Ebonyi State House of Assembly has given a 24-hour ultimatum to all illegal motor park operators in Abakaliki to shut down operation or face the full wrath of the law. This was contained in a statement signed by the state Assembly’s Public Relations Officer, Sylvester Egede and made available to newsmen shortly after the Ebonyi […]

Ebonyi Assembly bans illegal motor parks

2024 Changing Faces Women's Leadership Seminar

grandyd Tue, 12/05/2023 - 16:14

LIVE: The 2024 General Assembly is now underway in Washington, DC, bringing together Jewish communities nationwide to confront unprecedented challenges. 

Proceeding to the discovery phase means both parties must collect and exchange evidence.

Former French MP Meyer Habib describes his worries about France's future as antisemitism soars across Europe and violence becomes normalized.

Taiwan accepts World Health Organization invitation despite political caveat from China

Nazir SiyalKARACHI: Jeroen Willems, Head of Cooperation at the European Union Mission to Pakistan, called upon Speaker of the Provincial Assembly of Sindh, Syed Awais Qadir Shah, here on Tuesday. CEU Mission to Pakistan leader Jeroen was accompanied by Ms. … read more

“Ixe! If it wasn’t for solar energy, we would have closed down, you can be sure. We had to stop due to the pandemic on 15 March 2020, but the energy costs were fixed,” said Erika Cazuza, administrative and financial manager of the Brazilian Cooperative of Rural Producers of Monteiro (Capribom). Ixe is a word […]

2000 disassembly guide

The very weak forces of attraction caused by the Casimir effect can now be used to manipulate microscopic gold flakes and turn them into a light-trapping tool

Title: Vaping May Trigger Lung Damage Like That Seen in Emphysema
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/27/2019 12:00:00 AM

Title: Blood in Semen
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 8/12/2022 12:00:00 AM

Title: furosemide
Category: Medications
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 8/10/2022 12:00:00 AM

Understanding the evolution of chromatin conformation among species is fundamental to elucidate the architecture and plasticity of genomes. Nonrandom interactions of linearly distant loci regulate gene function in species-specific patterns, affecting genome function, evolution, and, ultimately, speciation. Yet, data from nonmodel organisms are scarce. To capture the macroevolutionary diversity of vertebrate chromatin conformation, here we generate de novo genome assemblies for two cryptodiran (hidden-neck) turtles via Illumina sequencing, chromosome conformation capture, and RNA-seq: Apalone spinifera (ZZ/ZW, 2n = 66) and Staurotypus triporcatus (XX/XY, 2n = 54). We detected differences in the three-dimensional (3D) chromatin structure in turtles compared to other amniotes beyond the fusion/fission events detected in the linear genomes. Namely, whole-genome comparisons revealed distinct trends of chromosome rearrangements in turtles: (1) a low rate of genome reshuffling in Apalone (Trionychidae) whose karyotype is highly conserved when compared to chicken (likely ancestral for turtles), and (2) a moderate rate of fusions/fissions in Staurotypus (Kinosternidae) and Trachemys scripta (Emydidae). Furthermore, we identified a chromosome folding pattern that enables "centromere–telomere interactions" previously undetected in turtles. The combined turtle pattern of "centromere–telomere interactions" (discovered here) plus "centromere clustering" (previously reported in sauropsids) is novel for amniotes and it counters previous hypotheses about amniote 3D chromatin structure. We hypothesize that the divergent pattern found in turtles originated from an amniote ancestral state defined by a nuclear configuration with extensive associations among microchromosomes that were preserved upon the reshuffling of the linear genome.

Exogenous substances, including drugs and chemicals, can transfer into human seminal fluid and influence male fertility and reproduction. In addition, substances relevant in the context of sports drug testing programs, can be transferred into the urine of a female athlete (after unprotected sexual intercourse) and trigger a so-called adverse analytical finding. Here, the question arises as to whether it is possible to distinguish analytically between intentional doping offenses and unintentional contamination of urine by seminal fluid. To this end, 480 seminal fluids from nonathletes were analyzed to identify concentration ranges and metabolite profiles of therapeutic drugs that are also classified as doping agents. Therefore, a screening procedure was developed using liquid chromatography connected to a triple quadrupole mass spectrometer, and suspect samples (i.e., samples indicating the presence of relevant compounds) were further subjected to liquid chromatography-high-resolution accurate mass (tandem) mass spectrometry. The screening method yielded 90 findings (including aromatase inhibitors, selective estrogen receptor modulators, diuretics, stimulants, glucocorticoids, beta-blockers, antidepressants, and the nonapproved proliferator-activated receptor delta agonist GW1516) in a total of 81 samples, with 91% of these suspected cases being verified by the confirmation method. In addition to the intact drug, phase-I and -II metabolites were also occasionally observed in the seminal fluid. This study demonstrated that various drugs including those categorized as doping agents partition into seminal fluid. Monitoring substances and metabolites may contribute to a better understanding of the distribution and metabolism of exogenous substances in seminal fluid that may be responsible for the impairment of male fertility.

SIGNIFICANCE STATEMENT

This study demonstrates that doping agents as well as clinically relevant substances are transferred/eliminated into seminal fluid to a substantial extent and that knowledge about drug levels (and potential consequences for the male fertility and female exposure) is limited. The herein generated new dataset provides new insights into an important and yet little explored area of drug deposition and elimination, and hereby a basis for the assessment of contamination cases by seminal fluid in sports drug testing.

BACKGROUND AND PURPOSE:

Low-field 64 mT portable brain MRI has recently shown diagnostic promise for MS. This study aimed to evaluate the utility of portable MRI (pMRI) in assessing dissemination in space (DIS) in patients presenting with optic neuritis and determine whether deploying pMRI in the MS clinic can shorten the time from symptom onset to MRI.

MATERIALS AND METHODS:

Newly diagnosed patients with optic neuritis referred to a tertiary academic MS center from July 2022 to January 2024 underwent both point-of-care pMRI and subsequent 3T conventional MRI (cMRI). Images were evaluated for periventricular (PV), juxtacortical (JC), and infratentorial (IT) lesions. DIS was determined on brain MRI per 2017 McDonald criteria. Test characteristics were computed by using cMRI as the reference. Interrater and intermodality agreement between pMRI and cMRI were evaluated by using the Cohen . Time from symptom onset to pMRI and cMRI during the study period was compared with the preceding 1.5 years before pMRI implementation by using Kruskal-Wallis with post hoc Dunn tests.

RESULTS:

Twenty patients (median age: 32.5 years [interquartile range {IQR}, 28–40]; 80% women) were included, of whom 9 (45%) and 5 (25%) had DIS on cMRI and pMRI, respectively. Median time interval between pMRI and cMRI was 7 days (IQR, 3.5–12.5). Interrater agreement was very good for PV (95%, = 0.89), and good for JC and IT lesions (90%, = 0.69 for both). Intermodality agreement was good for PV (90%, = 0.80) and JC (85%, = 0.63), and moderate for IT lesions (75%, = 0.42) and DIS (80%, = 0.58). pMRI had a sensitivity of 56% and specificity of 100% for DIS. The median time from symptom onset to pMRI was significantly shorter (8.5 days [IQR 7–12]) compared with the interval to cMRI before pMRI deployment (21 days [IQR 8–49], n = 50) and after pMRI deployment (15 days [IQR 12–29], n = 30) (both P < .01). Time from symptom onset to cMRI in those periods was not significantly different (P = .29).

CONCLUSIONS:

In patients with optic neuritis, pMRI exhibited moderate concordance, moderate sensitivity, and high specificity for DIS compared with cMRI. Its integration into the MS clinic reduced the time from symptom onset to MRI. Further studies are warranted to evaluate the role of pMRI in expediting early MS diagnosis and as an imaging tool in resource-limited settings.

PURPOSE

Meeting scholarly activity requirements continues to be a challenge in many family medicine (FM) residency programs. Studies comprehensively describing FM resident scholarship have been limited. We sought to identify institutional factors associated with increased scholarly output and meeting requirements of the Accreditation Council for Graduate Medical Education (ACGME).

OBJECTIVES

Our goals were to: (1) describe scholarly activity experiences among FM residents compared with ACGME requirements; (2) classify experiences by Boyer’s domains of scholarship; and (3) associate experiences with residency program characteristics and scholarly activity infrastructure.

METHODS

This was a cross-sectional survey. The survey questions were part of an omnibus survey to FM residency program directors conducted by the Council of Academic Family Medicine Educational Research Alliance (CERA). All ACGME-accredited US FM residency program directors, identified by the Association of Family Medicine Residency Directors, were sampled.

RESULTS

Of the 691 eligible program directors, 298 (43%) completed the survey. The respondents reported that 25% or more residents exceeded ACGME minimum output, 17% reported that 25% or more residents published their work, and 50% reported that 25% or more residents delivered conference presentations. Programs exceeding ACGME scholarship requirements exhibit robust infrastructure characterized by access to faculty mentorship, scholarly activity curricula, Institutional Review Board, medical librarian, and statistician.

CONCLUSIONS

These findings suggest the need for codified ACGME requirements for scholarly activity infrastructure to ensure access to resources in FM residency programs. By fostering FM resident engagement in scholarly activity, programs help to create a culture of inquiry, and address discrepancies in funding and output among FM residency programs.

As misinformation about the upcoming US elections rockets across social media, creating chaos, companies need to be honest about where this content is coming from, says Annalee Newitz

Hurricane Helene hit a quartz mine in North Carolina that is key to global semiconductor production, which could impact the entire tech industry. Here is everything we know so far

A man from Eugene, Oregon, pleaded guilty to federal hate crimes on Tuesday after he spray-painted antisemitic graffiti on a synagogue in 2023 and 2024.

Senate Republicans met on Tuesday night to hear from the three candidates to succeed Mitch McConnell, and Rick Scott left with two new endorsements.

1. Bypolls LIVE: Voting begins for Wayanad LS seat and 31 Assembly seats in 10 States; Priyanka Gandhi makes debut  The Hindu
2. Priyanka Gandhi's Debut, Bypolls In 31 Assembly Seats: All You Need To Know  NDTV
3. Watch: Rahul Gandhi tries Kerala's longest zipline in bid to promote tourism after landslides  The Times of India
4. Let's ensure resounding victory together: Rahul to Wayanad voters  The Hindu
5. Hope people of Wayanad give me chance to represent them, says Priyanka Gandhi  Telegraph India

Someone has to speak out against the pro-Hamas factions.

While buzzy social media moments, massive celebrity endorsements and viral memes were everywhere during the U.S. election campaign, those who study social media and pop culture say it's likely that smaller social media interactions had a larger impact on the outcome.

SEMI Radradra’s sister has directly contradicted reports in the Fiji Times that her brother was leaving the NRL for French rugby.

Dans une étude, on rapporte qu’un médicament antidiabétique très utilisé retarde les effets négatifs du vieillissement sur les fonctions cognitives.

The secretary of the Union Ayush Ministry, Dr Rajesh Kotecha, will inaugurate the 61st Ayurveda Seminar organized by the Kottakkal Aryavaidyasala (Kottakkal AVS) on November 10 at Kottakkal in

Informa Connect's Copay, Reimbursement and Access Congress
November 18-20, 2024 | Hilton Penn’s Landing in Philadelphia, PA
Drug Channels readers save 10% with code USAVE24*

The access and affordability landscape is undergoing a seismic shift. Evolving legislation, disruptive market forces and the ever-growing complexities of cost sharing programs threaten patient adherence and commercialization strategies. Are you ready?

A program driven by marketplace insights and led by industry trailblazers, Copay, Reimbursement and Access Congress is back November 18-20 and will deliver up-to-date insights necessary to enhance patient affordability, ensure program sustainability and navigate the regulatory landscape. In a time where remaining compliant has never been more complex and program innovation has never been more important, be sure to join your industry counterparts to drive adherence, access and commercialization forward.

Why attend the Copay, Reimbursement and Access Congress?

Keeping up with shifting market dynamics in the midst of maximizing access, while also meeting business objectives is a challenging task and brings about many questions for access professionals.

• Is your program sustainable and innovative to better support patients?
• Accumulators, maximizers, AFPs – What are your next steps to ensure effective reimbursement strategies?
• In an election year, what is the future of health policy?

Experts will tackle these questions and more as the industry comes together to benchmark best practices to accelerate access and commercialization. Do not miss your chance to join seasoned leaders, your peers and leading solution providers as they navigate marketplace trends and dive into the impact coupons, benefit design, accumulators, maximizers, alternative funding programs and drug pricing legislation have on patient affordability and out-of-pocket costs. This is your chance to gain critical insights on industry standards, forward-thinking strategies to optimize your copay and cost sharing programs and so much more.

Content highlights:

• Over 20 hours of content, including 7+ dedicated sessions to help decipher copay legislation
• Crucial perspectives from Pfizer, Sanofi, Janssen, Teva, Ascendis Pharma, Melinta Therapeutics, GSK, HIV + Hepatitis Policy Institute and more
• Insights direct from enforcement agents on the top trends and actions within the copay and patient services space
• Illuminating case study, Navigating the Patient Journey in a Shifting Copay Landscape from Spark Therapeutics
• 465 minutes of valuable in-person networking with colleagues and counterparts to expand your network and establish powerful partnerships
• Additional content access through Streamly, a platform that gives you 12-month access to all of the available conference content** to review at your leisure
• And more!

Download the agenda and register today—Be sure to use your exclusive promo USAVE24 to save 10% off* of your registration

See you there!

*Cannot be combined with other offers, promotions or applied to an existing registration. Other restrictions may apply.
**Pending speaker permissions

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The content of Sponsored Posts does not necessarily reflect the views of HMP Omnimedia, LLC, Drug Channels Institute, its parent company, or any of its employees. To find out how you can promote an event on Drug Channels, please contact Paula Fein (paula@DrugChannels.net).

Today’s guest post comes from Kimberley Chiang, Vice President of Biopharma Commercial Solutions at CoverMyMeds

Kimberley highlghts the crucial roles of field reimbursement managers in removing access and reimbursement barriers. She then identifies the keys to successful implementation of field reimbursement services.

To learn more, register for CoverMyMeds' November 13, 2024, webinar: Specialty Therapies & Field Reimbursement Services: Driving Better Outcomes for Brands and Patients.

Read on for Kimberley’s insights.
Read more »

The type 2 diabetes mellitus drug semaglutide is effective for weight loss in non-diabetic overweight or obese adults, when taken alongside a reduced-calorie diet and exercise, researchers have found.

The Pakistani Taliban on Monday claimed responsibility for the January 30 mosque attack in Peshawar which left 100 people dead and over 220 injured

Dec 14, 2023

The Belfer Center's National Security Fellows (NSFs), as part of the Defense, Emerging Technology, and Strategy (DETS) program, developed and taught the "For the Common Defense" study group throughout the Fall 2023 semester. Each “Common Defense” seminar is an in-depth exploration of a national security or defense-related subject taught by senior defense officials. Over the course of eight seminars, this study group examined key foreign policy topics, including Russia’s invasion of Ukraine and great power competition.

 

Apr 29, 2024

Stephen Walt argues that rejecting diplomacy by citing Neville Chamberlain's deal with the Nazis is a willfully ignorant use of history.

Mercury Packing Party for Troops

Les tendances du march� neuf

BAREMINERALS� SKINLONGEVITY� TV ADVERTISEMENT

�I think it is an opportunity for nurses to learn a skillset you don�t learn in nursing school.� � Jeffin Bush

Väike-kirjurähn on Euroopa väikseim rähn, olles kõigest varblase mõõtu. The Lesser Spotted Woodpecker is the smallest woodpecker in Europe, being only the size of a sparrow.

My latest short story is out in The Magazine of Fantasy & Science Fiction. When I first started writing short stories, back in the 90s, F&SF was one of the ‘big three’ that I really wanted to get a story in to cross off my bucket list. The big three were Asimov’s, F&SF, and Analog. […]

EFL chairman Rick Parry tells BBC Sport's Dan Roan about his hopes for the new football regulator as the Football Governance Bill has its second reading before parliament.

61% of Medicare-eligible adults have a medlinkBMI/medlink of 27 or higher, indicating they could potentially benefit from a GLP-1 receptor agonist like semaglutide for weight loss (!--ref1--).

Semaglutide, a medlinkweight loss/medlink medication, did not increase the risk of depressive symptoms, suicidal thoughts, or suicidal behavior. The

The anti-obesity medication semaglutide may help to prevent medlinkheart attacks/medlink, medlinkstrokes/medlink, and other major adverse cardiovascular

Highlights: Asthma, chronic bronchitis, and emphysema are all chronic respiratory conditions that can cause shortne

With FDA approval, UCSF Benioff Children's Hospital Oakland pioneers gene therapy for beta thalassemia, a rare genetic blood disorder, potentially alleviating

Beta-thalassemia, also known as (and) #946;-thalassemia is a genetic disorder marked by reduced or absent beta chain synthesis of medlinkhemoglobin/medlink,

Innovative semaglutide hydrogel may revolutionize diabetes treatment by reducing the need for injections to just once a month, improving patient convenience.

Compared to other diabetes medications, semaglutide might offer added protection against Alzheimer's for type 2 diabetes patients.