or kids.

Edmunds.com’s roundup of new vehicles at the 2014 LA Auto Show

The continent faces a new emissions scandal as family vehicles grow bigger and heavier

A man in Hanahan, South Carolina, was nearly crushed by a SUV after he was thrown from the car as it flipped over.

The debut of Rolls-Royce's £405,000 Cullinan Black Badge has attracted a younger brand of car buyers with the average age of Rolls-Royce customers falling to 42-years-old.

Floyd Mayweather revealed he gifted his oldest daughter, Iyanna, a $152,500 car for Christmas. Instagram photos show the car as a 2020 AMG G 63 SUV built by Mercedes-Benz.

Subaru announced the release of the new Forester GT model - named the F.U.*.K.S edition - at the Singapore Motorshow last weekend. The rude acronym appeared to be deliberate.

Rebel Wilson picked up some food - and a parking ticket - as she stepped out in Los Angeles on Tuesday. 

Antonio Basco made headlines last week when he invited strangers to attend his partner Margie Reckard's funeral on Friday given they had very few family members left who could help him mourn.

Footage captures the terrifying incident close to the ExCeL centre in Canning Town, East London.

Chris Bray, 37, and his wife Jess live on Christmas Island, a 52-square-mile Australian territory in the Indian Ocean. The couple invented car 'shoes' to protect the crabs.

About a year ago, my friend and Radio 2 colleague Vassos Alexander told me he’d placed a deposit on a car that didn’t exist. The name of that car was the Jaguar I-Pace

Florida Sen. Marco Rubio is considering a possible presidential run. The incident took place at a 'Team Marco 2016' summit where he was speaking to 300 donors at the Delano Hotel in South Beach.

The debut of Rolls-Royce's £405,000 Cullinan Black Badge has attracted a younger brand of car buyers with the average age of Rolls-Royce customers falling to 42-years-old.

Chris Brown is sparing no expenses to feel safe-- at least while out on the roadways. According to TMZ the singer paid more than $350,000 for a customized Rezvani SUV Tank that is bulletproof.

German Chancellor Angela Merkel was pledging her support to the nation's car industry at the annual Frankfurt IAA car show when Greenpeace protestors made their way inside the building.

All roads lead to Germany next week as the Frankfurt Motor Show gets under way. Mercedes-Benz will be showing off its first-ever SUV.

Ford unveiled its smart new Edge fiveseater sports utility vehicle this week. The Edge will go on sale here next year from around £30,000

A man in Hanahan, South Carolina, was nearly crushed by a SUV after he was thrown from the car as it flipped over.

She came under fire after charging fans $950 for a video chat on FaceTime and $250 for a follow-back on Instagram amid the global COVID-19 pandemic.