Stage III nonsmall cell lung cancer (NSCLC) represents a wide range of tumour (T1 to T4) and nodal (N0 to N3) components, requiring variable management and a multidisciplinary approach. Recent advancements in minimally invasive techniques, molecular biology and novel drug discoveries have accelerated the refinement of stage III NSCLC management. The latest developments in staging include the forthcoming update of the nodal component in the 9th TNM (tumour–node–metastasis) edition, which emphasises the critical role for endobronchial ultrasonography in mediastinal staging. Recent treatment developments include the use of immunotherapy and targeted molecular therapy in both the neoadjuvant and adjuvant setting, either in combination with other modalities or used alone as consolidation. Surgical and radiotherapy advancements have further enhanced patient outcomes. These developments have significantly improved the prognosis for patients with stage III NSCLC. Fast-changing recommendations have also brought about a challenge, with clinicians facing a number of options to choose from. Therefore, a multimodal approach by a multidisciplinary team has become even more crucial in managing stage III NSCLC.

Palliative care pertains to the holistic multidimensional concept of "patient-centred" care. It is an interprofessional specialty, primarily aiming to improve quality of care for cancer patients and their families, from the time of diagnosis of malignant disease, over the continuum of cancer care, and extending after the patient's death to the period of bereavement to support the patient's family. There are various complex and frequently unmet needs of lung cancer patients and their families/caregivers, not only physical but also psychological, social, spiritual and cultural. Systematic monitoring of patients’ symptoms using validated questionnaires and patient-reported outcomes (PROs), on a regular basis, is highly encouraged and recommended in recent guidelines on the role of PRO measures in the continuum of cancer clinical care. It improves patient–physician communication, physician awareness of symptoms, symptom control, patient satisfaction, health-related quality of life and cost-effectiveness. This implies that all treating physicians should improve their skills in communication with lung cancer patients/relatives and become more familiar with this multidimensional assessment, repeatedly screening patients for palliative care needs. Therefore, they should receive education and training to develop palliative care knowledge, skills and attitudes. This review is dedicated to lung cancer palliative care essentials that should be within the competences of treating physicians, i.e. pneumologists/thoracic oncologists.

A nudibranch from the midnight zone has fingers on its tail, collects food with a hood, and glows.

Tim Miller hopes Amazon's anthology series will help viewers appreciate the "blood, sweat, and tears" Firewalk Studios put into the scrapped game.

The City of Vancouver council has reneged on a previous commitment to a living wage for its employees.

The post City of Vancouver to lowest paid workers: Let them eat cuts! appeared first on rabble.ca.

The beast was awakened. Indeed, it might have just stirred from a slumber but it was instantly on the alert.

Andrey Bogut’s knee injury has potentially sidelined him for the NBA playoffs and casts doubt on his role for the Boomers.

Legendary Tiger Maurice Rioli was posthumously inducted into the Australian Football Hall of Fame last night.

LEADING Aboriginal academic Marcia Langton has blasted Bill Shorten over his claim Labor could sign a treaty with Indigenous Australians.

"I look forward to any contest, where of course it will be for branch members to select those they wish to represent them in Holyrood in the 2026 Scottish Parliament elections.”

The cast regulars (Anna Marie, Chris and Kelley) are joined by Robert and newcomer Corey to discuss this week's news. A heated debate about free-to-play mechanics breaks out as the crew is split on Genshin Impact and other mobile titles while Chris eats chocolate covered almonds. Three weeks to go until Extra Life!

The post RPG Cast – Episode 560: “Kmart Breath of the Wild” appeared first on RPGamer.

Alex, Anna Marie, Chris, and Kelley come together to discuss the news of the week. #JRPGJuly is well underway for everyone on the cast. Anna Marie makes every evil choice she can. Alex dives into Anime: The Game. Chris shouldn't be playing Elder Scrolls Online because his arm hurts, and yet he still is? Meanwhile, we lost Kelley somewhere in the wastelands when she wandered off to hug all the monsties.

The post RPG Cast – Episode 591: “Save the Baby? Eat the Baby?” appeared first on RPGamer.

Kelley finds out that Alice is made of Lego. Josh asks if his cat even lifts, bro. Chris puts everything into the Final Fantasy XVI bucket. And everyone gets KEMCO shamed.

The post RPG Cast – Episode 614: “The Burned Pirated Disc Is a Feature” appeared first on RPGamer.

Johnathan Stringer tries to sate your Saturn lust with a Satiator. Kelley Ryan was a naysayer, then she took a chaos to the knee. And Chris Privitere tries to calculate his age in internet memes.

The post RPG Cast – Episode 623: “Great Value Gundams” appeared first on RPGamer.

Kelley tries to capture a goat. Robert is trapped in a corner by the nightmares. Josh upgrades his tank and hopes to get a good ending this time. Will Chris beat FFXVI this week?

The post RPG Cast – Episode 685: “You Erased My Save, Now You Have to Beat It” appeared first on RPGamer.

ublisher Bethesda Softworks and developer MachineGames have released a gameplay deep dive video for Indiana Jones and the Great Circle that is nearly 15 minutes in length.

"From locations and puzzles to gear and combat, MachineGames Audio Director, Pete Ward, takes us on a whirlwind journey through the world of The Great Circle," reads the description to the video. "Get ready for launch with this look at Indy’s grand adventure."

View the gameplay deep dive below:

Indiana Jones and the Great Circle will launch for the Xbox Series X|S, PC via Steam and Microsoft Store, and Xbox Game Pass on December 9.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463033/indiana-jones-and-the-great-circle-gets-gameplay-deep-dive/

The Real Housewives of Salt Lake City is TV’s best soap opera, week after week offering twists more shocking than secret twins and characters returning from the dead. That’s because it’s all real, happening in the most haunted suburb in the continental United States.

Where else do two women connect over knowing the long-lost birth father of one’s child? Is there another city where women squabble over body positivity in a parking lot off the side of a snowy mountain? Surely, there’s no other place on Earth where Lisa Barlow could come across anywhere near a voice of reason.

But that all happens here in Salt Lake City. Five episodes in, Season 5 has continued to evolve into the most captivating season in modern Real Housewives history, carried by the ever-changing bonds between our OGs and a team of wonderfully bizarre newbies.

Read more at The Daily Beast.

A hotel worker called 911 to request urgent assistance before musician Liam Payne fell to his death from the third floor of the building in Buenos Aires on Wednesday.

The 31-year-old British singer and former member of the boy band One Direction died after he “jumped from the balcony of his room,” Buenos Aires Security Ministry Communications Director Pablo Policicchio told the Associated Press. He added that police had been called to the Casa Sur Hotel in the Argentine capital after receiving an emergency call shortly after 5 p.m. local time about an “aggressive man who could be under the influence of drugs or alcohol.”

A transcript of a 911 call published by the BBC shows a worker at the hotel telling the operator that they have “a guest who is high on drugs and who is trashing the room” and the staff therefore “need someone to come.”

Read more at The Daily Beast.

Today in "person you already like says something you already agree with, but it’s still good to hear them say it" news, Arkane founder and im-simmy RPG studio WolfEye head Raphael Colantonio has spoken on Microsoft’s decision to shutter Prey (2017) studio Arkane Austin - alongside a handful of others - back in May.

Colantonio, who founded Arkane in 1999 and departed in 2017 to form Weird West studio WolfEye, recently chatted to Jeremy Peel for PC Gamer about Arkane’s closure, saying:

I think if you look a little bit, it's obvious that Arkane Austin was a very special group of people that have made some cool things and that could pull it off again. I think it was a decision that just came down to, 'We need to cut something.' Was it to please the investors, the stock market? They're playing a different game.

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Stationeers and Icarus developers RocketWerkz are making a spiritual successor to beloved space sim Kerbal Space Program, which is currently titled "Kitten Space Agency" in a flagrant display of adherence to wholesome internet trends. It's based on an actual Kerbal Space Program 2 pitch the studio threw at Take-Two subsidiary Private Division back in the day. RocketWerkz CEO and original DayZ creator Dean Hall has hired several former KSP and KSP2 developers to work on the game, and is describing it on social media as a "KSP killer".

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Inflexion Games are closing their UK office, laying off staff and restructuring their main Canadian studio after failing to find commercial success with their Victorian fantasy survival game Nightingale. Reportedly, at least 22 people have been let go.

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The Steam Deck is something of a talisman for gaming on Linux, its popularity and penguin-powered SteamOS having almost singlehandedly dragged it past MacOS as the second-most-used operating system among Steam users. Sadly, this also means the Valve handheld is the primary casualty when developers decide to stop bothering with Linux support, as Respawn Entertainment have decided to do for Apex Legends.

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Stroll on down to Uncle Capcom's garage, girls and boys, because it's time to meddle with a cat's voicebox, ride a combat peacock and meticulously injure a vast, blubbery teddybear. By which I mean, the Monster Hunter Wilds beta is now live on Steam through to 4th November at 2.59am GMT. That's 2.59am sharp. If you're hurrying along at 3am on Monday absolutely desperate to polish the aesthetics of a small enslaved catperson, you can sod off and play Dragon Age: The Veilguard instead.

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Steam's built-in game recording feature has been usable in beta since the summer, but it has now been properly launched for every user, following a client update to Steam yesterday. It's basically another method of capturing funny ragdoll glitches and posting them on the "lol-games-are-dumb" channel of your friend's Discord. Or for posting that flukey knife throw in Call Of Duty to Twitter, as if you really meant to kill the man from across the map all along. Or saving a clip for your personal records, like the footage of that time you yeeted an innocent citizen off the 50-foot wall of a castle town in Dragon's Dogma 2. We all do that, right? Right?

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Back in the misty reaches of time (March) popular farming sim Stardew Valley got a big update that added more pets to the game (it also let you drink mayonaise but let's not get sidetracked). Those new cats, dogs, and turtles had the cute distinction of being able to wear hats, should you choose to kit your wee friends out. Now, following many months of smaller updates to the game, it seems those hats are causing a problem. "[If] you are experiencing performance issues in Stardew Valley 1.6, remove all hats from pets," said creator Eric Barone in a xeet. When asked the lore-accurate cause of this problem, he blamed: "a strange rash".

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Putting aside my natural annoyance at Metal Gear Solid Delta: Snake Eater for almost beating out the Twarhammer series in the headline real estate wars, I am more than a little excited to play. Some days, you simply must feast on a tree frog, and while we still don’t have a solid release date, that day doesn’t feel too far away. Good news for stealth fans, and perhaps gooder news for a dozen strapline writers sweating profusely, soiling themselves in anticipation of using “kept you waiting, huh?”.

Until then, I at least have a steady drip feed of new information to keep me sated, the latest of which is the substantial hint that there'll be some new dialogue in the game, as per the video below. Alongside that, the previously pseudonymous Suzetta Miñet - who was credited with voicing EVA in MGS3 and Peace Walker - has revealed herself to be Jodi Benson, the voice of Ariel in Disney’s The Little Mermaid. Cheers for the spot, Automaton West.

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When I was a competitive long-distance runner at school, breath control was paramount. We were never really taught this, mind. It was an art you picked up through practice: how to breathe before the race, saturating your blood with O2 without dizzying yourself; when to permit the shorter, emergency breaths and when to apply restraint; when to deepen your inhales and charge yourself up for an attack on a hill.

And then, how to organise your body around your breath, straightening your posture to expand your lungs without tipping back too far and squandering muscle power; how to breath in time with your stride and the movement of your shoulders, so as to firm up your momentum and shave a miraculous-feeling minute off your finishing time. All this, plus various daft psychological war gambits of my own devising. When overtaking or being overtaken, I used to seal my lips shut on that side and breath through the other corner of my mouth, to make it look like I was hardly out of breath at all.

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Take-Two Interactive have sold their publishing label Private Division to an unnamed party, along with five of Private Division's "live and unreleased titles". The GTA 6 publisher have also finally confirmed that they have shut down OlliOlli World and Rollerdrome devs Roll7 together with Kerbal Space Program 2 creators Intercept Games, months after performing mass layoffs at both studios.

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I first played Taiko no Tatsujin in an arcade (in Japan, because I am very cool), where it's controlled by hitting a recreation of an actual taiko drum. It was fun enough that I wish there was a taiko drum peripheral available for PC now the series is on our platform.

Taiko no Tatsujin: Rhythm Festival is out now via Steam, where it offers over 70 songs to drum through, and a subscription service through which to unlock over 700 more. Maybe I should try to get my Donkey Konga drums working on PC, but I'll probably settle for playing it with a gamepad.

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Could tower defence be the ultimate "it's Friday and I am here in body only" genre? I haven't really thought about it before, but Rift Riff's effusively laidback crowd control has me pondering those optimal moments in any tower defender when the incoming horde hits the flamer-MG triangle just right, and you can settle back comfortably into the role of clockwatcher.

Rift Riff encourages this behaviour by being nice to look at. Created by a trio of developers including Hidden Folks designer Adriaan de Jongh, it's a world of spacey, sun-carved mountains, forests and monoliths. The towers resemble the sacred architecture of Monument Valley, and the colour scheme and general ambience remind me of Cocoon. There's a demo, if you fancy it.

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Let’s try and get you up to speed on the fascinating oddity that is simulation game Ecosystem, on the off chance that Nate's coverage of it hasn't stuck with you like an unwelcome brain parasite you’re nonetheless unwilling to get removed for fear of the lingering emptiness it might cause (he once described an eel as “a quaver with erectile dysfunction”). Broadly speaking, this game is Spore’s evolutionary-biology-degree-having cousin. It’s been in early access for about three years now, but with the latest "Crustacean" update, it’s just hit 1.0. Once again, carcinization has come for all things.

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Great God Grove is, in a word, bonkers. I’ve stopped a small community from completing a blood ritual, played the role of matchmaker to a group of lonely hearts that involved organising a date with god, and plastered a statue with paint as part of a revolutionary movement to uplift the power of art. My time with GGG has been a pick n’ mix of colourful escapades, and together with its story of godly woes, striking art style, vacuum-based puzzle-solving, and nightmare-inducing puppet work, I’m now a die-hard LimboLane devotee.

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After a star explodes, the resulting supernova remnant collapses in on itself and could begin the cycle again, creating generations of stars enriched with heavy elements

Astronomers have identified patterns within the motion of stars stretching across the Milky Way, hinting at the presence of a vast wave

The first 18 satellites of a planned Chinese mega constellation are brighter than all but 500 stars in the sky, raising fears of a huge impact on astronomy

Bacteria grown from carbon compounds in asteroids could be turned into a kind of nutritionally balanced milkshake

My first sight of Saturn through a telescope inspired my love of space. Dig out your telescopes or visit your local astronomy club, and you may be lucky enough to spot our sixth planet's stunning thick band of rings, says Leah Crane

The Euclid space telescope's massive “cosmic atlas” promises to shed light on fundamental questions in physics and cosmology

Anil Ananthaswamy's Why Machines Learn: The elegant maths behind modern AI explores the mechanics of the AI revolution, but doesn't examine its ethics

AI companies hope that feeding ever more data to their models will continue to boost performance, eventually leading to human-level intelligence. Behind this hope is the "transformer", a key breakthrough in AI, but what happens if it fails to deliver?

A neural network can recreate the classic computer game Doom despite using none of its code or graphics, hinting that generative AI could be used to create games from scratch in future

CAPTCHA tests are supposed to distinguish humans from bots, but an AI system mastered the problem after training on thousands of images of road scenes

Treat yourself to a Becky Lynch book signing, games with the Dropout stars, Kevin Smith’s Dogma, and so much more!

This is a sponsored article brought to you by Khalifa University of Science and Technology.

A total of eight intense competitions to inspire creativity and innovation along with 13 forums dedicated to diverse segments of robotics and artificial intelligence will be part of the 36th edition of the IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2024) in Abu Dhabi.

These competitions at the Middle East and North Africa (MENA) region’s first-ever global conference and exhibition from 14-18 October 2024 at the Abu Dhabi National Exhibition Center (ADNEC) will highlight some of the key aspects of robotics. These include physical or athletic intelligence of robots, remote robot navigation, robot manipulation, underwater robotics, perception and sensing as well as challenges for wildlife preservation.

This edition of IROS is one of the largest of its kind globally in this category because of active participation across all levels, with 5,740 authors, 16 keynote speakers, 46 workshops, 11 tutorials, as well as 28 exhibitors and 12 startups. The forums at IROS will explore the rapidly evolving role of robotics in many industry sectors as well as policy-making and regulatory areas. Several leading corporate majors, and industry professionals from across the globe are gathering for IROS 2024 which is themed “Robotics for Sustainable Development.”

“The intense robotics competitions will inspire creativity, while the products on display as well as keynotes will pave the way for more community-relevant solutions.” —Jorge Dias, IROS 2024 General Chair

Dr. Jorge Dias, IROS 2024 General Chair, said: “Such a large gathering of scientists, researchers, industry leaders and government stakeholders in Abu Dhabi for IROS 2024 also demonstrates the role of UAE in pioneering new technologies and in providing an international platform for knowledge exchange and sharing of expertise. The intense robotics competitions will inspire creativity, while the products on display as well as keynotes will pave the way for more community-relevant solutions.”

The competitions are:

• 2nd AI Olympics With RealAIGym: Is AI Ready for Athletic Intelligence in the Real World? focusing on the physical or athletic intelligence of robots

• The Earth Rovers Challenge on remote robot navigation

• Robotic Construction Challenge and the euROBIN Manipulation Skill Versatility Challenge (MSVC) on robot manipulation

• Underwater Robotics Challenges on innovation and problem-solving in underwater robotics and artificial intelligence

• ROAD-IROS: Automatic Data Annotation Challenge for ROAD Dataset on perception and sensing

• 21st F1Tenth Autonomous Racing Competition

• IEEE RAS Quadruped Robot Challenge (QRC), focusing on navigation

In addition to these competitions, the Falcon Monitoring Challenge (FMC) will focus on advancing the field of wildlife tracking and conservation through the development of sophisticated, noninvasive monitoring systems.

Khalifa University

IROS 2024 will also include three keynote talks on ‘Robotic Competitions’ that will be moderated by Professor Lakmal Seneviratne, Director, Center for Autonomous Robotic Systems (KU-CARS), Khalifa University. The keynotes will be delivered by Professor Pedro Lima, Institute for Systems and Robotics, Instituto Superior Técnico, University of. Lisbon, Portugal; Dr. Timothy Chung, General Manager, Autonomy and Robotics, Microsoft, US; and Dr. Ubbo Visser, President of the RoboCup Federation, Director of Graduate Studies, and Associate Professor of Computer Science, University of Miami, US.

The forums at IROS 2024 will include:

• Robotics in Africa Forum

• Marine Robotics in Ocean Decade Initiative for Sustainable Development

• Robots for Sustainability and Sustainable Robots

• Government Forum: Funding for Robotics Research, Human-Avatars Symbiosis: Can you imagine a future society where you can remotely control multiple avatars?

• Moonshot R&D Program Goal 3 Forum. Envisioning a Future of Human-Robot Co-living: Potential for Robotics to Transform Human Lives

Other forums include:

• Sustainable Medical and Surgical Robotics

• Empowering Diverse Voices in Robotics, Robotics & AI in the UAE: Research Innovation and Entrepreneurship

• Europe Regulates Artificial Intelligence: the Challenge for Robotics, Industrial Opportunities and Socio-Economic Impact of Medical Robotics

• The Future of Work: AI-Enhanced Robotics and Human Interaction Research in M3S

• Robots for a Better Tomorrow: Wellbeing Through Advanced Technology.

One of the largest and most important robotics research conferences in the world, IROS 2024 provides a platform for the international robotics community to exchange knowledge and ideas about the latest advances in intelligent robots and smart machines. A total of 3,344 paper submissions representing 60 countries, have been received from researchers and scientists across the world. China tops the list with more than 1,000 papers, the US with 777, Germany with 302, Japan with 253, and the UK and South Korea with 173 each. The UAE remains top in the Arab region with 68 papers.

One of the largest and most important robotics research conferences in the world, IROS 2024 provides a platform for the international robotics community to exchange knowledge and ideas.

For eight consecutive years since 2017, Abu Dhabi has remained first on the world’s safest cities list, according to online database Numbeo, which assessed 329 global cities for the 2024 listing. This reflects the emirate’s ongoing efforts to ensure a good quality of life for citizens and residents. With a multicultural community, Abu Dhabi is home to people from more than 200 nationalities, and draws a large number of tourists to some of the top art galleries in the city such as Louvre Abu Dhabi and the Guggenheim Abu Dhabi, as well as other destinations such as Ferrari World Abu Dhabi and Warner Bros. World™ Abu Dhabi.

Because of its listing as one of the safest cities, Abu Dhabi continues to host several international conferences and exhibitions. Abu Dhabi is set to host the UNCTAD World Investment Forum, the 13th World Trade Organization (WTO) Ministerial Conference (MC13), the 12th World Environment Education Congress in 2024, and the IUCN World Conservation Congress in 2025.

IROS 2024 is sponsored by IEEE Robotics and Automation Society, Abu Dhabi Convention and Exhibition Bureau, the Robotics Society of Japan (RSJ), the Society of Instrument and Control Engineers (SICE), the New Technology Foundation, and the IEEE Industrial Electronics Society (IES).

More information at https://iros2024-abudhabi.org/

Aside from offering a more powerful console, the PS5 Pro also packs a sneaky theme for PlayStation fans to uncover - something Sony hadn't previously discussed.

Kurt "CyberGuy" Knutsson shares tips and suggestions for how to get the best use out of the updated Calendar app available with the latest iOS update.

One Arsenal star is on the list of the top ten Premier League players for increased transfer value in 2019.

… a big upset in his Davis Cup debut on Friday, defeating Spaniard ….