A system for adaptive cooling and energy harvesting comprising at least one thermoelectric device capable of acting as a thermoelectric cooler and as a thermoelectric generator, a hierarchical multiple-level control system, and electronics controlled by the control system and connected to the thermoelectric device. The electronics selectively configure the thermoelectric device in at least in a thermoelectric cooler operating mode and in a thermoelectric generation operating mode. The thermoelectric device can incorporate quantum-process and quantum-well materials for higher heat transfer and thermoelectric generation efficiencies. The invention provides for thermoelectric devices to additionally operate in temperature sensing mode. The hierarchical control system can comprise a plurality of control system, each of which can operate in isolation and can be interconnected with additional subsystems associated with other hierarchical levels. The hierarchical control system can comprise linear (additive) control, bilinear (additive and multiplicative) control, nonlinear control, and hysteresis.

News you don't want to miss for May 5:

1. "UC Berkeley is in negotiations to purchase — and then potentially tear down — a 111-year-old rent-controlled apartment building on Walnut Street where some residents have lived for more than 25 years," Berkeleyside reports.…

A method includes embedding clothing with at least one sensor and at least one control unit; a power unit powering on the at least one sensor and the at least one control unit; the at least one sensor monitoring a sensed condition; the at least one control unit conducting a heat prediction based on the sensed condition; and the at least one control unit controlling threads within the clothing based on the heat prediction to actively adjust properties of the clothing.

For computer game controller thumb protection, a sheath of resilient, breathable fabric is tailored to conform closely to the distal and proximal thumb phalanx profiles. Stitched to the sheath is a single, continuous strip of thin, elastomer permeated fabric as a taction pad. Taction pad stitching follows the pad edge perimeter. The taction pad covers the pad area of the distal phalanx with a dog-leg extension over the first interproximal joint and proximal phalanx. A hook and loop swatch at a loose distal end of the dog-leg secures the end of the extension to a corresponding swatch of hook and loop material secured to the sheath.

Putting the AirTurn BT-200S-4 bluetooth foot controller to the test for hands-free DAW control.

In this podcast, The Evil Chocolate Cookie gives us a demonstration of the Tap Strap 2, a single handed all-in-one wearable keyboard, mouse & air gesture controller.

Tap is a wearable keyboard and mouse that enables you to type, mouse and control any Bluetooth enabled device, using any surface and in any position. Tap has accelerometers built into each finger ring, which register which fingers you are tapping and sending the associated letter, number, symbol, or macro to a paired Bluetooth device.

Tap is the only ergonomic solution that allows you to type in any position that is comfortable to your specific body without being bound to a desk. Tap’s design takes stress off your median nerve, allowing for hours of typing without strain. Tap also allows you to write without hunching forward, which causes posture problems as well as neck, shoulder and back pain.

Learning to Tap takes about 2 Hours – which is approximately 10 times faster than it takes to learn to QWERTY touch-typing. You learn to Tap using finger combinations, not key locations, making it usable in a variety of situations where you could not use a QWERTY. The fastest way to learn is by playing our free TapGenius Learning Game, which takes you through the Tap Alphabet using a series of fast, engaging challenges.

'Top voice stars' of the 'Trolls' sequel were reportedly not told beforehand that the animated movie would be skipping theaters and premiering straight on VOD.

Plugin Boutique has announced a sale on the Zenith by Audiaire, offering 30% off regular on the advanced MIDI processor plugin. Zenith allows any continuous controllers in a device to be modified by an independent sequencer lane, with each lane running at a unique rate and number of steps. As a feature-rich MIDI processor with […]

The post Audiaire’s Zenith MIDI controller & sequencer on sale at 30% OFF appeared first on rekkerd.org.

Happy weekend, Mefites! I'm in search of some nice things to idly think about that aren't in my immediate view. I'd like to see a wikipedia page you like, of something that isn't in your home.

As always this is just a conversation starter not a limiter; let us know how things are with you, what media are you enjoying, etc. Just no politics please.

There have been few surprise hits in the world of patchable instruments like Make Noise's 0-Coast. But they just might have another hit - a tabletop, patchable, clockable controller-sequencer. And it's adorable - and US$399.

The post Make Noise 0-CTRL is the controller-sequencer followup to 0-Coast appeared first on CDM Create Digital Music.

Thanks. It just seems odd that it's exactly every 7th chromatic note. Seems like too big a coincidence. Anyway, may have to buy a new one. Cheers, CAM

TedISTed - Many of these Videos Are NOW In Bundle Files To DownLoad from TedISTheOneGod.Net AND IN MultiGigaByteSite From and THIS NOW From Ted WHO IS Ted AND Ted! WHO IS Ted AND Other Names And Titles And Autherities And Many Other Things Since Existence....

This item belongs to: movies/opensource_movies.

This item has files of the following types: Metadata

Draft Redbooks, last updated: Wed, 6 May 2020

This IBM® Redbooks® publication is a detailed technical guide to the IBM System Storage™ SAN Volume Controller (SVC), which is powered by IBM Spectrum® Virtualize V8.3.1.

Katherine man Lorenzo Deegan is sentenced to 10 years by the Northern Territory Supreme Court after fatally assaulting his ex-partner while on parole.

Controlled Environmental Agriculture promises to be cleaner and greener. It’s focussed on technology and it’s essentially about bringing food production closer to the point of consumption. We examine the potential and the pitfalls.

Adelaide councils are considering a range of options to address the problem of abandoned shopping trolleys including GPS tracking, locking systems and a bounty for returned trolleys.

A power company is remotely turning home air conditioners off in a trial to manage peak electricity demand, but will consumers hand over the remote control?

A woman has been left in shock and with a deep distrust of cyber security laws after her ex-boyfriend used an app to control her car and stalk her.

What began as a great adventure led to the worst day of Colin Caudell's life as he watched a truck run over his wife while she was working as a traffic controller.

After bypassing theaters, Universal's animated sequel shattered on-demand records. AMC vows to stop running the studio's films.

AMC Theatres has hit hard at Universal Pictures, announcing it will no longer play any of the studio's films in the wake of NBCUniversal CEO Jeff Shell's promise to open titles on premium and in theaters at the same time. Universal used the PVOD format to release "Trolls World Tour" on April 10 amid the […]

A surprise digital success story is now sparking a battle between U.S. movie theater chain AMC and the prominent Hollywood studio.

The singers released a 90s-hip-hop inspired music video

From a friend: Please explain to me your enthusiasm for controlled digital lending. Please let me know what you think...

TROLLING PHYSICS Existed in comics way before the internet

Donald Trump's kept it pretty low key on Twitter in recent days. That didn't stop him from penning a little St. Paddy's Day sentiment though. If only he'd spell checked before sending it off though. Then again, would we expect anything less than this from the guy with a wide-reaching, well-developed reputation already for spelling shit in his own language incorrectly?

Yeah, yeah, we know. Here are some Trump Memes to smooth it over.

Say what you will about the President, but there's no denying that his Twitter habits have given us hours of entertainment. His latest Twitter escapade was regarding Time Magazine's 'Person of the Year' issue. On Saturday  President Trump tweeted "Time Magazine called to say that I was PROBABLY going to be named "Man (Person) of the Year," like last year, but I would have to agree to an interview and a major photo shoot. I said probably is no good and took a pass. Thanks anyway!" Parodies from comedians such as Julia Louis Dreyfuss and Billy Eichner began pouring in, along with riffs on New Yorker cartoons. Here are some of our favorites. 

And on a side note, here are some of our favorite tremendous Trump memes that are nearly unbelievable.

Donald Trump Jr. tried to sweet talk Twitter, and NOBODY was having it. Does the guy just want to be mocked by the masses on a continually often basis at this point, or what? 

Just when we thought we'd never get anything better than Donald Trump grasping that orb, we get this dark-humored, delightfully awkward pic that just oozes cringe. Naturally, people were ready to flood Twitter with some entertaining captions. 

Poor ol' Joe Biden has been the subject of many memes in this election cycle. Whether you love him or hate him, you have to admit that they've been pretty amusing. This particular meme mocks a campaign avatar where one can insert their image next to text that says "I'm on team Joe!" It's moderately cringey to say the least, but cringey makes for the best meme material.

We thought you ought to know.. J.K. Rowling's social and political commentary is always hot news. Her views on morality, equality, compassion and love are no secret to fans of her work, and no secret to users of Twitter. Join PotterCast for a discussion of fame, social responsibility (or not) and tweets.

Episode 269 — Troll in the Timeline!

Pottercast is hosted by Melissa Anelli, John Noe, Frankie Franco, and Zack Luye.

Find the latest episode and explore Pottercast interviews, discussions and more at Pottercast.com

Visit the-leaky-cauldron.org for the latest and greatest from Harry Potter's Wizarding World.

The House of Representatives.

The Houston Astros cheated and Mike Fiers shined the brightest light on their scheme, LZ Granderson writes.

Hydroxychloroquine, the drug President Trump hailed as a coronavirus killer, had no beneficial effect for COVID-19 patients in two controlled trials.

Jeff Shell, whose 'Trolls World Tour' comments upset theater owners, reaffirms that digital releases will be part of Universal Pictures' new reality.

Celtic legend Chris Sutton has bitten back Robbie Savage on Twitter, as the Hoops finished the week top of the Scottish Premiership table, after Rangers’ 1-1 draw against Hearts.

Celtic fans have trolled Rangers after their 2-1 win against Aberdeen in the Scottish Premiership, with some supporters claiming that they've already won the title and that Neil Lennon's side should be named as Champions.

Mila Kunis has found a way to let Vice President Mike Pence know she's not fond of him. Every. Single. Month.

Sony has introduced a new product called the Reon Pocket, which operates like a mobile air conditioner that fits inside clothing.

A team of researchers at the University of California at San Diego have created a soft robotic lens that responds to eye movements.

NAD+ is a central metabolite participating in core metabolic redox reactions. The prokaryotic NAD synthetase enzyme NadE catalyzes the last step of NAD+ biosynthesis, converting nicotinic acid adenine dinucleotide (NaAD) to NAD+. Some members of the NadE family use l-glutamine as a nitrogen donor and are named NadEGln. Previous gene neighborhood analysis has indicated that the bacterial nadE gene is frequently clustered with the gene encoding the regulatory signal transduction protein PII, suggesting a functional relationship between these proteins in response to the nutritional status and the carbon/nitrogen ratio of the bacterial cell. Here, using affinity chromatography, bioinformatics analyses, NAD synthetase activity, and biolayer interferometry assays, we show that PII and NadEGln physically interact in vitro, that this complex relieves NadEGln negative feedback inhibition by NAD+. This mechanism is conserved in distantly related bacteria. Of note, the PII protein allosteric effector and cellular nitrogen level indicator 2-oxoglutarate (2-OG) inhibited the formation of the PII-NadEGln complex within a physiological range. These results indicate an interplay between the levels of ATP, ADP, 2-OG, PII-sensed glutamine, and NAD+, representing a metabolic hub that may balance the levels of core nitrogen and carbon metabolites. Our findings support the notion that PII proteins act as a dissociable regulatory subunit of NadEGln, thereby enabling the control of NAD+ biosynthesis according to the nutritional status of the bacterial cell.

NAD+ is a central metabolite participating in core metabolic redox reactions. The prokaryotic NAD synthetase enzyme NadE catalyzes the last step of NAD+ biosynthesis, converting nicotinic acid adenine dinucleotide (NaAD) to NAD+. Some members of the NadE family use l-glutamine as a nitrogen donor and are named NadEGln. Previous gene neighborhood analysis has indicated that the bacterial nadE gene is frequently clustered with the gene encoding the regulatory signal transduction protein PII, suggesting a functional relationship between these proteins in response to the nutritional status and the carbon/nitrogen ratio of the bacterial cell. Here, using affinity chromatography, bioinformatics analyses, NAD synthetase activity, and biolayer interferometry assays, we show that PII and NadEGln physically interact in vitro, that this complex relieves NadEGln negative feedback inhibition by NAD+. This mechanism is conserved in distantly related bacteria. Of note, the PII protein allosteric effector and cellular nitrogen level indicator 2-oxoglutarate (2-OG) inhibited the formation of the PII-NadEGln complex within a physiological range. These results indicate an interplay between the levels of ATP, ADP, 2-OG, PII-sensed glutamine, and NAD+, representing a metabolic hub that may balance the levels of core nitrogen and carbon metabolites. Our findings support the notion that PII proteins act as a dissociable regulatory subunit of NadEGln, thereby enabling the control of NAD+ biosynthesis according to the nutritional status of the bacterial cell.

Geralyn Spollett
Jan 1, 2003; 16:
Case Studies

NAD+ is a central metabolite participating in core metabolic redox reactions. The prokaryotic NAD synthetase enzyme NadE catalyzes the last step of NAD+ biosynthesis, converting nicotinic acid adenine dinucleotide (NaAD) to NAD+. Some members of the NadE family use l-glutamine as a nitrogen donor and are named NadEGln. Previous gene neighborhood analysis has indicated that the bacterial nadE gene is frequently clustered with the gene encoding the regulatory signal transduction protein PII, suggesting a functional relationship between these proteins in response to the nutritional status and the carbon/nitrogen ratio of the bacterial cell. Here, using affinity chromatography, bioinformatics analyses, NAD synthetase activity, and biolayer interferometry assays, we show that PII and NadEGln physically interact in vitro, that this complex relieves NadEGln negative feedback inhibition by NAD+. This mechanism is conserved in distantly related bacteria. Of note, the PII protein allosteric effector and cellular nitrogen level indicator 2-oxoglutarate (2-OG) inhibited the formation of the PII-NadEGln complex within a physiological range. These results indicate an interplay between the levels of ATP, ADP, 2-OG, PII-sensed glutamine, and NAD+, representing a metabolic hub that may balance the levels of core nitrogen and carbon metabolites. Our findings support the notion that PII proteins act as a dissociable regulatory subunit of NadEGln, thereby enabling the control of NAD+ biosynthesis according to the nutritional status of the bacterial cell.

The prostate-specific membrane antigen (PSMA) is an excellent target for theranostic applications in prostate cancer (PCa). However, PSMA-targeted radioligand therapy can cause undesirable effects due to high accumulation of PSMA radiotracers in salivary glands and kidneys. This study assessed orally administered monosodium glutamate (MSG) as a potential means of reducing kidney and salivary gland radiation exposure using a PSMA targeting radiotracer. Methods: This prospective, double-blind, placebo-controlled study enrolled 10 biochemically recurrent PCa patients. Each subject served as his own control. [¹⁸F]DCFPyl PET/CT imaging sessions were performed 3 – 7 days apart, following oral administration of either 12.7 g of MSG or placebo. Data from the two sets of images were analyzed by placing regions of interest on lacrimal, parotid and submandibular glands, left ventricle, liver, spleen, kidneys, bowel, urinary bladder, gluteus muscle and malignant lesions. The results from MSG and placebo scans were compared by paired analysis of the ROI data. Results: A total of 142 pathological lesions along with normal tissues were analyzed. As hypothesized a priori, there was a significant decrease in maximal standardized uptake values corrected for lean body mass (SULmax) on images obtained following MSG administration in the parotids (24 ± 14%, P = 0.001), submandibular glands (35 ± 11%, P<0.001) and kidneys (23 ± 26%, P = 0.014). Significant decreases were also observed in lacrimal glands (49 ± 13%, P<0.001), liver (15 ± 6%, P<0.001), spleen (28 ± 13%, P = 0.001) and bowel (44 ± 13%, P<0.001). Mildly lower blood pool SULmean was observed after MSG administration (decrease of 11 ± 13%, P = 0.021). However, significantly lower radiotracer uptake in terms of SULmean, SULpeak, and SULmax was observed in malignant lesions on scans performed after MSG administration compared to the placebo studies (SULmax median decrease 33%, range -1 to 75%, P<0.001). No significant adverse events occurred and vital signs were stable following placebo or MSG administration. Conclusion: Orally administered MSG significantly decreased salivary gland, kidney and other normal organ PSMA radiotracer uptake in human subjects, using [¹⁸F]DCFPyL as an exemplar. However, MSG caused a corresponding reduction in tumor uptake, which may limit the benefits of this approach for diagnostic and therapeutic applications.

The human MASTL (Microtubule-associated serine/threonine kinase-like) gene encodes an essential protein in the cell cycle. MASTL is a key factor preventing early dephosphorylation of M-phase targets of Cdk1/CycB. Little is known about the mechanism of MASTL activation and regulation. MASTL contains a non-conserved insertion of 550 residues within its activation loop, splitting the kinase domain, and making it unique. Here, we show that this non-conserved middle region (NCMR) of the protein is crucial for target specificity and activity. We performed a phosphoproteomic assay with different MASTL constructs identifying key phosphorylation sites for its activation and determining whether they arise from autophosphorylation or exogenous kinases, thus generating an activation model. Hydrogen/deuterium exchange data complements this analysis revealing that the C-lobe in full-length MASTL forms a stable structure, whereas the N-lobe is dynamic and the NCMR and C-tail contain few localized regions with higher-order structure. Our results indicate that truncated versions of MASTL conserving a cryptic C-Lobe in the NCMR, display catalytic activity and different targets, thus establishing a possible link with truncated mutations observed in cancer-related databases.