This is a paper produced as part of the PROP2 (Practitioner Research: Outcomes and Partnership) programme, a partnership between the Centre for Research on Families and Relationships (CRFR) at the University of Edinburgh and Iriss that was about health and social care in Scotland. This paper was written by Geraldine Ditta from Alzheimer Scotland who participated in the PROP2 programme. People living with dementia are at risk of becoming socially isolated and disconnected from their local communities. Reactions from others on being told someone has dementia can have a significant impact on the person with dementia’s sense of self. This study sought to explore the perceptions of people with dementia in relation to attitudes within their communities and how they subsequently respond. Semi-structured interviews were carried out to examine how they feel about their lives with dementia.

Rachel Maddow reminds Americans how Trump told his followers, "You don’t need to vote. I have so many votes." The Republican candidate said multiple times that he had the votes he needed to become president, implicating something other than votes would give him power.

Votes are still being counted in many states, almost one week after the election. Republicans are close to getting control of the U.S. House but Newsweek reports many races are too close to call. I'm not ready to put on a foil hat but isn't it worth looking into some of the odd things surrounding the 2024 election?

I'm not saying the election was "rigged" or unfair. All I am suggesting is that there are strange things about the 2024 election that merit a second look. Since democracy of the free world is at stake, it's worth the trouble.

Trump Doesn't Need Votes and Secret With Moses Mike

As Maddow noted, Trump telling voters he doesn't need their vote is a red flag. The GOP candidate said it multiple times. Trump also made several comments about the "secret" he and Speaker Mike Moses Johnson had about the election.

read more

By Carly Tennes Published: November 10th, 2024

By Ryan Menezes Published: November 11th, 2024

By Keegan Kelly Published: November 11th, 2024

Timothy Zahn's Star Wars novel Heir to the Empire was first released in hardcover on May 1, 1991.

Looking for a hugely entertaining alphabet book that also has an uplifting message of empowerment for young readers? I highly recommend T. REXES CAN'T TIE THEIR SHOES by Anna Lazowski and Steph Laberis, launching June 29th, 2021 from Doubleday Books For Young Readers. The back matter also has an alphabetized factoid list of "all the amazing things animals CAN do!"

This is an alphabet book that can be appreciated by grown-ups as well as young readers, with lots of potential discussion points. The illustrations of animals in ridiculous situations are so SOOOOO FUN --- omigosh, even as I'm writing this post, I went back to look through the digital ARC and can't decide which is my favourite, though I'm leaning toward the "Cheetahs can't chew bubble gum" page.

I asked debut picture book author Anna Lazowski if she had any advice for young writers, and here's what she said:

"Write what you want to write, because as you move through the publishing process, it will become incredibly important for you to truly believe in your work. The rejections in this industry are endless, and they come at every stage. Critique partners might reject elements of your manuscript, agents will reject your work, and once you're on submission to editors, they will reject your work. Then once you're finally published, some reviewers will reject your work. If you don't fully believe in your stories, this will be extremely hard to take. It's hard as it is, so make sure you're all in on the work you're doing. It will make the rest a little bit easier to navigate."

Wise advice. Thank you, Anna! And congrats to you and Steph on your upcoming launch!

----

Also see other Advice For Young Writers and Illustrators From Children's Book Creators and my other Interviews With Children's Book Creators.

Image at the top of this post was created for my new #BookADay book journal. For more info about Donalyn Miller's #BookADay challenge, see Donalyn's post in the Nerdy Book Club blog.

By Sara Truuvert

When your novel is deemed "the greatest idea for a book ever", you're probably on to something. That certainly seems to be the case for debut author Victor Piñeiro, whose novel Time Villains has garnered a starred review from Kirkus and a spot as an Amazon Best Book of the Month. The book promises time-hopping high jinx, historic and literary Easter eggs, and even some one-sentence Puerto Rican recipes.

Time Villains follows sandwich-obsessed Javi Santiago, who has to nail his homework assignment if he wants to pass sixth grade. The assignment seems simple enough: if you could invite any three people to dinner, who would they be? Plus, Javi has his best friend Wiki and little sister Brady to help him. What could go wrong? Turns out, a lot! The trio accidentally uses an antique dining table to summon the dinner guests for real. Now, Blackbeard the Pirate is on the loose, and Javi, Wiki, and Brady must figure out how to send him back (perhaps with the help of other historical figures...). Time Villains is the first novel in a three-part series. It launched on July 6th, 2021 with Sourcebooks and is widely available to order. 

Victor Piñeiro is an author and a Creative Director at HBO Max. He has also done a multitude of other cool things, like teach, make documentaries, lead content/social strategies for Big Spaceship, YouTube, Hasbro, and Google, and answer these interview questions while caring for his two-week-old child. You can find out more about Victor on his website, Twitter, and Instagram. 

Q. A huge congratulations on your literary debut! Would you tell me a bit about your journey to publication?

A. Thank you! Being a published author has been the dream since I was a kid, so it’s been quite the journey! In my teens and twenties I couldn’t silence my inner critic long enough to write novels, so I turned to poetry and screenplays, writing and producing documentaries for a spell. I finally coaxed a book out in 2017 after writing daily on my (long) commute for three years. It was a very unconventional first book—the only kind I could coax out on my first try—so I shelved it and started working on Time Villains. 

Three drafts in I sent Time Villains to a bunch of agents, and after chatting with a few, a friend put me in touch with Elana Roth Parker. I feel so incredibly lucky to work with Elana—she saw the seed of something in my draft and we developed it into something far more compelling. When Annie Berger at Sourcebooks showed interest in the book, it felt like winning the lottery twice. Annie and the whole team have been the most incredible partners—thoroughly brilliant and a complete joy to work with. And here we are—the book just hit shelves this week and I’m not sure what to do with myself!

Q. Would you please introduce us to the novel’s hero, Javi Santiago? (I must know what level of dedication to sandwiches it takes to be classified as ‘sandwich-obsessed’!)

A. Javi’s an aspiring chef and sandwichéaste (think cinéaste but for sandwiches) who’ll do anything to pass sixth grade. He’s a zany kid with an overactive imagination and a penchant for asking deep questions about food (because what makes a sandwich a sandwich, really?). He peppers in one-sentence recipes throughout the book—some of Puerto Rico’s most delectable dishes, mixed in with his own recipes (like the Spanglish Sandwich aka The Spanglo Sando™). And while he’s fun and eccentric, underneath the silliness he’s a first generation Puerto Rican kid struggling with imposter syndrome as he tries to excel at something in his life. 

Q. You offer us such a hilarious dynamic between your protagonists – we have the almost-failing student, Javi, paired with his best friend, Wiki, the human Wikipedia/young professor (plus, Javi’s little sister, who wants to be the president’s bodyguard!). How did you land on this dynamic? Is it something you envisioned from the get-go?

A. The characters were floating around my head disparately but when I put them together I realized how fun their dynamic would be. 

I know a few folks who are so brilliant they seem weighed down by their intelligence—it’s made them world-weary. I thought that’d be really fun to capture in an extremely-precocious sixth grader. As I was coming up with the character I remembered a line in a hip hop song I love, “Catch me solving mysteries like Wikipedia Brown.” And that’s where Wiki’s name emerged and the character solidified in my head.

In terms of Brady, I knew I wanted a hot-headed sibling/partner to steal the spotlight and do much of the butt kicking because I love that dynamic in stories, going all the way back to Frodo and Sam. I also have a few friends with wild kid sister energy and they’re the life of any party, so I knew I wanted to bring that to the trio. 

Q. You had to develop a wide array of voices for this story, including kid Mozart, the Earl of Sandwich, and Blackbeard the Pirate. Was that a challenge? A joy? A spiralling research nightmare?

A. A spiralling research dream! This series gives me the best excuse to research my favorite folks in history and fiction, and it’s been a blast. I loved reading old texts on pirates, delving into the specifics of Mozart at age twelve and dusting off copies of old novels with iconic characters as I researched this book. And I knew nothing about the Earl of Sandwich before writing this, but how could Javi not invite him?

There was one aspect of research that was a bit frustrating. A big focus of this series is exploring characters more representative of the world’s history and fiction, because I’m hoping this book is ultimately a gateway to other books, characters and historical figures for kids to explore. Finding a wealth of information about some historical and mythological figures from other cultures was incredibly difficult. I knew it wouldn’t be easy, but I wasn’t prepared for it to be quite so challenging—which invigorated me to include more of them in the book!

Q. You have such lovely, concise, concrete writing advice available on your website. Is there any advice my-novel-is-getting-published Victor would give I’m-starting-to-write-a-novel Victor?

A. So much advice! I think there are a few super important things that would’ve had me writing novels decades ago, so I take any chance I can get to relay them to other aspiring/young writers.

1. An hour a day can be enough. I always thought I needed to quit my job and write eight hours a day to finish a novel, which held me back for years. Then I read a Murakami interview where he said he completed his first novel by writing an hour a day after work. In that moment I felt like the universe gave me permission to write mine. 

2. Lower the bar far lower than you’re comfortable with for that first draft. (No, lower!) There are passages in the first draft of my books that are barely intelligible, but I now know that’s okay. The first draft is about discovery and getting the story out of your head and onto the page. It’s far too early to be precious about anything. Just get it all out and see what you’ve got when you’re done.

3. Don’t dread rewriting—it’s far more fun than expected. Before writing my first book I was terrified of it, but it’s become one of my favorite aspects of writing. (Which is a good thing considering it’s 75-90% of what you do as a writer!) 

Q. Do you have any advice for young writers in general?

A. Absolutely. Besides everything I said above, read about writing and join online writing communities. Screenwriting books are great for story structure basics, Stephen King’s On Writing is great for process, Brandon Sanderson’s free writing course on YouTube is absolutely brilliant, Neil Gaiman and David Mamet’s Master Class courses are gold, and Reddit’s /r/writing is a fantastic place to learn alongside others in the trenches. I also love John Truby and Lisa Cron’s books. But maybe it’s best to start with this short Ira Glass video. Or this brilliant reflection on writing advice Chuck Wendig just wrote.

Q. Finally, I read that you used to be a documentary filmmaker and a blogger. What are some questions you would ask Blackbeard, if you met him?

A. It’d be one of those long interviews—the kind that take up the entire documentary and usually take the film crew multiple days to shoot—because I’d want to lead up to asking him how many people he actually killed. (Some historians say almost zero!) And I’d also want to ask him a lot of questions about Stede Bonnet, “The Gentleman Pirate” who was an equally fascinating and thoroughly hilarious character. He was rich, had a midlife crisis, became a pirate, and got thoroughly swindled by Blackbeard. (Side note: I was so happy when I heard the news that Taika Waititi would be creating a show about him!) Finally, I’d ask him to get battle ready. Before a skirmish Blackbeard would light fuses or small candles in his beard, since the smoke gave him a demonic appearance. It was his favorite scare tactic. I’d love to see it live!

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Sara Truuvert completed her MLitt in Creative Writing at the University of St Andrews. She also holds a Certificate in Creative Writing from the Humber School for Writers and a BA in English, Drama, and the History and Philosophy of Science from the University of Toronto. Her work has appeared in the Literary Review of Canada among other publications.

For more interviews, see the Inkygirl Interview Archive. Also see Advice For Young Writers and Illustrators, a compilation of tips generously offered by children's book creators Inkygirl.com has interviewed over the years.

Garden ponds are increasingly becoming popular among homeowners. The scramble for ponds can be attributed to their aesthetics, growing appreciation for wildlife and environmental awareness. As homeowners increasingly become aware of the need to maintain a sustainable ecosystem, they are more willing to adopt unique ideas such as keeping garden ponds. But are garden ponds really sustainable?[...]

In the quest for a more sustainable future, the Finnish city of Lahti has taken a remarkable step with an innovative pilot program called the Textile Deposit scheme. This incentivized recycling program aims to encourage locals to actively sort and recycle their textile waste instead of sending it to the landfill. [...]

Join the Program in Judaic Studies and the Department of Religion on Tuesday, November 19, for this talk delivered by Ilana Pardes. Lunch will be available before the event's start, between 11:30am–12:00pm only. The account of the rise of Israelite kingship in the Book of Samuel is one of the greatest narratives of antiquity that has been passed down to us. Far from being a dry chronicle, it offers both an unblinking perspective on political realities and a daring representation of the humanness, the nakedness, of royal figures. The talk will revolve around the encounter of King David and the wise woman of Tekoa (2 Samuel 14). Special attention will be given to the dramas behind the scenes, to the hidden links between the parabolic tale of the wise woman and the story of the House of David. All are welcome to attend, but space is limited – please RSVP to judaic@princeton.edu and note any dietary needs. More about Ilana Pardes Ilana Pardes is the Katharine Cornell Professor of Comparative Literature at the Hebrew University of Jerusalem. She is currently a Visiting Professor in the Program in Judaic Studies Program at Princeton University. Her work has focused on the nexus of Bible, literature, and culture as well as on questions of gender, aesthetics, and hermeneutics. She is the author of Countertraditions in the Bible: A Feminist Approach (Harvard University Press, 1992), The Biography of Ancient Israel: National Narratives in the Bible (University of California Press, 2000), Melville's Bibles (University of California, 2008), Agnon's Moonstruck Lovers: The Song of Songs in Israeli Culture (The Samuel and Althea Stroum Lectures in Jewish Studies, University of Washington Press, 2013), The Song of Songs: A Biography (Princeton University Press, Lives of Great Religious Books, 2019), and Ruth: A Migrant’s Tale (Yale University Press, Jewish Lives, 2022).

Time to drill down into the cold, hard cash.
( Photos: 2, Comments: 133 )

Welcome to an enlightening exploration into the world of macronutrients. These fundamental components of our diet — proteins, carbohydrates, and fats — play integral roles in our body’s physiological functions. While they’re clearly important to our health and well-being, they often remain shrouded in mystery for most of us. By learning more about macronutrients, you’ll understand how ... Read more

The post Macronutrients Unveiled: A Comprehensive Look at Their Roles in a Balanced Diet appeared first on Star Two.

The claustrum seems to act as a switchboard, telling different parts of the brain when to turn on and off. But what happens when the switchboard operator steps away?

College students often use posters to help spruce up their dorm. At the University of Chicago, they get a chance to borrow works by prominent artists for a year.

Kids at a tribal school in Arizona are preparing for their own election to determine their favorite school lunch: pizza or chicken nuggets? And they're learning about democracy along the way.

The following article, The First Wave of Hollyweirdos Leaving America, was first published on The Black Sphere.

Too bad we can't send the FBI to raid the houses of all the dumb ass Leftists who promised to leave if Trump was elected.

Continue reading The First Wave of Hollyweirdos Leaving America ...

Teixeira leaked highly classified Pentagon documents to an online platform popular with gamers.

6 Weird House Smells: Which Ones Are Concerning?

1. 'There's a guy in Indian team whose Test average is 63...': Tim Paine wants Rohit and Gambhir to open their eyes  Hindustan Times
2. EXCLUSIVE | Dhruv Jurel can be the X-factor India are looking for in Australia, says Suresh Raina  The Times of India
3. Former Australia captain tips India youngster to shine Down Under  ICC Cricket
4. Not Rishabh Pant or Yashasvi Jaiswal; Ex- Australian captain backs this Indian young player to impress everyone in Border-Gavaskar Trophy, says 'class above all his teammates on this tour'  SportsTak
5. Why India should play Jurel as a specialist batsman at Perth  The Indian Express

A scumbag, left-wing (is there any other kind?) doctor in Iowa is facing an uncertain future at his hospital after he began posting obscene wishes on social media saying that he hopes the children of Trump voters are murdered. The creep is question is one Dr. Mayank Sharma, 35, a pediatric cardiology fellow for the […]

The post Iowa Pediatrician Blistered for Telling Trump Voters that He Hopes Their Children Die appeared first on The Lid.

"I think they say they want autonomy. I think their actions don't say the same thing," Airbnb CEO Brian Chesky recently said in an interview.

A tech recruiting firm left a database unsecured that exposed emails, passport numbers and partial SSNs of job seekers, a security researcher says.

Jude Law added that people in middle age should start to reflect on their relationship patterns.

An underwater rover deployed by the Minderoo-UWA Deep-Sea Research Centre captured remarkable footage 3,300-meters down at the bottom of the Tonga Trench. It shows a rarely-seen bigfin squid (Magnapinna) "taking a walk" on its 13-foot tentacles. Watch below.

There have only been around 20 documented sightings of this beautifully bizarre creature in two decades. — Read the rest

The post Deep sea video of weird sea creature walking around on its 13-foot "legs" appeared first on Boing Boing.

The following article, Unhinged Liberal Women Cry On Social Media Over Trump’s Victory And Falsely Claim They’ve Lost All Their Rights, was first published on Conservative Firing Line.

(Natural News) Liberals have been working hard to portray Trump as a misogynist, and it worked on a lot of women – with some of them buying into the false narrative that he will work against women so wholeheartedly that they are now having very public meltdowns over his victory. Revolver put together some of the …

Continue reading Unhinged Liberal Women Cry On Social Media Over Trump’s Victory And Falsely Claim They’ve Lost All Their Rights ...

The following article, Will These Deranged Celebrities Who Promised To End Their Lives Or Flee The Country If Trump Wins Actually Follow Through?, was first published on Conservative Firing Line.

(Natural News) Similar to what happened in 2016, a host of celebrities and influencers made wild claims that they would leave the country or even end their lives if Donald Trump won another term in the White House. Will any of them actually follow through? Take Rob Reiner, for instance. He promised to “set himself on …

Continue reading Will These Deranged Celebrities Who Promised To End Their Lives Or Flee The Country If Trump Wins Actually Follow Through? ...

The quirky folks at Fodor’s let me share some of the world’s weirdest plants, fungi, and microorganisms to inspire your #plantnerd bucket list (I’ve seen 5 out of 10 of these weirdos out in the wild!) 10 Plants From Around the World That Will Upset and Delight | Fodor’s Travel

The article EIT Elsewhere | Sharing the World’s Weirdest Plants on Fodor’s Travel originated at EverInTransit.com

Republican primary opponents like Ron DeSantis said that every time they announced another indictment, his poll numbers got better. They should have known better. But they were blinded by hate.

The post BOOM: Trump Prosecutors React To New Post-Election Realities… Here’s Their Plan appeared first on Clash Daily.

A few weeks ago, we needed some hardware fast. After some back and forth with the vendor, they promised “expedited delivery”. That sounded like a good thing, but it meant nothing. To us, expedited delivery meant overnight delivery. That’s what we had in our head. Our experiences elsewhere equated expedited as overnight, but expedited isn’t… keep reading

Pro-Trump businessmen Elon Musk (the richest man in the world) and Vivek Ramaswamy have officially joined the incoming Trump administration. President-elect Donald Trump announced in a statement published Tuesday that […]

The post Breaking: Musk, Ramaswamy Officially Join Trump Administration - Their Job Is to Destroy Bureaucracy appeared first on The Western Journal.

Nonphotochemical quenching (NPQ) is a mechanism of regulating light harvesting that protects the photosynthetic apparatus from photodamage by dissipating excess absorbed excitation energy as heat. In higher plants, the major light-harvesting antenna complex (LHCII) of photosystem (PS) II is directly involved in NPQ. The aggregation of LHCII is proposed to be involved in quenching. However, the lack of success in isolating native LHCII aggregates has limited the direct interrogation of this process. The isolation of LHCII in its native state from thylakoid membranes has been problematic because of the use of detergent, which tends to dissociate loosely bound proteins, and the abundance of pigment–protein complexes (e.g. PSI and PSII) embedded in the photosynthetic membrane, which hinders the preparation of aggregated LHCII. Here, we used a novel purification method employing detergent and amphipols to entrap LHCII in its natural states. To enrich the photosynthetic membrane with the major LHCII, we used Arabidopsis thaliana plants lacking the PSII minor antenna complexes (NoM), treated with lincomycin to inhibit the synthesis of PSI and PSII core proteins. Using sucrose density gradients, we succeeded in isolating the trimeric and aggregated forms of LHCII antenna. Violaxanthin- and zeaxanthin-enriched complexes were investigated in dark-adapted, NPQ, and dark recovery states. Zeaxanthin-enriched antenna complexes showed the greatest amount of aggregated LHCII. Notably, the amount of aggregated LHCII decreased upon relaxation of NPQ. Employing this novel preparative method, we obtained a direct evidence for the role of in vivo LHCII aggregation in NPQ.

Expert

Otto Overkamp
Trans. Amer. Math. Soc. 377 (), 5863-5903.
Abstract, references and article information

P. Lochak
St. Petersburg Math. J. 35 (), 477-535.
Abstract, references and article information

Monkeys on the loose Forty-three monkeys escaped from a research facility in South Carolina, USA. The rhesus macaque monkeys fled last Wednesday after a keeper left their pen open at Alpha Genesis -- a company that breeds primates for medical...

Proteins in the α-macroglobulin (αM) superfamily use thiol esters to form covalent conjugation products upon their proteolytic activation. αM protease inhibitors use theirs to conjugate proteases and preferentially react with primary amines (e.g. on lysine side chains), whereas those of αM complement components C3 and C4B have an increased hydroxyl reactivity that is conveyed by a conserved histidine residue and allows conjugation to cell surface glycans. Human α2-macroglobulin–like protein 1 (A2ML1) is a monomeric protease inhibitor but has the hydroxyl reactivity–conveying histidine residue. Here, we have investigated the role of hydroxyl reactivity in a protease inhibitor by comparing recombinant WT A2ML1 and the A2ML1 H1084N mutant in which this histidine is removed. Both of A2ML1s' thiol esters were reactive toward the amine substrate glycine, but only WT A2ML1 reacted with the hydroxyl substrate glycerol, demonstrating that His-1084 increases the hydroxyl reactivity of A2ML1's thiol ester. Although both A2ML1s conjugated and inhibited thermolysin, His-1084 was required for the conjugation and inhibition of acetylated thermolysin, which lacks primary amines. Using MS, we identified an ester bond formed between a thermolysin serine residue and the A2ML1 thiol ester. These results demonstrate that a histidine-enhanced hydroxyl reactivity can contribute to protease inhibition by an αM protein. His-1084 did not improve A2ML1's protease inhibition at pH 5, indicating that A2ML1's hydroxyl reactivity is not an adaption to its acidic epidermal environment.

Juntuo Zhou
Nov 30, 2020; 0:RA120.002384v1-mcp.RA120.002384
Research

Oktawia Nilsson
Nov 17, 2020; 0:jlr.RA120000920v1-jlr.RA120000920
Research Articles

Apolipoprotein A-I (ApoA-I) of high-density lipoprotein (HDL) is essential for the transportation of cholesterol between peripheral tissues and the liver. However, specific mutations in Apolipoprotein A-I (ApoA-I) of high-density lipoprotein (HDL) are responsible for a late-onset systemic amyloidosis, the pathological accumulation of protein fibrils in tissues and organs. Carriers of these mutations do not exhibit increased cardiovascular disease risk despite displaying reduced levels of ApoA-I/ HDL-cholesterol. To explain this paradox, we show that the HDL particle profile of patients carrying either L75P or L174S ApoA-I amyloidogenic variants a higher relative abundance of the 8.4 nm vs 9.6 nm particles, and that serum from patients, as well as reconstituted 8.4 and 9.6 nm HDL particles (rHDL), possess increased capacity to catalyze cholesterol efflux from macrophages. Synchrotron radiation circular dichroism and hydrogen-deuterium exchange revealed that the variants in 8.4 nm rHDL have altered secondary structure composition and display a more flexible binding to lipids compared to their native counterpart. The reduced HDL-cholesterol levels of patients carrying ApoA-I amyloidogenic variants are thus balanced by higher proportion of small, dense HDL particles and better cholesterol efflux due to altered, region-specific protein structure dynamics.

The histopathological subtype of lung adenocarcinoma (LUAD) is closely associated with prognosis. Micropapillary or solid predominant LUAD tends to relapse after surgery at an early stage, whereas lepidic pattern shows a favorable outcome. However, the molecular mechanism underlying this phenomenon remains unknown. Here, we recruited 31 lepidic predominant LUADs (LR: low-risk subtype group) and 28 micropapillary or solid predominant LUADs (HR: high-risk subtype group). Tissues of these cases were obtained and label-free quantitative proteomic and bioinformatic analyses were performed. Additionally, prognostic impact of targeted proteins was validated using The Cancer Genome Atlas databases (n=492) and tissue microarrays composed of early-stage LUADs (n=228). A total of 192 differentially expressed proteins were identified between tumor tissues of LR and HR and three clusters were identified via hierarchical clustering excluding eight proteins. Cluster 1 (65 proteins) showed a sequential decrease in expression from normal tissues to tumor tissues of LR and then to HR and was predominantly enriched in pathways such as tyrosine metabolism and ECM-receptor interaction, and increased matched mRNA expression of 18 proteins from this cluster predicted favorable prognosis. Cluster 2 (70 proteins) demonstrated a sequential increase in expression from normal tissues to tumor tissues of LR and then to HR and was mainly enriched in pathways such as extracellular organization, DNA replication and cell cycle, and high matched mRNA expression of 25 proteins indicated poor prognosis. Cluster 3 (49 proteins) showed high expression only in LR, with high matched mRNA expression of 20 proteins in this cluster indicating favorable prognosis. Furthermore, high expression of ERO1A and FEN1 at protein level predicted poor prognosis in early-stage LUAD, supporting the mRNA results. In conclusion, we discovered key differentially expressed proteins and pathways between low-risk and high-risk subtypes of early-stage LUAD. Some of these proteins could serve as potential biomarkers in prognostic evaluation.

How do Eurasian kleptocracies earn and use their money? 9 November 2021 — 1:00PM TO 2:30PM Anonymous (not verified) 22 October 2021 Chatham House and Online

This event explores the presence of corrupt funds from Eurasia in Western democracies, what they are used for, and how they can be constrained.

The Pandora Papers once again shone the spotlight on the UK being home to corrupt funds from kleptocracies, where the ruling elite abuse their political power for private gain.

In recent years much focus has been placed on this term, and the possible effects such money could have on Western democracies.

• How do such states create this wealth in the first place?
• How do these funds make their way to the UK?
• Is the term kleptocracy appropriate for the majority of countries in Eurasia?
• What evidence is there that such funds are ‘weaponized’ to achieve foreign policy goals?

This event discusses the term, how it can be applied, and the differences between how ’grey’ funds are used by various countries. It also highlights how the UK and the wider international community can counteract these flows, both from a legal point of view, and via other methods.

After much anticipation, the National Institute of Standards and Technology (NIST) issued its first Post Quantum Cryptography (PQC) standards today. They are intended to defeat efforts by quantum computers powerful […]

The post NIST Issues Post Quantum Cryptography Standards and Calls for their Adoption appeared first on HPCwire.

A federal judge on Tuesday sentenced former Massachusetts Air National Guardsman Jack Teixeira to 15 years in prison for stealing classified information and sharing it online.

Watch a discussion between three educators who ran for their state legislatures about their experiences on the campaign trail.

Teachers felt that iPads "provide no educational function in the classroom" and are often used to play games in class.

When can we expect the Islanders to get healthy?