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Plasma N-Glycans as Emerging Biomarkers of Cardiometabolic Risk: A Prospective Investigation in the EPIC-Potsdam Cohort Study

OBJECTIVE

Plasma protein N-glycan profiling integrates information on enzymatic protein glycosylation, which is a highly controlled ubiquitous posttranslational modification. Here we investigate the ability of the plasma N-glycome to predict incidence of type 2 diabetes and cardiovascular diseases (CVDs; i.e., myocardial infarction and stroke).

RESEARCH DESIGN AND METHODS

Based on the prospective European Prospective Investigation of Cancer (EPIC)-Potsdam cohort (n = 27,548), we constructed case-cohorts including a random subsample of 2,500 participants and all physician-verified incident cases of type 2 diabetes (n = 820; median follow-up time 6.5 years) and CVD (n = 508; median follow-up time 8.2 years). Information on the relative abundance of 39 N-glycan groups in baseline plasma samples was generated by chromatographic profiling. We selected predictive N-glycans for type 2 diabetes and CVD separately, based on cross-validated machine learning, nonlinear model building, and construction of weighted prediction scores. This workflow for CVD was applied separately in men and women.

RESULTS

The N-glycan–based type 2 diabetes score was strongly predictive for diabetes risk in an internal validation cohort (weighted C-index 0.83, 95% CI 0.78–0.88), and this finding was externally validated in the Finland Cardiovascular Risk Study (FINRISK) cohort. N-glycans were moderately predictive for CVD incidence (weighted C-indices 0.66, 95% CI 0.60–0.72, for men; 0.64, 95% CI 0.55–0.73, for women). Information on the selected N-glycans improved the accuracy of established and clinically applied risk prediction scores for type 2 diabetes and CVD.

CONCLUSIONS

Selected N-glycans improve type 2 diabetes and CVD prediction beyond established risk markers. Plasma protein N-glycan profiling may thus be useful for risk stratification in the context of precisely targeted primary prevention of cardiometabolic diseases.




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Genetic Susceptibility Determines {beta}-Cell Function and Fasting Glycemia Trajectories Throughout Childhood: A 12-Year Cohort Study (EarlyBird 76)

OBJECTIVE

Previous studies suggested that childhood prediabetes may develop prior to obesity and be associated with relative insulin deficiency. We proposed that the insulin-deficient phenotype is genetically determined and tested this hypothesis by longitudinal modeling of insulin and glucose traits with diabetes risk genotypes in the EarlyBird cohort.

RESEARCH DESIGN AND METHODS

EarlyBird is a nonintervention prospective cohort study that recruited 307 healthy U.K. children at 5 years of age and followed them throughout childhood. We genotyped 121 single nucleotide polymorphisms (SNPs) previously associated with diabetes risk, identified in the adult population. Association of SNPs with fasting insulin and glucose and HOMA indices of insulin resistance and β-cell function, available from 5 to 16 years of age, were tested. Association analysis with hormones was performed on selected SNPs.

RESULTS

Several candidate loci influenced the course of glycemic and insulin traits, including rs780094 (GCKR), rs4457053 (ZBED3), rs11257655 (CDC123), rs12779790 (CDC123 and CAMK1D), rs1111875 (HHEX), rs7178572 (HMG20A), rs9787485 (NRG3), and rs1535500 (KCNK16). Some of these SNPs interacted with age, the growth hormone–IGF-1 axis, and adrenal and sex steroid activity.

CONCLUSIONS

The findings that genetic markers influence both elevated and average courses of glycemic traits and β-cell function in children during puberty independently of BMI are a significant step toward early identification of children at risk for diabetes. These findings build on our previous observations that pancreatic β-cell defects predate insulin resistance in the onset of prediabetes. Understanding the mechanisms of interactions among genetic factors, puberty, and weight gain would allow the development of new and earlier disease-management strategies in children.




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Association Between the Use of Antidepressants and the Risk of Type 2 Diabetes: A Large, Population-Based Cohort Study in Japan

OBJECTIVE

This study aimed to reveal the associations between the risk of new-onset type 2 diabetes and the duration of antidepressant use and the antidepressant dose, and between antidepressant use after diabetes onset and clinical outcomes.

RESEARCH DESIGN AND METHODS

In this large-scale retrospective cohort study in Japan, new users of antidepressants (exposure group) and nonusers (nonexposure group), aged 20–79 years, were included between 1 April 2006 and 31 May 2015. Patients with a history of diabetes or receipt of antidiabetes treatment were excluded. Covariates were adjusted by using propensity score matching; the associations were analyzed between risk of new-onset type 2 diabetes and the duration of antidepressant use/dose of antidepressant in the exposure and nonexposure groups by using Cox proportional hazards models. Changes in glycated hemoglobin (HbA1c) level were examined in groups with continuous use, discontinuation, or a reduction in the dose of antidepressants.

RESULTS

Of 90,530 subjects, 45,265 were in both the exposure and the nonexposure group after propensity score matching; 5,225 patients (5.8%) developed diabetes. Antidepressant use was associated with the risk of diabetes onset in a time- and dose-dependent manner. The adjusted hazard ratio was 1.27 (95% CI 1.16–1.39) for short-term low-dose and 3.95 (95% CI 3.31–4.72) for long-term high-dose antidepressant use. HbA1c levels were lower in patients who discontinued or reduced the dose of antidepressants (F[2,49] = 8.17; P < 0.001).

CONCLUSIONS

Long-term antidepressant use increased the risk of type 2 diabetes onset in a time- and dose-dependent manner. Glucose tolerance improved when antidepressants were discontinued or the dose was reduced after diabetes onset.




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Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study

OBJECTIVE

Coronary artery disease (CAD) is a major challenge in patients with type 2 diabetes (T2D). Coronary computed tomography angiography (CCTA) provides a detailed anatomic map of the coronary circulation. Proteomics are increasingly used to improve diagnostic and therapeutic algorithms. We hypothesized that the protein panel is differentially associated with T2D and CAD.

RESEARCH DESIGN AND METHODS

In CAPIRE (Coronary Atherosclerosis in Outlier Subjects: Protective and Novel Individual Risk Factors Evaluation—a cohort of 528 individuals with no previous cardiovascular event undergoing CCTA), participants were grouped into CAD (clean coronaries) and CAD+ (diffuse lumen narrowing or plaques). Plasma proteins were screened by aptamer analysis. Two-way partial least squares was used to simultaneously rank proteins by diabetes status and CAD.

RESULTS

Though CAD+ was more prevalent among participants with T2D (HbA1c 6.7 ± 1.1%) than those without diabetes (56 vs. 30%, P < 0.0001), CCTA-based atherosclerosis burden did not differ. Of the 20 top-ranking proteins, 15 were associated with both T2D and CAD, and 3 (osteomodulin, cartilage intermediate-layer protein 15, and HTRA1) were selectively associated with T2D only and 2 (epidermal growth factor receptor and contactin-1) with CAD only. Elevated renin and GDF15, and lower adiponectin, were independently associated with both T2D and CAD. In multivariate analysis adjusting for the Framingham risk panel, patients with T2D were "protected" from CAD if female (P = 0.007), younger (P = 0.021), and with lower renin levels (P = 0.02).

CONCLUSIONS

We concluded that 1) CAD severity and quality do not differ between participants with T2D and without diabetes; 2) renin, GDF15, and adiponectin are shared markers by T2D and CAD; 3) several proteins are specifically associated with T2D or CAD; and 4) in T2D, lower renin levels may protect against CAD.




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Inoreader mobile apps updated to support Automatic Night Mode, Microblogs, Sort by Magic and popularity indicators.

Hey, it’s been quite some time without updates on this front, but our latest updates to our Android and iOS…




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Get Free Local COVID-19 Alerts with Inoreader

Everyone is concerned as the novel Coronavirus spreads at rapid rates across all countries of the world. We believe every…




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How we made our Free COVID-19 Alerting System and how you can build your own for any topic

Ever since we launched our Free COVID-19 Alerting System, we’ve been continuously asked how we made it. In this blog…




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Convert Almost Any Webpage Into RSS Feed With Inoreader’s Web Feeds

So, you wanted to follow this nice website for new content, but it doesn’t have an RSS feed yet? Don’t…




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¿Se Están Cerrando las Puertas? Respuestas a la Migración Venezolana en América Latina y el Caribe

MPI llevó a cabo un seminario en línea para marcar el lanzamiento de: Un portal sobre Migración en América Latina y el Caribe; y un informe que examina los efectos de las políticas migratorias y de integración en 11 países en América Latina y el Caribe ante el aumento de la migración venezolana y nicaragüense.




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Expert Podcast: Understanding How English Learners Count in ESSA Reporting

This podcast features a discussion between MPI's Margie McHugh and Julie Sugarman about how to understand the varying composition of states' English Learner (EL) subgroup under ESSA, and why understanding these technical differences matters when making decisions about how ELs and schools are faring. They also talk about different groups of ELs: newcomers, students with interrupted formal education, and long-term ELs, and data collection around these different cohorts.




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Expert Podcast: Meeting Seasonal Labor Needs in the Age of COVID-19

Governments are facing urgent pandemic-related questions. One of the more pressing ones: Who is going to harvest crops in countries that rely heavily on seasonal foreign workers? In this podcast, MPI experts examine ways in which countries could address labor shortages in agriculture, including recruiting native-born workers and letting already present seasonal workers stay longer. Catch an interesting discussion as border closures have halted the movement of seasonal workers even as crops are approaching harvest in some places.




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A Study of Pregnancy and Birth Outcomes among African-Born Women Living in Utah

Resettled African refugee women may experience particularly acute complications during pregnancy, birth, and the child's early infancy. Yet health care-providers and policymakers may not be aware of the particular challenges that these women and their children face. This report, examining women giving birth in Utah over a seven-year period, compares perinatal complications of the African born and a segment of the U.S. born.




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Diabetes Self-management Education and Support in Type 2 Diabetes: A Joint Position Statement of the American Diabetes Association, the American Association of Diabetes Educators, and the Academy of Nutrition and Dietetics

Margaret A. Powers
Apr 1, 2016; 34:70-80
Position Statements




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Therapeutic Inertia is a Problem for All of Us

Stephen Brunton
Apr 1, 2019; 37:105-106
Editorials




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Opportunities and Challenges for Biosimilars: What's on the Horizon in the Global Insulin Market?

Lisa S. Rotenstein
Oct 1, 2012; 30:138-150
Features




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Baseball and Linguistic Uncertainty

In my youth I played an inordinate amount of baseball, collected baseball cards, and idolized baseball players. I've outgrown all that but when I'm in the States during baseball season I do enjoy watching a few innings on the TV.

So I was watching a baseball game recently and the commentator was talking about the art of pitching. Throwing a baseball, he said, is like shooting a shotgun. You get a spray. As a pitcher, you have to know your spray. You learn to control it, but you know that it is there. The ball won't always go where you want it. And furthermore, where you want the ball depends on the batter's style and strategy, which vary from pitch to pitch for every batter.

That's baseball talk, but it stuck in my mind. Baseball pitchers must manage uncertainty! And it is not enough to reduce it and hope for the best. Suppose you want to throw a strike. It's not a good strategy to aim directly at, say, the lower outside corner of the strike zone, because of the spray of the ball's path and because the batter's stance can shift. Especially if the spray is skewed down and out, you'll want to move up and in a bit.

This is all very similar to the ambiguity of human speech when we pitch words at each other. Words don't have precise meanings; meanings spread out like the pitcher's spray. If we want to communicate precisely we need to be aware of this uncertainty, and manage it, taking account of the listener's propensities.

Take the word "liberal" as it is used in political discussion.

For many decades, "liberals" have tended to support high taxes to provide generous welfare, public medical insurance, and low-cost housing. They advocate liberal (meaning magnanimous or abundant) government involvement for the citizens' benefit.

A "liberal" might also be someone who is open-minded and tolerant, who is not strict in applying rules to other people, or even to him or herself. Such a person might be called "liberal" (meaning advocating individual rights) for opposing extensive government involvement in private decisions. For instance, liberals (in this second sense) might oppose high taxes since they reduce individuals' ability to make independent choices. As another example, John Stuart Mill opposed laws which restricted the rights of women to work (at night, for instance), even though these laws were intended to promote the welfare of women. Women, insisted Mill, are intelligent adults and can judge for themselves what is good for them.

Returning to the first meaning of "liberal" mentioned above, people of that strain may support restrictions of trade to countries which ignore the health and safety of workers. The other type of "liberal" might tend to support unrestricted trade.

Sending out words and pitching baseballs are both like shooting a shotgun: meanings (and baseballs) spray out. You must know what meaning you wish to convey, and what other meanings the word can have. The choice of the word, and the crafting of its context, must manage the uncertainty of where the word will land in the listener's mind.


Let's go back to baseball again.

If there were no uncertainty in the pitcher's pitch and the batter's swing, then baseball would be a dreadfully boring game. If the batter knows exactly where and when the ball will arrive, and can completely control the bat, then every swing will be a homer. Or conversely, if the pitcher always knows exactly how the batter will swing, and if each throw is perfectly controlled, then every batter will strike out. But which is it? Whose certainty dominates? The batter's or the pitcher's? It can't be both. There is some deep philosophical problem here. Clearly there cannot be complete certainty in a world which has some element of free will, or surprise, or discovery. This is not just a tautology, a necessary result of what we mean by "uncertainty" and "surprise". It is an implication of limited human knowledge. Uncertainty - which makes baseball and life interesting - is inevitable in the human world.

How does this carry over to human speech?

It is said of the Wright brothers that they thought so synergistically that one brother could finish an idea or sentence begun by the other. If there is no uncertainty in what I am going to say, then you will be bored with my conversation, or at least, you won't learn anything from me. It is because you don't know what I mean by, for instance, "robustness", that my speech on this topic is enlightening (and maybe interesting). And it is because you disagree with me about what robustness means (and you tell me so), that I can perhaps extend my own understanding.

So, uncertainty is inevitable in a world that is rich enough to have surprise or free will. Furthermore, this uncertainty leads to a process - through speech - of discovery and new understanding. Uncertainty, and the use of language, leads to discovery.

Isn't baseball an interesting game?




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Jabberwocky. Or: Grand Unified Theory of Uncertainty???


Jabberwocky, Lewis Carroll's whimsical nonsense poem, uses made-up words to create an atmosphere and to tell a story. "Billig", "frumious", "vorpal" and "uffish" have no lexical meaning, but they could have. The poem demonstrates that the realm of imagination exceeds the bounds of reality just as the set of possible words and meanings exceeds its real lexical counterpart.

Uncertainty thrives in the realm of imagination, incongruity, and contradiction. Uncertainty falls in the realm of science fiction as much as in the realm of science. People have struggled with uncertainty for ages and many theories of uncertainty have appeared over time. How many uncertainty theories do we need? Lots, and forever. Would we say that of physics? No, at least not forever.

Can you think inconsistent, incoherent, or erroneous thoughts? I can. (I do it quite often, usually without noticing.) For those unaccustomed to thinking incongruous thoughts, and who need a bit of help to get started, I can recommend thinking of "two meanings packed into one word like a portmanteau," like 'fuming' and 'furious' to get 'frumious' or 'snake' and 'shark' to get 'snark'.

Portmanteau words are a start. Our task now is portmanteau thoughts. Take for instance the idea of a 'thingk':

When I think a thing I've thought,
I have often felt I ought
To call this thing I think a "Thingk",
Which ought to save a lot of ink.

The participle is written "thingking",
(Which is where we save on inking,)
Because "thingking" says in just one word:
"Thinking of a thought thing." Absurd!

All this shows high-power abstraction.
(That highly touted human contraption.)
Using symbols with subtle feint,
To stand for something which they ain't.

Now that wasn't difficult: two thoughts at once. Now let those thoughts be contradictory. To use a prosaic example: thinking the unthinkable, which I suppose is 'unthingkable'. There! You did it. You are on your way to a rich and full life of thinking incongruities, fallacies and contradictions. We can hold in our minds thoughts of 4-sided triangles, parallel lines that intersect, and endless other seeming impossibilities from super-girls like Pippi Longstockings to life on Mars (some of which may actually be true, or at least possible).

Scientists, logicians, and saints are in the business of dispelling all such incongruities, errors and contradictions. Banishing inconsistency is possible in science because (or if) there is only one coherent world. Belief in one coherent world and one grand unified theory is the modern secular version of the ancient monotheistic intuition of one universal God (in which saints tend to believe). Uncertainty thrives in the realm in which scientists and saints have not yet completed their tasks (perhaps because they are incompletable). For instance, we must entertain a wide range of conflicting conceptions when we do not yet know how (or whether) quantum mechanics can be reconciled with general relativity, or Pippi's strength reconciled with the limitations of physiology. As Henry Adams wrote:

"Images are not arguments, rarely even lead to proof, but the mind craves them, and, of late more than ever, the keenest experimenters find twenty images better than one, especially if contradictory; since the human mind has already learned to deal in contradictions."

The very idea of a rigorously logical theory of uncertainty is startling and implausible because the realm of the uncertain is inherently incoherent and contradictory. Indeed, the first uncertainty theory - probability - emerged many centuries after the invention of the axiomatic method in mathematics. Today we have many theories of uncertainty: probability, imprecise probability, information theory, generalized information theory, fuzzy logic, Dempster-Shafer theory, info-gap theory, and more (the list is a bit uncertain). Why such a long and diverse list? It seems that in constructing a logically consistent theory of the logically inconsistent domain of uncertainty, one cannot capture the whole beast all at once (though I'm uncertain about this).

A theory, in order to be scientific, must exclude something. A scientific theory makes statements such as "This happens; that doesn't happen." Karl Popper explained that a scientific theory must contain statements that are at risk of being wrong, statements that could be falsified. Deborah Mayo demonstrated how science grows by discovering and recovering from error.

The realm of uncertainty contains contradictions (ostensible or real) such as the pair of statements: "Nine year old girls can lift horses" and "Muscle fiber generates tension through the action of actin and myosin cross-bridge cycling". A logically consistent theory of uncertainty can handle improbabilities, as can scientific theories like quantum mechanics. But a logical theory cannot encompass outright contradictions. Science investigates a domain: the natural and physical worlds. Those worlds, by virtue of their existence, are perhaps coherent in a way that can be reflected in a unified logical theory. Theories of uncertainty are directed at a larger domain: the natural and physical worlds and all imaginable (and unimaginable) other worlds. That larger domain is definitely not coherent, and a unified logical theory would seem to be unattainable. Hence many theories of uncertainty are needed.

Scientific theories are good to have, and we do well to encourage the scientists. But it is a mistake to think that the scientific paradigm is suitable to all domains, in particular, to the study of uncertainty. Logic is a powerful tool and the axiomatic method assures the logical consistency of a theory. For instance, Leonard Savage argued that personal probability is a "code of consistency" for choosing one's behavior. Jim March compares the rigorous logic of mathematical theories of decision to strict religious morality. Consistency between values and actions is commendable says March, but he notes that one sometimes needs to deviate from perfect morality. While "[s]tandard notions of intelligent choice are theories of strict morality ... saints are a luxury to be encouraged only in small numbers." Logical consistency is a merit of any single theory, including a theory of uncertainty. However, insisting that the same logical consistency apply over the entire domain of uncertainty is like asking reality and saintliness to make peace.




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We're Just Getting Started: A Glimpse at the History of Uncertainty


We've had our cerebral cortex for several tens of thousands of years. We've lived in more or less sedentary settlements and produced excess food for 7 or 8 thousand years. We've written down our thoughts for roughly 5 thousand years. And Science? The ancient Greeks had some, but science and its systematic application are overwhelmingly a European invention of the past 500 years. We can be proud of our accomplishments (quantum theory, polio vaccine, powered machines), and we should worry about our destructive capabilities (atomic, biological and chemical weapons). But it is quite plausible, as Koestler suggests, that we've only just begun to discover our cerebral capabilities. It is more than just plausible that the mysteries of the universe are still largely hidden from us. As evidence, consider the fact that the main theories of physics - general relativity, quantum mechanics, statistical mechanics, thermodynamics - are still not unified. And it goes without say that the consilient unity of science is still far from us.

What holds for science in general, holds also for the study of uncertainty. The ancient Greeks invented the axiomatic method and used it in the study of mathematics. Some medieval thinkers explored the mathematics of uncertainty, but it wasn't until around 1600 that serious thought was directed to the systematic study of uncertainty, and statistics as a separate and mature discipline emerged only in the 19th century. The 20th century saw a florescence of uncertainty models. Lukaczewicz discovered 3-valued logic in 1917, and in 1965 Zadeh introduced his work on fuzzy logic. In between, Wald formulated a modern version of min-max in 1945. A plethora of other theories, including P-boxes, lower previsions, Dempster-Shafer theory, generalized information theory and info-gap theory all suggest that the study of uncertainty will continue to grow and diversify.

In short, we have learned many facts and begun to understand our world and its uncertainties, but the disputes and open questions are still rampant and the yet-unformulated questions are endless. This means that innovations, discoveries, inventions, surprises, errors, and misunderstandings are to be expected in the study or management of uncertainty. We are just getting started. 




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Review Article – Within a single lifetime: Recent writings on autism

AHP readers will be interested in a review article now available online from History of the Human Sciences “Within a single lifetime: Recent writings on autism.” Written by Gregory Hollin the piece reviews five recent books on autism.




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Forthcoming in JHBS: Quêtelet on Deviance, McClelland on Leadership, Psychological Warfare, and More

A number of articles now in press at the Journal of the History of the Behavioral Sciences will be of interest to AHP readers. Full details below. “Uncovering the metaphysics of psychological warfare: The social science behind the Psychological Strategy Board’s operations planning, 1951–1953,” Gabrielle Kemmis. Abstract: In April 1951 president Harry S. Truman established … Continue reading Forthcoming in JHBS: Quêtelet on Deviance, McClelland on Leadership, Psychological Warfare, and More




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Forthcoming HOPOS Special Issue on Descriptive Psychology and Völkerpsychologie

Two pieces forthcoming in a special issue of HOPOS, the official journal of the International Society for the History of Philosophy of Science, will be of interest to AHP readers. The special issue, “Descriptive Psychology and Völkerpsychologie—in the Contexts of Historicism, Relativism, and Naturalism,” is guest-edited by Christian Damböck, Uljana Feest, and Martin Kusch. Full details … Continue reading Forthcoming HOPOS Special Issue on Descriptive Psychology and Völkerpsychologie




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May HoP, including a Special Section: Who Was Little Albert? The Historical Controversy

Photographs of John Watson (left) and Rosalie Rayner (right) via Ben Harris. The May 2020 issue of History of Psychology is now online. The issue includes a special section on “Who Was Little Albert? The Historical Controversy.” Full details follow below. Special Section: Who Was Little Albert? The Historical Controversy“Journals, referees, and gatekeepers in the … Continue reading May HoP, including a Special Section: Who Was Little Albert? The Historical Controversy




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Forthcoming in HHS: Homosexual Aversion Therapy, Comte on Organism-Environment Relationships

Two forthcoming pieces in History of the Human Sciences may be of interest to AHP readers. Full details below. “Cold War Pavlov: Homosexual aversion therapy in the 1960s,” by Kate Davison. Abstract: Homosexual aversion therapy enjoyed two brief but intense periods of clinical experimentation: between 1950 and 1962 in Czechoslovakia, and between 1962 and 1975 … Continue reading Forthcoming in HHS: Homosexual Aversion Therapy, Comte on Organism-Environment Relationships




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Seeking Participants for a Study on How COVID-19 is Affecting Sex and Relationships

The COVID-19 coronavirus pandemic is causing a number of societal changes that are new to nearly all of us, with governments around the world locking down cities and countries in an attempt to slow the spread of the virus. This situation is pushing some people together, but pulling others apart—and we’ve never seen anything quite like it in the modern era. Countless media articles have been written about the ways in which this is affecting people’s sex lives and relationships; however, most of them are purely speculative. This led some of my colleagues at the Kinsey Institute and I to wonder what’s really happening—and we’ve designed a study to help us better understand how emergency situations like this affect people’s sexual and romantic lives, which may help us to better plan and prepare for similar events in the future.



  • Professional Issues in Psychology

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How Do You Help a Partner Who is Depressed? Advice From a Sex Therapist

Depression is one of the most common mental health issues in the United States. In fact, according to the National Institutes of Mental Health, 1 in 14 Americans experienced an episode of major depression in the last year alone. Given the circumstances surrounding the current COVID-19 coronavirus pandemic, many in the mental health community predict that the number will be even higher this year because these circumstances are creating a “perfect storm” of depression risks. The widespread prevalence of depression has a lot of implications for our lives, even if we don’t personally have depression ourselves. Many of us will have loved ones, such as a romantic partner, who develops depression at some point. In these situations, it’s common for people to wonder how they can help their partner most effectively. So what should they do?




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The gender-fluid history of the Philippines | France Villarta

In much of the world, gender is viewed as binary: man or woman, each assigned characteristics and traits designated by biological sex. But that's not the case everywhere, says France Villarta. In a talk that's part cultural love letter, part history lesson, he details the legacy of gender fluidity and inclusivity in his native Philippines -- and emphasizes the universal beauty of all people, regardless of society's labels.




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How to create meaningful connections while apart | Priya Parker

Author Priya Parker shares tools for creating meaningful connections with friends, family and coworkers during the coronavirus pandemic -- and shows how we can take advantage of gatherings that are unique to this moment of social distancing. "We don't necessarily need to gather more," she says. "We need to gather better." (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded March 27, 2020)




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How forgiveness can create a more just legal system | Martha Minow

Pardons, commutations and bankruptcy laws are all tools of forgiveness within the US legal system. Are we using them frequently enough, and with fairness? Law professor Martha Minow outlines how these merciful measures can reinforce racial and economic inequality -- and makes the case for creating a system of restorative justice that focuses on accountability and reconciliation rather than punishment.




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It's OK to feel overwhelmed. Here's what to do next | Elizabeth Gilbert

If you're feeling anxious or fearful during the coronavirus pandemic, you're not alone. Offering hope and understanding, author Elizabeth Gilbert reflects on how to stay present, accept grief when it comes and trust in the strength of the human spirit. "Resilience is our shared genetic inheritance," she says. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and head of curation Helen Walters. Recorded April 2, 2020)




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In uncertain times, think like a mother | Yifat Susskind

There's a simple and powerful way to confront the world's most pressing crises, says women's rights activist Yifat Susskind: think like a mother. As she puts it: "When you think like a mother, you prioritize the needs of the many, not the whims of the few." Follow along as she shares moving stories of people around the world who embody this mindset -- and shows how it can also help you see beyond suffering and act to build a better world.




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An ethical plan for ending the pandemic and restarting the economy | Danielle Allen

As COVID-19 continues to spread, the world is facing two existential threats at once: a public health emergency and an economic crisis. Political theorist Danielle Allen describes how we can ethically and democratically address both problems by scaling up "smart testing," which would track positive cases with peer-to-peer software on people's cell phones -- so we can end the pandemic and get back to work. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and business curator Corey Hajim. Recorded April 6, 2020)




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How to co-parent as allies, not adversaries | Ebony Roberts and Shaka Senghor

When Shaka Senghor and Ebony Roberts ended their relationship, they made a pact to protect their son from its fallout. What resulted was a poetic meditation on what it means to raise a child together, yet apart. In this moving and deeply personal talk, Senghor and Roberts share their approach to co-parenting -- an equal, active partnership that rolls with the punches and revels in the delights of guiding their child through the world with thought and intention.




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An ode to living on Earth | Oliver Jeffers

If you had to explain to a newborn what it means to be a human being living on Earth in the 21st century, what would you say? Visual artist Oliver Jeffers put his answer in a letter to his son, sharing pearls of wisdom on existence and the diversity of life. He offers observations of the "beautiful, fragile drama of human civilization" in this poetic talk paired with his original illustrations and animations.




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Crisis support for the world, one text away | Nancy Lublin

What if we could help people in crisis anytime, anywhere with a simple text message? That's the idea behind Crisis Text Line, a free 24-hour service that connects people in need with trained, volunteer crisis counselors -- "strangers helping strangers around the world, like a giant global love machine," as cofounder and CEO Nancy Lublin puts it. Learn more about their big plans to expand to four new languages, providing a third of the globe with crucial, life-saving support. (This ambitious plan is a part of the Audacious Project, TED's initiative to inspire and fund global change.)




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Professorship in decision making at Wharton, Operations, Information and Decisions (OID), University of Pennsylvania

APPLICATION DEADLINE OCTOBER 15, 2019 The Operations, Information and Decisions Department at the Wharton School is seeking applicants for a full-time, tenure track, Assistant Professor faculty position in the area of decision-making. Our decision-making faculty is comprised of scholars with a diverse set of backgrounds and interests, and we encourage applicants with degrees in economics, […]

The post Professorship in decision making at Wharton, Operations, Information and Decisions (OID), University of Pennsylvania appeared first on Decision Science News.




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57th Edwards Bayesian Research Conference, Feb 27-29, 2020, Fullerton, CA

SUBMISSION DEADLINE DECEMBER 13, 2019 In this conference, investigators present original research on a variety of topics related to judgment and decision making, including but not limited to: Decision making under risk, uncertainty, and ambiguity Intertemporal choice Cognitive models of judgment and decision making Mathematical and statistical methodology for analyzing behavioral data Applications of JDM […]

The post 57th Edwards Bayesian Research Conference, Feb 27-29, 2020, Fullerton, CA appeared first on Decision Science News.




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How visualizing inferential uncertainty can mislead readers about treatment effects in scientific results

STANDARD ERRORS VS STANDARD DEVIATIONS Click to enlarge There’s an ancient haiku that goes: People confuse a well-estimated mean with a certain outcome Ok, that’s not true. But Jake Hofman, Dan Goldstein, and Jessica Hullman have a new paper (recently accepted at CHI 2020) about this. They bet you’ll think the results of their paper […]

The post How visualizing inferential uncertainty can mislead readers about treatment effects in scientific results appeared first on Decision Science News.




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Teenagers Who Believe They Are Particularly Intelligent Tend To Be More Narcissistic And Happier With Life

By Emily Reynolds. But self-assessed intelligence was not actually related to objective measures of intelligence




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ESSA Forces Uncomfortable Conversations in Massachusetts Over School Spending

Relying on newly available data under ESSA, a local advocacy group found several districts that spend more money on wealthy students than poor students, despite the state's intentions.




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Educational Opportunities and Performance in Massachusetts

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.




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Massachusetts Ranks Second on Quality Counts Annual Report Card

The state, which earned a B-plus, led the nation in K-12 achievement rankings and outperformed other states in several key academic indicators, but fell short on funding equity.




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This State Leads the Pack in Nurturing Most Students. Can It Help the Rest?

Massachusetts ranks high in laying the groundwork for moving through its educational system, but officials are keenly aware that children in poverty, those with special needs, and English-learners can fall short.




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Educational Opportunities and Performance in Massachusetts

This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.




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N.C. High Court Hears Case on Who's in Charge of K-12

Arguments before North Carolina's supreme court centered on whether lawmakers overstepped by giving more authority to the state's elected superintendent and taking it away from the state school board.




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Online Charter Schools in North Carolina Petition to Go From Pilot to Permanent

The state's two virtual charter schools have earned poor marks from the state's accountability system in the few years they've been operating.




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North Carolina Teachers Turn Out in Droves for Daylong Protest

A sea of red-clad teachers took to the streets around North Carolina's legislative building in Raleigh to fight for higher pay and more school funding. See photos from the event.




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Utah Ruling Highlights Sticky Issue of Partisan School Board Elections

In Florida, Indiana, Kansas, North Carolina, Tennessee and Utah, Republicans are arguing that candidates for local and state school boards should run on party tickets.




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Educational Opportunities and Performance in North Carolina

This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.




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Elementary School Teachers in North Carolina Turn Attention to Cursive Writing

Cursive writing is experiencing a resurgence of sorts in North Carolina elementary schools thanks to a state law that was passed in 2013.




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Betsy DeVos Greenlights ESSA Plans for Nebraska and North Carolina

U.S. Ed Secretary DeVos has approved plans for 46 states, plus the District of Columbia and Puerto Rico. Still waiting: California, Florida, Oklahoma, and Utah.