Bajaj Allianz Life focused on making life insurance accessible to all, says MD & CEO Tarun Chugh; special emphasis on Tier 2 and 3 markets

This basic smartwatch tracks a lot of parameters and also lets you easily call contacts from your wrist

This comes after the Congress appointed Subhankar Sarkar as the president of the West Bengal Pradesh Congress Committee in September, replacing Adhir Ranjan Chowdhury

Mr. Salim also highlighted that in the upcoming byelections, the Left Front in West Bengal has made seat adjustments considering parties outside the Left Front

With saturation of European and American markets, Asian tea producers are eyeing untapped African market for exports

It's time India re-visited its Western alliances for the attitude and approach that the West reserves for the nation when it comes to security cooperation of the kind that they might not have visualised outside of China, India's bug-bear, asserts N Sathiya Moorthy.

Shipra Rohatgi and Sanjana Chatlani have set up successful ventures that tap the potential of calligraphy

Hyderabad FC scripted a sensational comeback to sink Kerala Blasters 2-1 in a thrilling Indian Super League match.

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Crude production in the country has dropped to less than half its level in 1998

Benchmark indices ended the day higher, led by strong gains across global markets, including the Asian markets. Dow Futures also gained almost 1 per cent in trade after the NASDAQ recouped all its losses for the year and turned positive for

During the global health crisis, the video conferencing industry seems to have gained traction. While various other industries have been impacted badly due to the coronavirus outbreak, there has been a positive impact on the video conferencing market. This helps companies

Wicket-keeper batsman KL Rahul on Sunday made sure to answer as many questions from fans as he did an 'Ask Rahul' session on Twitter.

In the latest Candyology 101 podcast, Maria and I tackled a little-celebrated candy bar, the Whatchamacallit. We’re also trying out a new format, which is a little shorter, like a handful of fun size candy bars!

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

Lens proteins become increasingly cross-linked through nondisulfide linkages during aging and cataract formation. One mechanism that has been implicated in this cross-linking is glycation through formation of advanced glycation end products (AGEs). Here, we found an age-associated increase in stiffness in human lenses that was directly correlated with levels of protein–cross-linking AGEs. α-Crystallin in the lens binds to other proteins and prevents their denaturation and aggregation through its chaperone-like activity. Using a FRET-based assay, we examined the stability of the αA-crystallin–γD-crystallin complex for up to 12 days and observed that this complex is stable in PBS and upon incubation with human lens–epithelial cell lysate or lens homogenate. Addition of 2 mm ATP to the lysate or homogenate did not decrease the stability of the complex. We also generated complexes of human αA-crystallin or αB-crystallin with alcohol dehydrogenase or citrate synthase by applying thermal stress. Upon glycation under physiological conditions, the chaperone–client complexes underwent greater extents of cross-linking than did uncomplexed protein mixtures. LC-MS/MS analyses revealed that the levels of cross-linking AGEs were significantly higher in the glycated chaperone–client complexes than in glycated but uncomplexed protein mixtures. Mouse lenses subjected to thermal stress followed by glycation lost resilience more extensively than lenses subjected to thermal stress or glycation alone, and this loss was accompanied by higher protein cross-linking and higher cross-linking AGE levels. These results uncover a protein cross-linking mechanism in the lens and suggest that AGE-mediated cross-linking of α-crystallin–client complexes could contribute to lens aging and presbyopia.

State-of-the-art electron microscopy reveals the large-scale organization of the proteins that regulate neurotransmitter release

This spectacular image – which took the best part of a year to create – shows the fine structure of a nerve terminal at high resolution, revealing, for the very first time, an intricate network of fine filaments that controls the movements of synaptic vesicles.

The brain is soft and wet, with the consistency of a lump of jelly. Yet, it is the most complex and highly organized structure that we know of, containing hundreds of billions of neurons and glial cells, and something on the order of one quadrillion synaptic connections, all of which are arranged in a very specific manner.

Related: 3D model of a nerve terminal in atomic detail | Mo Costandi

Related: Blowing up the brain to reveal its finer details

New Brunswick's chief medical officer of health, said the province will introduce a new policy that's independent of the phase two recovery stage announced Friday.

Mother’s Day 2020: THIS video of Sonnalli Seygall and her mom twinning and dancing together is the cooles  Times of India

Actress Sonnalli Seygall, who rose to fame with Luv Ranjan’s hit franchise ‘Pyaar Ka Punchnama’, was recently seen in ‘Jai Mummy Di’ with Sunny Singh. The film released earlier this year and just ahead of Mother’s Day, Sonnalli and her Mummy shot a cover of the super hit song, ‘Mummy Nu Pasand’.

Turkey is a 'hot-climate' culture, meaning that people are relationship-oriented rather than task-oriented.

THE Treasury has bombarded us all week with facts, figures and forecasts making the case for the UK to remain in the European Union. Its big report, on Monday, warned Brexit would tip the country into a year-long recession, resulting in up to 820,000 job losses within two years.

Though it’s one of the smallest teams in OM, OM Colombia, lead by Colombian Martha Ardila, makes big plans for the future.

Among one of the companies that ended up in Rakesh Jhunjhunwala’s shopping cart during the January-March quarter was another Tata Group company -- Rallis India.

App Annie’s latest report highlights that Zoom is the most downloaded app on iOS amongst all users. But it has also put focus on privacy and security.

Internet Service Providers Association of India (ISPAI) said this was a good opportunity for the sector. The association also raised its long-standing demand of allowing active infrastructure sharing to include internet service provider (ISP) players, which is available to all other licences.

While our immediate priority must be to protect people from the pandemic and contain its spread, ensuring food security and preventing more people to fall below poverty line (BPL) should also be on focus.

The concept is straight from the Soviet playbook: Plant false information and use it to influence the attitudes of another country’s people and government. This “active measures” technique from the Cold War era appears to have been resurrected with alarming success by the Kremlin in its attack on the 2016 presidential election—and has been echoed in tactics used by President Donald Trump and his associates, according to Clint Watts, a senior fellow at the Foreign Policy Research Institute.

“Part of the reason active measures have worked in this US election is because the commander in chief has used Russian active measures at times against his opponents,” Watts, a former FBI agent, recently testified to the Senate Intelligence Committee.

Key to this equation have been RT and Sputnik international, two Russian state-sponsored news outlets. Both reach only relatively small audiences in the US (RT is estimated to reach about 8 million people via cable television), but their impact has been magnified greatly online, with their stories reposted on what Watts calls “gray” conspiracy sites like Breitbart News and InfoWars. Twitter bots and other social media accounts further amplify the stories. And in several cases, Trump or his associates have directly cited phony Russian propaganda in a speech or interview. Here are some examples:

A false report of a terrorist attack at a NATO base in Turkey: Last July, RT and Sputnik each reported on a fire at the Incirlik base, framing it as potential sabotage. Pro-Russian and pro-Trump Twitter accounts spread and magnified the false reports, but mainstream news organizations didn’t pick up the report because it wasn’t true, as Watts explained in a piece for the Daily Beast. Yet, in mid August, Paul Manafort—Trump’s campaign chairman at the time—escalated the story to a terrorist attack, complaining on CNN that US media outlets were not adequately covering it. Politifact debunked Manafort’s claims, noting that Turkish authorities had reported small, peaceful demonstrations outside the base, but no actual assault on the base.

The case of the phony Benghazi email: On October 10, Wikileaks released a batch of emails hacked from campaign chairman John Podesta’s email account. About 5 pm ET that day, Sputnik News published a story about leaked Clinton campaign emails with the headline “Hillary confidante: Benghazi was ‘preventable’; State Department negligent.” Roughly an hour later, Trump told supporters at a rally in Pennsylvania that Clinton ally Sidney Blumenthal had called the Benghazi attack “almost certainly preventable.” “This just came out a little while ago,” Trump said. Those words weren’t actually Blumenthal’s and Sputnik later deleted the story – but by then the headline had spread far and wide.

False claims of pervasive voter fraud: RT has been attempting to delegitimize the American electoral process since 2012 by calling the U.S. voting system fraudulent, according to the declassified version of the report the Director of National Intelligence released this past January. In his Senate testimony, Watts called this the “number one theme" pushed by Russian outlets. In October 2016, a Kremlin-controlled think tank circulated a strategy document that said Russia should end its pro-Trump propaganda “and instead intensify its messaging about voter fraud to undermine the U.S. electoral system’s legitimacy and damage Clinton’s reputation in an effort to undermine her presidency,” according to a Reuters investigation. 

That same month, Trump pushed hard on the theme that the election was rigged; on Oct. 17 Trump tweeted “Of course there is large scale voter fraud happening on and before election day.” The sources his campaign pointed to were all debunked by Politifact, which noted that Trump had also tweeted in 2012 about dead voters delivering Obama’s win.

The Swedish attack that wasn’t: Trump’s strategy of running with false information didn’t stop when he won the election – and hasn’t been limited to Russian-owned media properties: He’s also used Fox News reports in a similar way. In February, Trump appeared to imply at a Florida rally that a terrorist attack had occurred the previous night in Sweden. Sweden itself had no idea what he meant and the Swedish Embassy reached out to ask for clarification. Twitter users, including many Swedes, ridiculed Trump’s statement, with references ranging from IKEA to the Swedish Chef character from the “Muppets.” Trump later said that he was referring to a Fox News story on violence allegedly perpetrated by refugees. That report, which aired the night before Trump’s rally, did not mention a specific terror-related attack; it focused on reports that rape and gun violence had increased since Sweden began taking in a record number of refugees in 2015.

Wiretapping claims pushed by a Fox News personality: In March, even though Trump's claim about Obama wiretapping Trump Tower had been directly debunked by top US intelligence officials, the president seized on a baseless claim by Fox News analyst Andrew Napolitano that British spies had wiretapped Trump at former President Obama’s request. Fox News later disavowed Napolitano’s statement. Trump continued to repeat his conviction that he’d been wiretapped, even though American and British intelligence officials insist there is no basis for the claims.

The murder of DNC staffer Seth Rich: Trump allies recently pushed another story that started as a conspiracy theory online and was fueled by Russian news outlets. Fox’s Sean Hannity aired several segments focusing on the unsubstantiated claim that Rich was behind the Clinton campaign email leaks and then murdered for his actions, even though police have said he was likely killed in a robbery attempt. When the claims were thoroughly debunked, Fox retracted the story from its website – but not before it had been spread by Trump ally and former House Speaker Newt Gingrich. Even after Fox pulled the story, Gingrich told the Washington Post, “I think it is worth looking at.”

In his Senate testimony, Watts noted that Trump is vulnerable to further manipulation by the Russians: He warned that Russian-linked Twitter accounts are actively trying to engage the president by sending him conspiracy theories. “Until we get a firm basis on fact and fiction in our own country, get some agreement about the facts,” Watts said, “we’re going to have a big problem.”

Tune into our new show Fox League Live on Channel 502 Monday to Friday at 6.30pm and on Saturday at 3pm and Sunday at 5pm.

Tune into our new show Fox League Live on Channel 502 Monday to Friday at 6.30pm and on Saturday at 3pm and Sunday at 5pm.

Mexico's health ministry confirmed 1,938 new cases of coronavirus infection on Saturday, along with 193 additional deaths, as government models projected that infections could peak this weekend.

The Labour MP and A&E doctor on her run-in with the health secretary and her shifts on the hospital frontline

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When Rosena Allin-Khan stood up in the House of Commons last Tuesday to address the health secretary, Matt Hancock, she anticipated being stonewalled. She didn’t expect to become the story.

In her other life, the MP for Tooting is an A&E doctor and intensive care specialist and has been working 12-hour hospital shifts throughout the pandemic. Allin-Khan reported that the government’s failures were contributing to a greater loss of life and she wanted answers on its testing strategy. The health secretary awkwardly responded by suggesting that Allin-Khan’s testimony was untrue and moreover, that she “might do well to take a leaf out of the shadow secretary of state’s book in terms of tone”.

25-26 January 2018 - The first annual meeting of the G20 Global Infrastructure Connectivity Alliance will bring together policy makers and practitioners to discuss the state of play in global connectivity, innovative practices and the outlook for connectivity.

Current carbon prices are falling short of the levels needed to reduce greenhouse gas emissions driving climate change, but even moderate price increases could have a significant impact, according to new OECD research.

Current carbon prices are falling short of the levels needed to reduce greenhouse gas emissions driving climate change, but even moderate price increases could have a significant impact, according to new OECD research.

The jobs gap between well-educated young people and those who left school early has continued to widen during the crisis. A good education is the best insurance against a lack of work experience, according to the latest edition of the OECD’s annual Education at a Glance.

This scoping document brings forward relevant in vitro and ex vivo thyroid assays to the attention of OECD member countries, and provide recommendations for their further development/use, and also, to identify aspects of the thyroid signalling pathway that are not covered and would require further attention

The OECD has published guidance to facilitate the ecological risk assessment of organometallic and organic metal salt substances. A strategy is presented based on key steps that first consider the fate of these substances in the environment, the identification of moieties of concern, and subsequently the selection of an appropriate path forward to either assess the inorganic moiety and/or the individual substance.

It would be wrong for charges against the Texas governor to be allowed through the courts