M. Mahmood Hussain
Jan 1, 2003; 44:22-32
Reviews

Remembering Rosemary Hollis (1952-2020) News Release sysadmin 12 June 2020

Professor Rosemary Hollis, a highly respected authority on the Middle East, died suddenly last week. Rosy is remembered with great respect and affection, as a colleague and a friend.

Ahmed Elshafei, Ana Cristina Ferreira, Miguel Sánchez and Abdelghani Zeghib
Trans. Amer. Math. Soc. 377 (), 5837-5862.
Abstract, references and article information

Denise Uwamariya and Xiangfeng Yang
Theor. Probability and Math. Statist. 111 (), 167-179.
Abstract, references and article information

The bacterial enhancer-binding protein (bEBP) FlrC, controls motility and colonization of Vibrio cholerae by regulating the transcription of class-III flagellar genes in σ54-dependent manner. However, the mechanism by which FlrC regulates transcription is not fully elucidated. Although, most bEBPs require nucleotides to stimulate the oligomerization necessary for function, our previous study showed that the central domain of FlrC (FlrCC) forms heptamer in a nucleotide-independent manner. Furthermore, heptameric FlrCC binds ATP in “cis-mediated” style without any contribution from sensor I motif 285REDXXYR291 of the trans protomer. This atypical ATP binding raises the question of whether heptamerization of FlrC is solely required for transcription regulation, or if it is also critical for ATPase activity. ATPase assays and size exclusion chromatography of the trans-variants FlrCC-Y290A and FlrCC-R291A showed destabilization of heptameric assembly with concomitant abrogation of ATPase activity. Crystal structures showed that in the cis-variant FlrCC-R349A drastic shift of Walker A encroached ATP-binding site, whereas the site remained occupied by ADP in FlrCC-Y290A. We postulated that FlrCC heptamerizes through concentration-dependent cooperativity for maximal ATPase activity and upon heptamerization, packing of trans-acting Tyr290 against cis-acting Arg349 compels Arg349 to maintain proper conformation of Walker A. Finally, a Trp quenching study revealed binding of cyclic-di-GMP with FlrCC. Excess cyclic-di-GMP repressed ATPase activity of FlrCC through destabilization of heptameric assembly, especially at low concentration of protein. Systematic phylogenetic analysis allowed us to propose similar regulatory mechanisms for FlrCs of several Vibrio species and a set of monotrichous Gram-negative bacteria.

Insulin receptor substrate 2 (IRS2) is an essential adaptor that mediates signaling downstream of the insulin receptor and other receptor tyrosine kinases. Transduction through IRS2-dependent pathways is important for coordinating metabolic homeostasis, and dysregulation of IRS2 causes systemic insulin signaling defects. Despite the importance of maintaining proper IRS2 abundance, little is known about what factors mediate its protein stability. We conducted an unbiased proteomic screen to uncover novel substrates of the Anaphase Promoting Complex/Cyclosome (APC/C), a ubiquitin ligase that controls the abundance of key cell cycle regulators. We found that IRS2 levels are regulated by APC/C activity and that IRS2 is a direct APC/C target in G₁. Consistent with the APC/C's role in degrading cell cycle regulators, quantitative proteomic analysis of IRS2-null cells revealed a deficiency in proteins involved in cell cycle progression. We further show that cells lacking IRS2 display a weakened spindle assembly checkpoint in cells treated with microtubule inhibitors. Together, these findings reveal a new pathway for IRS2 turnover and indicate that IRS2 is a component of the cell cycle control system in addition to acting as an essential metabolic regulator.

LONDON and TORONTO, Sept. 30, 2024 — Alphawave Semi, a global leader in high-speed connectivity and compute silicon for the world’s technology infrastructure, has unveiled the availability of the industry’s […]

The post Alphawave Semi and TSMC Collaborate on 3nm UCIe Die-to-Die Subsystem for AI and HPC appeared first on HPCwire.

U.S. fighter jets escorted a small plane flown by a U.S. Army soldier out of restricted air space over New York City during the United Nations General Assembly.

Quantum error correction specialist Riverlane today released a fascinating report — The Quantum Error Correction Report 2024 — that’s worth scanning; IBM and 28 collaborators last week released V-score, a […]

The post Quantum Nuggets: Riverlane’s 2024 QEC Study, IBM’s V-score, Twisted Semiconductors appeared first on HPCwire.

PITTSBURGH, Feb. 22, 2024 — Ansys and Intel Foundry have collaborated to provide multiphysics signoff solutions for Intel’s innovative 2.5D chip assembly technology, which uses EMIB technology to connect the […]

The post Ansys, Intel Foundry Collaborate on Multiphysics Analysis Solution for EMIB 2.5D Assembly Tech appeared first on HPCwire.

How can everyday people help foster and protect democracy? Detailing her work fighting for people power as an activist in Madagascar, Ketakandriana Rafitoson discusses how citizen assemblies — meetings where ordinary citizens get educated about democracy — empower communities to protect their rights, debate important civic questions and take action to create a brighter future.

A bill prohibiting anti-Semitism in Florida's public schools and universities is going to Republican Gov. Ron DeSantis.

The No. 4 Texas Longhorns kicked off their season with a 119-47 win over Southeast Missouri State (SEMO) on Sunday at Moody Center. This victory marked Texas' 13th consecutive home opener win, establishing a strong start to the 2024-2

Mahsa Altafi
Oct 23, 2024; 44:e0518242024-e0518242024
Systems/Circuits

Neural circuits supporting innate behaviors, such as feeding, exploration, and social interaction, intermingle in the lateral hypothalamus (LH). Although previous studies have shown that individual LH neurons change their firing relative to the baseline during one or more behaviors, the firing rate dynamics of LH populations within behavioral episodes and the coordination of behavior-related LH populations remain largely unknown. Here, using unsupervised graph-based clustering of LH neurons firing rate dynamics in freely behaving male mice, we identified distinct populations of cells whose activity corresponds to feeding, specific times during feeding bouts, or other innate behaviors—social interaction and novel object exploration. Feeding-related cells fired together with a higher probability during slow and fast gamma oscillations (30–60 and 60–90 Hz) than during nonrhythmic epochs. In contrast, the cofiring of neurons signaling other behaviors than feeding was overall similar between slow gamma and nonrhythmic epochs but increased during fast gamma oscillations. These results reveal a neural organization of ethological hierarchies in the LH and point to behavior-specific motivational systems, the dysfunction of which may contribute to mental disorders.

Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer's disease (AD) facilitates the identification of new targets for effective treatments. Recently available large-scale multiomics datasets provide opportunities to use computational approaches for such studies. Here, we devised a novel disease gene identification (digID) computational framework that consists of a semi-supervised deep learning classifier to predict AD-associated genes and a protein–protein interaction (PPI) network-based analysis to prioritize the importance of these predicted genes in AD. digID predicted 1,529 AD-associated genes and revealed potentially new AD molecular mechanisms and therapeutic targets including GNAI1 and GNB1, two G-protein subunits that regulate cell signaling, and KNG1, an upstream modulator of CDC42 small G-protein signaling and mediator of inflammation and candidate coregulator of amyloid precursor protein (APP). Analysis of mRNA expression validated their dysregulation in AD brains but further revealed the significant spatial patterns in different brain regions as well as among different subregions of the frontal cortex and hippocampi. Super-resolution STochastic Optical Reconstruction Microscopy (STORM) further demonstrated their subcellular colocalization and molecular interactions with APP in a transgenic mouse model of both sexes with AD-like mutations. These studies support the predictions made by digID while highlighting the importance of concurrent biological validation of computationally identified gene clusters as potential new AD therapeutic targets.

MANUEL PLANELLES, EL PAÍS, Paris- “Agriculture is seen as a threat in the fight against climate change,” Maria Helena Semedo warns. The Deputy Director-General of the Food and Agriculture Organization [...]

Informal Seminar: Human resources policies - Invitation for all Permanent Representatives

 Friday, 12 October 2018 - 15.00 to 17.30 (Green Room)

This special seminar calls us to take a new look at how to channel our knowledge, stimulate innovative thinking and guide our actions to expedite agri-food system transformation and achieve [...]

Part of the visual album of Joan Baez' "Whistle Down the Wind," this cover of Joe Henry's "Civil War" was directed by New York University's Deborah Willis

Carleton Watkins' 19th-Century Photographs of Yosemite Valley (Produced and Narrated by: Brendan McCabe. Text by Bruce Hathaway). Read more at https://www.smithsonianmag.com/history/john-muirs-yosemite-10737/

The office of Kamloops Mayor Reid Hamer-Jackson is being relocated to the basement of city hall.

North American door control system leader's engineering work is critical for passenger safety

New 3D CAD software increases productivity, quality, and efficiency

OM Ukraine and experts in crisis management held a seminar for pastors serving on both sides of the conflict line in Eastern Ukraine.

The Certified Family Life Educator credential, available through the Human Development and Family Studies degree program, was recently endorsed by the U.S. Department of Veterans Affairs and the Office of Head Start.

Both the AFT and the NEA vowed to engage their members more deeply this year in deciding who to back for the White House. How well have they done?

Penn State Altoona’s Ivyside Dance Ensemble will present its fall 2024 performance at 7:30 p.m. Nov. 14-15 in the Wolf Kuhn Theatre of the Misciagna Family Center for Performing Arts. The performance will consist of seven dances from director KT Huckabee, choreographer and instructor Jaye Mackinson, and returning guest choreographer Ana Rossi-Lanzendorfer.

Azamat was living in the streets, but through the ministry of OM team members in Central Asia he moved into rehabilitation and then seminary.

All eyes will be on the Congress and INDIA bloc as 31 constituencies vote in Assembly bypolls across 10 states, apart from Lok Sabha bypolls in Kerala's Wayanad

Ahead of the voting in the first phase of Assembly elections in Jharkhand on Wednesday, the Returning Officer for Ranchi Assembly constituency, Utkarsh Kumar said that the mock poll will begin at 5.30 am after which polling will commence.

All eyes will be on the Congress and INDIA bloc as 31 constituencies vote in Assembly bypolls across 10 states, apart from Lok Sabha bypolls in Kerala's Wayanad

The exclusive fan event will take place in Seoul on November 24

Expanded oversight of Pharmacy Benefits Managers possible Legislation to further regulate the Pharmacy Benefits Manager industry was passed by the General Assembly in late June and sent to the Governor with unanimous bipartisan support. HB 219, sponsored by Rep. Andria Bennett, Sen. Spiros Mantzavinos, Senate President Pro Tempore Dave Sokola, and Rep. Mike Smith, would […]

Jharkhand Assembly Elections 2024: झारखंड में आज पहले चरण में 15 जिलों की 43 सीटों पर मतदान हो रहा है. वहीं केरल की वायनाड लोकसभा सीट पर भी वोटिंग जारी है.

Wilmington, Del. (March 10, 2022) – From a field of ten Delaware high school students, Natalie Kim Ramos, a senior from Saint Mark’s High School, earned the title of 2022 Poetry Out Loud Delaware State Champion at the virtual state finals held on March 10. The first runner-up was Kai Schmiedel from Delaware Valley Classical […]

The foundation of Delaware’s democracy is its General Assembly. A body that has governed both the colony and state of Delaware for over three hundred years, it has been the voice of the people in our government and has affected almost every aspect of our lives. Dr. Carol Hoffecker’s “Democracy in Delaware” discusses the role […]

Wilmington, Del. (March 3, 2023) – From a field of twelve Delaware high school students, Maiss Hussein, a junior from Paul M. Hodgson Vocational Technical High School, earned the title of 2023 Poetry Out Loud Delaware State Champion at the state finals held on March 2 at the Smyrna Opera House. The first runner-up was […]

Session included measures to improve Delaware’s economy, create jobs, reform the Department of Correction, and combat addiction crisis Highlights of the 2017 legislative session include: Restructuring Economic Development: House Bill 226 restructures the way Delaware attracts good-paying jobs to Delaware and keeps them here, with a focus on entrepreneurship, innovation and small business development. Modernizing […]

Sponsors in the Child and Adult Care Food Program (CACFP) can receive reimbursement for meals served in compliance with program regulations at qualifying child care centers, adult day care centers, emergency shelters, family day care homes and afterschool programs. Sponsors may be reimbursed for up to two meals and one snack per participant each day. Participant eligibility is tied to income eligibility guidelines that are adjusted annually by the USDA.

During a stop at the Delaware Agriculture Education & Commodities Building at the Delaware State Fair, Governor John Carney announced an additional 3,827 acres on 54 farms are now permanently preserved for future generations.

Groundbreaking ceremony touted $56 million for early education, senior care, and community programs   WILMINGTON, Del. – Governor John Carney joined U.S. Senator Tom Carper, State Senator Darius Brown, State Representative Stephanie T. Bolden, other elected officials, and community members at a groundbreaking ceremony for the new Kingswood Community Center.   Kingswood Community Center, managed by […]

Microsoft announced it has acquired Semantic Machines, a conversational AI startup providing chatbots and AI chat apps founded in 2014 having $20.9 million in funding from investors. The acquisition will help Microsoft catch up with Amazon Alexa, though the latter is more focused on enabling consumer applications of conversational AI.

Microsoft will use Semantic Machine’s acquisition to establish a conversational AI center of excellence in Berkeley to help it innovate in natural language interfaces.

Microsoft has been stepping up its products in conversational AI. It launched the digital assistant Cortana in 2015, as well as social chatbots like XiaoIce. The latest acquisition can help Microsoft beef up its ‘enterprise AI’ offerings.

As the use of NLP (natural language processing) increases in IoT products and services, more startups are getting traction from investors and established players. In June last year, Josh.ai, avoice-controlled home automation software has raised $8M.

Followed by it was SparkCognition that raised $32.5M Series B for its NLP-based threat intelligence platform.

It appears Microsoft’s acquisition of Semantic Machines was motivated by the latter’s strong AI team. The team includes technology entrepreneur Daniel Roth who sold his previous startups Voice Signal Technologies and Shaser BioScience for $300M and $100M respectively. Other team members include Stanford AI Professor Percy Liang, developer of Google Assistant Core AI technology and former Apple chief speech scientist Larry Gillick.

Hi! I've made some 1-point waveform "markers" that I want to overlay in my plots to aid visualization (with the added advantage, w.r.t. normal Viva markers, that they update location automatically upon refreshing simulation data).

For example, the plot below shows an spectrum along with two of these markers, which I create with the function "singlePointWave", and the Assembler output definitions also as shown below.

The problem is: as currently created and defined, Assembler is unable to plot these elements. I can send their expressions to the calculator and plotting works from there, BUT ONLY after first enabling the "Allow Any Units" in the target Viva subwindow.

Thus, I suspect Assembler is failing to plot my markers because they "lack" other information like axes units and so on. How could I add whatever is missing, so that these markers can plot automatically from Assembler?

Thanks in advance for any help!

Jorge.

P.S. I also don't know why, but nothing works without those "ymax()" in the output definitions--I suspect they are somehow converting the arguments to the right data type expected by singlePointWave(). Ideas how to fix that are also welcome! ^^

procedure( singlePointWave(xVal yVal)
    let( (xVect yVect wave)
        xVect = drCreateVec('double list(xVal));
        yVect = drCreateVec('double list(yVal));
        wave = drCreateWaveform(xVect yVect);
    );
);

Hello Community,

I have encountered an issue that is a mystery to me and hope somebody could give me a clue about what is happening in Cadence and maybe even a solution?

I am running a test scripted in a SKILL file that sequentially opens two different projects with MC analyses and in between I get an error message box and also multiple logs in CIW with exactly the same text.

Both projects run a simulation with a call like this:

historyName = maeRunSimulation(?session sessionName ?waitUntilDone t)

After this the script closes the current project, opens the next project and executes the same line with maeRunSimulation() for the second project. Then immediately this error message happens, and also is logged repeatedly in the CIW window

The message box looks like this:

The logs I get in CIW:

nil
hiCancelProgressBox(_axlNetlistCreateProgressBar)
nil
hiCancelProgressBox(_axlUILoadForm)
nil
when(dwindow('axlDataViewessWindow1) hiMapWindow(dwindow('axlDataViewessWindow1)))
t
when(dwindow('axlRunSummaryessWindow1) hiMapWindow(dwindow('axlRunSummaryessWindow1)))
t
ERROR (ASSEMBLER-1600): Cannot find an active session named fnxSession0.
You can only modify an ADE Assembler session that is active.
Perhaps the session name was misspelled or has not yet been created.
Verify the session name matches an existing ADE Assembler session.

1>
ERROR (ASSEMBLER-1600): Cannot find an active session named fnxSession0.
You can only modify an ADE Assembler session that is active.
Perhaps the session name was misspelled or has not yet been created.
Verify the session name matches an existing ADE Assembler session.

*WARNING* hiDisplayAppDBox: modal dbox 'adexlMessageDialog' is already displayed!
ERROR (ASSEMBLER-1600): Cannot find an active session named fnxSession0.
You can only modify an ADE Assembler session that is active.
Perhaps the session name was misspelled or has not yet been created.
Verify the session name matches an existing ADE Assembler session.

*WARNING* hiDisplayAppDBox: modal dbox 'adexlMessageDialog' is already displayed!
ERROR (ASSEMBLER-1600): Cannot find an active session named fnxSession0.
You can only modify an ADE Assembler session that is active.
Perhaps the session name was misspelled or has not yet been created.
Verify the session name matches an existing ADE Assembler session.

This blog describes an efficient way to name the histories saved by the simulation runs in Virtuoso ADE Assembler.(read more)

Hi,

I'm searching for a way to get a quick overview of too low cpk-values after a montecarlo sim. The non-MC results have the spec and thus the easy/understandable red/green/(yellow) colorcoding, but for MC sims I don't get a highlight for high variations inside the limits.

Is this possible (besides copying each expression into avg()+3*std()) and ..-..)?

It would be really handy to scan through finished sims...

(My final application is then to export the table for my reports and documentation...)

Regards,

leo

$73.8m mega-project will be the first of its kind in the city.