lt Political Opposition and Policy Alternatives in Zambia By www.chathamhouse.org Published On :: Thu, 19 Oct 2017 13:30:00 +0000 Political Opposition and Policy Alternatives in Zambia 31 October 2017 — 10:30AM TO 11:30AM Anonymous (not verified) 19 October 2017 Chatham House, London In Zambia’s 2016 national election, the Patriotic Front (PF) was re-elected by a narrow margin. The PF’s Edgar Lungu secured 50.35 per cent of the vote according to the Electoral Commission of Zambia, narrowly avoiding a second round, while his main rival, Hakainde Hichilema, won 47.67 per cent. The UPND, led by Mr Hichilema, alleges electoral fraud and has challenged the result in the courts and through direct protests. Mr Hichilema was imprisoned for 100 days.At this meeting, Hakainde Hichilema will discuss his UPND priorities, how to strengthen opposition parties and their role in Zambia’s democratic future. Read transcript Full Article
lt Use of antiviral drug in poultry is blamed for drug resistant strains of avian flu By www.bmj.com Published On :: Thursday, June 30, 2005 - 21:55 Full Article
lt Mental Health Bill promises more tailored and dignified treatment for people detained By www.bmj.com Published On :: Thursday, November 7, 2024 - 13:06 Full Article
lt Development and validation of outcome prediction models for aneurysmal subarachnoid haemorrhage: the SAHIT multinational cohort study By www.bmj.com Published On :: Thursday, January 18, 2018 - 16:21 Full Article
lt SGLT-2 inhibitors for diabetes may help prevent dementia, study finds By www.bmj.com Published On :: Wednesday, August 28, 2024 - 22:30 Full Article
lt The Commonwealth reimagined By www.chathamhouse.org Published On :: Tue, 18 Oct 2022 10:27:13 +0000 The Commonwealth reimagined 8 November 2022 — 6:00PM TO 7:00PM Anonymous (not verified) 18 October 2022 Chatham House and Online Ghana’s minister of foreign Affairs, the Hon. Shirley Ayorkor Botchwey, discusses her vision for a modern Commonwealth and how it can evolve and match demands from its members. The death of HM Queen Elizabeth II has focused attention on the future of the Commonwealth. The Commonwealth is an expanding voluntary organization of 56 independent countries in Africa, Asia, the Americas, Europe, and the Pacific. Its appeal is increasingly beyond the circle of former British colonies – ex-French colonies Togo and Gabon officially joined in October 2022 and the ex-Portuguese colony, Angola, has applied. The Commonwealth Secretariat, established in 1965, is its main intergovernmental agency, which coordinates and carries out much of the Commonwealth’s work, supported by a network of more than 80 organizations. King Charles III now heads the Commonwealth, which is focused on shared goals of prosperity, democracy and peace. However, the future of the Commonwealth and its purpose are unclear, and the organization needs to develop a sharper agenda on what its international contribution can be across its 56 state members and their peoples. The minister discusses key questions including: What should a modern Commonwealth look like and how can it best operate? How can the organization impact policies and actions at a country level? What role will young people play in the future of the Commonwealth? How can the organization harness collective resources and technology to tackle major global issues such as climate change? Can the issue of mobility and immigration among member states be managed? Full Article
lt Built for net zero By www.chathamhouse.org Published On :: Mon, 21 Nov 2022 20:17:13 +0000 Built for net zero 12 December 2022 — 6:00PM TO 7:00PM Anonymous (not verified) 21 November 2022 Chatham House and Online How can sustainable infrastructure deliver on low-carbon commitments? Demand for sustainable infrastructure is increasing in scale and complexity as developed and developing countries seek to accelerate the transition to low-carbon economies while improving living standards for all. Delivering on net zero will require significant public and private investment, with spending on physical assets alone requiring a yearly commitment of at least $7 trillion according to estimates by the International Federation of Consulting Engineers (FIDIC). To ensure the successful build-out of modern green infrastructure across target sectors from transport and energy to water, innovative financing and collaborative project delivery models are needed to support climate commitments, energy-efficiency, and sustainable living options. This discussion examines how construction design and infrastructure strategies should evolve to deliver on sustainability goals, remain competitive, and maximize societal outcomes. The discussion, supported by EY, explores these key questions: What are the main drivers and restraints for governments in delivering green infrastructure? What is the role of investors in promoting sustainable infrastructure? Where should investment be targeted for maximum impact? Who are the key stakeholders that should be involved in infrastructure delivery and what does successful collaboration look like? How can civil society and local governments play a greater role in urban design to deliver safe, resilient infrastructure with positive societal outcomes? As with all members events, questions from the audience drive the conversation. Read the transcript. Full Article
lt Russia’s aggression and a crisis for multilateralism By www.chathamhouse.org Published On :: Thu, 23 Mar 2023 15:07:13 +0000 Russia’s aggression and a crisis for multilateralism 30 March 2023 — 1:00PM TO 2:00PM Anonymous (not verified) 23 March 2023 Chatham House and Online In conversation with Dmytro Kuleba, minister of foreign affairs of Ukraine, about how multilateral organizations struggle to respond adequately to Russia’s full-scale invasion of Ukraine. As a permanent member of the UN Security Council, Russia pursues this war in defiance of the umbrella organization’s multiple resolutions condemning the invasion, along with its war crimes, annexation of territory, deliberate targeting of civilian nuclear infrastructure, cultural extermination, and global disinformation campaign. This event explores the following questions: How should the response of the UN to Russian aggression be assessed? What can be done to uphold the guiding principles of the UN Charter? Is there a ‘UN problem’ or a ‘Russia problem’? How can trust and the legitimacy of multilateral cooperation be restored in times of strategic rivalry and rising global tensions? Who can drive such an effort? Is post-Soviet transfer of the UN Security Council seat to Russia a cause of current impunity? This event features a live in-person audience in Kyiv as well as in London and online. Full Article
lt All women with suspected endometriosis should be offered ultrasound scans, says NICE By www.bmj.com Published On :: 2024-11-12T07:26:00-08:00 The National Institute for Health and Care Excellence (NICE) has recommended that all women with suspected endometriosis be offered an early transvaginal ultrasound scan, even if the pelvic or abdominal examination is normal.In its updated guideline1 on the diagnosis and management of endometriosis, NICE recommends specialist ultrasound as an alternative to magnetic resonance imaging for investigating suspected cases of the condition in secondary care.The updated guideline follows recent reports from both the National Confidential Enquiry into Patient Outcome and Death2 and Endometriosis UK which highlighted problems with delayed diagnoses, partly owing to a lack of awareness among healthcare professionals of the condition and how it presents. Such delays can result in prolonged suffering, ill health, and risks to fertility, the reports warned.Other new and updated recommendations include asking women with suspected endometriosis if any first degree relatives have a history of the condition, and considering neurodiversity when taking into account... Full Article
lt Culture notes: Populists of the world unite By www.chathamhouse.org Published On :: Wed, 25 May 2022 09:11:06 +0000 Culture notes: Populists of the world unite The World Today rsoppelsa.drupal 25 May 2022 America’s hard-right has successfully played a long game at home, and now it’s schmoozing Europe. We should be worried, says Catherine Fieschi The politics of advanced democracies is a rather Janus-faced affair these days. No sooner have we breathed a sigh of relief at the results of the French presidential election than a leaked United States Supreme Court document on Roe v Wade signals American abortion rights are under threat. Yes, Europe seems to be maintaining political unity in its support of Ukraine, and the US is lavishing eye-watering sums on it both in military and humanitarian aid. Yet one cannot help but feel that these might be short-lived spells of relief in the face of mounting storm clouds on the political horizon. Both at the domestic and international level, populist politics looks to be gathering pace still. On the domestic front, we should be cautious in our relief. In the French elections Emmanuel Macron was indeed re-elected, and comfortably so, but there is no denying the space occupied by populist politicians on the left and the right. In the first round, Marine Le Pen gained 23 per cent of the vote, left populist candidate Jean-Luc Mélenchon 22 per cent, and far-right candidate Éric Zemmour 7 per cent. Add to this a record low turnout, and the picture is one of a system in which mainstream politics has overall been rejected in favour of various populist options. The Hungarians weren’t so lucky, and Viktor Orbán’s capture of the media and quashing of the opposition over his years in power delivered solid victory. What should be cause for further concern is what is happening in the United States, as well as its potential impact on European politics. A quick flick through American politics today suggests dysfunctionalities of staggering magnitude and depth, and the full extent of the success of the right-wing Republican project, as confirmed by the intention to reverse Roe v Wade. Any reversal of Roe v Wade is a further step towards a drastic re-territorialization of American politics: into red states and blue states, into urban v rural, into places where taxes fund public education and public goods and where they won’t. It is also about a re-territorialization of institutional power away from the federal and into state institutions. The words of JD Vance, the Ohio Republican senatorial candidate – author of the rather good memoir Hillbilly Elegy – pander to an ‘American heartlands’ view of the United States’ role in the world. Asked about the fate of Ukraine, Vance simply replied that he ‘didn’t really care what happens to Ukraine one way or another’. On an even more basic level, we would do well to keep in mind that there were 440 anti-voter bills in 49 states at the end of 2021 and rising, calling into question citizens’ basic rights to vote. Republicans have pursued this agenda relentlessly. They have played a long game and invested in media, education and minor and not so minor projects – all of which have secured them a social and political base that is well-disposed towards the deep reversal of the American liberal global project and that of its allies across the world. The arrival of the Fox News-driven Conservative Political Action Conference in Hungary in May is deeply worrying And it is perhaps on this last point that we should be most alarmed. Between May 18-20, the Conservative Political Action Conference, an American conclave of the right, was held in Europe. Viktor Orbán gave the keynote speech, and other speakers included the Brazilian President Jair Bolsonaro’s son, Eduardo, and the president of Spain’s far-right party Vox, Santiago Abascal, as well as some well-known American Trumpian voices, including Trump himself. Marine Le Pen, whose earlier appearance at the conference had met with rapturous applause, chose not to cosy-up too closely to Orbán in the run-up to the French parliamentary elections in June but she sent her deputy. The export of the Fox News-driven conference from across the Atlantic is deeply worrying. Up until now populists have failed in their attempts at international alliances. At the European Union level their nationalism has always been in the way of their working together, and their groups tend to be short-lived or ineffective as a result. As for American attempts in Europe, the one led by Steve Bannon, the former White House adviser, in 2020 that aimed to create an Academy for the Judeo-Christian West ended as a damp squib – possibly not helped by his dismissal from the White House amid charges of defrauding donors. But something may be changing: the conference’s embrace of Orbán and an international smattering of ‘strongmen’ hailing from the hard-right, aligned with Putin and sup-ported by Trump and a media empire, suggests that we are entering a Trumpian-infused second act that in its triumphal revanchism is seeking to create an international right-wing populist, or even authoritarian front. This is about politics, media, but also money – something European populist parties have been short of. As Marine Le Pen explained to French voters, her party is so poor it had to borrow money from a Russian bank. As some have pointed out, the Russian aggression against Ukraine has complicated matters when it comes to Russian funding of disinformation to the West. Many routes have been shut down. But a new route between the US and Hungary as a platform to floss Europe with dirty money is a good replacement to the old Russian route. Full Article
lt Why the UK must deliver on Nordic-Baltic security By www.chathamhouse.org Published On :: Fri, 16 Dec 2022 12:02:39 +0000 Why the UK must deliver on Nordic-Baltic security Expert comment NCapeling 16 December 2022 Hard choices are needed but it is crucial the UK provides security and leadership to its European partners given the wider context of the war in Ukraine. The UK’s role in Nordic-Baltic security has been growing over the past decade. The region is key to core British strategic interest and engagement, and UK threat assessment closely aligns with long-held regional perspectives – the 2021 Integrated Review defines Russia as ‘the most acute threat to our security’. Since Russia’s invasion of Ukraine, the UK’s strong stance towards Moscow and the concrete steps taken to assist Ukraine and strengthen defence and deterrence on NATO’s eastern flank have been widely appreciated in the Nordic-Baltic region. The UK is seen as a reliable partner but, for it to continue to deliver in the region, difficult choices must be made with regards to UK defence spending and military capabilities, and London’s more global ambitions. The UK is a major contributor to NATO’s deterrence posture on the eastern flank, serving as a framework nation for NATO’s Enhanced Forward Presence (EFP) battlegroup in Estonia, and contributing to another battlegroup in Poland. UK remains crucial to regional security Coupled with its contribution to NATO’s Baltic Air Policing mission and maritime forces in the area, the UK is a crucial security partner both in the region and in a broader arch across Europe. The UK offers military capability, strong political will, a long-standing tradition of engagement in the Nordic-Baltic area, and fast decision-making Over the past decade and a half, the UK has been developing a dense network of bilateral and minilateral relations in the region which are major assets in the current security environment. It leads the Joint Expeditionary Force (JEF) which is a military cooperation format highly valued for its flexibility in responding to the needs of the participating nations – including non-NATO Sweden and Finland – and is increasingly focused on the North Atlantic, High North and wider Baltic areas. The UK has also seen increased bilateral defence cooperation with Norway, Denmark, Estonia, and other regional allies and partners. There are reasonable expectations that Germany or France may at some point assume a greater role in this part of Europe, building on France’s participation in the EFP in Estonia, and Germany’s lead of the EFP in Lithuania. However, while Paris remains more focused on NATO’s southern (and south-eastern) flank and building the European Union’s defence role, Berlin often underperforms as a leading or an organizing power of collaborative efforts across Europe. Both also have a credibility problem in the Nordic-Baltic region due to their past policies towards Russia that occasionally reappear when discussing military support to Ukraine or how to treat Russia in the post-war European security order. By contrast, the UK offers military capability, strong political will, a long-standing tradition of engagement in the Nordic-Baltic area, and fast decision-making. The latter is exemplified by the bilateral security guarantees provided to Sweden and Finland during their accession to NATO, and the surge of assets sent to the region in the wake of Russia’s full-scale invasion of Ukraine such as an additional battlegroup and Chinook helicopters to Estonia, as well as forward-deployed elements of the Standing Joint Force Headquarters to Latvia and Lithuania as part of the JEF. Such pragmatic and resolute engagement help substantiate the UK’s post-Brexit claim that although it left the EU, it did not leave Europe. London also understands and facilitates the pivotal role that the US plays in European security – a shared perspective with the Nordic-Baltic partners. Only the US – which has just recently decided to step up its military presence in the Baltics – has a greater appeal than the UK as a major ally. But Washington’s truly global responsibilities make it more difficult for it to play a regional leadership role. With the context of the war in Ukraine, the centre of gravity of European security is moving east. The Nordic-Baltic region is likely to feature more prominently in the upcoming refresh of the UK’s Integrated Review, as the war in Ukraine and NATO’s new forward defence approach will focus UK attention and military capabilities on Europe for the foreseeable future. But the UK still has limited resources and, despite the worsening security environment, there is currently no commitment by the Rishi Sunak government to increase defence spending beyond two per cent of GDP, as set out in the recently-published Autumn Statement. This difficult fiscal reality contrasts UK ambition to also increase its footprint and engagement in the Indo-Pacific, a region highlighted by Rishi Sunak in his first foreign policy speech. London is already confronted with increasing expectations from its Nordic and Baltic partners, which are rattled by Russia’s aggression and seek more engagement and commitments from larger and more resourceful allies, and are insisting on prompt implementation of NATO’s new defence and deterrence plans. This all comes on top of the resources that further assistance to Ukraine will require in the coming months and years. Balancing competing priorities and demands from partners is routine for a major power with global ambition but, in the current context, if the UK government fails to prioritize and increase resources, over-extension is in sight for its armed forces. The war in Ukraine confirms that, beyond the rhetoric around the ‘Indo-Pacific tilt’, the Euro-Atlantic is – and will remain – the priority theatre of engagement for the UK. To keep delivering in the Nordic-Baltic region and remain a reliable partner, UK ambitions should be set clearly, and expectations managed with regional partners. A good example is the recent UK-Estonia joint statement and defence roadmap, which is an attempt to reconcile London’s vision of modern deterrence with Tallinn’s preference for ‘more boots on the ground’. The UK gains many benefits from deepening and widening its engagement in the Nordic-Baltic region, and not only by showcasing its regional leadership at a time of dire need or having more weight in Europe and across the Atlantic The joint statement also clarifies initial misunderstandings regarding the upcoming withdrawal of the second UK battlegroup deployed to Estonia in the wake of Russia’s invasion of Ukraine – support Tallinn expected to continue ‘as long as necessary’ but London saw as temporary. It offsets the poor political ‘optics’ of the withdrawal while providing solid ground for deepening the common agenda in the near future. By the 2023 NATO summit in Vilnius, progress on implementing the roadmap will be a crucial measure of success for the bilateral relationship, and for the UK’s broader regional role. It should serve as an opportunity for the UK to reflect on its force development priorities and balance, with Baltic partners arguing in favour of the UK rebuilding some mass in its armed forces and providing more resources to the land component. Much to gain for the UK The UK gains many benefits from deepening and widening its engagement in the Nordic-Baltic region, and not only by showcasing its regional leadership at a time of dire need or having more weight in Europe and across the Atlantic in strategic debates about future security architecture. Full Article
lt Culture notes: Will the EU find its voice at last? By www.chathamhouse.org Published On :: Mon, 30 Jan 2023 13:09:06 +0000 Culture notes: Will the EU find its voice at last? The World Today mhiggins.drupal 30 January 2023 Russia’s invasion of Ukraine has galvanized the bloc, but doubt remains about how it can capitalize on this moment, writes Catherine Fieschi. Despite its reticence to believe that Russia would attack Ukraine, once Vladimir Putin’s tanks rolled across the Donbas, the European Union finally grasped the momentous nature of the events unfolding on its eastern flank. The immediate reaction of Europe’s member states was one of unity, resolve and uncharacteristically rapid decision-making, at least on sanctions and energy policy. That they would need to act in concert across a concatenation of crises that would be either triggered (energy), worsened (inflation) or heightened (geopolitical instability) by Putin’s move was obvious. And so, Europe’s collective narrative of this past year slid into place, and it goes something like this: We gave Russia the benefit of every doubt, including after their invasion of Crimea when we still tried to bring them back to the negotiating table, but Putin has made the fundamental choice of turning away from democracy and the rule of law. Europe had long been in need of an arc to follow Now, the narrative goes on, we have to treat them as enemies and give ourselves the means to become resilient in the face of aggression as Ukraine is all that stands – both symbolically and geographically – between us and the chaos of a Europe-wide war. Like any good narrative, it is anchored in previous trials and exploits. Having learnt from its failure to coordinate action during the eurozone crisis and then the migration crisis, Europe was keen to make the most of its resilience in the face of the Covid pandemic in the form of the joint vaccine purchases and a massive recovery plan. The Russian invasion of Ukraine is an added – albeit dramatic and costly – opportunity to pursue further collective action and discover the next chapter of its shared purpose, as a political and perhaps even a defence alliance. Europe had long been in need of an arc to follow. In the aftermath of the Second World War, peace and prosperity seemed enough. But the new multipolar world that emerged from the ashes of the Cold War and then 9/11 were more difficult to navigate for a largely commercial and regulatory alliance. Could the EU, then, ever find its political voice? David vs Goliath While Brexit and Covid created rallying points, the shock and tragedy of the invasion delivered everything the EU needed in narrative terms: a David and Goliath story, with the opportunity to feature on Team David in European terms while allying with the United States, and a ‘band of brothers’ element to shore up a union bruised by the defection of a key but troubled member. Above all, the appearance of an arch-villain in the form of Vladimir Putin put Europe back into the familiar and mythical territory of the 1940s and then the Cold War. When on May 28, 2016, Putin seated himself on the throne of the Byzantine emperors in Mount Athos’ Protaton Church in Greece in a scene truly worthy of Game of Thrones, the writing should have been on the wall. That day he explicitly laid out his aim to appoint himself as the new Eastern emperor who would fight the decadence of the West. ‘Today,’ Putin told the world, ‘we restore the values of patriotism, historical memory and traditional culture.’ Later, he cited Ukraine as the biggest unfinished mission of his years in power. That Europe – and Germany in particular – had taken so long to decipher Putin’s dark designs only adds to the narrative’s epic quality, positioning Europe as a victim of its own good faith and open heart. Cracks in the narrative But the narrative is not free from cracks. The Baltic states would argue that they had long warned of Putin’s nefarious intentions; and Poland has always been convinced of the threat posed by its neighbour. Full Article
lt Ultrashort Oncologic Whole-Body [18F]FDG Patlak Imaging Using LAFOV PET By jnm.snmjournals.org Published On :: 2024-10-01T04:08:08-07:00 Methods to shorten [18F]FDG Patlak PET imaging procedures ranging from 65–90 to 20–30 min after injection, using a population-averaged input function (PIF) scaled to patient-specific image-derived input function (IDIF) values, were recently evaluated. The aim of the present study was to explore the feasibility of ultrashort 10-min [18F]FDG Patlak imaging at 55–65 min after injection using a PIF combined with direct Patlak reconstructions to provide reliable quantitative accuracy of lung tumor uptake, compared with a full-duration 65-min acquisition using an IDIF. Methods: Patients underwent a 65-min dynamic PET acquisition on a long-axial-field-of-view (LAFOV) Biograph Vision Quadra PET/CT scanner. Subsequently, direct Patlak reconstructions and image-based (with reconstructed dynamic images) Patlak analyses were performed using both the IDIF (time to relative kinetic equilibrium between blood and tissue concentration (t*) = 30 min) and a scaled PIF at 30–60 min after injection. Next, direct Patlak reconstructions were performed on the system console using only the last 10 min of the acquisition, that is, from 55 to 65 min after injection, and a scaled PIF using maximum crystal ring difference settings of both 85 and 322. Tumor lesion and healthy-tissue uptake was quantified and compared between the differently obtained parametric images to assess quantitative accuracy. Results: Good agreement was obtained between direct- and image-based Patlak analyses using the IDIF (t* = 30 min) and scaled PIF at 30–60 min after injection, performed using the different approaches, with no more than 8.8% deviation in tumor influx rate value (Ki) (mean difference ranging from –0.0022 to 0.0018 mL/[min x g]). When direct Patlak reconstruction was performed on the system console, excellent agreement was found between the use of a scaled PIF at 30–60 min after injection versus 55–65 min after injection, with 2.4% deviation in tumor Ki (median difference, –0.0018 mL/[min x g]; range, –0.0047 to 0.0036 mL/[min x g]). For different maximum crystal ring difference settings using the scan time interval of 55–65 min after injection, only a 0.5% difference (median difference, 0.0000 mL/[min x g]; range, –0.0004 to 0.0013 mL/[min x g]) in tumor Ki was found. Conclusion: Ultrashort whole-body [18F]FDG Patlak imaging is feasible on an LAFOV Biograph Vision Quadra PET/CT system without loss of quantitative accuracy to assess lung tumor uptake compared with a full-duration 65-min acquisition. The ultrashort 10-min direct Patlak reconstruction with PIF allows for its implementation in clinical practice. Full Article
lt Preclinical Evaluation of 177Lu-OncoFAP-23, a Multivalent FAP-Targeted Radiopharmaceutical Therapeutic for Solid Tumors By jnm.snmjournals.org Published On :: 2024-10-01T04:08:08-07:00 Fibroblast activation protein (FAP) is abundantly expressed in the stroma of most human solid tumors. Clinical-stage radiolabeled FAP ligands are increasingly used as tools for the detection of various cancer lesions. To unleash the full therapeutic potential of FAP-targeting agents, ligands need to remain at the tumor site for several days after administration. We recently described the discovery of OncoFAP, a high-affinity small organic ligand of FAP with a rapid accumulation in tumors and low uptake in healthy tissues in cancer patients. Trimerization of OncoFAP provided a derivative (named TriOncoFAP, or OncoFAP-23) with improved FAP affinity. In this work, we evaluated the tissue biodistribution profile and the therapeutic performance of OncoFAP-23 in tumor-bearing mice. Methods: OncoFAP-23 was radiolabeled with the theranostic radionuclide 177Lu. Preclinical experiments were conducted on mice bearing SK-RC-52.hFAP (BALB/c nude mice) or CT-26.hFAP (BALB/c mice) tumors. 177Lu-OncoFAP and 177Lu-FAP-2286 were included in the biodistribution study as controls. Toxicologic evaluation was performed on Wistar rats and CD1 mice by injecting high doses of OncoFAP-23 or its cold-labeled counterpart, respectively. Results: 177Lu-OncoFAP-23 emerged for its best-in-class biodistribution profile, high and prolonged tumor uptake (i.e., ~16 percentage injected dose/g at 96 h), and low accumulation in healthy organs, which correlates well with its potent single-agent anticancer activity at low levels of administered radioactivity. Combination treatment with the tumor-targeted interleukin 2 (L19-IL2, a clinical-stage immunocytokine) further expands the therapeutic window of 177Lu-OncoFAP-23 by potentiating its in vivo antitumor activity. Proteomics studies revealed a potent tumor-directed immune response on treatment with the combination. OncoFAP-23 and natLu-OncoFAP-23 exhibited a favorable toxicologic profile, without showing any side effects or signs of toxicity. Conclusion: OncoFAP-23 presents enhanced tumor uptake and tumor retention and low accumulation in healthy organs, findings that correspond to a strongly improved in vivo antitumor efficacy. The data presented in this work support the clinical development of 177Lu-OncoFAP-23 for the treatment of FAP-positive solid tumors. Full Article
lt Xsight Labs Launches E1 SoC Built on TSMC’s 5nm Tech for AI Workloads By www.hpcwire.com Published On :: Wed, 16 Oct 2024 15:54:54 +0000 Oct. 16, 2024 — Xsight Labs, a leading fabless semiconductor company providing end-to-end connectivity solutions for next-generation hyperscale, edge, and AI data center networks, has announced the tape-out of the […] The post Xsight Labs Launches E1 SoC Built on TSMC’s 5nm Tech for AI Workloads appeared first on HPCwire. Full Article
lt Sam LaPorta, Tristan Wirfs, Dalton Kincaid among injured in NFL's Week 10 By www.upi.com Published On :: Mon, 11 Nov 2024 09:54:18 -0500 All-Pro left tackle Tristan Wirfs and tight ends Sam LaPorta and Dalton Kincaid were among key players injured in Week 10 of the NFL season. Full Article
lt Pure Storage Embraces Next-Gen Networking for AI with Ultra Ethernet Consortium Membership By www.hpcwire.com Published On :: Tue, 13 Aug 2024 18:03:01 +0000 SANTA CLARA, Calif., Aug. 13, 2024 — Pure Storage today announced that it joined Ultra Ethernet Consortium (UEC), a Linux Foundation initiative dedicated to building a complete, open, and accessible Ethernet-based […] The post Pure Storage Embraces Next-Gen Networking for AI with Ultra Ethernet Consortium Membership appeared first on HPCwire. Full Article
lt Ultra Accelerator Link Consortium Launches with Industry Leaders, Opens Membership to Drive AI Connectivity Standards By www.hpcwire.com Published On :: Tue, 29 Oct 2024 22:38:54 +0000 BEAVERTON, Ore., Oct. 29, 2024 — Ultra Accelerator Link (UALink) Consortium, led by Board Members from AMD, Amazon Web Services (AWS), Astera Labs, Cisco, Google, Hewlett Packard Enterprise (HPE), Intel, Meta […] The post Ultra Accelerator Link Consortium Launches with Industry Leaders, Opens Membership to Drive AI Connectivity Standards appeared first on HPCwire. Full Article
lt MLPerf Releases Latest Inference Results and New Storage Benchmark By www.hpcwire.com Published On :: Wed, 13 Sep 2023 13:12:25 +0000 MLCommons this week issued the results of its latest MLPerf Inference (v3.1) benchmark exercise. Nvidia was again the top performing accelerator, but Intel (Xeon CPU) and Habana (Gaudi1 and 2) […] The post MLPerf Releases Latest Inference Results and New Storage Benchmark appeared first on HPCwire. Full Article Features Habana Labs Intel MLCommons MLPerf Nvidia
lt U.S. Air Force seeing ‘good progress’ on new B-21 Raider stealth bombers By www.upi.com Published On :: Tue, 21 Sep 2021 13:02:09 -0400 An arms contractor is making "good progress" on the production of five B-21 Raider stealth bombers, U.S. Air Force Secretary Frank Kendall disclosed during a speech on Monday. Full Article
lt IonQ Announces 3rd Quarter 2024 Financial Results By www.hpcwire.com Published On :: Thu, 07 Nov 2024 14:01:38 +0000 COLLEGE PARK, Md., Nov. 7, 2024 — IonQ (NYSE: IONQ), a leader in the quantum computing industry, has announced financial results for the quarter ended September 30, 2024. “We had yet […] The post IonQ Announces 3rd Quarter 2024 Financial Results appeared first on HPCwire. Full Article
lt Repairs to Tampa Bay Rays' Tropicana Field from Hurricane Milton put at $55.7 million By www.upi.com Published On :: Tue, 12 Nov 2024 17:27:58 -0500 It will cost $55.7 million to repair Tropicana Field, home to the MLB Tampa Bay Rays, in time for the 2026 home opener, St. Petersburg., Fla., city officials said Tuesday. Full Article
lt Intel’s Altera Unveils New FPGA Tools and Kits to Boost AI and Edge Applications By www.hpcwire.com Published On :: Mon, 23 Sep 2024 18:19:26 +0000 Sept. 23, 2024 — Altera, an Intel Company, today unveiled an array of FPGA hardware, software and development tools that make its programmable solutions more accessible across a broader range of […] The post Intel’s Altera Unveils New FPGA Tools and Kits to Boost AI and Edge Applications appeared first on HPCwire. Full Article
lt Altair’s HPC and Simulation Solutions Advance Motivo’s Aerospace Prototyping By www.hpcwire.com Published On :: Fri, 18 Oct 2024 03:48:32 +0000 TROY, Mich., Oct. 17, 2024 — Altair, a global leader in computational intelligence, is proud to announce its collaboration with Motivo, a product engineering firm for clients in the mobility, […] The post Altair’s HPC and Simulation Solutions Advance Motivo’s Aerospace Prototyping appeared first on HPCwire. Full Article
lt Asthma Drug Still Being Prescribed to Kids Despite Potential Mental Health Risks By www.scientificamerican.com Published On :: Fri, 19 Jan 2024 17:00:00 GMT The allergy and asthma drug montelukast, also known as Singulair, can cause psychiatric side effects—and researchers aren’t sure why Full Article Health Pharmaceuticals Mind & Brain Mental Health
lt Farmers in Crisis, Long Overlooked, Are Finally Getting Mental Health Support By www.scientificamerican.com Published On :: Thu, 15 Feb 2024 11:45:00 GMT Amid a mounting mental health crisis among farmers, experts are working to make help more accessible Full Article Agriculture Health Mind & Brain Mental Health
lt Despite improvements, salt in restaurant meals remains high, can hurt the heart By www.upi.com Published On :: Mon, 21 Oct 2024 05:00:07 -0400 Consumers thinking of dining out for their next meal may want to consider one instruction for the server -- hold the salt. Full Article
lt Weight-loss surgery in teens brings long-term health benefits, study concludes By www.upi.com Published On :: Wed, 30 Oct 2024 18:29:38 -0400 Weight-loss surgery in adolescents with severe obesity can lead to long-term health benefits, such as more frequent remission of type 2 diabetes than in adults who undergo the same treatment, a large, NIH-funded study. Full Article
lt Study: Deaths from cardiovascular disease surge among adults 25-64 in rural areas By www.upi.com Published On :: Tue, 12 Nov 2024 06:39:14 -0500 Deaths from cardiovascular disease have surged among adults ages 25 to 64 living in rural areas, a new study shows. Full Article
lt Ansys, Intel Foundry Collaborate on Multiphysics Analysis Solution for EMIB 2.5D Assembly Tech By www.hpcwire.com Published On :: Thu, 22 Feb 2024 18:08:53 +0000 PITTSBURGH, Feb. 22, 2024 — Ansys and Intel Foundry have collaborated to provide multiphysics signoff solutions for Intel’s innovative 2.5D chip assembly technology, which uses EMIB technology to connect the […] The post Ansys, Intel Foundry Collaborate on Multiphysics Analysis Solution for EMIB 2.5D Assembly Tech appeared first on HPCwire. Full Article
lt Ansys Enables 3D Multiphysics Visualization of Next-Gen 3D-IC Designs with NVIDIA Omniverse By www.hpcwire.com Published On :: Wed, 19 Jun 2024 18:47:48 +0000 PITTSBURGH, June 19, 2024 — Ansys today announced that it is adopting NVIDIA Omniverse application programming interfaces (APIs) to offer 3D-IC designers valuable insights from Ansys’ physics solver results through […] The post Ansys Enables 3D Multiphysics Visualization of Next-Gen 3D-IC Designs with NVIDIA Omniverse appeared first on HPCwire. Full Article
lt Altair Partners with European Space Agency to Advance AI-Driven Aerospace Innovation By www.hpcwire.com Published On :: Wed, 13 Nov 2024 02:57:36 +0000 TROY, Mich., Nov. 12, 2024 — Altair, a global leader in computational intelligence, has entered into collaboration agreement with the European Space Agency (ESA) through the ESA Partnership Initiative for […] The post Altair Partners with European Space Agency to Advance AI-Driven Aerospace Innovation appeared first on HPCwire. Full Article
lt Indiana jury finds Richard Allen guilty on all charges in murder of 2 teen girls By www.upi.com Published On :: Mon, 11 Nov 2024 17:34:50 -0500 The Indiana man accused of killing two teenage girls in a wooded area near Delphi was found guilty on Monday and faces a mid-December sentencing date. Full Article
lt VA to eliminate copays for telehealth, expand online emergency care to rural veterans By www.upi.com Published On :: Mon, 11 Nov 2024 23:53:12 -0500 The U.S. Department of Veterans Affairs announced plans Monday to eliminate copayments for all VA telehealth services, while expanding online emergency care access for rural veterans. Full Article
lt Watch: HBO, Max teases new seasons of 'White Lotus,' 'Hacks,' 'Gilded Age,' 'AJLT' By www.upi.com Published On :: Mon, 11 Nov 2024 09:54:55 -0500 A new HBO Max teaser offers a glimpse of the upcoming shows viewers can look forward to in the next year. Full Article
lt Watch: Rita Ora offers heartfelt tribute to Liam Payne during MTV's EMAs By www.upi.com Published On :: Mon, 11 Nov 2024 13:24:46 -0500 MTV's Europe Music Awards included a heartfelt tribute to late musician Liam Payne. Full Article
lt Blake Shelton, Taylor Sheridan working on a singing competition series for CBS By www.upi.com Published On :: Mon, 11 Nov 2024 16:57:20 -0500 Country music star Blake Shelton and writer-producer Taylor Sheridan are working on a new reality competition series for CBS called "The Road." Full Article
lt A Healthy Sign Of High IQ By www.spring.org.uk Published On :: Tue, 22 Oct 2024 16:00:51 +0000 It could be possible to increase your IQ. Full Article Intelligence
lt The Hobbies That Halt Cognitive Decline In Seniors (M) By www.spring.org.uk Published On :: Tue, 22 Oct 2024 17:00:53 +0000 Your brain could stay sharp for years just by doing these simple activities. Full Article Dementia subscribers-only
lt 1 in 4 Adults Believe They Have ADHD — Are You Missing The Signs? (M) By www.spring.org.uk Published On :: Fri, 25 Oct 2024 17:00:03 +0000 The most common ADHD symptoms in adults are often different to those in children. Full Article ADHD subscribers-only
lt How Light Pollution Could Be Affecting Your Brain Health (M) By www.spring.org.uk Published On :: Mon, 28 Oct 2024 18:00:10 +0000 A study reveals the hidden dangers of night time light pollution for brain health. Full Article Dementia subscribers-only
lt A Classic Childhood Sign Of Good Adult Mental Health By www.spring.org.uk Published On :: Tue, 05 Nov 2024 17:00:24 +0000 Children brought up like this tend to be happier as adults. Full Article Child Psychology
lt The Best Exercise For Brain Health Revealed By 98 Studies By www.spring.org.uk Published On :: Sun, 10 Nov 2024 17:00:25 +0000 Which types of exercise can help keep the brain healthy? Full Article Boost Brain Power
lt Survey: People Are Losing Hope In Mental Health Recovery (M) By www.spring.org.uk Published On :: Tue, 12 Nov 2024 18:00:13 +0000 Is people's empathy reducing towards those struggling with mental health issues? Full Article Mental Health subscribers-only
lt How regenerative agriculture brings life back to the land | Gabe Brown By www.ted.com Published On :: Thu, 10 Oct 2024 14:43:06 +0000 Over his decades of farming and ranching, Gabe Brown has noticed a troubling trend: the conventional farming techniques he used were degrading the soil and harming nature. He shares how his family farm turned things around by adopting regenerative agricultural practices — and shows how the wider food system can use these same methods to improve food quality and revitalize the land. Full Article Higher Education
lt A medical mythbuster's mission to improve health care | Joel Bervell By www.ted.com Published On :: Mon, 14 Oct 2024 14:16:25 +0000 Joel Bervell was one of the only Black students in his medical school program. After noticing how misconceptions about race were embedded in health care, he turned to social media to raise awareness about the harmful impact of biases in medicine. He unpacks the long history of race-based health care disparities — and shows what the medical field can do to better serve all patients. Full Article Higher Education
lt A hospital in the cloud bringing health care anywhere in the world | Mohamed Aburawi By www.ted.com Published On :: Tue, 15 Oct 2024 19:52:14 +0000 What if AI could help connect you with the right medical care, exactly when you need it? Health systems entrepreneur, surgeon and TED Fellow Mohamed Aburawi explores how his digital health platform, Speetar, uses AI to bridge the healthcare gap in underserved regions, like his native Libya, by connecting patients with doctors who truly understand their needs. Full Article Higher Education
lt Cultural Frame Switching: Different Language, Different Personality By feeds.feedblitz.com Published On :: Thu, 19 Aug 2021 16:07:49 +0000 Bilingual individuals demonstrate different personality characteristics when speaking different languages. Marketers making media and language decisions when addressing multilingual markets should add this finding to their list of influencing factors. The post Cultural Frame Switching: Different Language, Different Personality appeared first on Neuromarketing. Click the icon below to listen. Full Article Neuromarketing bilingual cultural frame switching language
lt Neuro-Loyalty: New Speaker Reel For Roger Dooley By feeds.feedblitz.com Published On :: Fri, 03 May 2024 16:27:15 +0000 Roger Dooley, international keynote speaker and author, just launched a new, three-minute speaker reel video featuring highlights of his Neuro-Loyalty speech based on the ideas in his award-winning book, FRICTION. The post Neuro-Loyalty: New Speaker Reel For Roger Dooley appeared first on Neuromarketing. Full Article Neuromarketing customer experience loyalty Neuro-Loyalty Neuromarketing 2.0 speaking speaking engagements
lt Exploring the Impact of IV Nutrition Therapy on Mental Health By www.whatispsychology.biz Published On :: Tue, 19 Mar 2024 19:53:22 +0000 Many people who want to be healthy often try to eat a balanced diet and get regular exercise. However, most foods today simply do not contain the nutrition they did in the past. If your goal is to improve your physical and mental health, your body may still require essential nutrients. IV nutrition therapy is […] The post Exploring the Impact of IV Nutrition Therapy on Mental Health first appeared on What is Psychology?. Full Article Abnormal Psychology Biopsychology Definitions Psychology News Depression IV nutrition therapy IV nutrition therapy mental health mental benefits of IV nutrition therapy newsnow stress IV nutrition therapy