Animal models of bacterial infection have been widely used to explore the in vivo activity of antibacterial drugs. These data are often submitted to the U.S. Food and Drug Administration to support human use in an investigational new drug application (IND). To better understand the range and scientific use of animal models in regulatory submissions, a database was created surveying recent pneumonia models submitted as part of IND application packages. The IND studies were compared to animal models of bacterial pneumonia published in the scientific literature over the same period of time. In this review, we analyze the key experimental design elements, such as animal species, immune status, pathogens selected, and route of administration, and study endpoints.

A 4-year surveillance of carbapenem-resistant Acinetobacter spp. isolates in Argentina identified 40 strains carrying bla_NDM-1. Genome sequencing revealed that most were Acinetobacter baumannii, whereas seven represented other Acinetobacter spp. The A. baumannii genomes were closely related, suggesting recent spread. bla_NDM-1 was located in the chromosome of A. baumannii strains and on a plasmid in non-A. baumannii strains. A resistance gene island carrying bla_PER-7 and other resistance determinants was found on a plasmid in some A. baumannii strains.

T cell–expressed PD-L1 exerts tolerogenic effects on tumor immunity in pancreatic cancer.

Understanding how coronary blood vessels form and regenerate during development and progression of cardiac diseases will shed light on the development of new treatment options targeting coronary artery diseases. Recent studies with the state-of-the-art technologies have identified novel origins of, as well as new, cellular and molecular mechanisms underlying the formation of coronary vessels in the postnatal heart, including collateral artery formation, endocardial-to-endothelial differentiation and mesenchymal-to-endothelial transition. These new mechanisms of coronary vessel formation and regeneration open up new possibilities targeting neovascularization for promoting cardiac repair and regeneration. Here, we highlight some recent studies on cellular mechanisms of coronary vessel formation, and discuss the potential impact and significance of the findings on basic research and clinical application for treating ischemic heart disease.

Background:

Research on the relationship of meat, fish, and egg consumption and mortality among prostate cancer survivors is limited.

Background:

We assessed the ability to supplement existing epidemiologic/etiologic studies with data on treatment and clinical outcomes by linking to publicly available cancer registry and administrative databases.

BACKGROUND AND PURPOSE:

Not all tandem occlusions diagnosed on traditional vascular imaging modalities, such as MRA, represent actual complete ICA occlusion. This study aimed to explore the utility of high-resolution vessel wall imaging in identifying true ICA tandem occlusions and screening patients for their suitability for endovascular recanalization.

SUMMARY:

Use of mechanical thrombectomy for stroke has increased since the publication of trials describing outcome improvement when used in the anterior circulation. These results, however, cannot be directly translated to the posterior circulation. While a high NIHSS score has demonstrated an association with poor outcomes in posterior stroke, the NIHSS is weighted toward hemispheric disease, and complex scores potentially delay definitive imaging diagnosis. We performed a retrospective analysis to ascertain whether any rapidly obtainable demographic or clinical and imaging data have a correlation with patient outcome postthrombectomy. Seventy-three cases were audited between September 2010 and October 2017. Presenting with a Glasgow Coma Scale score of >13 meant that the odds of reaching the primary end point of functional independence (defined as a 90-day modified Rankin Scale score of 0–2) were 5.70 times greater; similarly, presenting with a posterior circulation ASPECTS of >9 resulted in the odds of reaching the primary end point being 4.03 times greater. Older age correlated to a lower odds of independence (0.97, p = .04).

BACKGROUND AND PURPOSE:

Vessel wall imaging is increasingly performed in the diagnostic work-up of patients with ischemic stroke. The aim of this study was to compare vessel wall enhancement after intra-arterial thrombosuction with that in patients not treated with thrombosuction.

BACKGROUND AND PURPOSE:

It is currently not completely clear how well radiologists perform in evaluating large-vessel occlusion on CTA in acute ischemic stroke. The purpose of this study was to investigate potential factors associated with diagnostic error.

Real estate insiders and experts said it is essential to develop strict penalties to combat those operating fraudulent property businesses to protect the legitimate rights of consumers and legitimate enterprises.

The decision to list your home for resale is a big one. No doubt it came about after much thought, weighing pros and cons, and series of long discussions. However, once you decide to put your home on the market, get ready for the next big discussion: interior design.

थैलेसीमिया मुख्यत: एक जेनेटिक यानी अनुवांशिक बीमारी है जो माता-पिता से उनके बच्चों में होती है। इस बीमारी में बच्चों में खून की कमी होने लगती है, जो कि सेहत के लिए बहुत हानिकारक होता है।

Getting married is one of life’s most memorable — and emotional — milestones in life. But with tight restrictions on gatherings due to COVID-19 pandemic, couples throughout Windsor and Essex County who had scheduled their weddings for this spring or summer have had little choice but to postpone their big day. “Weddings are an extremely […]

Inside a mountain in the Arctic, Microsoft is building a backup of open-source software that it says will keep the code safe for 1000 years

Up until now mask-wearing had only been an unenforced suggestion by the company.

STATE PENSIONS are calculated by National Insurance contributions - but can you top up any missed years?

Ready-to-connect readycables® save you time on cable assembly and are guaranteed to last 36 months

A Facebook executive challenges the Arm processor community to create tech building blocks for augmented reality glasses

Your weekly selection of awesome robot videos

Michael Kratsios, the fourth U.S. Chief Technology Officer, explains administration policies at the Fall Conference of the Stanford Institute for Human-Centered Artificial Intelligence

Not every actor is Linney-caliber.

Record low bond yields are pushing superannuation funds and insurers into alternative investments.

Take a break from PAX East 2016 for some gentle RPG sound waves. Anna Marie confesses her obsession with rebuilding the moon. Alex confesses his...

Comfortable and chic, these are perfect transitional pieces for spring. Layer a thin polo neck underneath on chillier days, or style with a fitted blazer to look smarter

Whether it’s printed and high-necked or floral and ruffled, brighten your lockdown by dressing up to stay in

The COVID-19 pandemic has placed unprecedented pressure on societies worldwide, given the pandemic's rapid, often deadly spread. In health care, the pandemic has raised the pressing question of how society should allocate scarce resources during a crisis.

Staff of the magazine that kicked off the French New Wave say its new elite owners pose a threat to editorial independence

The mass resignation of the staff of Cahiers du Cinéma, the film journal that launched the French New Wave, has reignited debate in France about the possibility of critical independence in a society whose major stakeholders frequently operate in several spheres.

On Thursday, the 15 staff writers and editors announced their resignation, saying they believed its new owners posed a threat to the magazine’s cherished independence.

The singer who played a key role in early rock music's popularity died Saturday at 87 years old.

The newly-remastered images show the icy surface of Europa, the sixth of Jupiter’s moons and the fourth largest, in enhanced color. All three high-resolution images were captured along the same longitude of Europa as NASA’s Galileo spacecraft flew by on September 26, 1998, in the eighth of the spacecraft’s 11 targeted flybys of the icy [...]

The U.S. government reported more catastrophic economic fallout from the coronavirus crisis on Friday as the pandemic pierced the very walls of the White House and California gave the green light for its factories to restart after a seven-week lockdown.

The Juventus defender took aim at the pair in his upcoming autobiography but is now finding himself on the receiving end

This interactive map for Assassin's Creed Odyssey will help you find everything you need, like ainigmata ostraka and tombs.

Shelling of Tripoli's Mitiga airport early on Saturday, part of an intensified barrage of artillery fire on the capital in recent days, hit fuel tanks and damaged passenger planes, the Transport Ministry said in a statement.

Arsenal and England midfielder Jordan Nobbs will be a columnist for 90min & BBC Sport pundit at the Women's World Cup in France this summer, as Phil Neville's Lionesses' look to secure a maiden World Cup triumph. Two wins from our first two games is obviously what we were all hoping for. The first game of a World Cup, or any other major tournament, is never going to be one where you're playing at your absolute best. But the 2-1 win over was Scotland was great given the pre-match hype, the..

Bucket hats With approval from all aspects of runways, bucket...

The post Beachwear Essentials For The Season appeared first on Man's World India.

Behind the scenes: Some ask "Why are we here?" after the Senate accomplished little in its first week back as coronavirus cases continue to rise in DC.

Two officials tied to then-Gov. Chris Christie had been sentenced to prison for their roles in creating massive traffic jams on the N.J.-N.Y. crossing.

An analysis by Norwegian scientists has found a low level of heavy metals in processed fish products in the country. Commercially available items were collected from 2015 to 2018 and analyzed as composite samples for mercury, lead, arsenic, and cadmium. Levels of cadmium, lead, and arsenic were low and human exposure to these metals would... Continue Reading

JEFFERSON CITY, Mo. (AP) - A Missouri House panel has dismissed a sexual harassment complaint against a state lawmaker after an investigation that spanned several months.

Minutes of the Missouri House Ethics Committee obtained by The Associated Press through an open-records request show the complaint was dismissed last week ...

Provisions for credit losses were $30.2 million, an increase of 397.9 per cent from a year earlier

'You can’t have a going out of business sale when you can’t get your business open'

Too many of America’s workplaces are not representative of our communities. In a divided country, we have a duty to advance diversity and inclusion

We’re living in a country of growing division and tension, and it’s having an impact at work. But it’s often the case that when we walk into the office – where we spend the majority of our time – we don’t address these issues.

And yet there’s so much to talk about – from growing societal inequality and America’s racial divide to single-digit minority representation in corporate America. (Just 1% of the nation’s Fortune 500 CEOs are black, only 4% are women, and even fewer are openly gay).

Revealed: records show law enforcement has called demonstrators possible ‘domestic terrorism’ threats

US law enforcement officials preparing for fresh Keystone XL pipeline protests have privately discussed tactics to stop activists “by any means” and have labeled demonstrators potential “domestic terrorism” threats, records reveal.

Internal government documents seen by the Guardian show that police and local authorities in Montana and the surrounding region have been preparing a coordinated response in the event of a new wave of protests opposing the controversial Keystone XL tar sands pipeline, which would carry crude oil from Canada to Montana, South Dakota and Nebraska.

The brain has a powerful ability to remember and connect events separated in time. And now, in a new study in mice, scientists have shed light on how the brain can form such enduring links.

One person is now in charge of Google’s six messaging apps.