A 'hybrid model' for hosting the Champions Trophy will not be accepted by Pakistan, according to its Cricket Board chairman Mohsin Naqvi.

India has informed the International Cricket Council it will not travel to the Champions Trophy, according to hosts Pakistan.

John Hayward's pictures feature in a new version of A Shropshire Lad by A. E. Housman.

More than 1,000 images of the national park are being made available for use free of charge.

James Barnor, who has photographed the likes of Muhammad Ali, is being honoured in Accra.

A nature reserve's photography club is holding its annual display at the end of August.

Striking image of a whale feeding wins photo award

Stunning shots of gannets, goldfinch and grouse on show as the Bird Photographer of the Year award winners are announced

A picture of a fox cub has won a prestigious European Wildlife Photographer of the Year award.

For 15 years, David Gilliver has been a pioneer in the technique of painting with light.

A new study traces the farming heritage of Wales and shows there's more to the common sheep pen than meets the eye.

Wigan Athletic goalkeeper Tom Watson saves all three penalties in a shootout victory over Nottingham Forest U21s to send them through to the EFL Trophy knockout phase.

Watch the moment phone thieves were caught after stealing 35 phones in south-east London.

Nineteen years and 10 miles separated Zambia's football team from a lost, golden generation on a fateful night in Libreville.

1. NASA Alert: Massive 'God of Chaos' Asteroid Apophis Makes Closest Pass by Earth Yet  Bizz Buzz
2. NASA alert! 'God of Chaos' asteroid approaching Earth on November 13 sparks worldwide concern  The Times of India
3. Nasa Alert: Massive 'God of Chaos' asteroid Apophis nears earth in closest pass yet  CNBCTV18
4. Giant Meteorite To Hit Earth On November 13? What We Know  News18
5. 'Astonishingly close': A colossal space rock could wreak havoc on Earth in 2029  Business Today

1. iPhone SE 4 expected to launch in March 2025, supply chain data suggests  Business Standard
2. iPhone SE4 is likely to launch soon and here are 5 big upgrades we are expecting  India Today
3. Apple iPhone SE 4 to launch next year, likely to become the cheapest iPhone to support Apple Intelligence...  Moneycontrol
4. iPhone SE 4 may spell trouble for iPhone 16 and premium Android phones, here’s why  Hindustan Times
5. iPhone SE 4 Camera Production to Begin Soon Ahead of Anticipated Debut in March 2025: Report  Gadgets 360

Joe Biden’s stupid, corrupt regime can’t even get a simple Veterans Day message right. As the nation came together to celebrate those who served out country, Biden’s Department of Defense pushed out a social media message telling Americans “Veterans Day, honoring all who served.” While, that is a perfectly fine message, the DoD added a […]

The post Biden’s Nitwit Dept. of Defense Uses Photo of Chinese Jet in Veterans Day Message appeared first on The Lid.

velocityconf: RT @OReillyAnimals Advice, please! Elephant Listening Project asks for ideas/solutions/help with 3 practical problems http://t.co/Y90YP3maoz

Apple has released iOS 17.7.1 and iPadOS 17.7.1 for iPhone and iPad users who are not running iOS 18, which was just updated to includes support for Apple Intelligence with iOS 18.1 and iPadOS 18.1. The software updates include important security fixes, making them important updates to install if you’re still running the prior major ... Read More

Apple Intelligence is here on Mac, iPhone, and iPad, and while the system requirements are strict, the Apple devices that are new and powerful enough to use the AI tools now gain some really fantastic features. We’re going to show you six helpful Apple Intelligence features and uses that you’ll find beneficial to your workflow, ... Read More

If you have several iPhone’s, as many people do when they buy a new iPhone, upgrade, get a hand-me-down, develop iPhone software, or develop mobile sites or apps where you test things on multiple devices, you might be in a situation where iPhone Mirroring on the Mac is using an iPhone that you do not ... Read More

The iOS 18 update is a fun one with some intriguing new features, mostly for visual tweaks like adding dark mode icons and color hues, and of course there’s Apple Intelligence AI features if your iPhone is new enough to support those features. One of the other major changes in iOS 18 and iPadOS 18 ... Read More

I’m not sure why, but Brazil seems to be somewhat overlooked by photographers. It doesn’t quite add up for those who have extensively traveled the country. It’s such a beautiful nation. Hopefully, this guide to the best places in Brazil for photography will encourage a few photographers to give this wonderfully diverse country a chance. In this guide, I’ll delve into some of the top spots to capture stunning photos in Brazil, while also addressing some of the logistical challenges […]

The post The Best Places in Brazil for Photography appeared first on Brendan van Son Photography.

The genres of photography are so often mischaracterized. But, most of these genres are at least pretty obvious. In street photography, you’re photographing the street life. In landscape photography, you’re photographing the landscapes. And of course in wildlife photography you’re photographing the, well, you get the idea. So what is travel photography? What makes travel photography so interesting is that it isn’t a subject that you’re photographing: it’s an activity. But also, it is a subject…? Wait… let me explain. […]

The post What is Travel Photography? appeared first on Brendan van Son Photography.

I’ve been toying at the idea of recording a podcast about my thoughts on AI photography for a while now. For a while, I’ve put it off because I really don’t know if I want to add any more volume to a subject that’s already been talked about and debated for a while. But, it seems like AI photography, or even just AI photography tools aren’t going anywhere. So, here are my thoughts, questions, and my own personal ethics when […]

The post Is AI Photography Here to Stay? Ethics, Goals, and Questions. appeared first on Brendan van Son Photography.

Most classroom walls display rules about arriving on time or raising hands to speak. Tim Smyth’s has a sign reminding students: “You’re Not Allowed to Ask Which is Better, Marvel or DC.” Even as he sidesteps fervent debates about which comic book publisher is superior, Smyth leans into comics and graphic novels in his 10th and 11th grade social studies classes at Wissahickon High School in Ambler, Pa. He believes they can offer students an engaging entry point into history and world cultures.

Donald Trump's proposed tariffs would hit the consumer tech sector, raising prices on US consumers' favorite gadgets, an October report found.

This article describes the current findings on phonics and phonological awareness instruction. It uses a question & answer format to explore 10 common questions that teachers ask about teaching phonics and phonemic awareness. Here are a few key questions addressed in the article: What are phonics and phonemic awareness? Should phonemic awareness be paired with print and taught together? Should phonological awareness be coordinated with phonics instruction? What is the best sequence for teaching phonics?

Recently, I posted commentary on Emily Hanford’s reporting and the critical response it received from some in the literacy community. I defended the major thrust of her work and called out criticisms I thought to be illogical, ill conceived, or ill intended — criticism more aimed at maintaining status quo than promoting literacy.

Sometimes our WordPress plugin users need to create an Admin user account for their sites. In this tutorial I will share a small PHP code with you that can be used to create a WordPress Administrator user to your site. Alternatively, you can also create a WordPress admin user via MySQL. You will need to […]

The post Add a WordPress Admin User Account via PHP appeared first on Tips and Tricks HQ.

If you run an eCommerce website, you may prefer to use a graphic as the call-to-action button for your subscription-style products or services. Below you can find a number of different subscription buttons suitable for use on a website’s landing page or the product page. Want some Buy Now button or Add to Cart button […]

The post Subscription Button Graphics for eCommerce Websites appeared first on Tips and Tricks HQ.

In this blog post, you can find a range of different ‘Buy Now’ buttons that can be used on a website as the ‘call-to-action’ button for a product or service you are trying to sell. There is a range of different size buttons, in a number of different colors to fit with the aesthetics of […]

The post Buy Now Button Graphics for eCommerce Websites appeared first on Tips and Tricks HQ.

Write out each letter of the alphabet. Cut them out in squares and tape them to your clothes and body. Call out a letter for your child to peel off of you until they are all gone.

agilePHM We are launching a new product called agilePHM In Industrial IoT, I have been working with PHM  (Prognostics and Health Management) for a while and it is a well known discipline Prognostics and Health management(PHM)  is an engineering discipline focused on predicting the time at which a system or a component will no longer perform its intended [...]

Google DeepMind’s AlphaFold 3 is available to access by researchers around the world via open-source. Google DeepMind, the tech giant’s… Continue reading Google DeepMind opens AlphaFold 3 up to researchers worldwide

The post Google DeepMind opens AlphaFold 3 up to researchers worldwide appeared first on ReadWrite.

Many fans of Huawei on Friday were disappointed that its much-anticipated phone, Mate XT - more than twice the price of the iPhone 16 Pro Max - was not available for walk-in customers.

The Internet Archive, an online repository of web pages, was offline Thursday after its founder confirmed a major cyberattack that exposed the data of millions of users and left the site defaced.

President Cyril Ramaphosa's lawyers say former spy boss Arthur Fraser's claims about the Phala Phala break-in are like something from a movie - but are founded on nothing more than baseless speculation.

The MK Party continued its campaign against accountability for corruption, with its deputy leader, John Hlophe, suggesting National Director of Public Prosecutions Shamila Batohi was "misleading the nation" about the Guptas' extradition.

Time's arrow may not be as unidirectional as we were led to believe. According to Scientific American, a group of quantum physical researchers at the University of Toronto had observed evidence of what they're calling "negative time"—specifically, of photons exiting a material before they ever entered it, to begin with. — Read the rest

The post Physicists find evidence of "negative time" in photons appeared first on Boing Boing.

We've all met some of those 'precious moments' type Christians who are far too 'holy' to involve themselves in such trivialities as politics.

The post This Biblical Passage is VERY Political (Eph.1:20-23) appeared first on Clash Daily.

Trump asked the question: are you better now than when I was in office? America's answer could not have been more clear.

The post TRUMP TRIUMPHS: Victory Speech As He Completes The YUGE Comeback appeared first on Clash Daily.

We all know that *one* guy who acts like he's doing the world a favor just by showing up.

The post Demonic & Damned to Ridiculously Redeemed! (Eph.2:1-10) appeared first on Clash Daily.

With some of its infrastructure decaying and no premier division club using it, the somewhat abandoned Dobsonville Stadium offered the perfect setting for Sage Stephens to take his first steps as a Bafana Bafana player at the ripe age of 33.

Toni Annala, Marc Hoyois and Ryomei Iwasa
J. Amer. Math. Soc. 38 (), 243-289.
Abstract, references and article information

Alexander Kupers and Oscar Randal-Williams
J. Amer. Math. Soc. 38 (), 63-178.
Abstract, references and article information

Junyi Xie
J. Amer. Math. Soc. 38 (), 1-62.
Abstract, references and article information

Nonphotochemical quenching (NPQ) is a mechanism of regulating light harvesting that protects the photosynthetic apparatus from photodamage by dissipating excess absorbed excitation energy as heat. In higher plants, the major light-harvesting antenna complex (LHCII) of photosystem (PS) II is directly involved in NPQ. The aggregation of LHCII is proposed to be involved in quenching. However, the lack of success in isolating native LHCII aggregates has limited the direct interrogation of this process. The isolation of LHCII in its native state from thylakoid membranes has been problematic because of the use of detergent, which tends to dissociate loosely bound proteins, and the abundance of pigment–protein complexes (e.g. PSI and PSII) embedded in the photosynthetic membrane, which hinders the preparation of aggregated LHCII. Here, we used a novel purification method employing detergent and amphipols to entrap LHCII in its natural states. To enrich the photosynthetic membrane with the major LHCII, we used Arabidopsis thaliana plants lacking the PSII minor antenna complexes (NoM), treated with lincomycin to inhibit the synthesis of PSI and PSII core proteins. Using sucrose density gradients, we succeeded in isolating the trimeric and aggregated forms of LHCII antenna. Violaxanthin- and zeaxanthin-enriched complexes were investigated in dark-adapted, NPQ, and dark recovery states. Zeaxanthin-enriched antenna complexes showed the greatest amount of aggregated LHCII. Notably, the amount of aggregated LHCII decreased upon relaxation of NPQ. Employing this novel preparative method, we obtained a direct evidence for the role of in vivo LHCII aggregation in NPQ.

Epoxide hydrolases (EHs) have been characterized and engineered as biocatalysts that convert epoxides to valuable chiral vicinal diol precursors of drugs and bioactive compounds. Nonetheless, the regioselectivity control of the epoxide ring opening by EHs remains challenging. Alp1U is an α/β-fold EH that exhibits poor regioselectivity in the epoxide hydrolysis of fluostatin C (compound 1) and produces a pair of stereoisomers. Herein, we established the absolute configuration of the two stereoisomeric products and determined the crystal structure of Alp1U. A Trp-186/Trp-187/Tyr-247 oxirane oxygen hole was identified in Alp1U that replaced the canonical Tyr/Tyr pair in α/β-EHs. Mutation of residues in the atypical oxirane oxygen hole of Alp1U improved the regioselectivity for epoxide hydrolysis on 1. The single site Y247F mutation led to highly regioselective (98%) attack at C-3 of 1, whereas the double mutation W187F/Y247F resulted in regioselective (94%) nucleophilic attack at C-2. Furthermore, single-crystal X-ray structures of the two regioselective Alp1U variants in complex with 1 were determined. These findings allowed insights into the reaction details of Alp1U and provided a new approach for engineering regioselective epoxide hydrolases.

The main protease (3CL Mpro) from SARS–CoV-2, the etiological agent of COVID-19, is an essential enzyme for viral replication. 3CL Mpro possesses an unusual catalytic dyad composed of Cys145 and His41 residues. A critical question in the field has been what the protonation states of the ionizable residues in the substrate-binding active-site cavity are; resolving this point would help understand the catalytic details of the enzyme and inform rational drug development against this pernicious virus. Here, we present the room-temperature neutron structure of 3CL Mpro, which allowed direct determination of hydrogen atom positions and, hence, protonation states in the protease. We observe that the catalytic site natively adopts a zwitterionic reactive form in which Cys145 is in the negatively charged thiolate state and His41 is doubly protonated and positively charged, instead of the neutral unreactive state usually envisaged. The neutron structure also identified the protonation states, and thus electrical charges, of all other amino acid residues and revealed intricate hydrogen-bonding networks in the active-site cavity and at the dimer interface. The fine atomic details present in this structure were made possible by the unique scattering properties of the neutron, which is an ideal probe for locating hydrogen positions and experimentally determining protonation states at near-physiological temperature. Our observations provide critical information for structure-assisted and computational drug design, allowing precise tailoring of inhibitors to the enzyme's electrostatic environment.