ABSTRACTWe document the effort over the last 30 years to respond to the call by women advocates at the International Conference on Population and Development for more woman-initiated single or dual-purpose contraceptive methods by developing the Caya contoured diaphragm, an innovative diaphragm designed to meet the needs of women and their partners and expand options for nonhormonal barrier contraception. We describe the complex and interrelated set of activities undertaken to develop the product using a human-centered design process and how we are working to create a corollary sustainable market. This review includes the evidence generated around improved acceptability among couples in low- and middle-income countries and depicts challenges and practical actions on how to dispel misconceptions about diaphragm use. Importantly, we share programmatic lessons learned on increasing universal access to this new sexual and reproductive health technology. Following our new model for increasing access to new and underutilized methods, Caya is now registered and being marketed in nearly 40 countries worldwide.

The phase 3 VISION trial demonstrated that [¹⁷⁷Lu]Lu-PSMA-617 prolonged progression-free survival and overall survival (OS) in prostate-specific membrane antigen [PSMA]–positive metastatic castration-resistant prostate cancer (mCRPC) patients who progressed on taxane-based chemotherapy and androgen receptor–signaling inhibitors (ARSIs). The U.S. expanded-access program (EAP; NCT04825652) was opened to provide access to [¹⁷⁷Lu]Lu-PSMA-617 for eligible patients until regulatory approval was obtained. This study aimed to evaluate the efficacy and safety profile of [¹⁷⁷Lu]Lu-PSMA-617 within the EAP and compare the results with those from the VISION trial. Methods: Patients enrolled in the EAP at 4 institutions in the United States with available toxicity and outcome data were included. Outcome measures included OS, a prostate-specific antigen (PSA) response rate (RR) of at least 50%, and incidences of toxicity according to Common Terminology Criteria for Adverse Events version 5.0. Differences in baseline characteristics, outcome data, and toxicity between the EAP and VISION were evaluated using t testing of proportions and survival analyses. Results: In total, 117 patients with mCRPC who received [¹⁷⁷Lu]Lu-PSMA-617 within the EAP between May 2021 and March 2022 were eligible and included in this analysis. Patients enrolled in the EAP were more heavily pretreated with ARSI (≥2 ARSI regimens: 70% vs. 46%; P < 0.001) and had worse performance status at baseline (Eastern Cooperative Oncology Group score ≥ 2: 19% vs. 7%; P < 0.001) than VISION patients. EAP and VISION patients had similar levels of grade 3 or higher anemia (18% vs. 13%; P = 0.15), thrombocytopenia (13% vs. 8%; P = 0.13), and neutropenia (3% vs. 3%; P = 0.85) and similar PSA RRs (42% vs. 46%; P = 0.50) and OS (median: 15.1 vs. 15.3 mo; P > 0.05). Conclusion: Patients with PSMA-positive mCRPC who received [¹⁷⁷Lu]Lu-PSMA-617 within the EAP were later in their disease trajectory than VISION patients. Patients enrolled in the EAP achieved similar PSA RRs and OS and had a safety profile similar to that of the VISION trial patients.

Life simulation game Inzoi will launch on PC via Steam early access on 28th March 2025, publishers Krafton have announced. Billed as a potential Sims 4 usurper, and equipped with syrupy Unreal Engine 5 visuals, it was originally slated for launch this year.

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Roblox is making changes in an attempt to keep younger players safe in the online platform. Beginning later this month, children under the age of 13 will no longer be able to search, discover or play unrated experiences within Roblox, and will be unable to access social hangout experiences.

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Let’s try and get you up to speed on the fascinating oddity that is simulation game Ecosystem, on the off chance that Nate's coverage of it hasn't stuck with you like an unwelcome brain parasite you’re nonetheless unwilling to get removed for fear of the lingering emptiness it might cause (he once described an eel as “a quaver with erectile dysfunction”). Broadly speaking, this game is Spore’s evolutionary-biology-degree-having cousin. It’s been in early access for about three years now, but with the latest "Crustacean" update, it’s just hit 1.0. Once again, carcinization has come for all things.

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PlayStation 5 Pro is out, and with plenty of availability, scalpers are shifting the £700 console at a loss and turning their attention to a key accessory instead

As our submersible descended, the waters grew darker around us. Looming teeth, some as long as a man’s leg, skirted the edge of our floodlights. The captain was sure this area held caves filled with golden bounty, but to those creatures of the deep it was our flesh and blood that were the true prizes… […]

In Canada, your IP address has the right to remain silent. Elon Musk is suing OpenAI for not being Open. Apple faces a class action not allowing competitive access to backup services and the World Server Throwing Competition in March 2024 is accused of being too violent towards servers.   All this and more on the […]

The post Hashtag Trending Mar.4- Canadian police need a search warrant to access IP address; Musk sues OpenAI; World Server Throwing Competition too violent? first appeared on ITBusiness.ca.

A FORMER bikini model has lodged a formal complaint with the Queensland Police Service after officers accessed her personal file more than 1400 times.

The Federation of Pharmaceutical Entrepreneurs (FOPE) has identified potential opportunities for Indian pharmaceutical companies to expand in Australia. Further, the India─Australia Economic Cooperation and Trade

The outcome of the 2024 U.S. presidential election could reshape policies from health care at home to nuclear proliferation abroad

The outcome of the 2024 U.S. presidential election could set the climate agenda, reshape public education and shift the dynamics of global science collaboration.

Informa Connect's Copay, Reimbursement and Access Congress
November 18-20, 2024 | Hilton Penn’s Landing in Philadelphia, PA
Drug Channels readers save 10% with code USAVE24*

The access and affordability landscape is undergoing a seismic shift. Evolving legislation, disruptive market forces and the ever-growing complexities of cost sharing programs threaten patient adherence and commercialization strategies. Are you ready?

A program driven by marketplace insights and led by industry trailblazers, Copay, Reimbursement and Access Congress is back November 18-20 and will deliver up-to-date insights necessary to enhance patient affordability, ensure program sustainability and navigate the regulatory landscape. In a time where remaining compliant has never been more complex and program innovation has never been more important, be sure to join your industry counterparts to drive adherence, access and commercialization forward.

Why attend the Copay, Reimbursement and Access Congress?

Keeping up with shifting market dynamics in the midst of maximizing access, while also meeting business objectives is a challenging task and brings about many questions for access professionals.

• Is your program sustainable and innovative to better support patients?
• Accumulators, maximizers, AFPs – What are your next steps to ensure effective reimbursement strategies?
• In an election year, what is the future of health policy?

Experts will tackle these questions and more as the industry comes together to benchmark best practices to accelerate access and commercialization. Do not miss your chance to join seasoned leaders, your peers and leading solution providers as they navigate marketplace trends and dive into the impact coupons, benefit design, accumulators, maximizers, alternative funding programs and drug pricing legislation have on patient affordability and out-of-pocket costs. This is your chance to gain critical insights on industry standards, forward-thinking strategies to optimize your copay and cost sharing programs and so much more.

Content highlights:

• Over 20 hours of content, including 7+ dedicated sessions to help decipher copay legislation
• Crucial perspectives from Pfizer, Sanofi, Janssen, Teva, Ascendis Pharma, Melinta Therapeutics, GSK, HIV + Hepatitis Policy Institute and more
• Insights direct from enforcement agents on the top trends and actions within the copay and patient services space
• Illuminating case study, Navigating the Patient Journey in a Shifting Copay Landscape from Spark Therapeutics
• 465 minutes of valuable in-person networking with colleagues and counterparts to expand your network and establish powerful partnerships
• Additional content access through Streamly, a platform that gives you 12-month access to all of the available conference content** to review at your leisure
• And more!

Download the agenda and register today—Be sure to use your exclusive promo USAVE24 to save 10% off* of your registration

See you there!

*Cannot be combined with other offers, promotions or applied to an existing registration. Other restrictions may apply.
**Pending speaker permissions

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The content of Sponsored Posts does not necessarily reflect the views of HMP Omnimedia, LLC, Drug Channels Institute, its parent company, or any of its employees. To find out how you can promote an event on Drug Channels, please contact Paula Fein (paula@DrugChannels.net).

Today’s guest post comes from Timothy Nielsen, Vice President of Customer Success at AssistRx.

Timothy discusses the affordability and patient journey challenges of specialty-lite products for patients, manufacturers, and health care providers. He explains how AssistRx's Advanced Access Anywhere (AAA) solution streamlines processes for specialty-lite products and facilitates enrollment via a digital hub.

To learn more, register for AssistRx's free webinar on October 8: Meet Your Patients Where They Are & Gain Visibility: Even at Retail.

Read on for Timothy’s insights.
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Today’s guest post comes from Greg Skalicky, President, EVERSANA and Faruk Abdullah, President, Professional Services & Chief Business Officer, EVERSANA

Greg and Faruk walk through the marketplace pressures driving Direct-to-Patient commercialization models. They argue that a technology-enabled infrastructure,  combined with clinical and reimbursement support specialists, can improve  patients' access to new therapies, shorten the time to therapy, and enable better overall clinical outcomes.

Click here to learn more about EVERSANA’s Direct-to-Patient care model.

Read on for Greg and Faruk’s insights.
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The New York legislature passed two bills on June 7, 2024 directed at children’s use of online technologies – the Stop Addictive Feeds Exploitation (SAFE) for Kids Act (S7694) that restricts access to addictive algorithmic feeds and the New York Child Data Protection Act (S7695) that bans sites from collecting, using, sharing or selling personal […]

Fort Health’s $5.5 million in funding was led by Twelve Below and Vanterra and included participation from Redesign Health, Blue Venture Fund and True Wealth Ventures.

The post Fort Health Secures $5.5M to Expand Access to Integrated Pediatric Mental Health Care appeared first on MedCity News.

Rogue Access Video - US

Gout as a Serious Health Issue

Researchers report that tap water access in densely populated neighborhoods of Delhi, India, is a strong predictor of the risk of contracting dengue.

Systematic review, based on 30 studies done on transgender issues in India from 2000 to 2019, reveals the problems faced by the transgenders in the country.

Access to a popular medlinkabortion pill/medlink will continue, as the US Supreme Court has ruled the drug can remain on the market while a lower court lawsuit is underway.

Colombo, December 10, 2013. At the request of the Colombo Municipal Council (CMC), the Central Environmental Authority (CEA), in collaboration with the International Water Management Institute (IWMI), organized a stakeholder meeting to discuss improvements that can be made to the management of municipal waste in the City of Colombo. The meeting was held at the […]

The post CEA partners with IWMI to improve Colombo’s municipal waste management and farmers’ access to organic fertilizers first appeared on International Water Management Institute (IWMI).

Actionable information from earth observation data will enable better water management for African governments, communities and companies.

The post IWMI project enables fast access to petabytes of analysis-ready water data in Africa first appeared on International Water Management Institute (IWMI).

New Campaign: Estrogen Therapy I.Q. (ETIQ) Kicks Off to Improve Access to Credible Facts About Menopause and Advances in

Three crucial actions have been suggested by global health authorities to reform regulations and ensure fair distribution of medical supplies during emergencies (!--ref1--).

Everyone could have access to clean energy within nine years if countries improve investments, according to new UN reports released. Annual investments

Medicaid telemedicine coverage is linked to meaningful growth in medlinktelemedicine/medlink use and increased healthcare access, according to a study

A draft recommendation aiming to eliminate Medicare funding for initial telehealth consultations with non-GP specialists is raising concerns about restricted

The Ministry of Health and Family Welfare delivered a compelling explanation on the pivotal role of Ayushman Bharat Health Accounts (ABHA) (!--ref1--)

The expansion of insurance coverage under the Affordable Care Act (ACA) correlated with a rise in patient admissions to accredited cancer hospitals in Pennsylvania (!--ref1--).

A survey of low-income adults in Arkansas, Kentucky, Louisiana, and Texas revealed that one in eight respondents who had enrolled in Medicaid at some

A new study finds that mandating mental and behavioral medlinkhealth insurance/medlink coverage for children significantly improves access to care.

The Indian mobile accessories market is set to explode owing to the exponential smartphone sales growth and domestic phone maker Intex aims to touch the Rs.100 crore mark.

The following is an overview of foods with high nutritional value which are generally affordable, accessible and have a longer shelf life.

Garena Free Fire Max Redeem Codes for October 31, 2024: Garena Free Fire Max codes can give you an edge over your opponents or to simply enhance your character's aesthetics. These codes can be used to get in-game items for free.

Embark on a gaming journey with Garena Free Fire MAX, a title that has become a staple in the Indian gaming community, especially after the ban of its predecessor. This battle royale game, known for its stunning graphics and engaging gameplay,

Embark on a thrilling gaming journey with Garena Free Fire MAX, a game that has become a household name among Indian gamers. Following the prohibition of its predecessor, Garena Free Fire, this battle royale game has climbed to the top of

Unlock the potential of Garena Free Fire Max with the Redeem Codes available on November 5, 2024. They grant you an upper hand against adversaries or allow you to customize your character's appearance with complimentary in-game items. These codes open doors

Sony has introduced the Chroma Collection accessories and a Fortnite Limited Edition DualSense wireless controller for PlayStation 5 users in India. These new offerings provide stylish customisation options with unique colours and designs, enhancing the gaming experience. The Chroma Collection features

Garena Free Fire Max Redeem Codes for November 7, 2024: Garena Free Fire Max codes can give you an edge over your opponents or to simply enhance your character's aesthetics. These codes can be used to get in-game items for free.

Embark on a gaming journey with Garena Free Fire MAX, a title that has become a staple in the Indian gaming community, especially after the ban of its predecessor. This battle royale game, known for its stunning graphics and engaging gameplay,

Embark on a thrilling gaming journey with Garena Free Fire MAX, a game that has become a household name among Indian gamers. Following the prohibition of its predecessor, Garena Free Fire, this battle royale game has climbed to the top of

Unlock the potential of Garena Free Fire Max with the Redeem Codes available on November 12, 2024. They grant you an upper hand against adversaries or allow you to customize your character's appearance with complimentary in-game items. These codes open doors

Free Airport Lounge Access Best Credit Cards List: एयरपोर्ट लाउंज एक्सेस क्रेडिट कार्ड को यात्रियों के लिए बनाया जाता है ताकि वह न सिर्फ सफर करें बल्कि एयरपोर्ट लाउंज का भी फायदा उठा सकें। ऐसे कई सारे क्रेडिट कार्ड हैं जिनमें

OpenAI is reportedly on track to launch its next AI model, codenamed "Orion," by December. Initially, OpenAI plans to provide early access to trusted partners like Microsoft, with a broader rollout anticipated later. Orion is expected to build on OpenAI's previous

Jewellery is the ultimate style weapon that instantly elevates your look from ho-hum to fab! You could pick any outfit to wear, the right accessories will boost your personality and add to sophistication. Acing up your jewellery styling can offer endless

Why Stride Ventures focuses on VC-backed loss-making companies