El secretario de Desarrollo Económico de Bogotá, Alfredo Batemán, habló en Caracol Radio sobre los próximos sitios en los que este evento comercial se realizará, en el marco de la temporada navideña.

La actriz y conferencista busca compartir algunas de las anécdotas que ha tenido a lo largo de su relación en pareja en la novedad de la editorial Oveja Negra 

En Caracol Radio estuvo Carlos Camargo, defensor del Pueblo

Animals — what on earth are they thinking? A panel of scientists explore the notion of animal cognition from what your dog means when it wags its tail, to the incredible problem-solving skills of crows, as part of the Aspen Ideas Festival.

 I just published a new law review article with the Seattle University Law Review entitled: Students for Fair Admissions: Affirming Affirmative Action and Shapeshifting Towards Cognitive Diversity? The article can be downloaded here: https://digitalcommons.law.seattleu.edu/sulr/vol47/iss4/7/. Here is the abstract:

The Roberts Court holds a well-earned reputation for overturning Supreme Court precedent regardless of the long-standing nature of the case. The Roberts Court knows how to overrule precedent. In Students for Fair Admissions v. Harvard (SFFA), the Court’s majority opinion never intimates that it overrules Grutter v. Bollinger, the Court’s leading opinion permitting race-based affirmative action in college admissions. Instead, the Roberts Court applied Grutter as authoritative to hold certain affirmative action programs entailing racial preferences violative of the Constitution. These programs did not provide an end point, nor did they require assessment, review, periodic expiration, or revision for greater institutional efficacy, including possible race-neutral alternatives. The programs also failed to break down stereotypes through the introduction of a critical mass to empower diverse voices. The programs thereby resembled prohibited quotas or racial balancing. As such, the programs at issue violated Grutter, which still governs race-based affirmative action in college admissions. More importantly, the Roberts court paved the way for more expansive diversity-based admissions programs by permitting institutions to value individual racial experiences, which authentically further an institution’s mission and interests. After SFFA, the use of race as a factor could well face time limits. Contrastingly, individualized racial experiences may benefit college applicants at institutions that embrace diversity in an authentic way without facing any time limitation. Further, institutions with distinct missions may value diversity in a race-conscious way but without any racial preference. In sum, the Roberts Court guides the use of race in college admissions toward a race-neutral, diversity-based paradigm such that institutions may still unlock the empirically proven benefits of cultural diversity with only de minimus interference from the courts. This approach rests upon a powerful policy basis that leads to superior innovation, macroeconomic outcomes, social cohesion and, therefore, superior national security for the United States. This approach thus could support a powerful interest convergence.

The article shows that Supreme Court did not overrule its prior affirmative action precedents, and in fact paved the way for universities to embrace cultural and cognitive diversity to enrich their educational missions. This is important because the case has been widely misconstrued.

My next article will extend the Court's holding to corporate DEI efforts and demonstrate that such efforts are not only remain lawful but also essential to rational human resources management.

Twelve of the island’s top female sports administrators were honoured at the Bermuda Olympic Association’s Women in Sports Leadership [WISL] Awards on Sunday [November 10]. Judy Simons, the former BOA president who died in January aged 71, was among those recognised at the ceremony organised by the BOA’s Gender Diversity & Inclusion Committee at the […]

Aunjanue Ellis spotlights the Early Risers' accomplishments.

Eric Holder sends special thanks to his family.

Tanner Correia has been recognised by the Bermuda Karting Association [BKA] after winning the Junior Cadet class and the Junior Highest Points trophy after an impressive Rubis National Championships season. Correia, who also shared the 9 Lives Good Sportsmanship Award with Hildegard Thomas, was presented with his trophies at the recent BKA awards ceremony at […]

Last weekend I had a lively discussion with a friend about Pagans she has met who don’t condone or accept the LGBT community, especially as it is intermingled with Paganism.  She has met some of this ilk (I have not) and described how they do not condone non-straight sexuality when it is expressed in Paganism, and how this type also has a limited view of what should be expressed as Paganism, and other expressions are wrong.

I gave her the impression I was surprised to hear this, but it was not surprise, but shock.  I knew intellectually that this type exists (since all types of everything exist,) but this was the first I had heard of actual encounters with such thinking.

We followers of Earth-based spirituality are persecuted and ridiculed enough with us doing it to ourselves.  Think of how Christine O’Donnell (who has no business holding public office, but that is another story) was openly ridiculed when an old clip of her surfaced where she stated she dabbled in witchcraft.  It tanked whatever chances she had in her Senatorial race, and was it because she was the wrong picture to put on the pagan community?  No, it was because any inference that one is a practicing pagan is social suicide in most parts of the United States.

We pagans need to be accepting of each other, and open to the great cosmos that is all of us.  There is no “right” or “wrong” way to be a pagan.

Those who think otherwise are suffering from cognitive dissonance.

An interesting recent review article (Wooster et al., "Animal cognition and culture mediate predator–prey interactions", Trends in Ecology & Evolution 2024) argues for bridging the academic silos of "predator-prey ecology" and "animal cognition and culture": Abstract: Predator–prey ecology and the study of animal cognition and culture have emerged as independent disciplines. Research combining these disciplines […]

“Power Grid” by Ram Joshi is licensed via CC BY-NC-ND 2.0. We’re proud to announce Creative Commons’ Legal Tools have been reviewed and accepted into the Digital Public Goods Alliance (DPGA) DPG Registry. The DPGA is a multi-stakeholder initiative, endorsed by the United Nations Secretary-General, that is working to accelerate the attainment of the UN…

The post CC Legal Tools Recognized as Digital Public Goods appeared first on Creative Commons.

A water catchment house design in Africa won Special Recognition in the Architectural Design category at the Design Educates Awards 2023. The design by Hong-En, Lin addresses the challenges of water scarcity and pollution in Africa by using local materials and traditional weaving techniques to create a clean and sustainable water source.[...]

Daniel Osherson, Princeton’s Henry R. Luce Professor in Information Technology, Consciousness, and Culture, Emeritus, known for his  creative scientific explorations with collaborators in many disciplines, died at home on Sept. 4. 

Tottenham boss Ange Postecoglou says their inconsistent start is down to him rather than his players after a fifth Premier League defeat.

Tottenham boss Ange Postecoglou accepts responsibility for his side's 2-1 Premier League defeat at home by a previously winless Ipswich.

Heterotrimeric G-proteins are signaling switches broadly divided into four families based on the sequence and functional similarity of their Gα subunits: Gs, Gi/o, Gq/11, and G12/13. Artificial mutations that activate Gα subunits of each of these families have long been known to induce oncogenic transformation in experimental systems. With the advent of next-generation sequencing, activating hotspot mutations in Gs, Gi/o, or Gq/11 proteins have also been identified in patient tumor samples. In contrast, patient tumor-associated G12/13 mutations characterized to date lead to inactivation rather than activation. By using bioinformatic pathway analysis and signaling assays, here we identified cancer-associated hotspot mutations in Arg-200 of Gα13 (encoded by GNA13) as potent activators of oncogenic signaling. First, we found that components of a G12/13-dependent signaling cascade that culminates in activation of the Hippo pathway effectors YAP and TAZ is frequently altered in bladder cancer. Up-regulation of this signaling cascade correlates with increased YAP/TAZ activation transcriptional signatures in this cancer type. Among the G12/13 pathway alterations were mutations in Arg-200 of Gα13, which we validated to promote YAP/TAZ-dependent (TEAD) and MRTF-A/B-dependent (SRE.L) transcriptional activity. We further showed that this mechanism relies on the same RhoGEF-RhoGTPase cascade components that are up-regulated in bladder cancers. Moreover, Gα13 Arg-200 mutants induced oncogenic transformation in vitro as determined by focus formation assays. In summary, our findings on Gα13 mutants establish that naturally occurring hotspot mutations in Gα subunits of any of the four families of heterotrimeric G-proteins are putative cancer drivers.

G protein–coupled receptors (GPCRs) initiate signaling cascades via G-proteins and beta-arrestins (βarr). βarr-dependent actions begin with recruitment of βarr to the phosphorylated receptor tail and are followed by engagement with the receptor core. βarrs are known to act as adaptor proteins binding receptors and various effectors, but it is unclear whether in addition to the scaffolding role βarrs can allosterically activate their downstream targets. Here we demonstrate the direct allosteric activation of proto-oncogene kinase Src by GPCR–βarr complexes in vitro and establish the conformational basis of the activation. Whereas free βarr1 had no effect on Src activity, βarr1 in complex with M2 muscarinic or β2-adrenergic receptors reconstituted in lipid nanodiscs activate Src by reducing the lag phase in Src autophosphorylation. Interestingly, receptor–βarr1 complexes formed with a βarr1 mutant, in which the finger-loop, required to interact with the receptor core, has been deleted, fully retain the ability to activate Src. Similarly, βarr1 in complex with only a phosphorylated C-terminal tail of the vasopressin 2 receptor activates Src as efficiently as GPCR–βarr complexes. In contrast, βarr1 and chimeric M2 receptor with nonphosphorylated C-terminal tail failed to activate Src. Taken together, these data demonstrate that the phosphorylated GPCR tail interaction with βarr1 is necessary and sufficient to empower it to allosterically activate Src. Our findings may have implications for understanding more broadly the mechanisms of allosteric activation of downstream targets by βarrs.

Erythromycin-resistance methyltransferases are SAM dependent Rossmann fold methyltransferases that convert A2058 of 23S rRNA to m6 2A2058. This modification sterically blocks binding of several classes of antibiotics to 23S rRNA, resulting in a multidrug-resistant phenotype in bacteria expressing the enzyme. ErmC is an erythromycin resistance methyltransferase found in many Gram-positive pathogens, whereas ErmE is found in the soil bacterium that biosynthesizes erythromycin. Whether ErmC and ErmE, which possess only 24% sequence identity, use similar structural elements for rRNA substrate recognition and positioning is not known. To investigate this question, we used structural data from related proteins to guide site-saturation mutagenesis of key residues and characterized selected variants by antibiotic susceptibility testing, single turnover kinetics, and RNA affinity–binding assays. We demonstrate that residues in α4, α5, and the α5-α6 linker are essential for methyltransferase function, including an aromatic residue on α4 that likely forms stacking interactions with the substrate adenosine and basic residues in α5 and the α5-α6 linker that likely mediate conformational rearrangements in the protein and cognate rRNA upon interaction. The functional studies led us to a new structural model for the ErmC or ErmE-rRNA complex.

Cognitive decline with age is a harmful process that can reduce quality of life. Multiple factors have been established to contribute to cognitive decline, but the overall etiology remains unknown. Here, we hypothesized that cognitive dysfunction is mediated, in part, by increased levels of inflammatory cytokines that alter allopregnanolone (AlloP) levels, an important neurosteroid in the brain. We assessed the levels and regulation of AlloP and the effects of AlloP supplementation on cognitive function in 4-month-old and 24-month-old male C57BL/6 mice. With age, the expression of enzymes involved in the AlloP synthetic pathway was decreased and corticosterone (CORT) synthesis increased. Supplementation of AlloP improved cognitive function. Interestingly, interleukin 6 (IL-6) infusion in young animals significantly reduced the production of AlloP compared with controls. It is notable that inhibition of IL-6 with its natural inhibitor, soluble membrane glycoprotein 130, significantly improved spatial memory in aged mice. These findings were supported by in vitro experiments in primary murine astrocyte cultures, indicating that IL-6 decreases production of AlloP and increases CORT levels. Our results indicate that age-related increases in IL-6 levels reduce progesterone substrate availability, resulting in a decline in AlloP levels and an increase in CORT. Furthermore, our results indicate that AlloP is a critical link between inflammatory cytokines and the age-related decline in cognitive function.

Glycosylation is a highly diverse set of co- and post-translational modification of proteins. For mammalian glycoproteins, glycosylation is often site-, tissue- and species-specific, and diversified by microheterogeneity. Multitudinous biochemical, cellular, physiological and organismic effects of their glycans have been revealed, either intrinsic to the carrier proteins or mediated by endogenous reader proteins with carbohydrate recognition domains. Furthermore, glycans frequently form the first line of access by or defense from foreign invaders, and new roles for nucleocytoplasmic glycosylation are blossoming. We now know enough to conclude that the same general principles apply in invertebrate animals and unicellular eukaryotes – different branches of which spawned the plants or fungi and animals. The two major driving forces for exploring the glycomes of invertebrates and protists are (i) to understand the biochemical basis of glycan-driven biology in these organisms, especially of pathogens, and (ii) to uncover the evolutionary relationships between glycans, their biosynthetic enzyme genes, and biological functions for new glycobiological insights. With an emphasis on emerging areas of protist glycobiology, here we offer an overview of glycan diversity and evolution, to promote future access to this treasure trove of glycobiological processes.

Oct. 17, 2024 — UC San Diego Alumnus Roman Gerasimov, who recently earned his doctorate from the university, has received the International Astronomical Union (IAU) Stars and Stellar Physics Division Award […]

The post UC San Diego Doctoral Graduate Recognized for Achievement in Astronomy appeared first on HPCwire.

Being a "weekend warrior" -- engaging in exercise once or twice per week -- may be as beneficial as regular sessions in decreasing the risk of cognitive decline that often leads to dementia, a new study concludes.

Your brain could stay sharp for years just by doing these simple activities.

You think you're informed, but here's why you might not be.

I mentioned on FB yesterday how much my cognitive style has changed as a result of my psychology training. One of the readers asked me to say more about how it had changed, so here’s my answer. Hopefully this post will show people how it is possible to dramatically change your cognitive style. – I’m […]

The post Changing Your Cognitive Style appeared first on Dr Alice Boyes.

Are you a clinician looking to master CBT for Perfectionism? Or, learn more about the CBT model of perfectionism below. CBT Model of Perfectionism Perfectionism is not the same thing as conscientiousness. For example, in a recent study of older adults, perfectionism was both associated with increased risk of mortality whereas conscientiousness was associated with […]

The post Cognitive Behavioral Therapy Model of Perfectionism appeared first on Dr Alice Boyes.

The core beliefs that cause the most common problems fall into the following 3 categories. These core beliefs commonly underlie depression and anxiety. Helpless Core Beliefs such as: “I’m incompetent” “I’m needy” “I’m weak” “I’m defective, I don’t measure up” “I’m a failure” Unlovable Core Beliefs such as: “I’m unlovable” “I’m different” “I’m bound to […]

The post How To Change Negative Core Beliefs: A Straightforward Guide to Cognitive Behavioral Therapy (CBT) appeared first on Dr Alice Boyes.

Stephanie Rudolph
Nov 8, 2023; 43:7554-7564
Symposium and Mini-Symposium

Targeting altered expression and/or activity of GABA (-aminobutyric acid) transporters (GATs) provide therapeutic benefit for age-related impairments, including cognitive dysfunction. However, the mechanisms underlying the transcriptional regulation of GATs are unknown. In the present study, we demonstrated that the stimulator of interferon genes (STING) upregulates GAT1 and GAT3 expression in the brain, which resulted in cognitive dysfunction. Genetic and pharmacological intervention of STING suppressed the expression of both GAT1 and GAT3, increased the ambient GABA concentration, and therefore, enhanced tonic GABA_A inhibition of principal hippocampal neurons, resulting in spatial learning and working memory deficits in mice in a type I interferon-independent manner. Stimulation of the STING->GAT pathway efficiently restored cognitive dysfunction in STING-deficient mice models. Our study uncovered for the first time that the STING signaling pathway regulates GAT expression in a cell autonomous manner and therefore could be a novel target for GABAergic cognitive deficits.

Countries today endorsed a set of wide-reaching guidelines that will boost the already vital [...]

Salzburg – Austria, marked a significant milestone as it celebrated the formal recognition of Traditional Hay Milk Farming in the Austrian Alpine Arc as a FAO Globally Important Agricultural [...]

Indonesia and Sao Tome and Principe receive their first designations from FAO along with Austria’s second system

Results based on answers to surveys completed by SOLIDWORKS employees

The 2016 National Teacher of the Year will represent Connecticut’s 5th district, becoming the first African-American woman from the state to serve in Congress.

A student-centered approach to teaching mathematics enables students to develop conceptual understanding and to grow as confident mathematicians.

The ALL IN Campus Democracy Challenge has recognized Pennsylvania College of Technology for its nonpartisan democratic engagement efforts that fostered high levels of student voter engagement in the 2022 midterm elections and for its commitment to ensuring that nonpartisan democratic engagement is a defining feature of campus life.

A documentary by a Penn State faculty filmmaker won an award in Canada and will screen Nov. 24 in Finland.

Loneliness and cognitive performance were related in the short term for older adults, according to a new study from researchers in the Penn State College of Health and Human Development.

Engaging in everyday physical activity has immediate benefits for brain health. Middle-aged people who participated in everyday movement showed improvement in cognitive processing speed equivalent to being four years younger, regardless of the activity's intensity level, according to a new study by researchers in the Penn State College of Medicine.

WILMINGTON – Delaware’s Ferris School has been selected as finalist for the 2021 PbS Barbara Allen-Hagen Award in the juvenile correction program category. This prestigious annual award, through the national continuous improvement program Performance-based Standards (PbS), is given in three categories: correction, detention, and community residential programs. Programs are recognized based on practices that exemplify […]

Governor to visit Delaware Small Businesses and Tourism locations WILMINGTON, Del. – In recognition of Small Business Week and National Travel and Tourism Week (May 2-8), Governor John Carney will join the Delaware Tourism Office to visit small businesses and attractions in Kent, New Castle and Sussex counties this week. Note to media: An advisory is included […]

Literacy Month is intended to recognize the extensive efforts of literacy partners to promote reading as an essential skill and a lifelong pleasure.

THE DELAWARE DIVISION OF VOCATIONAL REHABILITATION AND THE STATE REHABILITATION COUNCIL RECOGNIZES THE VALUE OF WORKPLACE INCLUSION AT ITS ANNUAL RECOGNITION AWARDS LUNCHEON Wilmington, DE, December 6, 2018 — The Delaware Department of Labor’s Division of Vocational Rehabilitation (DVR) and the State Rehabilitation Council (SRC) will celebrate workplace inclusion by honoring the value and contribution […]