At its peak, The Ride the Rockies Bicycle Tour attracted more than 2,000 cyclists annually for rides of 60 to 80 miles per day. It supported nonprofits in the more than 50 towns it visited over the years.

Mary J. Blige inspires the crowd through song.

Ride.bm said they are offering an “easy-to-access app that provides Bermudians and visitors alike with seamless, on-demand transportation.” A spokesperson said, “For decades, the number 295-4141 has been synonymous with safe and reliable transportation in Bermuda. Today, Ride.bm, powered by Central Dispatch, builds on that legacy, transforming a household number into a modern, easy-to-access app […]

The latest design in Bernews’ weekly Wallpaper Wednesday series features the iconic Bermuda longtail with a ‘flying with pride’ rainbow theme,  with the concept a nod to the statement made by OUTBermuda following the Privy Council’s ruling on marriage. Speaking after the ruling, OUTBermuda Deputy Chair Zakiya Johnson Lord said, “We hold our heads high. Our struggle is […]

The month of June is internationally recognized as Pride Month, and the latest design in Bernews’ weekly Wallpaper Wednesday series features the iconic Bermuda longtail with a ‘flying with pride’ rainbow theme. The design is available in two sizes; a Facebook profile cover image and also in a vertical format, ideally sized for use as […]

Nathan Armstrong and his Rider men’s Cross-Country teammates finished fifth as a team out of 13 teams at the Jasper Fall Invite. Noah Taylor led Rider over the 8K distance, the senior ran a 25.19.8 coming in eighth place out of the 100 athletes competing, Dominik Lisicky finished in 24th place with a time of […]

Bermuda riders Rai Burch, Tyler James, Kimoy Cruickshank, and Kayla Bardgett competed on the Grand Caraibe Tour in Martinique. Day one saw the competitors compete in 2 phases special classes at 3 height divisions. James was eliminated out of 44 starters in the 0.90 cm class, Cruickshank finished 25th and Bardgett finished 29th out of […]

[Updated: Police said the rider was holding a cat, and it is unclear what happened to the cat, if anything.] At approximately 5.30pm this afternoon [Sept 6], emergency services responded to a single vehicle accident on Swing Bridge in St. George’s. The Bermuda Fire and Rescue Service attended the scene where EMTs cared for the injured […]

[Written by Stephen Wright] Female motorcycle racer Mikayla Moore will be the star attraction on the final race day of the Bermuda Motorcycle Racing Association’s [BMRA] season at Southside Motorsports Park on Sunday [October 29]. The American rider is the champion of the Royal Enfield 2023 Build. Train. Race. Series – an initiative focusing on […]

[Written by Stephen Wright] Bermudian motorcycle racer Aeziah Divine will compete as a guest rider for Sencat Talent Team – Mortimer Racing in the R&G Talent Cup at the iconic Brands Hatch in Kent, England, next weekend. The 14-year-old will stand in for injured rider Alexander Rowan in the fourth round of the Moto3 class […]

‘Films at BUEI’ will screen the 2023 crime drama ‘The Bikeriders’ on September 28th. A spokesperson said, “‘Films at BUEI’ continues at the Bermuda Underwater Exploration Institute [BUEI] with the screening of the 2023 Crime/Drama, ‘The Bikeriders’ on Saturday, September 28th at 7:30pm in our Tradewinds Auditorium [Wheelchair Accessible]. “‘The Bikeriders’ is an American period […]

The rider of a motorcycle involved in a collision with a tractor trailer truck on Monday [Sept 23] in Southampton remains hospitalised. A police spokesperson said, “The rider of a motorcycle involved in a collision with a tractor trailer truck around 9am Monday, 23rd September 2024, at the junction of Middle Road and South Road […]

A collision in Paget yesterday involving a car and two motorcycles resulted in one of the motorcycle riders being injured. A police spokesperson said, “Shortly after 4:00 p.m. on Wednesday, September 25, 2024, police, Bermuda Fire and Rescue along with Emergency Medical Services, attended a serious road traffic collision involving a motor car and two motorcycles […]

A 33-year-old woman was treated for non-life-threatening injuries after her motorcycle collided with debris on North Shore Road in Hamilton Parish, causing two hours of traffic diversions. A police spokesperson said, “At last check, a female rider hurt in a reported single vehicle Hamilton parish collision around 8:55am Monday, 30th September 2024, received treatment at […]

The cruise ship ‘Star Pride’ recently visited the island, and a look at the ship in the east end is below. According to the 2024 schedule, the 436 foot long ship was carrying an estimated 212 passengers and 164 crew. To see more of our cruise ship coverage, click here. Related Stories Photos & Video: […]

The Carnival Pride and Norwegian Breakaway cruise ships recently visited the island, and a look at both of the vessels in Dockyard is below. To see more of our cruise ship coverage, click here. Related Stories Photos & Video: MS Insignia In St. George’s Photos & Video: MS Silver Shadow Visits Photos & Video: Cruise […]

Команда Trident, выступающая в Формуле 2, объявила о замене в составе на оставшиеся два этапа сезона. Вместо Ричарда Ферсхора за руль в Катаре и Абу-Даби сядет Макс Эстерсон.

NEWS – The VMAX VX2 PRO. This isn’t just any electric scooter; it’s a Swiss-engineered marvel that’s changing the game for urban commuters and thrill-seekers alike. Power That Packs a Punch Let’s talk power, because that’s where the VX2 PRO by VMAX really shines. This electric scooter comes with a 500-watt motor that can peak […]

Wildfire [UK/Ireland, Cathy Brady, 3.5] After going missing for a year, a bipolar woman (Nika McGuigan) drops in on her sister (Nora-Jane Noone), opening the wounds of shared tragedy. Raw, unsubtle family drama against the backdrop of Northern Irish politics as Brexit threatens a fragile peace.

The film is dedicated to the memory of lead actor McGuigan, who died of cancer last year.

40 Years a Prisoner [US, Tommy Oliver, 4] Documentary recounts the 1978 standoff between members of radical Black back-to-nature organization MOVE and Philadelphia police through the efforts of the son of two of the group members to secure their parole. A strong emotional hook greatly assists in telling a tenaciously complicated story.

I would like to have seen more on the genesis of the group and the first stages of their conflict with the mayor and police. So much needs to be unwound in the 1978 standoff that the even more astonishing story of a 1985 confrontation, which resulted in Philadelphia authorities dropping a satchel bomb from a helicopter, killing 11 and burning down 65 houses, goes unmentioned here. Another doc I haven’t seen, Let the Fire Burn, focuses on that part of the story.

True Mothers [Japan, Naomi Kawase, 4.5] Parents of a kindergartner react with dismay when a woman contacts them claiming to be his birth mother. Luminous, delicate drama of shifting perspectives.

Limbo [UK, Ben Sharrock, 4] Syrian oud player grapples with guilt over family left behind as he cools his heels with other refugee claimants at a center in the bleak and isolated Outer Hebrides. Moments of deadpan humor and stark landscapes layer this exploration of displacement.

to take (something) in (one's) stride

to take in one's stride: of a horse or its rider, to clear (an obstacle) without checking one's gallop; figurative to deal with (a matter) incidentally, without interrupting one's course of action, argument, etc. Also (chiefly U.S.) without possessive adjective.

at (a) pace

Chelsea’s 2023-2024 season under the new management of Mauricio Pochettino has been marked by highs and lows, showcasing both promise..

The post Chelsea 2023/24 Season Review: A Rollercoaster Ride appeared first on Chelsea FC Blog.

https://www.amazon.com/Outriders-Worldslayer-PlayStation-Included-Upgrade-Digital/dp/B0B47CBJT2/ref=sr_1_2?crid=39KZ05VNEE0X&keywords=ps4&psr=PDAY&qid=1696978848&s=pbdd&sprefix=ps%2Cpbdd%2C137&sr=1-2

Car manufacturers have made great strides in automobile safety in the last few decades. When I was a child, my family drove everywhere in a Volkswagen Beetle or a Microbus that didn't have seatbelts. Nor did they have crumple zones, antilock brakes, or airbags. Riding in the bed of a pickup truck was a regular experience. Fifty years later, my oldest child wanted to get a classic Beetle, but was dissuaded when my brother called them "death traps." Now she has children, and purchased an SUV the size of a tank to keep the kids safe.

The newer a car is, the safer it will be, but when does that become overkill? We know large SUVs are safer for the occupants, yet more dangerous for others around them. We also know that accidents can happen anywhere, but deadly accidents are more likely at high speeds on highways than a short trip to school. And we know that children learn situational awareness and how to test their limits and manage their fears by being in slightly unsafe situations, such as old-fashioned playgrounds. Today, we have young adults who are terrified at the idea of learning to drive.

Jason Torchinsky at Autopian asked reader's opinions on letting their child ride in a classic car such as the original Volkswagen Beetle, and got plenty of replies about how much automotive safety is enough, from farm kids who drove tractors at a young age to ultimate safety advocates. The best comment: "Being unsafe in a car was how I got kids in the first place."

In the waning days of his campaign, former President Donald Trump has further embraced some of Robert F. Kennedy Jr.’s incorrect or controversial views on health, including vaccines and fluoride.

The post Trump Embraces RFK Jr.’s Views on Vaccines, Fluoride appeared first on FactCheck.org.

The Vienna Dioscurides is an early 6th-century copy of De Materia Medica, a manuscript first created by the ancient Greek physician and pharmacologist Dioscurides. A precursor to all modern pharmacopeias, it remained in practical use until about 1600. The Vienna Dioscurides contains more than 400 pictures of animals and plants and is the earliest known manuscript to use a solid gold background. It is also the oldest surviving illustrated treatise on what type of animal?

The most-desired bike brands, what travel Pinkbike readers expect their next bike will have, and whether you're sold on mullets.
( Photos: 2, Comments: 112 )

East Kilbride stun Ayr United to reach the semi-finals of the SPFL Trust Trophy as Dunfermline Athletic and Livingston progress.

M. Mahmood Hussain
Jan 1, 2003; 44:22-32
Reviews

William R. Morrison
Oct 1, 1964; 5:600-608
Articles

Animals can sense the presence of microbes in their tissues and mobilize their own defenses by recognizing and responding to conserved microbial structures (often called microbe-associated molecular patterns (MAMPs)). Successful host defenses may kill the invaders, yet the host animal may fail to restore homeostasis if the stimulatory microbial structures are not silenced. Although mice have many mechanisms for limiting their responses to lipopolysaccharide (LPS), a major Gram-negative bacterial MAMP, a highly conserved host lipase is required to extinguish LPS sensing in tissues and restore homeostasis. We review recent progress in understanding how this enzyme, acyloxyacyl hydrolase (AOAH), transforms LPS from stimulus to inhibitor, reduces tissue injury and death from infection, prevents prolonged post-infection immunosuppression, and keeps stimulatory LPS from entering the bloodstream. We also discuss how AOAH may increase sensitivity to pulmonary allergens. Better appreciation of how host enzymes modify LPS and other MAMPs may help prevent tissue injury and hasten recovery from infection.

Aloïs Dusuel
Dec 9, 2020; 0:jlr.RA120000704v1-jlr.RA120000704
Research Articles

Bacterial lipopolysaccharides (LPSs or endotoxins) can bind most proteins of the lipid transfer/LPS-binding protein (LT/LBP) family in host organisms. The LPS-bound LT/LBP proteins then trigger either an LPS-induced proinflammatory cascade or LPS binding to lipoproteins that are involved in endotoxin inactivation and detoxification. Cholesteryl ester transfer protein (CETP) is an LT/LBP member, but its impact on LPS metabolism and sepsis outcome is unclear. Here, we performed fluorescent LPS transfer assays to assess the ability of CETP to bind and transfer LPS. The effects of intravenous (iv) infusion of purified LPS or polymicrobial infection (cecal ligation and puncture [CLP]) were compared in transgenic mice expressing human CETP and wild-type mice naturally having no CETP activity. CETP displayed no LPS transfer activity in vitro, but it tended to reduce biliary excretion of LPS in vivo. The CETP expression in mice was associated with significantly lower basal plasma lipid levels and with higher mortality rates in both models of endotoxemia and sepsis. Furthermore, CETPTg plasma modified cytokine production of macrophages in vitro. In conclusion, despite having no direct LPS binding and transfer property, human CETP worsens sepsis outcomes in mice by altering the protective effects of plasma lipoproteins against endotoxemia, inflammation, and infection.

TG-rich lipoprotein (TRL)-related biomarkers, including TRL-cholesterol (TRL-C), remnant-like lipoprotein particle-cholesterol (RLP-C), and apoC-III have been associated with atherosclerosis. However, their prognostic values have not been fully determined, especially in patients with previous CAD. This study aimed to examine the associations of TRL-C, RLP-C, and apoC-III with incident cardiovascular events (CVEs) in the setting of secondary prevention of CAD. Plasma TRL-C, RLP-C, and total apoC-III were directly measured. A total of 4,355 participants with angiographically confirmed CAD were followed up for the occurrence of CVEs. During a median follow-up period of 5.1 years (interquartile range: 3.9–6.4 years), 543 (12.5%) events occurred. Patients with incident CVEs had significantly higher levels of TRL-C, RLP-C, and apoC-III than those without events. Multivariable Cox analysis indicated that a log unit increase in TRL-C, RLP-C, and apoC-III increased the risk of CVEs by 49% (95% CI: 1.16–1.93), 21% (95% CI: 1.09–1.35), and 40% (95% CI: 1.11–1.77), respectively. High TRL-C, RLP-C, and apoC-III were also independent predictors of CVEs in individuals with LDL-C levels ≤1.8 mmol/l (n = 1,068). The addition of RLP-C level to a prediction model resulted in a significant increase in discrimination, and all three TRL biomarkers improved risk reclassification. Thus, TRL-C, RLP-C, and apoC-III levels were independently associated with incident CVEs in Chinese CAD patients undergoing statin therapy.

No abstract

The Rapid Trident 21 exercise to enhance interoperability between Ukraine, U.S. and NATO partners started Monday, with an opening ceremony, and will run through Oct. 1.

The U.S. Navy conducted a two-missile test flight of unarmed life-extended Trident II-D5LE missiles from the USS Wyoming in the Eastern Test Range off the coast of Cape Canaveral, Fla, the Navy announced.

Pietro Mazzoni
Apr 5, 2006; 26:3642-3645
BRIEF COMMUNICATION

In the jungles of Cambodia, villagers travel along abandoned railway tracks on a norry, a rickety transport of spare lumber with a speedy (and loud) motor attached Video, Photographs and Narration by Russ Juskalian

In the spring of 1961, black and white civil rights activists rode buses to protest the segregationist policies of the Deep South (Marian Holmes, Brian Wolly, Photos courtesy of Corbis, Getty Images and Library of Congress, Audio clips courtesy of Smithsonian Folkways. Read more at https://www.smithsonianmag.com/history/the-freedom-riders-then-and-now-45351758/

Lizzy, the avatar based on the novel’s Elizabeth Bennet, will hold period-accurate conversations with visitors at Jane Austen’s cottage home

Dave Campbell of Thunder Bay, Ont., is resting his legs after taking the ride of his life through the Western Cape of South Africa in the 800-kilometre bikepacking 'Rhino Run.' Here are some of the photos he shared from his six-day expedition at the end of October.

The Winnipeg Blue Bombers will face the Toronto Argonauts in their fifth straight Grey Cup appearance. The Bombers advanced to the CFL title game after disposing of the Saskatchewan Roughriders 38-22 in the West final Saturday night in Winnipeg.

Head coach Corey Mace, quarterback Trevor Harris and linebacker Jameer Thurman talk about coming up short in the CFL West Final. The Roughriders lost the the Winnipeg Blue Bombers 38-22 sending the Bombers to their fifth straight Grey Cup.

The National Capital Commission says it opened the Rideau Canal Skateway below its usual stands for ice thickness a few times last season — and plans to do the same this year. 

Education Week sat down with American Federation of Teachers President Randi Weingarten for a conversation about the recent wave of teacher activism and how the unions are preparing for the Janus decision.

The Brandywine community showed its Penn State pride at the campus' annual Homecoming & Family Day on Oct. 26. The day featured carnival games, an alumni reception, face painting, a petting zoo and more.

A bus carrying 25 passengers returning from a wedding plunged into a river late Tuesday in Gilgit-Baltistan.

Hemansh Kohli wore a green kurta at his mehendi ceremony

The actor got married in an intimate ceremony at a temple in Delhi on Tuesday