At Camp No 5, in Cox's Bazar, there are about 632,000 displaced people still living in terrible conditions. But an international humanitarian effort is helping people in the community in southern Bangladesh live a better life. 

What our senses allow us to experience may not reflect what actually exists. It may be a creation of our own consciousness, or a computer simulation designed by superintelligent beings

Wine tears – the drops that form inside a glass after wine is swirled in a glass – are caused by the formation of an unstable shock wave

When asteroid Armageddon is upon us, we can't just call Bruce Willis. Meet the people who really do watch the skies – and make detailed plans for our survival

This rare image shows massive pyrocumulonimbus clouds that form above fires and can funnel as much smoke into the lower stratosphere as moderate volcanic eruptions

Fancy bidding on a Christmas present steeped in science history? Find out what they'll set you back, and which present-day artefacts might be worth investing in

When asteroid Armageddon is upon us, we can't just call Bruce Willis. Meet the people who really do watch the skies – and make detailed plans for our survival

What our senses allow us to experience may not reflect what actually exists. It may be a creation of our own consciousness, or a computer simulation designed by superintelligent beings

Title: CRISPR Used Inside Person's Body For First Time
Category: Health News
Created: 3/4/2020 12:00:00 AM
Last Editorial Review: 3/4/2020 12:00:00 AM

Kathryn Knight

Kathryn Knight

Kathryn Knight

Antibody-drug conjugates (ADCs) employ overexpressed cell surface antigens to deliver cytotoxic payloads inside cancer cells. However, the relationship between target expression and ADC efficacy remains ambiguous. In this manuscript, we have addressed a part of this ambiguity by quantitatively investigating the effect of antigen expression levels on ADC exposure within cancer cells. Trastuzumab-valine-citrulline-monomethyl auristatin E was used as a model ADC, and four different cell lines with diverse levels of human epidermal growth factor receptor 2 (HER2) expression were used as model cells. The pharmacokinetics (PK) of total trastuzumab, released monomethyl auristatin E (MMAE), and total MMAE were measured inside the cells and in the cell culture media following incubation with two different concentrations of ADC. In addition, target expression levels, target internalization rate, and cathepsin B and MDR1 protein concentrations were determined for each cell line. All the PK data were mathematically characterized using a cell-level systems PK model for ADC. It was found that SKBR-3, MDA-MB-453, MCF-7, and MDA-MB-468 cells had ~800,000, ~250,000, ~50,000, and ~10,000 HER2 receptors per cell, respectively. A strong linear relationship (R² > 0.9) was observed between HER2 receptor count and released MMAE exposure inside the cancer cells. There was an inverse relationship found between HER2 expression level and internalization rate, and cathepsin B and multidrug resistance protein 1 (MDR1) expression level varied slightly among the cell lines. The PK model was able to simultaneously capture all the PK profiles reasonably well while estimating only two parameters. Our results demonstrate a strong quantitative relationship between antigen expression level and intracellular exposure of ADCs in cancer cells.

SIGNIFICANCE STATEMENT

In this manuscript, we have demonstrated a strong linear relationship between target expression level and antibody-drug conjugate (ADC) exposure inside cancer cells. We have also shown that this relationship can be accurately captured using the cell-level systems pharmacokinetics model developed for ADCs. Our results indirectly suggest that the lack of relationship between target expression and efficacy of ADC may stem from differences in the pharmacodynamic properties of cancer cells.

Microsoft has announced it will share new information on the Xbox Series X every month in 2020 starting with the May 7th episode of Inside Xbox, which will showcase gameplay from third-party partners. Microsoft is calling it "Xbox 20/20." The event starts at 8am PT / 11am ET. 

"These monthly moments will take place throughout the rest of the year and will be a way for us to engage, connect and celebrate with you about what’s in store for the next generation of gaming, including what’s next for Xbox Series X, Xbox Game Studios, Xbox Game Pass and Project xCloud," said Microsoft. "Every month will bring something different. Stay tuned to Xbox Wire for more details."

The company did reveal the July event will be focused on upcoming first-party games from Xbox Game Studios. 

"A number of our studio teams are looking forward to sharing first looks at new gameplay, insights from development teams being optimized for Xbox Series X, and brand-new game announcements," said Microsoft.  "We cannot wait to share this initial look at what some of those teams are working on."

A new teaser video of the May 7 Inside Xbox event has been posted online and the closed captions reveals it is the "New Xbox Sound." It is possible it is the new bootup screen for the Xbox Series X. View the video below:

The Inside Xbox event for May 7 can be watched from multiple streaming sites:

• Facebook
• Mixer
• Twitch
• Twitter
• YouTube (4K stream)

Read more information below:

This is a momentous year for Xbox, with our next-gen console paving the way for all our games and services to come together in even better ways. Here’s what 2020 looks like, just to start:

• Our goal remains to launch Xbox Series X and Halo Infinite this Holiday
• All 15 Xbox Game Studios teams are hard at work on next-generation games for Xbox Series X and Xbox Game Pass
• The best development teams around the world are working hard to have their games ready to play on Xbox Series X this holiday
• For PC players, we plan to support the community by making all our major releases at launch available with Xbox Game Pass for PC, including Halo Infinite, Wasteland 3, Minecraft Dungeons and of course, Microsoft Flight Simulator.
• We have new updates and titles lined up for Xbox Game Pass for console and PC
• We’re expanding Project xCloud into new countries and on new devices—and later this year Project xCloud and Xbox Game Pass will come together, enabling you and your friends to play together in more ways.

It’s a lot – and that’s saying something in 2020, a year which could be summed up as “a lot.” With all this in mind, we set out to create new touchpoints to celebrate gaming and share what’s next with our global community.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443394/xbox-series-x-news-planned-for-every-month-of-2020-starts-with-inside-xbox-gameplay-reveals-on-may-7/

When asteroid Armageddon is upon us, we can't just call Bruce Willis. Meet the people who really do watch the skies – and make detailed plans for our survival

A team of researchers say they have discovered a protein molecule inside a meteorite, the first extraterrestrial example ever found, but others are sceptical

Your weekly selection of awesome robot videos

This is a video of Youtuber Edward Sarkissian exploding an M67 frag grenade inside an 87-pound steel SentrySafe fire/waterproof home safe to see what will happen. What happens? It gets BLOWN UP. So, if you were wondering if "inside a home safe" would be a secure place to dispose of your extra grenades, the answer is not even for the first one, and definitely none after that. So while this safe may be fireproof, it certainly isn't *lobs dog toy like hand grenade, bounces off wall and back at my feet* fire-in-the-holeproof. Keep going for the video (everything up to 4:15 is prepping the grenade inside the safe), as well as a video of opening a safe with grenades taped to the outside (with $10,000 and a gold bar inside).

This is a terrifying elevator cam gif from Korea of an elevator that begins ascending before a man enters, tripping him and almost creating a classic horror movie death scene in real life. Thankfully he was able to escape. And this is exactly why I don't take elevators -- or escalators. "So you're a stair guy?" Please *jiggling belly* jetpack or grappling gun only. Thanks to PK, who agrees they always say use the stairs in case of emergency, and what's 2020 if not a nonstop emergency? Besides, how do you social distance in an elevator? I mean if somebody farts everyone smells it.

Today, Microsoft and Ebb Studios revealed that Xbox Series X would be getting the launch exclusivity for Scorn

A public disagreement between a trusted games journalist and the GTA community is showing Rockstar just how eager people are for a GTA 6 announcement

Chris confesses his lack of Fire Emblemy skill. Anna Marie confesses her love for melty slimes. Simon sleeps for most of the show. But all...

Going out into the natural world is good for your health and mind, and you can still get some of the same benefits even when stuck inside, says Graham Lawton

All 13 games from third-party developers coming to Xbox Series X.

… Trains for 1st Time inside Davis Cup Venue VALENCIA, Spain – World No … the Spanish national team’s Davis Cup quarterfinals against Germany. Nadal, who ….

There were fans in the stands for baseball in Taiwan on Friday, albeit spaced far apart as a safeguard against the spread of the coronavirus.

There were fans in the stands for baseball in Taiwan on Friday, albeit spaced far apart as a safeguard against the spread of the coronavirus.

A man has been arrested on suspicion of murder after a woman was shot inside a house during the coronavirus lockdown.

The ancient Roman city’s House of the Lovers has reopened to the public 40 years after it was severely damaged in 1980 by an earthquake

• Pompeii’s House of Lovers reopens to public

Continue reading...

Vice President Mike Pence's press secretary has the coronavirus, the White House said, making her the second person who works at the White House complex known to test positive for the virus this week. President Donald Trump, who publicly identified the affected Pence aide, said he was “not worried” about the virus spreading in the White House. Pence spokeswoman Katie Miller, who tested positive Friday, had been in recent contact with Pence but not with the president.

The hacker had access to personal information, the ability to change passwords and two-factor authentication, and could steal valuable in-game items from some of the 'richest' players in the game

Apple's over-ear headphones may be called 'AirPods Studio' & retail for $349  AppleInsiderView Full coverage on Google News

Jessika Floyd said ‘enough is enough’ and never looked back, writes Ernie Schramayr

Gaethje's family heritage was forged in Arizona copper mines, but a fighting spirit charted his path to a UFC title shot.

Sara Cherry, a microbiologist at the University of Pennsylvania, feels safer at work than almost anywhere else. That’s because she works inside a biosafety level 3 laboratory on the Penn campus in Philadelphia, where she is the scientific director of the High-Throughput Screening Core.

From puzzle-solving to empire-building — sweep the board, says Samuel Fishwick

PlayStation 5 uncovered: The Mark Cerny tech deep dive
Richard Leadbetter,
Eurogamer

If you're craving even more explanation on the PlayStation 5 than lead architect Mark Cerny shared during his in-depth chat a couple weeks ago, get comfy. Eurogamer shared part two of its chat with Cerny this week, and while there weren't any new revelations per se, there was more detail on the things we'd already heard about.

Mike Bloomberg has hired hundreds of paid "digital organizers" to boost his presidential bid on social media. A look inside the operation reveals potential downsides to this approach.

From throat swab to high-tech lab and back again in under 24 hours. This is COVID-19 testing in Sydney.

From throat swab to high-tech lab and back again in under 24 hours. This is COVID-19 testing in Sydney.

Farmer John Lever and his wife Lillian say their Koorana Crocodile Farm has just two weeks of food left to feed 3,000 crocodiles, so they're offering an 'adopt a croc' program to raise funds.

From throat swab to high-tech lab and back again in under 24 hours. This is COVID-19 testing in Sydney.

Sarah Ferguson is never one to do things by halves and to mark VE Day on Friday, the...

The world is shutting down but the AFL and NRL are among the very small handful of sports carrying on. The risks are real, writes David Mark, but their presence should be treasured for now.

Since coronavirus outbreak started, the NYPD has used at least 1.5 million surgical masks, 1.2 million gloves and 400,000 disinfectant wipes.

The former Coronation Street star has sparked envy with her stunning decor

A Food and Drug Administration (FDA) chemist and his son were arrested in Maryland today in connection with an alleged $2.27 million insider trading scheme.