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From colonialism to AI, this Booker-longlisted novel urges us to wake up to how we treat wild creatures and places

A new book from the science-writing legend is an Attenborough-esque romp through some of the wonders of the natural world. Just beware the title's misfiring metaphor

Title: Chronic Media Multi-Tasking Makes It Harder to Focus
Category: Health News
Created: 8/24/2009 4:10:00 PM
Last Editorial Review: 8/25/2009 12:00:00 AM

Title: Belly Fat May Hit Your Heart the Hardest
Category: Health News
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Title: New Drug Combo Helps Hard-to-Treat Hepatitis C
Category: Health News
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Title: Humans Hardwired to Feel Others' Pain, Study Finds
Category: Health News
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Title: Clues to Why COVID-19 Hits Men Harder Than Women
Category: Health News
Created: 8/26/2020 12:00:00 AM
Last Editorial Review: 8/27/2020 12:00:00 AM

The best way to predict the review score of a game is to play a demo of it. So never trouble another for what you can do yourself. For every minute you are playing you lose sixty seconds of ignorance. And without Pokémon tooth brushing games, life would be a mistake.

The post RPG Cast – Episode 547: “Cancer Inducing External Hardrive” appeared first on RPGamer.

Kelley hot boxes her cat. Chris authorizes Lunar to bring back Bill Clinton jokes. And Robert suffers feline gacha girls for us all.

The post RPG Cast – Episode 742: “Hard Candy Wii U Discs” appeared first on RPGamer.

The Nintendo Switch was the best-selling console in Japan with 241,803 units sold for October 2024, according to VGChartz estimates. The Nintendo Switch has now sold an estimated 34.30 million units lifetime in Japan.

The PlayStation 5 sold an estimated 49,056 units to bring its lifetime sales to 6.12 million units. The Xbox Series X|S sold 5,862 units to bring their lifetime sales to 0.64 million units. The PlayStation 4 sold an estimated 162 units to bring its lifetime sales to 9.68 million units.

PS5 sales compared to the same month for the PS4 in 2017 are down by nearly 53,000 units, while the Xbox Series X|S compared to the same month for the Xbox One are up by over 5,000 units. PS4 sold 101,851 units for the month of October 2017 and Xbox One sales were at 563 units.

Nintendo Switch sales compared to the same month a year ago are down by 41,368 units (-14.6%). PlayStation 5 sales are down by 17,208 (-26.0%) and Xbox Series X|S sales are down by 2,294 units (-28.1%). The PlayStation 4 is down by 5,362 units (-97.1%) year-over-year.

Looking at sales month-on-month, Nintendo Switch sales are down up nearly 67,000 units, the PlayStation 5 sales are down by over 4,000 units, and Xbox Series X|S sales are up by over 2,000 units.

2024 year-to-date, the Nintendo Switch has sold an estimated 2.47 million units, the PlayStation 5 has sold 1.16 million units, and the Xbox Series X|S has sold 0.09 million units.

Monthly Sales:

Japan hardware estimates for October 2024 (Followed by lifetime sales):

1. Switch - 241,803 (34,300,699)
2. PlayStation 5 - 49,056 (6,121,649)
3. Xbox Series X|S - 5,862 (636,764)
4. PlayStation 4 - 162 (9,679,626)

Weekly Sales:

Japan October 12, 2024 hardware estimates:

1. Switch - 55,097
2. PlayStation 5 - 11,810
   
3. Xbox Series X|S - 429
4. PlayStation 4 - 31

Japan October 19, 2024 hardware estimates:

1. Switch - 58,866
2. PlayStation 5 - 11,324
3. Xbox Series X|S - 1,612
4. PlayStation 4 - 36

Japan October 26, 2024 hardware estimates:

1. Switch - 67,736
2. PlayStation 5 - 11,951
3. Xbox Series X|S - 1,207
4. PlayStation 4 - 40

Japan November 2, 2024 hardware estimates:

1. Switch - 60,104
2. PlayStation 5 - 13,971
3. Xbox Series X|S - 2,614
4. PlayStation 4 - 55

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463008/switch-comfortably-best-seller-japan-hardware-estimates-for-october-2024/

The mystery surrounding Deadlock, Valve’s work-in-progress MOBA shooter, has largely evaporated. Its freely extendable invite system is about as effective at controlling player headcount as a disinterested football steward, meaning pretty much anyone with a clued-in Steam friend can get in and start poking around its secrets. And yet, being a lane-pushing wizard fighter in the Dota 2 vein, it’s already a vast tangle of interplaying abilities, items, strats, and often unspoken rules, of the kind that even experienced gankists will take hundreds of hours to learn. It’s been too much for poor Brendy, at any rate.

Still, Brendy is but one man. What if we had but four men, working in tandem to crush lanes and flatten Patrons just as Gabe intended? To find out if Deadlock is indeed more comprehensible as a team sport, Graham, Ed, Ollie, and James joined forces, promptly getting fucked up yet emerging from the warlock hospital with a deeper understanding of its workings. Or, at least, if anyone would keep playing.

Read more

Many people enjoy the experience of using AIs like ChatGPT or voice assistants like Alexa to find out information, but it turns out doing so makes it less likely you will spot inaccurate information

… the opening round of the Davis Cup World Group on hard court … . Kyrgios led Australia to the Davis Cup semi-finals this year, while Zverev ….

A band that measures the acidity of sweat could flag if athletes or manual workers are overexerting themselves

President-elect Donald Trump nominated Fox News host Pete Hegseth to serve as his Secretary of Defense, hailing him as a champion of his "peace through strength" policy.

The post Trump Nominates Fox News Host Pete Hegseth for Secretary of Defense: ‘Nobody Fights Harder for the Troops’ appeared first on Breitbart.

On the final day of Talk of the Nation, staff and colleagues have been faced with the dilemma of how to say goodbye. When your words fail, a greeting card can supply the right sentiment. Former Hallmark greeting card writer David Dickerson gives advice on saying goodbye.

The singer conveyed the richness of Bhojpuri and Maithili languages through her wide repertoire of songs

The grant program provides hardware startups with reimbursement for working with local manufacturers.

Founded in 1924 as J&G Hardie, Hardie Polymers, the Glasgow-based polymer supplier, celebrates its 100th anniversary.

When chemist Dora Richardson’s employer decided to terminate the breast cancer research on the drug Tamoxifen in the early 1970s, she and her colleagues continued the work in secret.

Chicken was once an expensive delicacy. In 1928, America’s quest for a better diet and a better standard of living was summarized by the campaign promise of “a chicken in every pot.” Today, chicken is a ubiquitous, low-cost source of protein, which we largely take for granted. Despite depletion of ocean-based stocks, fish hold similar potential. To begin this transformation, FDA must approve a scientifically-based innovative product—a faster growing genetically-engineered (GE) Atlantic salmon. When FDA Matters wrote about this subject 18 months ago, I believed the agency was near to approval of this first-ever food product from a GE animal. It is still not resolved and there are implications for all innovations that require FDA approval.

Maybe those pesky sites are good for something after all. 

It's been six years since Pfizer boldly announced the launch of its "clinical trial in a box". The REMOTE trial was designed to be entirely online, and involved no research sites: study information and consent was delivered via the web, and medications and diaries were shipped directly to patients' homes.

Despite the initial fanfare, within a month REMOTE's registration on ClinicalTrials.gov was quietly reduced from 600 to 283. The smaller trial ended not with a bang but a whimper, having randomized only 18 patients in over a year of recruiting.

Still, the allure of direct to patient clinical trials remains strong, due to a confluence of two factors. First, a frenzy of interest in running "patient centric clinical trials". Sponsors are scrambling to show they are doing something – anything – to show they have shifted to a patient-centered mindset. We cannot seem to agree what this means (as a great illustration of this, a recent article in Forbes on "How Patients Are Changing Clinical Trials" contained no specific examples of actual trials that had been changed by patients), but running a trial that directly engages patients wherever they are seems like it could work.

The less-openly-discussed other factor leading to interest in these DIY trials is sponsors' continuing willingness to heap almost all of the blame for slow-moving studies onto their research sites. If it’s all the sites’ fault – the reasoning goes – then cutting them out of the process should result in trials that are both faster and cheaper. (There are reasons to be skeptical about this, as I have discussed in the past, but the desire to drop all those pesky sites is palpable.)

However, while a few proof-of-concept studies have been done, there really doesn't seem to have been another trial to attempt a full-blown direct-to-patient clinical trial. Other pilots have been more successful, but had fairly lightweight protocols. For all its problems, REMOTE was a seriously ambitious project that attempted to package a full-blown interventional clinical trial, not an observational study.

In this context, it's great to see published results of the TAPIR Trial in vasculitis, which as far as I can tell is the first real attempt to run a DIY trial of a similar magnitude to REMOTE.

TAPIR was actually two parallel trials, identical in every respect except for their sites: one trial used a traditional group of 8 sites, while the other was virtual and recruited patients from anywhere in the country. So this was a real-time, head-to-head assessment of site performance.

And the results after a full two years of active enrollment?

• Traditional sites: 49 enrolled
• Patient centric: 10 enrolled

Even though we’re six years later, and online/mobile communications are even more ubiquitous, we still see the exact same struggle to enroll patients.

Maybe it’s time to stop blaming the sites? To be fair, they didn’t exactly set the world on fire – and I’m guessing the total cost of activating the 8 sites significantly exceeded the costs of setting up the virtual recruitment and patient logistics. But still, the site-less, “patient centric” approach once again came up astonishingly short.
Krischer J, Cronholm PF, Burroughs C, McAlear CA, Borchin R, Easley E, Davis T, Kullman J, Carette S, Khalidi N, Koening C, Langford CA, Monach P, Moreland L, Pagnoux C, Specks U, Sreih AG, Ytterberg S, Merkel PA, & Vasculitis Clinical Research Consortium. (2017). Experience With Direct-to-Patient Recruitment for Enrollment Into a Clinical Trial in a Rare Disease: A Web-Based Study. Journal of medical Internet research, 19 (2) PMID: 28246067

Over the past 20 years, technological advances have enabled inventors to go from strength to strength. And yet, according to the legendary inventor Dean Kamen, innovation has stalled. Kamen made a name for himself with inventions including the first portable insulin pump for diabetics, an advanced wheelchair that can climb steps, and the Segway mobility device. Here, he talks about his plan for enabling innovators.

How has inventing changed since you started in the 1990s?

Dean Kamen: Kids all over the world can now be inventing in the world of synthetic biology the way we played with Tinkertoys and Erector Sets and Lego. I used to put pins and smelly formaldehyde in frogs in high school. Today in high school, kids will do experiments that would have won you the Nobel Prize in Medicine 40 years ago. But none of those kids are likely in any short time to be on the market with a pharmaceutical that will have global impact. Today, while invention is getting easier and easier, I think there are some aspects of innovation that have gotten much more difficult.

Can you explain the difference?

Kamen: Most people think those two words mean the same thing. Invention is coming up with an idea or a thing or a process that has never been done that way before. [Thanks to] more access to technology and 3D printers and simulation programs and virtual ways to make things, the threshold to be able to create something new and different has dramatically lowered.

Historically, inventions were only the starting point to get to innovation. And I’ll define an innovation as something that reached a scale where it impacted a piece of the world, or transformed it: the wheel, steam, electricity, Internet. Getting an invention to the scale it needs to be to become an innovation has gotten easier—if it’s software. But if it’s sophisticated technology that requires mechanical or physical structure in a very competitive world? It’s getting harder and harder to do due to competition, due to global regulatory environments.

[For example,] in proteomics [the study of proteins] and genomics and biomedical engineering, the invention part is, believe it or not, getting a little easier because we know so much, because there are development platforms now to do it. But getting a biotech product cleared by the Food and Drug Administration is getting more expensive and time consuming, and the risks involved are making the investment community much more likely to invest in the next version of Angry Birds than curing cancer.

A lot of ink has been spilled about how AI is changing inventing. Why hasn’t that helped?

Kamen: AI is an incredibly valuable tool. As long as the value you’re looking for is to be able to collect massive amounts of data and being able to process that data effectively. That’s very different than what a lot of people believe, which is that AI is inventing and creating from whole cloth new and different ideas.

How are you using AI to help with innovation?

Kamen: Every medical school has incredibly brilliant professors and grad students with petri dishes. “Look, I can make nephrons. We can grow people a new kidney. They won’t need dialysis.” But they only have petri dishes full of the stuff. And the scale they need is hundreds and hundreds of liters.

I started a not-for-profit called ARMI—the Advanced Regenerative Manufacturing Institute—to help make it practical to manufacture human cells, tissues, and organs. We are using artificial intelligence to speed up our development processes and eliminate going down frustratingly long and expensive [dead-end] paths. We figure out how to bring tissue manufacturing to scale. We build the bioreactors, sensor technologies, robotics, and controls. We’re going to put them together and create an industry that can manufacture hundreds of thousands of replacement kidneys, livers, pancreases, lungs, blood, bone, you name it.

So ARMI’s purpose is to help would-be innovators?

Kamen: We are not going to make a product. We’re not even going to make a whole company. We’re going to create baseline core technologies that will enable all sorts of products and companies to emerge to create an entire new industry. It will be an innovation in health care that will lower costs because cures are much cheaper than chronic treatments. We have to break down the barriers so that these fantastic inventions can become global innovations.

This article appears in the November 2024 print issue as “The Inventor’s Inventor.”

NEW YORK – Moves by major US fast-food chains to temporarily scrub fresh onions off their menus on Oct 24, after the vegetable was named as the likely source of an E. coli outbreak at McDonald’s, laid bare the recurring nightmare for restaurants: Produce is a bigger problem for restaurants to keep free of contamination than beef. Onions are likely the culprit in the McDonald’s E. coli outbreak across the Midwest and some Western states that has sickened 49 people and killed one, the US Department of Agriculture said late on Oct 23. The company pulled the Quarter Pounder off its menu at one-fifth of its 14,000 US restaurants. In past years, beef patties dominated the dockets of food-borne-illness lawyers, before US federal health regulators cracked down on beef contamination after an E. coli outbreak linked to Jack in the Box burgers hospitalised more than 170 people across states and killed four. As a result, beef-related outbreaks became much rarer, experts say.

Dec 15, 2023

Mariana Budjeryn writes: War never stops at the border, especially on a continent like Europe. The European Union absorbed millions of Ukrainian war refugees and poured billions of euros into Ukraine's defenses and economic survival. The war permanently reshaped Europe: its demographics, political economy, and energy architecture are shifting in ways that will have irreversible long-term consequences. All of this is because in a very real sense Ukraine already is inextricably woven into the fabric of Europe: Ukraine’s pain is Europe’s pain and Ukraine’s gain will inevitably be Europe's gain, too.

Dec 20, 2023

Amy Harder, the founding Executive Editor of the climate policy publication Cipher News, expressed her surprise with several positive outcomes from the recent 28th Conference of the Parties of the United Nations Framework Convention on Climate Change (COP 28) in Dubai during a special episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.”

Feb 8, 2024

Eminent Harvard economist Richard Zeckhauser presented arguments for additional climate adaptation measures in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” The podcast is produced by the Harvard Environmental Economics Program.

May 24, 2024

Mohammad Tabaar writes that former Iranian President Raisi will be remembered for putting the country on the right path after a series of presidents who challenged the supreme leader's vision. He will be memorialized for positioning Iran as a nuclear threshold state and establishing it as a rising power—and for doing so not despite external pressure, but because of it.

Kids on Spending and Saving

Brad Hiranga, General Mills Business Unit Director, Pizza and Tacos Business Unit discusses the Bucking Couch and Bucking Couch Bowl.

When it comes to performance under pressure, Dale Jr. and Goodyear are forged from the same fire. Like Goodyear, the Earnhardt name has a long history in NASCAR and we�re proud to say we�re Driven Like Jr.

The Alloy Origins Core is a tenkeyless mechanical keyboard made of airplane-grade aluminum, which prompts the question: Why don't they make the whole plane out of keyboard?

Long COVID has made the last couple of months quite difficult for me. I supposed it’s inaccurate to say that slowing down has been hard for me to do, because I haven’t been given a choice in the matter. What’s been difficult is adapting, adjusting, and ultimately accepting the slow-down.

For those just catching up on the old news, I contracted COVID back in “wave zero,” the community-spread wave in late January of 2020 when none of us thought the virus was here yet. I was the father of the bride at a wedding whose guests included a family who had guests in their home who had recently arrived from Wuhan province in China. I got better, but I never got all the way better, and I’ve been dealing with chronic fatigue ever since.

The salient point: I want to do more than I am doing. I mean, sure, I want to do more than I am *able* to do, which is a pretty common desire among humans of all stripes, but especially among those whose abilities have been, for whatever reason, reduced in scope.

So what *am* I doing? Well, today I’m writing this, and then diving back into the marginalia for Book 18, which we can’t send to the printer until it has all its marginalia. A lot of the pieces are things like this one – concept sketches which I’ve revisited digitally and cleaned up so they look nicer.

The marginalia is a necessity born of the fact that Schlock Mercenary was not originally formatted for print. Comics should be written and illustrated to the page turn, with attention given to the reveal that occurs as the reader turns the page and uncovers the art and dialog of the next spread. I say “should” be because Schlock Mercenary definitely is NOT written that way.

When we put it into print, we can fit four regular-sized strips on a single page of the book. A week of strips has nine of these rectangular collections of panels, because Sundays have three, and those last three strips in the week need to all be on the same page. Since no amount of fudging the math will make 9 cleanly divisible by 4, a week of Schlock Mercenary takes up three pages of book, and those three pages have some white space.

Hence the marginalia. Sometimes a weekday installment is extra large, sometimes there’s a footnote, and sometimes I broke the pattern in other ways, and so sure, sometimes the white space has taken care of itself, but sometimes my layout shenanigans mean an entire half-page of the book needs a new picture.

So that’s what I’m working on. I wish I could do more, or do it faster, and maybe the booster shot I got two days ago will perk me up the way previous booster shots have, but I’m not going to wait for a cure before I get back to work. I’m just going to accept that I have to slow down.

Curious about Tim Hardaway Jr.‘s condition following his recent on-court injury? As fans discuss the Detroit Pistons’ nail-biting NBA Cup opener against the Miami Heat, many are also concerned about Hardaway’s recovery and when he might return to the lineup. Here’s a quick look at Tim Hardaway’s injury, recovery, and its impact on the Pistons. […]

The post Pistons’ Tim Hardaway Avoids Serious Injury After Head Collision appeared first on ComingSoon.net - Movie Trailers, TV & Streaming News, and More.

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The abnormalities associated with aging sperm cells might be exacerbated by elevated body mass index (BMI), suggests research that appears in the journal iDevelopmental Cell/i.

A new study examines how extreme weather, exacerbated by medlinkclimate change/medlink, impacts global production and consumption patterns among various income levels (!--ref1--).

Richard Simmons, a beloved figure in the world of fitness and health, passed away at the age of 76 in Los Angeles from natural causes. Simmons, known

Hard to Treat Diseases (HTDS) Melem Secret Launches New Line of Nutriceuticals

As website owners, we are continuously trying to rework on the existing design, to upgrade it to something more contemporary and user centric. As the online visitors instill...

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