El mandatario de la capital del Valle del Cauca se refirió en 6AM a la decisión del presidente Petro de decretar día cívico para ahorrar agua y energía 

El reconocido cantautor colombiano contó detalles en 6AM sobre su nuevo álbum en el que rinde un homenaje a sus raíces junto al Grupo Niche, Juan Luis Guerra y Gilberto Santa Rosa

En Caracol Radio estuvo Alejandro Eder, alcalde de Cali, e indicó que se necesita apoyo del Gobierno Nacional para garantizar la seguridad de la ciudadanía

En 6AM Hoy por Hoy de Caracol Radio, que se transmite desde la ciudad de Cali este viernes 28 de junio, estuvo Alejandro Eder, alcalde de la capital del Valle del Cauca, para brindar un panorama general de la situación actual de la ciudad.

En el programa 6AM Hoy por Hoy, habló Maritza Manrique, presidenta de Sinprotecol, de las razones por la cual suspenderán la huelga laboral 

En 6AM Hoy por Hoy de Caracol Radio y bajo el marco del conversatorio sobre el futuro de la educación en Colombia que se lleva a cabo en la Universidad del Magdalena, estuvo Sandra Muñoz, secretaria de Educación en Santa Marta, para hablar sobre lo que los estudiantes necesitan en esta región.

En 6AM de Caracol Radio estuvo Mabel Lara, secretaria de Turismo de Cali, para hablar sobre la iniciativa ‘Cali es donde debes estar’ y cómo buscarán potencializar a Colombia ante el mundo.

En Caracol Radio estuvo Cielo Rusinque, superintendente de Industria y Comercio, explicando las medidas de la entidad.

POLITICO’s California Playbook discusses the latest in state politics. How Kamala Harris’s upbringing and earlier campaigns shaped her candidacy. Finally, fashion designer Samuel Rose talks about his creative process and an upcoming exhibition.

Breaking down the race for California’s 9th Congressional District. Also, Sacramento’s Pulitzer Prize-winning political cartoonist Jack Ohman. Finally, the Nevada City Rancheria Nisenan Tribe buys back their ancestral homeland.

By Megan Myscofski

By Laura Fitzgerald

Updated Nov. 8, 4:30 p.m.

Polls are closed in California. Elections officials are beginning to process and count millions of mail-in ballots from California’s General Election.

The Secretary of State’s Office website shows an estimated 10,728,985 ballots had been counted by Friday at 4:30 p.m.

Every registered California voter was sent a mail-in ballot. The process offers greater convenience for voters, but also delays results because election staff must spend more time verifying signatures and handling late-arriving ballots.

Leading up to the election, statewide ballot returns were slightly lower compared to the 2020 General Election. On Monday, roughly 42% of ballots had been returned; in 2020, that number was closer to 49%, according to election firm Political Data, Inc.

County election officials have until Dec. 5 to process and count ballots. The Secretary of State will certify the results of the election on Dec. 13.

This page will be updated as results come in. See full California election results here. 

Presidential race

Vice President Kamala Harris won California’s 54 electoral college votes, according to a call by the Associated Press. (California’s electoral college lost one member after the 2020 census.) Harris’s projected win was called immediately after polls closed, far from a surprise in California. 

U.S. Senate

Democratic Representative Adam Schiff has won the race to fill the U.S. Senate seat held for decades by the late Sen. Dianne Feinstein, according to a call made by the Associated Press shortly after polls closed. He had 57.6% of the preliminary results on Friday afternoon. 

Republican challenger (and former Los Angeles Dodgers baseball star) Steve Garvey had 42.4% of early results Friday afternoon.

A special election to fill the remainder of Feinstein’s senate term also appeared on the ballot this election. The seat is currently held by Sen. Laphonza Butler, who was appointed as a caretaker by Governor Gavin Newsom shortly after Feinstein’s death. 

Schiff was also announced as the winner of this race, per the Associated Press.

Rep. Adam Schiff, D-Calif., the Democratic candidate for U.S. Senate in California, fields questions after voting in the state's primary election, March 5, 2024, in Burbank, Calif.AP Photo/Marcio Jose Sanchez, File

U.S. House of Representatives

District 3: 

Republican incumbent Rep. Kevin Kiley won the race Congressional District 3, according to a race call by the Associated Press. He led with 57.2% of the vote on Friday afternoon.

Democratic challenger Jessica Morse followed with 42.8% of early results Friday afternoon. Morse previously ran against Rep. Tom McClintock in 2018.

Morse conceded in a message to supporters posted on social media on Friday.

"Although we didn't have the outcome we wanted in this race, I am proud to have stood at a critical juncture in history with you," she said. "We sounded the alarm, mobilized neighbors and awoke civic engagement in our community. I know it feels like a red tsunami has come to wipe out our freedoms. But our work together over the previous year, knocking doors, making calls, writing postcards, has communicated directly to our community and helped reinforce the foundations of our democracy." 

District 6:

Democratic incumbent Ami Bera won the race for Congressional District 6, according to a race call from the Associated Press. He had 57.3% of early results on Friday. Bera, who was first elected in 2012, has served on the Science, Space and Technology and Foreign Affairs committees, among others, during his time in Congress.

Republican realtor and financial investigator Chris Bish followed with 42.7% of early results Friday.

District 7: 

Democratic incumbent Doris Matsui won her 11th two-year term in the House, according to a call by the Associated Press. Matusi, who was elected in 2005, had 65.4% of early results Friday afternoon.

Republican challenger Tom Silva followed with 34.6%. Silva served as a member of the armed forces for 33 years and on the school board in his hometown of Galt.

California’s 7th Congressional District includes central and south Sacramento neighborhoods including Downtown, Midtown, Arden-Arcade, Lemon Hill and Florin along with the cities of West Sacramento and Elk Grove.

Congresswoman Doris Matsui talks with attendees of the ground breaking for the Hanami Line, a cherry blossom park being built along the Sacramento River, Thursday, June 29, 2023.Andrew Nixon / CapRadio

California state Assembly

District 6:

Early results show Democrat Maggie Krell leading with 65.6% in the race to replace Assembly member Kevin McCarty, who is running for Sacramento mayor. Krell currently serves as a Deputy Attorney General in the California Department of Justice, and has also been a lawyer for Planned Parenthood.

Republican trade advocate Nikki Ellis follows with 34.4% of early results Friday afternoon.

The 6th Assembly District spans from Sacramento’s Land Park neighborhood to Natomas, including downtown and Midtown, East Sacramento, and parts of Arden-Arcade. 

District 7:

Early results show Republican incumbent Josh Hoover is leading with 53.6% in the race for the 7th Assembly District, a region that includes much of northeastern Sacramento County, including Fair Oaks, Rancho Cordova, Folsom, Citrus Heights and North Highlands. It also includes portions of Rosemont and Carmichael.

Democratic challenger Porsche Middleton follows with 46.4% of early results Friday afternoon.

District 10:

Democratic incumbent Stephanie Nguyen has 66.1% of the early results in the race to represent California’s 10th Assembly District. Nguyen was first elected to the role in 2022 and previously served on Elk Grove City Council. 

Retired engineer Vinaya Singh follows with 33.9% of early results Friday afternoon.

The 10th Assembly District spans much of southern Sacramento County.

By Manola Secaira

By Claire Morgan

How The Message started in LA.

[Written by Stephen Wright] Jediah Cumbermack will compete in the final leg of the seven-race Chuckwalla Motorcycle Racing Association [CMVA] series in Desert Centre, California, this weekend [April 15 and 16]. It will be the Bermudian’s second international meet of the year, having made his debut in the fifth round of the series in February, […]

Jediah Cumbermack was back in action competing in the final leg of the seven-race Chuckwalla Motorcycle Racing Association [CMVA] series in Desert Centre, California. He competed in the Formula Ultra Lightweight Class where he finished 2nd, clocking a six-lap time of 12:10.977, and he also competed in the Formula Ultra Lightweight Class, where he recorded […]

Putting humans on Mars has been one of NASA’s driving missions for years, but they are still in the early stages of deciding what exactly that mission architecture will look like. One major factor is where to get the propellant to send the astronauts back to Earth. Advocates of space exploration often suggest harvesting the …

Continue reading "Scaling Propellant Production on Mars is Hard"

The post Scaling Propellant Production on Mars is Hard appeared first on Universe Today.

In This Episode Erin and Weer’d discuss: a factual clarification about the procedure to get a Massachusetts Non-Resident License to Carry; a 4th Amendment case that went in the favor of liberty; a vehicular assault that was stopped by a … Continue reading →

In This Episode Erin and Weer’d discuss court cases involving: machine guns being ruled as bearable arms; California required to issue Non-Resident Carry permits; another challenge to the Maryland assault weapons ban. David brings us an interview with Jan Wolbrecht … Continue reading →

In This Episode Erin and Weer’d discuss: a 5th Circuit ruling that marijuana use can’t preclude gun ownership; switchblades now being legal in Massachusetts; Hawaii relaxing their laws on blade and impact weapons; a Hawaiian gun buyback with some dubious … Continue reading →

In This Episode Erin and Weer’d discuss: the journal of the Covenant school shooter; a school shooting in Georgia, and not only was the shooter arrested, but so was his father; the Ninth Circuit has stuck down some, but not … Continue reading →

In This Episode Erin and Weer’d discuss: bodycam video of the Georgia shooter and his father being interviewed last year, and it might surprise you; a defensive shooting at a pro-Israel demonstration in Newton, MA where the defender was arrested … Continue reading →

In This Episode Erin and Weer’d discuss: a minor but important change to Massachusetts’ new training requirements; the goofiness of the SKS used by the would-be Trump assassin; the 3rd Circuit Court of Appeals being petitioned to stop treating the … Continue reading →

In This Episode Erin and Weer’d discuss: a declaration that suspended the 2nd Amendment in a Florida city during Hurricane Helene; a police chief in Massachusetts who was reprimanded for speaking out against an unconstitutional law; Brandon Herrera’s re-creation of … Continue reading →

In This Episode Erin and Weer’d discuss: Gov. Maura Healey signing the emergency preamble to the new Massachusetts gun law, and its details are insane; SCOTUS hearing a case on “Ghost Guns” in Garland v. VanDerStok; 2023’s FBI Crime Statistics,  and … Continue reading →

Weer’d, Weer’d, Weer’d. It’s all about Weer’d this episode. In This Episode Erin and Weer’d discuss: the new NRA Executive Vice President’s disturbing (cat) skeleton in his closet; Tim Walz going “hunting”, and the questions it raises about his knowledge … Continue reading →

Weer’d is feeling sick after his colonoscopy, but Erin, David, and Oddball have come to the  rescue with an ACP Round Table. In This Episode We discuss: gun manufacturers handing over purchaser information taken from warranty cards to political groups; … Continue reading →

When Trump descended the escalator at Trump Tower in 2015 to announce his presidential campaign, he tapped into something that had been brewing in online spaces for years. What made Trump unique wasn’t just his message, but his ability to speak the language of internet culture – his unfiltered tweets, his willingness to be politically […]

The post The Alt-Right Pipeline and the Rise of Trump: How Digital Radicalization Found Its Political Voice appeared first on Feminist Majority Foundation.

It sits on a flat stretch of green, surrounded by the rolling hills and pretty palm trees of Southern California. It's an amazing little oasis, a quiet getaway. And it's the first building in California to receive Zero Carbon Certification from the International Living Future Institute. It's only the fourth building in the entire world to reach this status. This home is called Zero One by MariSol Malibu and it's the first of its kind.[...]

Altas Obscura tells us about the S.S. Relief--the formal name for an outhouse that floats in Lake Casitas near Ventura, California. The artificial lake is an important water reservoir for the thirsty people of southern California, so the Casitas Municipal Water District takes its cleanliness very seriously.

The lake is popular among boaters and fishermen. After a few hours out on the water, people need to relieve themselves. They can then paddle up to the S.S. Relief, which is a 2-seater outhouse that floats on the surface of the water. The waste is contained on the barge, so there's no contamination of the lake's purity.

Những phim tham gia Viet Film Fest 2024 đã chạm vào rất nhiều vấn đề của cộng đồng người Việt khắp nơi trên thế giới: kí ức thời hậu chiến, sự xung đột giữa các thế hệ, hành trình hội nhập trên quê hương mới và cái nhìn về Việt Nam.

President and CEO of Formula 1 Stefano Domenicali speaks to BBC Sport's Matt Warwick about his vision for the next decade.

Thousands of people have been evacuated from their homes in Ventura County, near Los Angeles.

As a digital company, your business is not bound by conventional borders and has the freedom and opportunity to reach customers anywhere in the world. And just as you look outward for new markets, customers are also looking beyond their physical borders for their goods and services. As a study by KPMG shows, online buyers […]

Islamic radicalisation in Central Asia 18 September 2024 — 10:00AM TO 11:30AM Anonymous (not verified) 20 August 2024 Chatham House and Online

Experts analyse rising foreign recruitment, current counter-radicalisation efforts and challenge past Chatham House predictions made of the Central Asia region.

In 2014, Chatham House released a report titled The Myth of Post-Soviet Muslim Radicalisation in the Central Asian Republics. At that time, a significant, Western-funded counter-radicalisation industry was addressing what was believed to be a major issue of Islamic violent extremism in the region.

Over the past decade, two key developments have occurred. First, Western interest in the region has declined in favour of traditional geopolitical concerns. Second, while violent extremism incidents within Central Asia remain rare, there has been a notable recruitment of Central Asians by foreign groups, with several attacks carried out by Central Asians overseas.

In this event, the original report’s authors, John Heathershaw and David Montgomery, will discuss whether the report’s arguments are still valid and how we might answer these questions today.

This raises several questions:

• What did the report accurately predict, and where did it fall short?
• How can we explain the lack of violent extremist organisations (VEOs) within Central Asia but the presence of Central Asians in VEOs abroad?
• Could repression by Central Asian states both domestically and transnationally have contributed to this issue?
• What, if anything, can the counter-radicalisation industry do today to address this problem more effectively?

Please note that in-person places are limited. Please wait for confirmation before participating. 

Saverio Cinti
Nov 1, 2005; 46:2347-2355
Research Articles

Switzerland-based reggae and dancehall recording artiste Cali P has expressed gratitude to the public for supporting his music, following the release of his latest single ' Secret Hater'. The song, which was produced jointly by himself and Suku...

Visual Abstract

The subcellular localization of Arf family proteins is generally thought to be determined by their corresponding guanine nucleotide exchange factors. By promoting GTP binding, guanine nucleotide exchange factors induce conformational changes of Arf proteins exposing their N-terminal amphipathic helices, which then insert into the membranes to stabilize the membrane association process. Here, we found that the N-terminal amphipathic motifs of the Golgi-localized Arf family protein, Arfrp1, and the endosome- and plasma membrane–localized Arf family protein, Arl14, play critical roles in spatial determination. Exchanging the amphipathic helix motifs between these two Arf proteins causes the switch of their localizations. Moreover, the amphipathic helices of Arfrp1 and Arl14 are sufficient for cytosolic proteins to be localized into a specific cellular compartment. The spatial determination mediated by the Arfrp1 helix requires its binding partner Sys1. In addition, the residues that are required for the acetylation of the Arfrp1 helix and the myristoylation of the Arl14 helix are important for the specific subcellular localization. Interestingly, Arfrp1 and Arl14 are recruited to their specific cellular compartments independent of GTP binding. Our results demonstrate that the amphipathic motifs of Arfrp1 and Arl14 are sufficient for determining specific subcellular localizations in a GTP-independent manner, suggesting that the membrane association and activation of some Arf proteins are uncoupled.

Hideaki Kuge
Dec 1, 2020; 61:1747-1763
Research Articles

Michael E. Abrams
Dec 1, 2020; 61:1538-1538
Images in Lipid Research

Jenny E. Kanter
Dec 8, 2020; 0:jlr.ILR120001217v1-jlr.ILR120001217
Images in Lipid Research

Human genetic studies recently identified an association of SNPs in the 17-β hydroxysteroid dehydrogenase 13 (HSD17B13) gene with alcoholic and nonalcoholic fatty liver disease development. Mutant HSD17B13 variants devoid of enzymatic function have been demonstrated to be protective from cirrhosis and liver cancer, supporting the development of HSD17B13 as a promising therapeutic target. Previous studies have demonstrated that HSD17B13 is a lipid droplet (LD)-associated protein. However, the critical domains that drive LD targeting or determine the enzymatic activity have yet to be defined. Here we used mutagenesis to generate multiple truncated and point-mutated proteins and were able to demonstrate in vitro that the N-terminal hydrophobic domain, PAT-like domain, and a putative α-helix/β-sheet/α-helix domain in HSD17B13 are all critical for LD targeting. Similarly, we characterized the predicted catalytic, substrate-binding, and homodimer interaction sites and found them to be essential for the enzymatic activity of HSD17B13, in addition to our previous identification of amino acid P260 and cofactor binding site. In conclusion, we identified critical domains and amino acid sites that are essential for the LD localization and protein function of HSD17B13, which may facilitate understanding of its function and targeting of this protein to treat chronic liver diseases.

The plasma membrane of neurons consists of distinct domains, each of which carries specialized functions and a characteristic set of membrane proteins. While this compartmentalized membrane organization is essential for neuronal functions, it remains controversial how neurons establish these domains on the laterally fluid membrane. Here, using immunostaining, lipid-MS analysis and gene ablation with the CRISPR/Cas9 system, we report that the pancreatic lipase-related protein 2 (PLRP2), a phospholipase A1 (PLA1), is a key organizer of membrane protein localization at the neurite tips of PC12 cells. PLRP2 produced local distribution of 1-oleoyl-2-palmitoyl-PC at these sites through acyl-chain remodeling of membrane phospholipids. The resulting lipid domain assembled the syntaxin 4 (Stx4) protein within itself by selectively interacting with the transmembrane domain of Stx4. The localized Stx4, in turn, facilitated the fusion of transport vesicles that contained the dopamine transporter with the domain of the plasma membrane, which led to the localized distribution of the transporter to that domain. These results revealed the pivotal roles of PLA1, specifically PLRP2, in the formation of functional domains in the plasma membrane of neurons. In addition, our results suggest a mode of membrane organization in which the local acyl-chain remodeling of membrane phospholipids controls the selective localization of membrane proteins by regulating both lipid-protein interactions and the fusion of transport vesicles to the lipid domain.