The Label's "The_Otherside" is this week's addition to Apple Arcade on the iPhone, iPad, and Apple TV. The game is described as both a turn-based RPG and a strategy board game:

Otherside is a turn based RPG and strategy board game where you will control four survivors who hope to push back the shadowy threat. Make your way through each level solving puzzles, fighting monsters, and destroying the spirit anchors that threaten our dimension.

Do you have what it takes to restore the town back to normal and save the day?

IBM (NYSE: IBM) announced today it will upgrade the University of Canterbury’s BlueFern High Performance Computing (HPC) facility, enhancing its ability to deliver quality science and technology outcomes and significantly increasing New Zealand’s research capacity.

Voldemort believes he has uncovered a new means of gaining the supreme power he craves in the depths of the oldest recorded history - a civilization lost over the centuries. But history is known to distort with time. Reeling from the loss of his Godfather, Harry must navigate grief, love, and growing up while surviving another year at Hogwarts as the Second War begins.

Getting to be there with her in the ghostly moonlight made everything Harry had gone through worth it... even if her brother was hellbent on tormenting them.

Moving was always stressful, but to be placed in a nationwide lockdown only a few weeks after moving was just too much for Ginny to think about. At least she had a fit neighbor keep her company... from two meters away, of course.

Auror Spook Kitty Fawley thought the difficult part of her return to the UK would be getting Sirius out of prison and recovering Harry from his Muggle relatives. Turns out that was the easiest thing she would do. To help them, Kitty will delve into a mystery deeper than any she faced in the field.

Raised by his godfather, following the events of Halloween 1981, Harry spends his childhood, hidden from the Wizarding World, preparing to face his destiny. However, his world is turned upside down when he reunites with the beautiful redhead he rescued down in the Chamber.

Their first meeting literally knocked them off...and it took them twelve hours to finally kiss. **Harry never went to Hogwarts-AU**

At a time when the world is piecing itself back together,
There are those who want to rip it apart again.
Teddy Lupin is about to learn how powerful his godfather truly is.

Head Auror Harry Potter hated the Department of Mysteries. He hated dealing with Unspeakables and disliked their holier than thou attitude. When Harry is called upon to identify a man who has been dead for years that the Unspeakables found, he suspects that there’s something more sinister going on.

On the cusp of the third wizarding war, the truth behind the events of Halloween 1981 and subsequent events finally come to light, when it is revealed that Harry Potter, forgotten and ignored by many, is the Boy Who Lived.

The Wizarding world finally knows that Lord Voldemort has returned, and the Second War has begun. As Harry prepares to enter his sixth year at Hogwarts, he is forced to deal with the trauma from his last encounter with Voldemort, the upcoming trial of Dolores Umbridge, Sirius's uncomfortable questions about his childhood, his budding relationship with Ginny Weasley, and the unknown shadow of what lies ahead as the "Chosen One" who must defeat Voldemort once and for all. This is an AU take of Half-Blood Prince following my previous story, Path Diverged.

Five times Teddy Lupin called Ginny Potter his mum. One time he called her grandmum. A few times he called Harry Potter his dad.

MSI komt met inruilprogramma voor upgrade naar Z490-moederbord  Hardware InfoHele verhaal bekijken via Google Nieuws

Well, someone outdid the previous version of Battleshots. Well played, sir or madam.

Check out all the partying over at After 12!

https://2k.com/en-US/blog/play-the-golf-club-2019-for-free-right-now/

Trial available on Xbox starting 12:00AM PT 5/7/20 through 11:59PM PT 5/13/20 and on Steam starting 10:00AM PT 5/7/20 through 9:59AM PT 5/14/20. Progress will transfer for people who purchase the full game.

2k is posting a free game play session each week

2K’s Give Back Project offers Free Play periods for the 2K community on Xbox and Steam

  Product Info: Developer: Arcade Distillery Publisher: Arcade Distillery Website: Plague Universe Twitter: @LucBernard / @ArcadeDistiller / @PlagueUniverse

MSI has announced an upgrade program if you are going to be purchasing one of their upcoming Z490 motherboards. This program is valid on motherboards purchased May 6th through June 15th.

The post MSI Announces Upgrade Program for Z490 Motherboards appeared first on ThinkComputers.org.

Today we will be taking a look at the ASRock Z490 PG Velocita Motherboard. While we are not allowed to tell you about performance of these parts, we are able to give you a technical preview.

The post ASRock Z490 PG Velocita Motherboard Technical Preview appeared first on ThinkComputers.org.

A newly discovered unpatchable hardware vulnerability in Xilinx programmable logic products could allow an attacker to break bitstream encryption, and clone intellectual property, change the functionality, and even implant hardware Trojans. The details of the attacks against Xilinx 7-Series and Virtex-6 Field Programmable Gate Arrays (FPGAs) have been covered in a paper titled "The

I love the clean and simple lines of the IKEA GODMORGON sink and wall cabinets for the bathroom. However, they can sometimes look a little standard or low grade. In this IKEA hack, we upgraded the GODMORGON vanity look with a live edge white oak countertop, chrome handles, Kohler top-mount sinks and wall-mounted Grohe faucets […]

The post IKEA bathroom vanity gets a luxurious live edge upgrade appeared first on IKEA Hackers.

We explore whether minimum wage increases result in substitution from lower-skilled to slightly higher-skilled labor. Using 2011-2016 American Community Survey data (ACS), we show that workers employed in low-wage occupations are older and more likely to have a high school diploma following recent statutory minimum wage increases. To better understand the role of firms, we examine the Burning Glass vacancy data. We find increases in a high school diploma requirement following minimum wage hikes, consistent with our ACS evidence on stocks of employed workers. We see substantial adjustments to requirements both within and across firms.

Like anyone who has ever spruced up their home, Melania Trump will have a few new touches to showcase Friday when guests visit the White House for only the second state dinner of the Trump presidency.

Schools chancellor Richard Carranza put the kibosh on the app in early April, several weeks into the city’s seismic shift to remote learning, citing concerns about Zoom’s privacy and security features.

After a recent release of a bunch of some new popular content sources, we are glad to announce a renovated and improved Twitter Feeds generator.

The post Upgraded Twitter Feeds Generator Is On The Fly! appeared first on RSSground.com.

It's not the government takeover that many Californians wanted for the fire-starting utility, but the deal Gavin Newsom struck with PG&E should help.

Public officials press for more social distancing as many beaches and public spaces close amid the coronavirus outbreak.

Mickey Wright was named greatest female golfer in history in a poll of experts

Some solar workers have been ordered down from rooftops after neighbors called the police, solar industry officials say.

The state isn't doing right by undocumented immigrants with a financial relief program that does nothing to address abusive labor practices.

PGA Tour golfer Jeff Sluman has sold his waterfront home in Florida for $3.65 million, the same price he paid for it in 2017.

Ford turns to electrified pickups, performance cars and SUVs to meet California's greenhouse gas regulations.

The Ryder Cup remains scheduled to take place in September despite other major golf tournaments being postponed.

The PGA Tour has been disrupted by the ongoing coronavirus pandemic - but will player eligibility be affected?

On paper at least, Nokia’s E6 smartphone could have been designed just for me. It keeps most of the design cues and form-factor first seen on the E71 and its successor the E72 – easy one handed operation, great physical QWERTY keyboard, rock solid build (well, the E71 at least), superb call quality, free turn-by-turn [...]

Accumulating evidence suggests that brown adipose tissue (BAT) is a potential therapeutic target for managing obesity and related diseases. PGAM family member 5, mitochondrial serine/threonine protein phosphatase (PGAM5), is a protein phosphatase that resides in the mitochondria and regulates many biological processes, including cell death, mitophagy, and immune responses. Because BAT is a mitochondria-rich tissue, we have hypothesized that PGAM5 has a physiological function in BAT. We previously reported that PGAM5-knockout (KO) mice are resistant to severe metabolic stress. Importantly, lipid accumulation is suppressed in PGAM5-KO BAT, even under unstressed conditions, raising the possibility that PGAM5 deficiency stimulates lipid consumption. However, the mechanism underlying this observation is undetermined. Here, using an array of biochemical approaches, including quantitative RT-PCR, immunoblotting, and oxygen consumption assays, we show that PGAM5 negatively regulates energy expenditure in brown adipocytes. We found that PGAM5-KO brown adipocytes have an enhanced oxygen consumption rate and increased expression of uncoupling protein 1 (UCP1), a protein that increases energy consumption in the mitochondria. Mechanistically, we found that PGAM5 phosphatase activity and intramembrane cleavage are required for suppression of UCP1 activity. Furthermore, utilizing a genome-wide siRNA screen in HeLa cells to search for regulators of PGAM5 cleavage, we identified a set of candidate genes, including phosphatidylserine decarboxylase (PISD), which catalyzes the formation of phosphatidylethanolamine at the mitochondrial membrane. Taken together, these results indicate that PGAM5 suppresses mitochondrial energy expenditure by down-regulating UCP1 expression in brown adipocytes and that its phosphatase activity and intramembrane cleavage are required for UCP1 suppression.

Accumulating evidence suggests that brown adipose tissue (BAT) is a potential therapeutic target for managing obesity and related diseases. PGAM family member 5, mitochondrial serine/threonine protein phosphatase (PGAM5), is a protein phosphatase that resides in the mitochondria and regulates many biological processes, including cell death, mitophagy, and immune responses. Because BAT is a mitochondria-rich tissue, we have hypothesized that PGAM5 has a physiological function in BAT. We previously reported that PGAM5-knockout (KO) mice are resistant to severe metabolic stress. Importantly, lipid accumulation is suppressed in PGAM5-KO BAT, even under unstressed conditions, raising the possibility that PGAM5 deficiency stimulates lipid consumption. However, the mechanism underlying this observation is undetermined. Here, using an array of biochemical approaches, including quantitative RT-PCR, immunoblotting, and oxygen consumption assays, we show that PGAM5 negatively regulates energy expenditure in brown adipocytes. We found that PGAM5-KO brown adipocytes have an enhanced oxygen consumption rate and increased expression of uncoupling protein 1 (UCP1), a protein that increases energy consumption in the mitochondria. Mechanistically, we found that PGAM5 phosphatase activity and intramembrane cleavage are required for suppression of UCP1 activity. Furthermore, utilizing a genome-wide siRNA screen in HeLa cells to search for regulators of PGAM5 cleavage, we identified a set of candidate genes, including phosphatidylserine decarboxylase (PISD), which catalyzes the formation of phosphatidylethanolamine at the mitochondrial membrane. Taken together, these results indicate that PGAM5 suppresses mitochondrial energy expenditure by down-regulating UCP1 expression in brown adipocytes and that its phosphatase activity and intramembrane cleavage are required for UCP1 suppression.

Phosphoglycerate kinase 1 (PGK1) plays important roles in glycolysis, yet its forward reaction kinetics are unknown, and its role especially in regulating cancer cell glycolysis is unclear. Here, we developed an enzyme assay to measure the kinetic parameters of the PGK1-catalyzed forward reaction. The Km values for 1,3-bisphosphoglyceric acid (1,3-BPG, the forward reaction substrate) were 4.36 μm (yeast PGK1) and 6.86 μm (human PKG1). The Km values for 3-phosphoglycerate (3-PG, the reverse reaction substrate and a serine precursor) were 146 μm (yeast PGK1) and 186 μm (human PGK1). The Vmax of the forward reaction was about 3.5- and 5.8-fold higher than that of the reverse reaction for the human and yeast enzymes, respectively. Consistently, the intracellular steady-state concentrations of 3-PG were between 180 and 550 μm in cancer cells, providing a basis for glycolysis to shuttle 3-PG to the serine synthesis pathway. Using siRNA-mediated PGK1-specific knockdown in five cancer cell lines derived from different tissues, along with titration of PGK1 in a cell-free glycolysis system, we found that the perturbation of PGK1 had no effect or only marginal effects on the glucose consumption and lactate generation. The PGK1 knockdown increased the concentrations of fructose 1,6-bisphosphate, dihydroxyacetone phosphate, glyceraldehyde 3-phosphate, and 1,3-BPG in nearly equal proportions, controlled by the kinetic and thermodynamic states of glycolysis. We conclude that perturbation of PGK1 in cancer cells insignificantly affects the conversion of glucose to lactate in glycolysis.

Join host David Price for a dive into all things tech: Round 43. Things go mobile as Senior Staff Writer at PC Advisor and Macworld UK Henry Burrell tells us why Sky getting into the market is a big deal. Quad-play ahoy. Then fellow Senior Staff Writer Lewis Painter (14 mins) tells us why No Man's Sky is still making the headlines, this time for making stuff up. How far have companies taken false advertising in recent years? Third up is Techworld editor Charlotte Jee (25 mins) to talk about how the government has perhaps avoided taking responsibility when it comes to sex-ed and instead suggested it ban sexting - is that even possible? Listen on to find out.  

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Accumulating evidence suggests that brown adipose tissue (BAT) is a potential therapeutic target for managing obesity and related diseases. PGAM family member 5, mitochondrial serine/threonine protein phosphatase (PGAM5), is a protein phosphatase that resides in the mitochondria and regulates many biological processes, including cell death, mitophagy, and immune responses. Because BAT is a mitochondria-rich tissue, we have hypothesized that PGAM5 has a physiological function in BAT. We previously reported that PGAM5-knockout (KO) mice are resistant to severe metabolic stress. Importantly, lipid accumulation is suppressed in PGAM5-KO BAT, even under unstressed conditions, raising the possibility that PGAM5 deficiency stimulates lipid consumption. However, the mechanism underlying this observation is undetermined. Here, using an array of biochemical approaches, including quantitative RT-PCR, immunoblotting, and oxygen consumption assays, we show that PGAM5 negatively regulates energy expenditure in brown adipocytes. We found that PGAM5-KO brown adipocytes have an enhanced oxygen consumption rate and increased expression of uncoupling protein 1 (UCP1), a protein that increases energy consumption in the mitochondria. Mechanistically, we found that PGAM5 phosphatase activity and intramembrane cleavage are required for suppression of UCP1 activity. Furthermore, utilizing a genome-wide siRNA screen in HeLa cells to search for regulators of PGAM5 cleavage, we identified a set of candidate genes, including phosphatidylserine decarboxylase (PISD), which catalyzes the formation of phosphatidylethanolamine at the mitochondrial membrane. Taken together, these results indicate that PGAM5 suppresses mitochondrial energy expenditure by down-regulating UCP1 expression in brown adipocytes and that its phosphatase activity and intramembrane cleavage are required for UCP1 suppression.

Boeing was awarded a $128.5 million modification to its Ground-based Midcourse Defense development and sustainment contract Thursday, according to the Pentagon.

Yukon officials say the territory's campgrounds will open to campers on June 4, but the territory's borders will remain closed. They also issued guidelines for some health care services to reopen.

The cartridge was meant to upgrade the processor and GPU in the Surface Hub 2S so as to allow rotation and multiple hubs to work together.

The Apgar score is a convenient method to rapidly assess the clinical status of the newborn infant. Recent literature suggests Apgar scores vary widely in preterm infants.

The Apgar signs for respiratory effort, grimace, and muscle tone demonstrated considerable disagreement in preterm infants ≤28 weeks’ gestation. Disagreement exists despite the level of respiratory intervention, continuous positive airway pressure, or intubation, and is likely independent of gestational age. (Read the full article)

The Walkman NW-ZX2 has Bluetooth compatibility, 128GB of internal storage, and a big price tag.

CyberPower's Gamer Xtreme midtower packs fluid 1080p gaming performance into a quality package, although it's not quite the top value in its class.

The Glass Enterprise Edition 2.0 boasts a newer Qualcomm processor that promises better performance and battery life. Google also swapped a micro-USB connectiong for a USB-C port that supports faster charging.

Gas leak was detected on a goods train transporting LPG on Saturday at Bhopal railway station in Madhya Pradesh, a Railways official said.