Hi,

Current and valid TCAs for Functional Safety are readily available at the FuSa "one-stop shop".

But I have not been able to find any archive repository for access to the obsoleted versions.

I would need to have also v1.4 of Xcelum TCA to investigate exact changes wrt previous projects.

Anyone knows how to find it?

Best regards,  Lars

Hi, I am uploading a register class, which can be used for modeling hardware registers. I am uploading the source code and examples on how to run it. I also have a user guide which has all the APIs listed and explained. The user guide is ARV.pdf in the attached tar file. I have named the class ARV, which stands for Architect's Register View. It has got very good randomization and coverage features. Users have told me that its better than RAL. You can download it from http://verisilica.info/ARV.php
. There is a limit of 750KB in this cadence website. The ARV file is 4MB. That is why, I am uploading it at this site. I have a big pdf documentation and a doxygen documentation there. That is the reason for the bigger file size. The password to open the ZIP file is ovm_arv. I hope, everyone will use these classes.

Please contact me for any help.
Regards ANil

What kind of vehicle is the 2025 Mercedes-Benz E-Class? What does it compare to? Mercedes-Benz’s E-Class is offered as a sedan or wagon with several powertrain choices. It squares off well against the BMW 5-Series and Audi A6 as well as the Volvo S90. Is the 2025 Mercedes-Benz E-Class a good car? It is a fine choice. The E-Class boasts a...

What kind of vehicle is the 2025 Mercdes-Benz S-Class? What does it compare to? The S-Class is Mercedes-Benz’s top sedan. It’s similar in concept to the BMW 7-Series and Audi A8, as well as the Lexus LS. Is the 2025 Mercdes-Benz S-Class a good car? It’s about as good as a sedan can get. The S-Class brims with tech and style, and...

Australian wine was showcased to retailers, distributors, sommeliers and media at key tasting events in Korea.

Secularism, Caste, and Class in Contemporary India Secularism, Caste, and Class in Contemporary India

Several local government units have announced the suspension of classes on Wednesday, November 13, due to tropical cyclones "Ofel" (international name: Usagi) and "Nika" (international name: Toraji).

It is still unclear if Eliezer Feldstein, the PM's media team advisor suspected of leaking the documents, did so at the prime minister's orders.

LUCENA CITY — Classes were suspended on Wednesday afternoon, Nov. 13, in Calaca City, Batangas province, due to the harmful presence of volcanic smog or “vog” from Taal Volcano. The Calaca public information office announced the suspension around 11:30 a.m. in a post on its Facebook page. “In accordance with the directive of the DepEd Calaca City Sub-Office and Calaca City DRRMO, the suspension of classes this afternoon is recommended for all public and private schools at all levels in Calaca City due to volcanic smog or “vog” from Taal Volcano,” the post said in Filipino. Local authorities advised the […]...

Keep on reading: Calaca City suspends classes due to 'vog' from Taal Volcano

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Title: FDA Approves Second Drug in New Class of Cholesterol-Lowering Medications
Category: Health News
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Last Editorial Review: 8/28/2015 12:00:00 AM

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Category: Health News
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Title: Parents, Look Out for Mental Health Issues as College Kids Return to Class
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Category: Health News
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The transcription factor (TF) cone-rod homeobox (CRX) is essential for the differentiation and maintenance of photoreceptor cell identity. Several human CRX variants cause degenerative retinopathies, but most are variants of uncertain significance. We performed a deep mutational scan (DMS) of nearly all possible single amino acid substitutions in CRX using a cell-based transcriptional reporter assay, curating a high-confidence list of nearly 2000 variants with altered transcriptional activity. In the structured homeodomain, activity scores closely aligned to a predicted structure and demonstrated position-specific constraints on amino acid substitution. In contrast, the intrinsically disordered transcriptional effector domain displayed a qualitatively different pattern of substitution effects, following compositional constraints without specific residue position requirements in the peptide chain. These compositional constraints were consistent with the acidic exposure model of transcriptional activation. We evaluated the performance of the DMS assay as a clinical variant classification tool using gold-standard classified human variants from ClinVar, identifying pathogenic variants with high specificity and moderate sensitivity. That this performance could be achieved using a synthetic reporter assay in a foreign cell type, even for a highly cell type-specific TF like CRX, suggests that this approach shows promise for DMS of other TFs that function in cell types that are not easily accessible. Together, the results of the CRX DMS identify molecular features of the CRX effector domain and demonstrate utility for integration into the clinical variant classification pipeline.

The class F of G protein-coupled receptors (GPCRs) consists of 10 Frizzleds (FZD_1–10) and Smoothened (SMO). FZDs bind and are activated by secreted lipoglycoproteins of the Wingless/Int-1 (WNT) family, and SMO is indirectly activated by the Hedgehog (Hh) family of morphogens acting on the transmembrane protein Patched. The advance of our understanding of FZDs and SMO as dynamic transmembrane receptors and molecular machines, which emerged during the past 14 years since the first-class F GPCR IUPHAR nomenclature report, justifies an update. This article focuses on the advances in molecular pharmacology and structural biology providing new mechanistic insight into ligand recognition, receptor activation mechanisms, signal initiation, and signal specification. Furthermore, class F GPCRs continue to develop as drug targets, and novel technologies and tools such as genetically encoded biosensors and CRISP/Cas9 edited cell systems have contributed to refined functional analysis of these receptors. Also, advances in crystal structure analysis and cryogenic electron microscopy contribute to the rapid development of our knowledge about structure-function relationships, providing a great starting point for drug development. Despite the progress, questions and challenges remain to fully understand the complexity of the WNT/FZD and Hh/SMO signaling systems.

Here, we highlight the case of a 31-yr-old man who had clinical features of primary hypertrophic osteoarthropathy (PHOAR) and harbored a homozygous variant (c.38C > A, p.Ala13Glu) in the HPGD gene, as indicated by whole-exome sequencing (WES). This variant has been previously classified by our laboratory as a variant of uncertain significance (VUS). However, another patient with the same phenotype and the same homozygous variant in HPGD was subsequently reported. In reassessing the variant, the absence of this variant in the gnomAD population database, supporting computational predictions, observation in homozygosity in two probands, and specificity of the phenotype for HPGD, all provide sufficient evidence to reclassify the HPGD c.38C > A, p.Ala13Glu variant as likely pathogenic.

The leak caught national intelligence officials by surprise and led to an embarrassing Air Force Inspector General investigation.

I would never have predicted there'd be an isometric tactics game based on run-and-gun series Metal Slug, yet here Metal Slug Tactics is, and I am here for it. We've been following its development for a while but it's out now on Steam, and seemingly as strong as its demo suggested.

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Sega are delisting several bundles of 'classic' games from digital stores, along with "select individual" games. On Steam specifically, this adds up to over 60 games in total, including several actual classics including the original Streets Of Rage trilogy, Crazy Taxi, and Jet Set Radio.

The games will be removed on December 6th but will remain playable to those who already own them.

Read more

The developers of hero shooter Overwatch 2 must have dropped a box full of old photographs while clearing the attic, spilling old snapshots of Route 66 onto the floor and getting snared in a nostalgic daze. The game is launching a "Classic" mode today that will let you play the first-person payload pusher as it (mostly) was back in 2016 when the first Overwatch launched. That means 6v6 fights, the original abilities of its heroes, and no limits to stop the entire team picking the same character.

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My strongest and most enduring memory of Grand Theft Auto will always be creasing into complete hysterics watching my mate pile into a crumpled police officer with a wooden baseball bat in GTA 3 after school one time. Young’uns these days just don’t appreciate how revolutionary it was to be able to hit a cop with a thing after he’d already fallen over. Suffice it to say I’ve got good memories of the open world series’ nascent forays into 3D, though never enough to tempt me into revisiting them, especially given the poor reception to Grand Theft Auto: The Trilogy - The Definitive Edition. I can sympathise. I’m annoyed just having to type a semicolon and a dash in the same game name.

If you’re in a similarly non-fussed position (I will never not be annoyed that ‘nonplussed’ doesn’t mean what it sounds like it should mean) I can’t imagine a lighting update that’s been available on the mobile versions for a while is enough to tempt you back. But what is a reporter's job if not pathetically treading water between chunklets of Grand Theft Auto news, upon the publishing of which Graham presses the button to release the nutritious pellets on which we all wholly subsist? I hope he doesn’t read that last sentence. I don’t get my pellet if the syntax becomes too convoluted. Moving swiftly on.

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From Goats to airplanes, Xbox Game Pass has another bumper month in store for subscribers. Here's everything you need to know about what is heading to PC and console this November 2024

Death Stranding, originally launched in 2019, has finally come to Xbox consoles five years after its initial debut as a Director's Cut version from Hideo Kojima.

Overwatch 2 is bringing 6v6 gameplay back from Overwatch 1 - and fans are overjoyed. Here's all we know so far, including when you can finally play the Classic mode

As artificial intelligence becomes more common in university classrooms, some professors are weighing the benefits — and downsides — of students using it for research projects.

The new Louisiana requirement that the Ten Commandments be displayed in every public classroom by Jan. 1 was temporarily blocked Tuesday. The judge said the law is "unconstitutional on its face."

Nobody loses games they already bought, but the clock is ticking.

Shea Weber is member of the Hockey Hall of Fame. The former defenceman headlined the 2024 class inducted Monday, joining Pavel Datsyuk, Jeremy Roenick, Natalie Darwitz and Krissy Wendell in the player category. David Poile and Colin Campbell entered as builders.

For a lot of folks who have been following Capcom’s fighting games over the years, the Marvel vs Capcom Fighting …

Continue reading "Marvel vs Capcom Fighting Collection: Arcade Classics Review – Switch, Steam Deck, and PS5 Covered"

I’m a Celebrity... Get Me Out of Here!’s 2024 campmates were finally confirmed on Monday, 11 November.

The former striker will depart the programme at the end of the 2024/25 season

For the first time in over two years, Overwatch 2 players will be able to group up in teams of six. A three-week event featuring that format starts tomorrow, November 12. But there’s a twist: you won’t be able to select Kiriko or Sombra, or battle it out with an additional player on each side on Push maps just yet. That’s because in Overwatch 2’s first real taste of 6v6, Blizzard is taking us all the way back to the beginning with a limited-time mode called Overwatch: Classic.

You will be able to experience Overwatch almost exactly as it was upon its May 2016 debut. That means you can choose from the first 21 heroes, who all have their original kits and abilities. That means Hanzo loses his Lunge jump but regains his dreaded Scatter Arrow, Bastion and Torbjorn are vastly different than they are now and Cassidy's Flashbang once again stun locks enemies for a moment. 

Symmetra reverts to being a support who can teleport allies almost anywhere on the map from the spawn room, while Mercy can will once again bring five dead teammates back to life. Ultimate abilities will charge up faster too.

In addition, just like in Overwatch for a brief period at the very beginning, there are initially no limits on hero selection. So if you and your teammates want to run with a composition of four Winstons and two Lucios, have at it. However, this will only apply for the first few days, after which Blizzard will apply the single hero limit rule for the rest of the event. Games will take place under the Quick Play ruleset, rather than the Competitive format.

The original 12 maps will be available too — including the assault maps that Blizzard retired from the main modes during the transition to Overwatch 2. While assault maps are still available in the Arcade and custom games, you'll once again be dealing with the notorious choke points of the otherwise gorgeous Hanamura, Temple of Anubis and Volskaya Industries.

Things won't be exactly as they were in May 2016, however. Original maps that have seen major reworks over the years — Dorado, Numbani, Route 66 and Watchpoint: Gibraltar — will appear as they are in the current game. You'll only be able to use the original default Overwatch skins and no, there are no loot boxes. The user interface remains the same too, which hopefully means the ping system will still be in place.

Blizzard doesn't plan for this to be a one-and-done deal. There will be other Overwatch: Classic events in the future, focusing on various moments in the game's history, like the infamous triple-tank, triple-support GOATS meta. This limited-time mode is also separate from the other 6v6 tests Blizzard plans to run in the coming months as it looks to measure players' interest in that format and garner feedback.

There's a good chance that this limited-time mode will bring some lapsed players back into the mix, even just for a sip of nostalgia. I first played Overwatch several months after its debut, so it'll be fun to see roughly how the game felt at the very beginning. I will be instalocking Mei every match so I can remember what it's like to freeze an opponent before giving them a cheeky wave and firing an icicle into their skull. Ah, memories...

Massachusetts Air National Guard member Jack Teixeira received a 15-year sentence in federal prison for leaking classified military documents on Discord in a Boston federal court, according to The Washington Post.

Teixeira appeared before the court earlier today and asked the judge for leniency. He also issued a statement apologizing for “all of the harm that I’ve caused, to my friends, family and those overseas.”

Defense attorney Michael Bachrach also claimed that Teixeira was subjected to bullying in high school and his military unit as an adjudicating factor for his actions. Judge Indira Talwani didn’t buy the defense’s bullying claims stating that the Air Force has already disciplined 15 other members connected to Teixeira for not taking more actions “that might have stopped him from doing this.”

Teixeira shared classified military documents as far back as late 2022 on a Discord server dedicated to the pixelated sandbox game Minecraft. The leak included information about the Ukrainian and Russian troop movements and military equipment used in the war in Ukraine and Russia's attempts to obtain more weapons from Egypt and Turkey. The documents eventually found their way to other Discord servers as well as 4chan and Telegram.

FBI officials arrested Teixeira at his home in April of last year. Teixeira originally agreed to a plea deal with federal prosecutors in March that included a 16-year prison sentence for pleading guilty to six counts of willful retention and transmission of national defense information and violating the Espionage Act. If he stuck with his not guilty plea and received a guilty verdict, Teixeira faced a much steeper maximum prison term of 60 years.

Participant reported relief from chronic low back pain and reduced need for pain-relief medications.

Settlement Overview Video. If you lived at Huronia, Rideau, or Southwestern Regional Centres, you may be eligible to make a claim.

Matt Snow CEO of DHG

Algiz-RT7 rugged tablet product presentation

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The Amgen Biotech Experience empowers teachers to bring biotechnology into their classrooms to spark students� love of science and features a hands-on curriculum that introduces students to the excitement of scientific discovery.

Advice you don't want from a maniac you don't trust.

We speak with historian Robin D. G. Kelley about the roots of Donald Trump’s election victory and the decline of Democratic support among many of the party’s traditional constituencies. Kelley says he agrees with Vermont Senator Bernie Sanders, who said Democrats have “abandoned” working-class people. “There was really no program to focus on the actual suffering of working people across the board,” Kelley says of the Harris campaign. He says the highly individualistic, neoliberal culture of the United States makes it difficult to organize along class lines and reject the appeal of authoritarians like Trump. “Solidarity is what’s missing — the sense that we, as a class, have to protect each other.”

Today I’m teaching a perilous topic: the eclipse of Darwinism. There was a period of several decades where you could make an honest intellectual argument against evolution, roughly from the time it was first published (1860) to the development of population genetics (say, roughly 1920). All the arguments since then are fundamentally garbage, but before […]

We've had a huge response to our class calculator this week, particularly across social media, following a major survey by BBC Lab UK. The survey suggests that traditional categories of working, middle and upper class are outdated and we all fit in to one of seven new classes.

The class calculator - which lets you work out where you might fit in amongst the new categories - has attracted about six million page views on the BBC News site, making it the second most popular article of 2013 to date. (The most viewed article this year has been the helicopter crash in Vauxhall in January.) Nearly 1.9 million of those views have come from those of you accessing the site on mobiles and tablets.

But one thing that really stands out is how widely the story has been shared across social media, with more than 300,000 shares so far. More than a quarter of links to the calculator have come from social networking sites.

More than half a million referrals came from Facebook alone, and about 107,000 from Twitter. This is a much higher number than we usually see shared across social media. If you compare the class calculator with the other top stories of the week, usually about 5% of known referrals come from social media sites.

So why has it proven so popular with our audience? Michael Orwell, a producer at BBC Lab UK, worked closely on the survey and said one of the best things about the project was that the audience contributed to new research with top academics.

The calculator itself, produced by the BBC News Visual Journalism team in collaboration with BBC Knowledge and Learning, lets everyone engage with the new model and discover where they might fit in.

Steve Herrmann is editor of the BBC News website.